A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19814 results in Negative / Null Result Report · page 126 of 661
Jing Luo, Zheng Dong, Hui Xie et al. · 2022 · Liver International
BACKGROUND & AIMS: Management of elderly patients with hepatocellular carcinoma (HCC) has become a major concern. Some data suggest that cryoablation improves the outcomes of elderly patients with HCC, but its efficacy and safety remain…
Mo Sadique, Sapna Ratan Shah, Sunil Kumar Sharma et al. · 2023 · Mathematics
Synovial joints are unique biological tribo-systems that allow for efficient mobility. Most of the synovial joint activities in the human body are accomplished due to the presence of synovial fluid. As a biological lubricant, synovial…
Qihan Ma, Jianbo Wang, Ming Xiong et al. · 2023 · Remote Sensing
The lockdowns from the coronavirus disease of 2019 (COVID-19) have led to a reduction in anthropogenic activities and have hence reduced primary air pollutant emissions, which were reported to have helped air quality improvements. However,…
Filiz Cebeci, Nahide Onsun, Ayşe Pekdemir et al. · 2013 · The Scientific World JOURNAL
BACKGROUND: Behcet's disease (BD) could be regarded as an autoimmune disease in many aspects. Autoimmune thyroid disease (ATD) is frequently accompanied by other various autoimmune diseases. Nevertheless, there is not still enough data showing the association between BD and ATD. In addition, no controlled study is present in the PubMed, which evaluates thyroidal autoimmunity using antithyroid peroxidase antibody in a large series of patients with BD. METHODS: We aimed to investigate the frequency of ATD in patients with BD. The study included 124 patients with BD and 99 age- and sex-matched he
Iván Chérrez-Ojeda, Emanuel Vanegas, Valeria L. Mata et al. · 2019 · Allergy Asthma and Clinical Immunology
Little is known about the association of urticarial vasculitis (UV) with thyroid autoimmunity. The latter has been mostly described in the setting of patients with chronic spontaneous urticaria (CSU). In this letter to the editor, we compare UV and CSU through retrospective analyses, which reveal that 41.7% patients with UV presented antithyroperoxidase (anti-TPO) and/or antithyroglobulin antibody (ATA) above the reference range, while only 4% patients with CSU had these antibodies elevated. There is a moderately strong association assessed by the Phi coefficient (φ = 0.420, p = 0.004). Furthe
S.F. Hall, R. Griffiths · 2016 · Current Oncology
Background: For oncologists and for patients, no site-specific clinical trial evidence has emerged for the use of concurrent chemotherapy with radiotherapy (ccrt) over radiotherapy (rt) alone for cancer of the hypopharynx (hpc) or for…
Marlene Grillon, Andy Wai Kan Yeung · 2022 · Healthcare
In this digital era, dental students often search for online resources for self-directed learning. YouTube is one of the most commonly sought online platforms for educational or instructional videos. No prior study has examined the…
Yasin Gholiee, Sadegh Salehzadeh, Shiva Khodaveisi · 2019 · New Journal of Chemistry
It is shown that while none of the E 5 n (E = Si, Ge, Sn, Pb; n = 0, 2−, 4−) bare clusters can be stabilized in planar pentagon ( D 5h ) geometry, E 5 4− ions as a five-membered planar ring form stable complexes with two {M(CO) 3 } (M =…
Jana Uhlinova, Anne Kuudeberg, Kaja Metsküla et al. · 2022 · BMC Nephrology
INTRODUCTION: Chronic kidney disease-mineral and bone disorders (CKD-MBD) is characterised by generalised vascular calcification (VC) and impaired bone health. We aimed to investigate the relationship between VC and bone mineral density (BMD) in CKD patients. METHODS: We performed a cross-sectional study of patients with different stages of CKD. For assessment of VC of abdominal aorta lateral lumbar X-rays (Kauppila score), the ankle-brachial index (ABI) and echocardiography were used. Total body densitometry provided BMD. RESULTS: Ninety patients (41% male, median age 64 years (range 29-87))
Jurriaan J. Mes, Diederik Esser, Dianne Somhorst et al. · 2022 · Plant Foods for Human Nutrition
Abstract The growing world population will increase the demand for new sustainable foods and ingredients. Here we studied the safety and tolerance of Lemna minor, a new sustainable vegetable crop from the duckweed family. Twenty-four…
Grayson C. Petter, Ryan C. Hickox, David M. Alexander et al. · 2022 · The Astrophysical Journal
Abstract The observed optical colors of quasars are generally interpreted in one of two frameworks: unified models that attribute the color to the random orientation of the accretion disk along the line of sight, and evolutionary models…
Josephine Terry, Jia Hoong Ong, Paola Escudero · 2015 · ICPhS
Distributional learning studies investigating the acquisition of the Dutch contrast /ɑ/-/a:/ by nonnative Dutch learners have reported mixed results. The present study extends the literature by examining whether (i) naive listeners are…
Sandra Waaijenborg, Oksana Korobko, Ko Willems van Dijk et al. · 2018 · PLoS ONE
Combining different metabolomics platforms can contribute significantly to the discovery of complementary processes expressed under different conditions. However, analysing the fused data might be hampered by the difference in their quality. In metabolomics data, one often observes that measurement errors increase with increasing measurement level and that different platforms have different measurement error variance. In this paper we compare three different approaches to correct for the measurement error heterogeneity, by transformation of the raw data, by weighted filtering before modelling
Tiago Pereira, Ana María Abreu, Alexandre Castro‐Caldas · 2013 · Perceptual and Motor Skills
This study aimed to assess how the capacity to acquire, form and consolidate motor memories might vary across different tasks and different groups (with and without motor expertise). 20 athletes and 21 non-athletes were tested on five…
Minh Tam Thi BUI, Trinh Quang Long · 2021 · Journal of risk and financial management
This paper identifies whether there was a performance difference among micro, small and medium enterprises (MSMEs) led by men and by women in Vietnam during the period 2005–2013 and aims to provide explanations for the differences, if any, in various performance indicators. The paper adopts a quantitative approach using a firm-level panel dataset in the manufacturing sector in 10 provinces/cities in Vietnam in five waves from 2005 to 2013. Fixed effect models are estimated to examine the influence of firm variables and demographic, human capital characteristics of owners/managers on firms’ val
Shuo Li, Peiliang Cong, Demei Yu et al. · 2019 · Transportation Research Record Journal of the Transportation Research Board
High friction surface treatment (HFST) has been proactively used as a solution to extreme friction demands at locations such as horizontal curves, ramps, bridge decks, and intersections. Considerable efforts have been made to evaluate the…
Peter Hagell, Stephen S. Smith · 2013 · Journal of Huntington s Disease
BACKGROUND: The carer impact of neurodegenerative disorders such as Huntington's disease (HD) is vast. Attempts to measure carer QoL in neurodegenerative disorders include the three-dimensional (Practical aspects of Caregiving, PC;…
William Hedén · 2016 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
The recent increase of smart meters in the residential sector has lead to large available datasets. The electricity consumption of individual households can be accessed in close to real time, and allows both the demand and supply side to…
Su Woong Jung, Won-Hee Cho, Jung-Woo Seo et al. · 2022 · The Journal of Infectious Diseases
BACKGROUND: Urine exosomal bkv-miR-B1-5p is associated with BK virus (BKV) nephropathy (BKVN); however, its posttransplantation changes and predictability for BKVN have not been determined in kidney transplant recipients (KTRs). METHODS:…
Patrick Royer, Elias Björnson, Martin Adiels et al. · 2024 · American Heart Journal
BACKGROUND AND AIMS: Recent developments in high-throughput proteomic technologies enable the discovery of novel biomarkers of coronary atherosclerosis. The aims of this study were to test if plasma protein subsets could detect coronary artery calcifications (CAC) in asymptomatic individuals and if they add predictive value beyond traditional risk factors. METHODS: Using proximity extension assays, 1,342 plasma proteins were measured in 1,827 individuals from the Impaired Glucose Tolerance and Microbiota (IGTM) study and 883 individuals from the Swedish Cardiopulmonary BioImage Study (SCAPIS)
Sabiq Muhtadi, Rezwana R. Razzaque, Ahmad Chowdhury et al. · 2023 · Journal of Medical Imaging
Purpose: We evaluate texture quantified from ultrasound Nakagami parametric images for non-invasive characterization of breast tumors, as Nakagami images can more faithfully represent intrinsic tumor characteristics than standard B-mode…
Jan Walter Benjamins, Ming Wai Yeung, Teemu Maaniitty et al. · 2021 · International Journal of Cardiology
BACKGROUND: Standard computed tomography angiography (CTA) outputs a myriad of interrelated variables in the evaluation of suspected coronary artery disease (CAD). But an important proportion of obstructive lesions does not cause significant myocardial ischemia. Nowadays, machine learning (ML) allows integration of numerous variables through complex interdependencies that optimize classification and prediction at the individual level. We evaluated ML performance in integrating CTA and clinical variables to identify patients that demonstrate myocardial ischemia through PET and those who ultimat
Amy D. Herschell, David J. Kolko, Ashley T. Scudder et al. · 2021 · Journal of Clinical Child & Adolescent Psychology
OBJECTIVE: This study (NIMH RO1 MH095750; ClinicalTrials.gov Identifier: NCT02543359) evaluated the effectiveness of three training models to implement a well-established evidence-based treatment, Parent-Child Interaction Therapy (PCIT).…
Angkana T. Huang, Henrik Salje, Ana Coello Escoto et al. · 2022 · PLoS Pathogens
Neutralizing antibodies are important correlates of protection against dengue. Yet, determinants of variation in neutralization across strains within the four dengue virus serotypes (DENV1-4) is imperfectly understood. Studies focus on structural DENV proteins, especially the envelope (E), the primary target of anti-DENV antibodies. Although changes in immune recognition (antigenicity) are often attributed to variation in epitope residues, viral processes influencing conformation and epitope accessibility also affect neutralizability, suggesting possible modulating roles of nonstructural prote
Sofonyas Abebaw Tiruneh, Daniel L. Rolnik, Helena Teede et al. · 2025 · Computers in Biology and Medicine
BACKGROUND: Pre-eclampsia (PE) contributes to more than one-fourth of all maternal deaths and half a million newborn deaths worldwide every year. Early screening and interventions can reduce PE incidence and related complications. We aim to 1) temporally validate three existing models (two machine learning (ML) and one logistic regression) developed in the same region and 2) compare the performances of the validated ML models with the logistic regression model in PE prediction. This work addresses a gap in the literature by undertaking a comprehensive evaluation of existing risk prediction mod
Nicole Stegmeier, Sameer R. Oak, Colin O’Rourke et al. · 2017 · Sports Health: A Multidisciplinary Approach
Background: Two versions of the International Knee Documentation Committee (IKDC) Subjective Knee Evaluation form currently exist: the original version (1999) and a recently modified pediatric-specific version (2011). Comparison of the…
A. Ross Otto · 2010 · Cognitive Science
Abstract Cunha and Caldieraro (2009) investigated whether sunk‐cost effects, which are well documented in hypothetical situations involving monetary investments, also occur in choice situations with purely behavioral investments. Their…
Fatih Kuzu · 2018 · Pakistan Journal of Medical Sciences
Background & Objectives: In diabetics, cardiac microvascular circulation disorder increases the risk of arrhythmia and sudden cardiac death. Tpeak-Tend (Tp-e) interval, Tp-e dispersion, and Tp-e/QT and Tp-e/QTc ratios measured by surface…
Akiko Ioka, Masami Inoue, Akihiro Yoneda et al. · 2015 · Journal of Epidemiology
BACKGROUND: In 2004, the Japanese government halted the 6-month mass screening program for neuroblastoma. We investigated whether its cessation had led to an increase not only in mortality due to this disease but also in the incidence of advanced-stage disease among older children. METHODS: Study subjects were neuroblastoma patients retrieved from the population-based Osaka Cancer Registry. Trends of incidence and mortality from neuroblastoma were analyzed by calendar year and birth cohort. Prognostic factors, including stage and v-myc avian myelocytomatosis viral oncogene neuroblastoma derive
K. Lance Gould, Nils P. Johnson, Amanda E. Roby et al. · 2025 · European Heart Journal
BACKGROUND AND AIMS: The randomized CENTURY trial tested the hypothesis that a comprehensive strategy integrating intense lifestyle modification and aggressive medical management to goals with revascularization reserved for severely reduced coronary flow capacity (CFC) by positron emission tomography (PET) would reduce risk factors, subsequent revascularization, death and myocardial infarction (MI) compared with standard of care in chronic stable coronary artery disease (CAD). METHODS: Participants were randomly assigned to standard or comprehensive care groups. Rest-stress PET quantified CFC