A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19808 results in Negative / Null Result Report · page 114 of 661
Kohei Ohnishi, Yuma Ono, Tatsuya Nomura et al. · 2014 · Scientific Reports
Abstract The combination between the spin-dependent and super-conducting (SC) transports is expected to provide intriguing properties such as crossed Andreev reflection and spin-triplet superconductivity. This may be able to open a new…
Endre Willassen, Jon-Ivar Westgaard, Jon Anders Kongsrud et al. · 2022 · PeerJ
To protect and restore ecosystems and biodiversity is one of the 10 challenges identified by the United Nations’s Decade of the Ocean Science. In this study we used eDNA from sediments collected in two fjords of the Svalbard archipelago…
Nikola Hrabovska, Erik Kajati, Iveta Zolotova · 2023 · Electronics
This research article presents an analysis of health data collected from wearable devices, aiming to uncover the practical applications and implications of such analyses in personalized healthcare. The study explores insights derived from…
Michael K. Urban, Kristy M. Labib, Shane C. Reid et al. · 2018 · HSS Journal®: The Musculoskeletal Journal of Hospital for Special Surgery
Background The treatment of postoperative pain is a challenge after posterior spinal fusions. Pain management using predominantly opioids is often associated with multiple adverse effects, while multimodal postoperative analgesia may…
Cécile Barbet, Guillaume Thierry · 2016 · Frontiers in Psychology
In sentence verification tasks involving under-informative statements such as Some elephants are mammals, some adults appear more tolerant to pragmatic violations than others. The underlying causes of such inter-individual variability remain however essentially unknown. Here, we investigated inter-individual variation in adults deriving the scalar inference "not all" triggered by the quantifier some. We first assessed the individual intolerance to pragmatic violations in adult participants presented with under-informative some-statements (e.g., Some infants are young). We then recorded event-r
Rebecca Hun Ping Cheung, Magdalena Mo Ching Mok · 2018 · Creativity Research Journal
Previous studies have suggested that teacher’s personality traits and pedagogy are the important areas of investigation in creativity research; however, little is known about the relationship between teachers’ personality traits and…
Christopher A. Wolters, Marcia A. Barnes, Paulina A. Kulesz et al. · 2016 · The Journal of Educational Research
The authors' purpose was to examine adolescents' reading motivation in relation to standardized assessments of reading comprehension and fluency. After a reading pretest, 60 ninth-grade students (M age = 14.9 years) were randomly assigned…
Sakae Konishi, Shingo Hatakeyama, Atsushi Imai et al. · 2020 · LUTS Lower Urinary Tract Symptoms
OBJECTIVES: To evaluate the effect of overactive bladder (OAB) and frailty on indoor fall events in community-dwelling adults aged 50 or older. METHODS: We conducted a cross-sectional study involving 723 adults between 2016 and 2017 in…
Pengcheng Niu, Wenya Li, Z. Zhang et al. · 2016 · Science and Technology of Welding & Joining
A 30–40 μm thick oxide layer was prefabricated on the top, butt or bottom surfaces of AA2024 sheets by micro-arc oxidation, which were then friction stir welded. Sheets without oxide layer were also welded with blowing oxygen along the…
Alice Foucart, Holly P. Branigan, Ellen Gurman Bard · 2010 · Journal of Experimental Psychology Learning Memory and Cognition
Determiner selection requires the retrieval of the noun's syntactic features (e.g., gender) and sometimes of its phonological features. Miozzo and Caramazza (1999) argued that the selection of determiners in Germanic languages is more…
Chen Xing, Fei Liu, Bin Wang et al. · 2019 · Journal of Climate
Abstract We analyzed global surface air temperature (SAT) responses to five major tropical volcanic eruptions from 1870 to 2005 using outputs from 97 historical and 58 Atmospheric Model Intercomparison Project (AMIP) runs that participated…
Mark Nieuwenstein, Hedderik van Rijn · 2012 · Judgment and Decision Making
Abstract According to the deliberation without attention (DWA) hypothesis, people facing a difficult choice will make a better decision after a period of distraction than after an equally long period of conscious deliberation, an effect…
Kayla M. Quinnies, Paul J. Bonthuis, Erin P. Harris et al. · 2015 · Biology of Sex Differences
BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh sex differences in rat hippocampus. In mice, circulating estradiol increases Gh mRNA in female but not in male medial preoptic area (mPOA); therefore, additional factors regulate sexually dimorphic Gh expression in the brain. Thus, we hypothesized that sex chromosomes interact with estradiol to promote sex differences in GH. Here, we as
Ludmila Pawlikowska, Jeffrey Nelson, Diana E. Guo et al. · 2018 · Molecular Genetics & Genomic Medicine
BACKGROUND: Hereditary hemorrhagic telangiectasia (HHT) is caused by mutations in TGFβ/BMP9 pathway genes and characterized by vascular malformations (VM) including arteriovenous malformations (AVM) in lung, liver, and brain, which lead to severe complications including intracranial hemorrhage (ICH) from brain VM. The clinical heterogeneity of HHT suggests a role for genetic modifier effects. Common variants in loci that modify phenotype severity in Tgfb knockout mice were previously reported as associated with lung AVM in HHT. Common variants in candidate genes were reported as associated wit
Liang He, Janne Pitkäniemi, Kauko Heikkilä et al. · 2016 · Brain and Behavior
BACKGROUND: Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time-to-event genome-wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date. METHODS: We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages o
Paul Montgomery, Thees F. Spreckelsen, Alice Burton et al. · 2018 · PLoS ONE
BACKGROUND: Omega-3 fatty acids are central to brain-development of children. Evidence from clinical trials and systematic reviews demonstrates the potential of long-chain Omega-3 supplementation for learning and behavior. However, findings are inconclusive and in need of robust replication studies since such work is lacking. OBJECTIVES: Replication of the 2012 DOLAB 1 study findings that a dietary supplementation with the long-chain omega-3 docosahexaenoic acid (DHA) had beneficial effects on the reading, working memory, and behavior of healthy schoolchildren. DESIGN: Parallel group, fixed-do
Caitlin E. Hill, Danika M. Brodak, Mary Bartlett Bunge · 2012 · Journal of Neurotrauma
Several recent studies suggest that predegenerated nerves (PDNs) or dissociated PDNs (dPDNs) can improve behavioral and histological outcomes following transplantation into the injured rat spinal cord. In the current study we tested the…
Roberta Marino, Viola Tanganelli, Annalisa Pietrobelli et al. · 2020 · American Journal of Physical Anthropology
OBJECTIVES: Sex estimation in subadult skeletal remains is still considered highly problematic. The aim of this research is to test the reliability of the method of subadult sex assessment proposed by Luna and co-workers in 2017, based on…
Toby Prike, Phoebe Blackley, Briony Swire‐Thompson et al. · 2023 · Cognitive Research Principles and Implications
Corrections are a frequently used and effective tool for countering misinformation. However, concerns have been raised that corrections may introduce false claims to new audiences when the misinformation is novel. This is because boosting the familiarity of a claim can increase belief in that claim, and thus exposing new audiences to novel misinformation-even as part of a correction-may inadvertently increase misinformation belief. Such an outcome could be conceptualized as a familiarity backfire effect, whereby a familiarity boost increases false-claim endorsement above a control-condition or
Hieab H.H. Adams, Vincentius J.A. Verlinden, Michele L. Callisaya et al. · 2015 · The Journals of Gerontology Series A
Human gait is a complex neurological and musculoskeletal function, of which the genetic basis remains largely unknown. To determine the influence of common genetic variants on gait parameters, we studied 2,946 participants of the Rotterdam…
Olga Stavrova, Lena Haarmann · 2019 · Motivation and Emotion
Abstract Although perceptions of subjective well-being (SWB) in unacquainted others have been shown to play a major role in impression formation, little is known about how accurate such perceptions are. In two original studies and one pre-registered replication, we explored the accuracy of life satisfaction and happiness judgments from texts and its underlying mechanisms (use of linguistic cues). Participants filled in life satisfaction and happiness measures and completed a brief writing task. Another sample of participants judged the targets’ life satisfaction and happiness from the obtained
Saranya Chitturi, Venkata Gopich, Talatam et al. · 2013 · Der pharmacia lettre
Recently, many studies have been oriented towards improving methods and efficiency of recovery from different fruit industry wastes. The investigations carried out were mainly aimed at evaluating Pectin content, Protease activity, Protein…
Burney, Saira, Muhammad Wasif Saif, Saif, Muhammad Wasif et al. · 2013 · PubMed
CONTEXT: Pancreatic cancer is the fourth leading cause of cancer mortality in the United States. Most of the patients are diagnosed in the metastatic staging. Consolidated risk factors include chronic pancreatitis, smoking and family…
Ivan Antonov, Andrey V. Marakhonov, Maria A. Zamkova et al. · 2018 · Journal of Bioinformatics and Computational Biology
The discovery of thousands of long noncoding RNAs (lncRNAs) in mammals raises a question about their functionality. It has been shown that some of them are involved in post-transcriptional regulation of other RNAs and form inter-molecular…
Hui Shi, Christopher Medway, James M. Bullock et al. · 2010 · PubMed
We have performed cross-platform comparisons of output from 4 GWAS in late-onset Alzheimer's disease (LOAD) - Reiman et al., 2007; Li et al., 2008; Beecham et al., 2008 and Carrasquillo et al., 2009 to search for new association signals.…
Joe M. Bridges · 2024 · Diagnosis
OBJECTIVES: Validate the diagnostic accuracy of the Artificial Intelligence Large Language Model ChatGPT4 by comparing diagnosis lists produced by ChatGPT4 to Isabel Pro. METHODS: This study used 201 cases, comparing ChatGPT4 to Isabel Pro. Systems inputs were identical. Mean Reciprocal Rank (MRR) compares the correct diagnosis's rank between systems. Isabel Pro ranks by the frequency with which the symptoms appear in the reference dataset. The mechanism ChatGPT4 uses to rank the diagnoses is unknown. A Wilcoxon Signed Rank Sum test failed to reject the null hypothesis. RESULTS: Both systems p
Andrew Mowat, Michael Crompton, Joanna L. Ziff et al. · 2018 · Human Genetics
Otosclerosis is a common form of hearing loss which typically presents in young adults. The disease has a familial, monogenic form and a non-familial form with a more complex aetiology. A previous genome wide association study identified evidence that variants within RELN are associated with the condition. Other genes in which an association has been reported include BMP2, COL1A1, FGF2, PPP2R5B and TGFB1. However, follow up studies have often failed to replicate initial positive results. The aim of this study was to establish if an association exists between eight single nucleotide polymorphis
Sadek Ahmed, Osama Saher, Heba Attia et al. · 2026 · Frontiers in Pharmacology
Introduction: Vaginal candidiasis remains a recurrent fungal infection affecting millions of women worldwide, necessitating innovative local delivery systems to overcome poor drug solubility and mucosal barriers. This study introduces Dual-Functional Hybrid Cationic PEGylated Proniosomes (DHCPP) as a smart nano-platform designed to boost the vaginal delivery of Fenticonazole Nitrate (FTN). Methods: DHCPP systems were fabricated via the coacervation phase separation method and optimized using a full 2 3 factorial design, achieving a high desirability value of 0.931. The optimized DHCPP exhibite
Jialin Fan, Yunpeng Xu · 2026 · Frontiers in Genetics
Dietary restriction (DR), defined as reduced caloric intake or selective limitation of specific nutrients without malnutrition, is one of the most robust interventions known to extend lifespan and healthspan across species. Studies from yeast to mammals demonstrate that DR elicits conserved genetic, transcriptional, and epigenetic programs that promote cellular maintenance and stress resistance. At the molecular level, DR engages evolutionarily conserved nutrient-sensing pathways, including insulin/IGF-1 signaling (IIS), the mechanistic target of rapamycin (mTOR), AMP-activated protein kinase
Galina Stoyancheva, Nikolina Mihaylova, Maria Gerginova et al. · 2025 · International Journal of Molecular Sciences
The human endometrium, previously considered a sterile environment, is now recognized as a low-biomass but biologically active microbial niche critical to reproductive health. Advances in sequencing technologies, particularly shotgun metagenomics, have provided unprecedented insights into the taxonomic and functional complexity of the endometrial microbiome. While 16S rRNA sequencing has delineated the distinction between Lactobacillus-dominant and non-dominant microbial communities, shotgun metagenomics has revealed additional diversity at the species and strain level, uncovering microbial si