Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Michael Rabbia, Maitea Guridi Ormazabal, Hannah Staunton et al. · 2024 · Journal of Neuromuscular Diseases
Background: Stride Velocity 95th Centile (SV95C) is the first wearable device-derived clinical outcome assessment (COA) to receive European Medicines Agency (EMA) qualification as a primary endpoint in ambulant patients with Duchenne muscular dystrophy (DMD) aged ≥4 years. Objective: To compare SV95C-in its first-ever clinical trial application as a secondary endpoint-with established motor function COAs used in the trial (Four-Stair Climb [4SC] velocity, North Star Ambulatory Assessment [NSAA], and Six-Minute Walk Distance [6MWD]). Methods: SV95C was a secondary endpoint in a subset (n = 47)
View details →DOI: 10.3233/jnd-230188Cited by 17 Negative / Null Result ReportOpen accessSocial Sciences
Sofia Ammassari, Duncan McDonnell, Annika Werner et al. · 2026 · European Journal of Political Research
Abstract Do young women and men join political parties for different reasons? To investigate, we theorize the following: first, women will be more attracted by social incentives and men by material ones, while purposive incentives will be…
View details →DOI: 10.1017/s1475676526100978Cited by 17 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Atif Mahmood, Asad Mehmood, Simone Terzani et al. · 2025 · Management Decision
Purpose The environmental, social and governance (ESG) topic has recently received increasing attention from scholars due to increasing regulations for firms’ non-financial disclosure with respect to environmental and social issues. For instance, the European Union (EU) recently issued the Corporate Sustainability Reporting Directive (CSRD) in December 2022 and implemented it starting in 2024 in member states. Non-financial disclosure is relevant for various stakeholders and could affect firm value. Therefore, this study aims to examine the effect of ESG disclosure on firm value in the EU cont
View details →DOI: 10.1108/md-10-2024-2480Cited by 17 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Enrique Rozengurt, G. Eibl · 2026 · Signal Transduction and Targeted Therapy
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease for which there is no effective treatment. A deep understanding of the mechanisms underlying the molecular pathogenesis, signaling pathways and risk factors leading to PDAC is of paramount importance for identifying novel targets, prognostic markers, preventive strategies, and signature markers for use in specific and personalized therapeutic procedures. Activating somatic mutations in the KRAS oncogene play a critical role in PDAC initiation and maintenance. Here, we highlight the complex interplay between KRAS signaling, the tr
View details →DOI: 10.1038/s41392-025-02499-yCited by 17 Negative / Null Result ReportOpen accessMedicine
Joe M. Bridges · 2024 · Diagnosis
OBJECTIVES: Validate the diagnostic accuracy of the Artificial Intelligence Large Language Model ChatGPT4 by comparing diagnosis lists produced by ChatGPT4 to Isabel Pro. METHODS: This study used 201 cases, comparing ChatGPT4 to Isabel Pro. Systems inputs were identical. Mean Reciprocal Rank (MRR) compares the correct diagnosis's rank between systems. Isabel Pro ranks by the frequency with which the symptoms appear in the reference dataset. The mechanism ChatGPT4 uses to rank the diagnoses is unknown. A Wilcoxon Signed Rank Sum test failed to reject the null hypothesis. RESULTS: Both systems p
View details →DOI: 10.1515/dx-2024-0033Cited by 17 Negative / Null Result ReportOpen accessImmunology and Microbiology
Galina Stoyancheva, Nikolina Mihaylova, Maria Gerginova et al. · 2025 · International Journal of Molecular Sciences
The human endometrium, previously considered a sterile environment, is now recognized as a low-biomass but biologically active microbial niche critical to reproductive health. Advances in sequencing technologies, particularly shotgun metagenomics, have provided unprecedented insights into the taxonomic and functional complexity of the endometrial microbiome. While 16S rRNA sequencing has delineated the distinction between Lactobacillus-dominant and non-dominant microbial communities, shotgun metagenomics has revealed additional diversity at the species and strain level, uncovering microbial si
View details →DOI: 10.3390/ijms262110796Cited by 17 Negative / Null Result Report
Xiaoxiao Ma · 2023 · Green and Low-Carbon Economy
Facing severe air pollution, the Chinese government has introduced bottom-up public participation in environmental policy. The increase in public environmental attention can promote the participation of all people in environmental…
View details →DOI: 10.47852/bonviewglce3202868Cited by 17 Negative / Null Result ReportOpen accessMedicine
Jie Wu, Jianan Ren, Qinjie Liu et al. · 2019 · Frontiers in Immunology
Background: Continuous veno–venous hemofiltration (CVVH) could influence immunomodulation by cytokine removal. Damage-associated molecular patterns (DAMPs) are released by injured cells and have roles in sepsis. We investigated if the magnitude of DAMPs removal was associated with mortality in patients with sepsis undergoing CVVH. Methods: We conducted a prospective, observational study on patients acquiring CVVH at department of surgery, Jinling Hospital. Circulating levels of DAMPs (mitochondrial DNA [mtDNA]; nuclear DNA [nDNA]; heat shock protein [HSP]70) and cytokines were measured at the
View details →DOI: 10.3389/fimmu.2018.03052Cited by 17 Negative / Null Result ReportOpen accessMedicine
Sarita Depani, Kondwani Joseph Banda, Simon Bailey et al. · 2015 · Pediatric Blood & Cancer
BACKGROUND: We previously reported a 28-day treatment protocol for children with endemic Burkitt lymphoma (BL) which included four doses of cyclophosphamide (CPM), intrathecal methotrexate and hydrocortisone (IT MTX/HC) at Queen Elizabeth…
View details →DOI: 10.1002/pbc.25612Cited by 17 Negative / Null Result ReportOpen accessMedicine
Moonkyoo Kong, Yu Jin Lim, Youngkyong Kim · 2018 · PubMed
Background: We conducted this study to contribute to resolving some controversial issues on management of nasopharyngeal carcinoma. Methods: Thirty-two patients with stage III-IVB nasopharyngeal carcinoma were included in this…
View details →DOI: 10.22034/apjcp.2018.19.6.1591Cited by 17 Negative / Null Result ReportMedicine
Aerlyn G. Dawn, Naomi Lawrence · 2013 · Dermatologic Surgery
BACKGROUND: Squamous cell carcinomas (SCCs) generally have been reported to be more prevalent on the lips than basal cell carcinomas (BCCs), but in our experience, BCCs of the lips are common, particularly in women. OBJECTIVES: To…
View details →DOI: 10.1111/dsu.12227Cited by 17 Negative / Null Result ReportEngineering
Lukas Koedijk, Ana Oprescu · 2022
The EU Green Deal mirrors the societal concern regarding climate change. In the software industry this means reducing the energy consumption of a program. This can be done by looking both at the hardware and the software used. We take a…
View details →DOI: 10.1109/ict4s55073.2022.00012Cited by 17 Negative / Null Result ReportOpen accessMedicine
Shao-rui Hao, Yan Ren, Shan-yan Zhang et al. · 2020 · Journal of Zhejiang University SCIENCE B
BACKGROUND: Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a…
View details →DOI: 10.1631/jzus.b2000211Cited by 17 Negative / Null Result ReportOpen accessMedicine
Tarek Mohamed Ashoor, Ahmad Mahmoud Hasseb, Ibrahim M. Esmat · 2020 · Korean journal of anesthesiology
Background: Nebulized heparin has been effectively used in the management of many pulmonary diseases. However, its effect on mechanically ventilated patients with acute exacerbation chronic obstructive pulmonary disease (AECOPD) has never…
View details →DOI: 10.4097/kja.19418Cited by 17 Negative / Null Result ReportOpen accessMedicine
Louise Katherine Bartolac, Jenna Lowe, George Koustas et al. · 2015 · Journal of Reproduction and Development
The aim of this study was to determine the optimum conditions for vitrifying in vitro produced day 7 porcine embryos using different vitrification devices and blastocoele collapse methods. Firstly embryos were collapsed by micro-pipetting,…
View details →DOI: 10.1262/jrd.2015-065Cited by 17 Negative / Null Result ReportOpen accessMedicine
Botao Ning, Sheng Ye, Yi Lyu et al. · 2020 · Translational Pediatrics
BACKGROUND: Sepsis has always been a challenge in pediatric intensive care unit (PICU) with poor prognosis. In order to evaluate the effect between routine continuous renal replacement therapy (CRRT) and high-volume hemofiltration (HVHF)…
View details →DOI: 10.21037/tp.2020.03.13Cited by 17 Negative / Null Result Report
Penghao Ye, Senmao Xia, Yu Xiong et al. · 2020 · International Journal of Environmental Research and Public Health
Thermal power generation based on coal-fired power plants has the advantages of stability and controllability and has been the largest source of electricity supply in China. Coal-fired power plants, however, are also accompanied by high…
View details →DOI: 10.3390/ijerph17228555Cited by 17 Negative / Null Result ReportOpen accessMedicine
Jayastu Senapati, Sanam Loghavi, Guillermo Garcia‐Manero et al. · 2024 · Haematologica
In myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) with TP53 aberrations, dissecting the interaction amongst patient, disease and treatment factors are important for therapeutic decisions and prognostication. This…
View details →DOI: 10.3324/haematol.2024.286465Cited by 17 Negative / Null Result ReportMedicine
Jae Hong Park, Isabelle Rivière, Xiuyan Wang et al. · 2017 · Journal of Clinical Oncology
7008 Background: CD19-specific chimeric antigen receptor (CAR) T cells have demonstrated high initial responses in patients with relapsed B-ALL. However, clinical characteristics associated with the durability of response remain undefined.…
View details →DOI: 10.1200/jco.2017.35.15_suppl.7008Cited by 17 Negative / Null Result ReportOpen accessMedicine
Suresh S. Ramalingam, Judy Foster, William E. Gooding et al. · 2010 · Cancer
BACKGROUND: Patients with extensive stage small cell lung cancer (SCLC) who develop disease progression with standard cisplatin-based therapy are reported to have a poor overall prognosis. Irinotecan and paclitaxel are active as single…
View details →DOI: 10.1002/cncr.24753Cited by 17 Negative / Null Result ReportOpen accessMedicine
Wen Sun, Yan Yang, Shidong Hu et al. · 2022 · Annals of Translational Medicine
Background: Patients in the intensive care unit (ICU) are often under stress and fail to cooperate well with invasive treatments. Analgesia and sedation are of great significance for reducing the suffering of patients and ensuring the…
View details →DOI: 10.21037/atm-22-477Cited by 17 Negative / Null Result Report
Joseph T. Yun, Brittany R. L. Duff, Patrick Vargas et al. · 2019 · Psychology & Marketing
Abstract Cause‐related marketing (CRM) refers to the phenomenon where brands partner with causes, such as nonprofit organizations. Consumers may see some CRM partnerships as less compatible than others, however the level of perceived…
View details →DOI: 10.1002/mar.21250Cited by 17 Negative / Null Result Report
Beryn A. Otieno, Helen F. Nahrung, Martin J. Steinbauer · 2019 · Forests
Research Highlights: We present the first attempts to model the distributions of the two cryptic and globally invasive species of Leptocybe invasa sensu lato (Fisher & LaSalle) (Hymenoptera: Eulophidae) in its purported country of origin,…
View details →DOI: 10.3390/f10020115Cited by 17 Negative / Null Result ReportOpen accessMedicine
Jing Li, YUE-YIN PAN, Ying Zhang · 2012 · Oncology Letters
Sorafenib is a highly selective multi-targeted agent and has been reported to have potent antitumor effects against various tumors, including human non-small cell lung cancer (NSCLC). In the present study, we explored the antitumor effect…
View details →DOI: 10.3892/ol.2012.1017Cited by 17 Negative / Null Result Report
Laila Kristoffersen, Ragnhild Støen, Håkon Bergseng et al. · 2019 · Acta Paediatrica
Abstract Aim We compared the pain relieving effect of skin‐to‐skin contact versus standard care in the incubator during screening for retinopathy of prematurity. Methods This randomised crossover study included 35 preterm infants of less…
View details →DOI: 10.1111/apa.14699Cited by 17 Negative / Null Result ReportOpen accessMedicine
Wanying Liang, Lihong Wang, Jian‐Hang Wei et al. · 2021 · Scientific Reports
Klotho, an important anti-aging protein, may be related to elevated blood pressure (BP) and arterial stiffness. We aimed to investigate associations between the serum klotho concentration and peripheral/central BP and arterial stiffness based on the carotid-femoral pulse wave velocity (cfPWV) in a Chinese population. We invited all inhabitants aged ≥ 18 years in two Dali communities for participation. The SphygmoCor system was used to record radial arterial waveforms. Aortic waveforms were derived using a generalized transfer function. The central BP was assessed by calibrating the brachial BP
View details →DOI: 10.1038/s41598-021-82258-5Cited by 17 Negative / Null Result ReportOpen accessEngineering
Daniel Rasbash, Kevin Joseph Dillman, Jukka Heinonen et al. · 2023 · Sustainability
Electrification is considered key to decarbonizing the transport sector. While electric vehicles (EVs) lack tailpipe emissions, battery and electricity production can lead to significant emissions. This study analysed whether EVs can effectively mitigate GHG emissions in North America, by calculating two GHG breakeven indicators for EVs and comparing them to internal combustion engine vehicles (ICEVs). EV life cycle emissions were compared to those of ICEVs in Canada, Mexico, and the USA. In addition, this study considered potential national electricity grids evolutions and improvements in bat
View details →DOI: 10.3390/su15032181Cited by 17 Negative / Null Result ReportOpen accessMedicine
Eyüp Özkan, Aslan Erdoğan, Ali Karagöz et al. · 2023 · Angiology
This study compared the predictive power of the systemic immune-inflammation index (SII) and Naples prognostic score (NPS) in determining the severity of coronary artery disease (CAD). The study included 1138 patients who underwent…
View details →DOI: 10.1177/00033197231170979Cited by 17 Negative / Null Result ReportOpen accessMedicine
Yun Gi Kim, Jong‐Il Choi, Ki Yung Boo et al. · 2019 · Clinical Cardiology
Abstract Background Age is a well‐established risk factor for thromboembolic events in patients with atrial fibrillation (AF). However, the mechanism underlying the association between age and thromboembolic events in AF remains unknown. Methods The prognostic value of age as a risk factor for thromboembolic events was analyzed using data from the Korean National Health Insurance Service (NHIS). In a large‐scale single‐center registry, cardiac hemodynamic parameters were examined to elucidate the cause of increased risk of thromboembolic events in older patients. Results NHIS sample cohort dat
View details →DOI: 10.1002/clc.23293Cited by 17 Negative / Null Result ReportOpen accessDentistry
Katja Bächli, Patrick R. Schmidlin, Florian J. Wegehaupt et al. · 2019 · Materials
To assess the remineralizing potential of dentin matrix proteins and enamel matrix derivatives (DMPs and EMDs) after application on artificially induced dentin lesions, given the hypothesis that these materials increase the mineral uptake, binding, and mineralization. Forty-eight caries-free human premolars were used. Teeth were cut, polished, and embedded, leaving an open window on the root surface, of which one-third was covered with a flowable composite to preserve the healthy untreated dentin. Then, samples were demineralized in Buskes solution for 33 days. A micro-CT scan prior to treatme
View details →DOI: 10.3390/ma12132116Cited by 17 