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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19814 results in Negative / Null Result Report · page 130 of 661

Negative / Null Result ReportNeuroscience

How does Stroop interference change with practice? A reappraisal from the musical Stroop paradigm.

Laurent Grégoire, Pierre Perruchet, Bénédicte Poulin-Charronnat · 2014 · Journal of Experimental Psychology Learning Memory and Cognition

Most earlier studies investigating the evolution of the Stroop effect with the amount of reading practice have reported data consistent with an inverted U-shaped curve, whereby the Stroop effect appears early during reading acquisition,…

View details →DOI: 10.1037/xlm0000044Cited by 12
Negative / Null Result ReportOpen accessMaterials Science

Significant effect on annealing temperature and enhancement on structural, optical and electrical properties of zinc oxide nanowires

Suriati Paiman, T. Hui Ling, M. Husham et al. · 2020 · Results in Physics

This paper focused on the growth of zinc oxide nanowires on unannealed and annealed indium tin oxide-coated-coated glass substrates on the structural, optical, and electrical properties towards surface acoustic wave (SAW) piezoelectric…

View details →DOI: 10.1016/j.rinp.2020.103185Cited by 12
Negative / Null Result ReportOpen accessMedicine

A cross-sectional study to assess response generated by ChatGPT and ChatSonic to patient queries about Epilepsy

Aditya Kumar Gudimella Tirumala, Shubham Mishra, Nritya Trivedi et al. · 2023 · Telematics and Informatics Reports

This article presents a study comparing the responses of two AI chatbots, ChatGPT and ChatSonic, regarding inquiries about epilepsy. Overall, ChatGPT and ChatSonic are very similar in terms of their capabilities and limitations and they…

View details →DOI: 10.1016/j.teler.2023.100110Cited by 12
Negative / Null Result ReportOpen accessMedicine

A Single Dose of Baicalin Has No Clinically Significant Effect on the Pharmacokinetics of Cyclosporine A in Healthy Chinese Volunteers

Ruijuan Liu, Xia Li, Jingyao Wei et al. · 2019 · Frontiers in Pharmacology

Despite its narrow therapeutic window and large inter-individual variability, cyclosporine A (CsA) is the first-line therapy following organ transplantation. Metabolized mainly by CYP3A and being a substrate of P-glycoprotein (P-gp), CsA is susceptible to drug-drug interactions. Baicalin (BG) is a drug used for adjuvant therapy of hepatitis in traditional Chinese medicine. Since its aglycone Baicalein (B) inhibits CYP3A and P-gP, co-administration might affect CsA pharmacokinetics. This study investigated the effect of BG on CsA pharmacokinetics. In a two-period study, 16 healthy volunteers re

View details →DOI: 10.3389/fphar.2019.00518Cited by 12
Negative / Null Result ReportMedicine

Biomimetic Human Lung Alveolar Interstitium Chip with Extended Longevity

Kun Man, Jiafeng Liu, Cindy Liang et al. · 2023 · ACS Applied Materials & Interfaces

Determining the mechanistic causes of lung diseases, developing new treatments thereof, and assessing toxicity whether from chemical exposures or engineered nanomaterials would benefit significantly from a preclinical human lung alveolar…

View details →DOI: 10.1021/acsami.3c04091Cited by 12
Negative / Null Result ReportOpen accessEngineering

Functional evaluation of a real-time EMG controlled prosthetic hand

Amlan Jyoti Kalita, Maibam Pooya Chanu, Nayan M. Kakoty et al. · 2025 · Wearable Technologies

Electromyogram (EMG)-controlled prosthetic hands have advanced significantly during the past two decades. However, most of the currently available prosthetic hands fail to replicate human hand functionality and controllability. To measure the emulation of the human hand by a prosthetic hand, it is important to evaluate the functional characteristics. Moreover, incorporating feedback from end users during clinical testing is crucial for the precise assessment of a prosthetic hand. The work reported in this manuscript unfolds the functional characteristics of an EMG-CoNtrolled PRosthetIC Hand ca

View details →DOI: 10.1017/wtc.2025.7Cited by 12
Negative / Null Result ReportOpen accessPsychology

Testing the Magnitude of Correlations Across Experimental Conditions

Simone Di Plinio · 2022 · Frontiers in Psychology

Correlation coefficients are often compared to investigate data across multiple research fields, as they allow investigators to determine different degrees of correlation to independent variables. Even with adequate sample size, such differences may be minor but still scientifically relevant. To date, although much effort has gone into developing methods for estimating differences across correlation coefficients, adequate tools for variable sample sizes and correlational strengths have yet to be tested. The present study evaluated four different methods for detecting the difference between two

View details →DOI: 10.3389/fpsyg.2022.860213Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

The (alleged) consequences of affective polarization: A survey experiment in nine democracies

Eelco Harteveld, Lars Erik Berntzen, Andrej Kokkonen et al. · 2026 · European Journal of Political Research

Abstract Affective polarization (or antipathy between supporters of opposing political camps) is considered a threat to societal cohesion and democratic stability worldwide. However, causal evidence of its impact remains scarce, especially outside the United States. Our study examines the individual-level consequences of affective polarization by manipulating it in a survey experiment in nine countries (Brazil, France, Germany, Italy, Poland, Spain, Sweden, the United Kingdom, and the United States; N ≈ 18,000) and subsequently assessing the downstream consequences for social avoidance and dis

View details →DOI: 10.1017/s1475676526101273Cited by 12
Negative / Null Result ReportOpen accessEnvironmental Science

Predicting microbial community structure and temporal dynamics by using graph neural network models

Kasper Skytte Andersen, Kai Zhao, Alexander de Linde Agerskov et al. · 2025 · Nature Communications

Understanding species-level abundance dynamics in complex microbial communities is key to managing microbial ecosystems, yet it remains a major challenge. In wastewater treatment plants (WWTPs), the presence and abundance of…

View details →DOI: 10.1038/s41467-025-64175-7Cited by 12
Negative / Null Result ReportOpen accessEngineering

Hybrid combinations of graphene nanoplatelet, carbon nanotube, and carbon black for tailored mechanical and triboelectric properties in polypropylene fibers

Yue Cheng, Jian Wang, Mingwang Shao et al. · 2025 · Advanced Composites and Hybrid Materials

Hybrid polymer composites with carbon fillers are of great interest for applications requiring specific mechanical, electrical, and thermal properties. However, studies on hybrid polymer composite fiber (HPCF) with multiple carbon fillers…

View details →DOI: 10.1007/s42114-025-01341-xCited by 12
Negative / Null Result ReportOpen accessEnvironmental Science

Determining sources of groundwater salinity in the multi-layered aquifer system of the bengal delta, Bangladesh

Anwar Zahid, Md. Aminur Rahman, M. Rashidul Hassan et al. · 2026 · BRAC University Journal

The study area lies on the coastal belt of the Bengal Delta, southern Bangladesh. This study bas been condocted to deteonine salinity sources in the multi-layered aquifers of the Bengal Delta. Dissolved major ions including chloride (Cr) and brontide (Br) were measured in groundwater of the coastal areas of Bangladesh to assess the source(s) of salinity. Ionic concentrations of 48 groundwater samples were analyzed for this study; samples were collected from observation wells installed at different depths down to 336 m. The major ion trends of the upper (<200 m deep) Sodium (Na')-Chloride (C

View details →DOI: 10.64501/tg9bbj82Cited by 12
Negative / Null Result ReportOpen accessMedicine

Central adiposity indices and inflammatory markers mediate the association between life’s crucial 9 and periodontitis in US adults

Jia-Jie Guo, Qi-Qi Hang, Ting Xu et al. · 2025 · Lipids in Health and Disease

BACKGROUND: Periodontitis, a chronic inflammatory disease, is closely linked to cardiovascular health. While Life's Essential 8 (LE8) evaluates cardiovascular metrics, recent recommendations suggest incorporating psychological health (PHQ-9) to form Life's Crucial 9 (LC9). However, evidence regarding the utility of LC9 in periodontal disease remains limited. METHODS: We analyzed data from 7,674 adults in the 2009-2014 NHANES cycles. LC9 scores were calculated by integrating LE8 and PHQ-9 metrics, then categorized into quartiles. The association between LC9 and periodontitis was examined using

View details →DOI: 10.1186/s12944-025-02619-1Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

Sustaining Exposure to Fact-Checks: Misinformation Discernment, Media Consumption, and Its Political Implications

Jeremy Bowles, Kevin Croke, Horacio Larreguy et al. · 2025 · American Political Science Review

Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to durably reduce susceptibility to misinformation, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. Sustained exposure to these fact-checks induced substantial internalization of fact-checked content, while increasing participants’ ability to discern new political and health misinformation upon

View details →DOI: 10.1017/s0003055424001394Cited by 12
Negative / Null Result ReportOpen accessMedicine

Parents perception of weight status of Mexican preschool children using different tools

M.a Cruces Souto-Gallardo, Arturo Jiménez–Cruz, Montserrat Bacardí‐Gascón · 2026 · Archivos Latinoamericanos de Nutrición

The aim of this study was to evaluate the ability of parents to estimate the weight status of preschool children attending the Instituto Mexicano del Seguro Social (IMSS) day-care centers using three different tools. A total of 100…

View details →DOI: 10.37527/2011.61.4.007Cited by 12
Negative / Null Result ReportOpen accessMedicine

Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial

Atul Malhotra, R GRUNSTEIN, Ali Azarbarzin et al. · 2026 · Nature Medicine

Obstructive sleep apnea (OSA) is associated with obesity and cardiovascular risk. The SURMOUNT-OSA master protocol comprised two, 52-week, randomized, double-blind, placebo-controlled phase 3 studies (study 1 and study 2) and demonstrated…

View details →DOI: 10.1038/s41591-025-04071-1Cited by 12
Negative / Null Result ReportOpen accessMaterials Science

Machine Learning Methodologies Applied to Magnetocaloric Perovskites Discovery

Luis E. Castro-Anaya, Eduardo Marese, Jaime A. Lozano et al. · 2025 · Journal of Chemical Information and Modeling

High Resolution Image Download MS PowerPoint Slide Traditionally, designing novel materials involves exploring new compositions guided by insights from previous work, relying on a trial-and-error approach, where continuous synthesis and characterization proceed until the properties meet the improvements. This method is inefficient due to the challenges of exploring vast chemical spaces. In this study, a machine-learning-based methodology is developed to assist the design from available data in the literature, allowing us to test in silico more than 1.2 million compositions. Two databases with

View details →DOI: 10.1021/acs.jcim.4c01944Cited by 12
Negative / Null Result ReportOpen accessPhysics and Astronomy

Very Bright, Very Blue, and Very Red: JWST CAPERS Analysis of Highly Luminous Galaxies with Extreme Ultraviolet Slopes at z = 10

Callum T. Donnan, Mark Dickinson, Anthony J. Taylor et al. · 2025 · The Astrophysical Journal

Abstract We present JWST/NIRSpec PRISM observations of three luminous ( M UV < −20) galaxies at z ∼ 10 observed with the CANDELS-Area Prism Epoch of Reionization Survey (CAPERS) Cycle 3 program. These galaxies exhibit extreme UV slopes compared to typical galaxies at z = 10. Of the three sources, two of them are a close pair (0 . ″ 22) of blue galaxies at z = 9.800 ± 0.003 and z = 9.808 ± 0.002 with UV slopes of β = −2.87 ± 0.15 and β = −2.46 ± 0.10, respectively, selected from PRIMER COSMOS NIRCam imaging. We perform spectrophotometric modeling of the galaxies, which suggests extre

View details →DOI: 10.3847/1538-4357/ae0a1fCited by 12
Negative / Null Result ReportOpen accessSocial Sciences

Media consolidation and news content quality

Marcel Garz, Märt Ots · 2025 · Journal of Communication

Abstract News organizations have been under financial pressure to streamline their activities for decades. Critics argue that this pressure undermines the quality of news, posing a severe threat to democracy. However, the effects of media consolidation on news quality are theoretically ambiguous and empirical evidence is scarce. To address this gap, we study the case of the Swedish newspaper industry between 2014 and 2022, a period where more than half of the country’s newspapers changed their owners. We collect over 2 million articles from 108 newspapers and apply state-of-the-art computation

View details →DOI: 10.1093/joc/jqae053Cited by 12
Negative / Null Result ReportOpen accessMaterials Science

Understanding shell coating effects to overcome quenching in single anisotropic upconversion nanoparticles

Yangjian Cai, Ming Lu, Xian Qin et al. · 2025 · Nature Communications

Shell coating is known to suppress luminescence quenching in spherical upconversion nanoparticles. However, the emergence of anisotropic nanoparticles with facet-selective, directional growth complicates the coating process, and the use of…

View details →DOI: 10.1038/s41467-025-60347-7Cited by 12
Negative / Null Result ReportOpen accessSocial Sciences

Women’s environmental quality of life is key to their overall quality of life and health: Global evidence from the WHOQOL-100

Suzanne M. Skevington, Kara Schick‐Makaroff, Christine Rowland et al. · 2024 · PLoS ONE

Gender inequalities in health-related quality of life (QoL) are generally few and small, even in large surveys. Many generic measures limit assessment to QoL overall and its physical and psychological dimensions, while overlooking internationally important environmental, social, and spiritual QoL domains. Unique cross-cultural legacy data was collected using four WHOQOL-100 surveys of adults living in 43 cultures world-wide (17,608 adults; ages 15-101). It was first used to examined gender profiles of its five QoL international domains, and their component facets. Few significant gender differ

View details →DOI: 10.1371/journal.pone.0310445Cited by 12
Negative / Null Result ReportOpen accessMedicine

Genetic predictors of GLP1 receptor agonist weight loss and side effects

Qiaojuan Jane Su, James R. Ashenhurst, Wanwan Xu et al. · 2026 · Nature

The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity. However, substantial inter-person variability exists in both…

View details →DOI: 10.1038/s41586-026-10330-zCited by 12
Negative / Null Result ReportOpen accessPhysics and Astronomy

Orbital Eccentricity in a Neutron Star–Black Hole Merger

Gonzalo Morrás, G. Pratten, P. Schmidt · 2026 · The Astrophysical Journal Letters

Abstract The observation of gravitational waves (GWs) from merging black holes and neutron stars provides a unique opportunity to discern information about their astrophysical environment. Two signatures that are considered powerful tracers to distinguish between different binary formation channels are general relativistic spin-induced orbital precession and orbital eccentricity. Both effects leave characteristic imprints in the GW signal that can be extracted from observations. To date, neither precession nor eccentricity has been confidently discerned in merging neutron star–black hole binar

View details →DOI: 10.3847/2041-8213/ae474cCited by 12
Negative / Null Result ReportOpen accessNeuroscience

Quantitative and Qualitative Exploration of Meaningful Change on the Vineland Adaptive Behavior Scales (Vineland™-II) in Children and Adolescents with Autism Without Intellectual Disability Following Participation in a Clinical Trial

Susanne Clinch, Stacie Hudgens, Elizabeth Gibbons et al. · 2023 · Patient Related Outcome Measures

Purpose: Adaptive Behavior Scale is often used in autism spectrum disorder (ASD) trials. The Adaptive Behavior Composite Score (VABS-ABC) is the standardized overall score (the average of the Socialization, Communication and Daily Living…

View details →DOI: 10.2147/prom.s385542Cited by 12
Negative / Null Result ReportImmunology and Microbiology

Characterization of newly revealed sequences in the infectious myonecrosis virus genome in Litopenaeus vannamei

Duan S. Loy, Bradley J. Blitvich, John Dustin Loy et al. · 2015 · Journal of General Virology

Infectious myonecrosis virus (IMNV) causes significant economic losses in farmed shrimp, where associated mortality in ponds can reach 70 %. To explore host/pathogen interactions, a next-generation sequencing approach using lymphoid organ…

View details →DOI: 10.1099/vir.0.000137Cited by 12
Negative / Null Result ReportOpen accessMedicine

Ilixadencel, a Cell-based Immune Primer, plus Sunitinib Versus Sunitinib Alone in Metastatic Renal Cell Carcinoma: A Randomized Phase 2 Study

Magnus Lindskog, Anna Laurell, Anders Kjellman et al. · 2022 · European Urology Open Science

Background: The prognosis of patients with synchronous metastatic renal cell carcinoma (mRCC) is poor. Whereas single-agent tyrosine kinase inhibition (TKI) is clearly insufficient, the effects can be enhanced by combinations with immune checkpoint inhibitors. Innovative treatment options combining TKI and other immune-stimulating agents could prove beneficial. Objective: To evaluate the clinical effects on metastatic disease when two doses of allogeneic monocyte-derived dendritic cells (ilixadencel) are administrated intratumorally followed by nephrectomy and treatment with sunitinib compared

View details →DOI: 10.1016/j.euros.2022.03.012Cited by 12
Negative / Null Result ReportOpen accessMedicine

High-sensitivity troponin I with or without ultra-sensitive copeptin for the instant rule-out of acute myocardial infarction

Fabrizio Ricci, Franz–Josef Neumann, Nicole Rübsamen et al. · 2022 · Frontiers in Cardiovascular Medicine

Background The instant, single-sampling rule-out of acute myocardial infarction (AMI) is still an unmet clinical need. We aimed at testing and comparing diagnostic performance and prognostic value of two different single-sampling biomarker strategies for the instant rule-out of AMI. Methods From the Biomarkers in Acute Cardiac Care (BACC) cohort, we recruited consecutive patients with acute chest pain and suspected AMI presenting to the Emergency Department of the University Medical Center Hamburg-Eppendorf, Hamburg, Germany. We compared safety, effectiveness and 12-month incidence of the comp

View details →DOI: 10.3389/fcvm.2022.895421Cited by 12
Negative / Null Result ReportOpen accessMedicine

<p>Effects of early administration of insulin-like growth factor-1 on cognitive function in septic encephalopathy</p>

Yang� Yang, Shengru Liang, Yuqian Li et al. · 2019 · Neuropsychiatric Disease and Treatment

BACKGROUND: Both protective and therapeutic functions of insulin-like growth factor-1 (IGF-1) in brain injury have been reported, but its effects on cognitive sequelae after septic encephalopathy (SE) remain unclear. MATERIALS AND METHODS:…

View details →DOI: 10.2147/ndt.s190845Cited by 12
Negative / Null Result ReportOpen accessNursing

The Impact of Higher Protein Intake in Patients with Prolonged Mechanical Ventilation

Shih‐Wei Huang, Horng‐Chyuan Lin, Yu-Feng Chou et al. · 2022 · Nutrients

Prolonged mechanical ventilation (PMV) is associated with poor outcomes and a high economic cost. The association between protein intake and PMV has rarely been investigated in previous studies. This study aimed to investigate the impact of protein intake on weaning from mechanical ventilation. Patients with the PMV (mechanical ventilation ≥6 h/day for ≥21 days) at our hospital between December 2020 and April 2022 were included in this study. Demographic data, nutrition records, laboratory data, weaning conditions, and survival data were retrieved from the patient’s electronic medical records.

View details →DOI: 10.3390/nu14204395Cited by 12
Negative / Null Result ReportComputer Science

Significant Association Rule Mining with High Associability

Subrata Datta, Kalyani Mali · 2021

Traditional support-confidence framework based association rule mining approaches often generate huge number of rules including the insignificant ones. These insignificant association rules are useless in knowledge discovery. One of the…

View details →DOI: 10.1109/iciccs51141.2021.9432237Cited by 12
Negative / Null Result ReportOpen accessMedicine

Impact of Pancreatic Resection on Survival in Locally Advanced Resectable Gastric Cancer

Shih-Chun Chang, Chi-Ming Tang, Puo‐Hsien Le et al. · 2021 · Cancers

Whether gastric adenocarcinoma (GC) patients with adjacent organ invasion (T4b) benefit from aggressive surgery involving pancreatic resection (PR) remains unclear. This study aimed to clarify the impact of PR on survival in patients with locally advanced resectable GC. Between 1995 and 2017, patients with locally advanced GC undergoing radical-intent gastrectomy with and without PR were enrolled and stratified into four groups: group 1 (G1), pT4b without pancreatic resection (PR); group 2 (G2), pT4b with PR; group 3 (G3), positive duodenal margins without Whipple’s operation; and group 4 (G4)

View details →DOI: 10.3390/cancers13061289Cited by 12