Negative / Null Result ReportOpen accessMedicine
Eisaku Miyauchi, Tatsuo Matsuda, Kazuma Kiyotani et al. · 2018 · Cancer Science
Recent clinical trials of non-small cell lung cancer with immune checkpoint inhibitors revealed that patients with epidermal growth factor receptor (EGFR) mutations had more unfavorable outcomes compared with those with wild-type EGFR.…
View details →DOI: 10.1111/cas.13919Cited by 21 Negative / Null Result ReportMedicine
Sebastian Richards-Taylor, Charles Tilley, Eleanor Jaynes et al. · 2017 · Pancreas
OBJECTIVE: Pancreatic neuroendocrine tumors (NETs) (pNETs) have a varied prognosis according to their grade. The European Neuroendocrine Tumor Society grading system uses assessment of the proliferation index via Ki-67 immunohistochemistry…
View details →DOI: 10.1097/mpa.0000000000000933Cited by 21 Negative / Null Result ReportOpen accessMedicine
Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino et al. · 2019 · EJNMMI Research
Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been used to estimate the skull attenuation in brain scans. The zero echo time (ZTE) pulse sequence is also expected to provide a better MRAC estimation in brain PET scans. The difference in quantitative measurements of cerebral blood flow (CBF) using H215O-PET/MRI was compared between the two MRAC methods, AB and ZTE. Twelve patients with cerebrovascular disease (4 males, 43.2 ± 11.7 years) und
View details →DOI: 10.1186/s13550-019-0494-9Cited by 21 Negative / Null Result Report
S. L. Matheson, A. M. Shepherd, V. J. Carr · 2014 · Psychological Medicine
Background. True findings about schizophrenia remain elusive; many findings are not replicated and conflicting results are common. Well-conducted systematic reviews have the ability to make robust, generalizable conclusions, with good…
View details →DOI: 10.1017/s0033291714000166Cited by 21 Negative / Null Result ReportOpen accessMedicine
Anna Katri, Aneta Dąbrowska, Henrik Löfvall et al. · 2019 · Arthritis Research & Therapy
BACKGROUND: Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on salmon calcitonin and are expected to inhibit bone resorption and to be chondroprotective. In this study, we investigated if combining a standard of care NSAID (naproxen) with a KBP resulted in improvement in pain
View details →DOI: 10.1186/s13075-019-1819-9Cited by 21 Negative / Null Result ReportOpen accessMedicine
Osama Sobhi Moaket, Sarah Eyad Obaid, Fawaz Eyad Obaid et al. · 2025 · International Journal of Molecular Sciences
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), stroke, and depression, are marked by progressive neuronal dysfunction and loss, yet current treatments remain largely symptomatic with limited disease-modifying efficacy. Glucagon-like peptide-1 (GLP-1), an incretin hormone traditionally associated with metabolic regulation, has emerged as a promising neuroprotective agent. Its receptor, GLP-1R, is expressed in key brain regions implicated in cognition, emotion, and motor control, including the hippocampus, frontal cortex, and substantia nigra. GLP-1R a
View details →DOI: 10.3390/ijms262110743Cited by 21 Negative / Null Result ReportOpen accessEngineering
Jianghui Zheng, Guoliang Wang, Leiping Duan et al. · 2025 · Nature Nanotechnology
Abstract Triple‐junction solar cells theoretically outperform their double-junction and single‐junction counterparts in power conversion efficiency, yet practical perovskite–perovskite–silicon devices have fallen short of both theoretical limits and commercial targets. To address surface defects in the top perovskite junction, we introduce a piperazine-1,4-diium chloride treatment, which replaces less stable lithium fluoride. For interfacing the top and middle perovskite junctions, we optimize the size of gold nanoparticles deposited on atomic layer-deposited tin oxide for best ohmic contactin
View details →DOI: 10.1038/s41565-025-02015-xCited by 21 Negative / Null Result ReportOpen accessComputer Science
Emma Croxford, Yanjun Gao, Elliot First et al. · 2025 · npj Digital Medicine
Electronic Health Records (EHRs) contain vast clinical data that are difficult for providers to synthesize. Generative AI with Large Language Models (LLMs) can summarize records to reduce cognitive burden, but ensuring accuracy requires…
View details →DOI: 10.1038/s41746-025-02005-2Cited by 21 Negative / Null Result ReportOpen accessMedicine
Natalia Spasova, Desislava Somleva, Bozhidar Krastev et al. · 2024 · Folia Medica
Introduction : Trimethylamine-N-oxide (TMAO) is a metabolite produced by intestinal microbiota. It is well recognized as an independent risk marker for cardiovascular and renal diseases and mortality. Aim : The aim of the present study was…
View details →DOI: 10.3897/folmed.66.e132325Cited by 21 Negative / Null Result Report
A. Cazor, A. Schmidt, J. Shatrov et al. · 2022 · Knee Surgery, Sports Traumatology, Arthroscopy
Abstract Purpose The purpose of this study was to evaluate the clinical outcomes and survivorship at minimum 10‐year follow‐up of patients undergoing primary valgisation high tibial osteotomy (HTO) for medial osteoarthritis (OA), treated…
View details →DOI: 10.1007/s00167-022-07122-zCited by 21 Negative / Null Result ReportOpen accessNeuroscience
Lloyd Christopher Smith · 2026 · Zenodo (CERN European Organization for Nuclear Research)
This paper forms part of Mirror Programme, Volume I: Observerhood. Mirror Mathematics II develops the formal threshold layer of the Mirror Mathematics arc. Building on Mirror Mathematics I, it asks when a self-model becomes observer-relevant rather than merely predictive, self-referential or descriptive. The paper introduces a minimal Mirror observer predicate grounded in self-model reliability, action-guidance, cost-sensitive repair and positive viability coupling under perturbation. The central condition is expressed through a salience functional measuring whether the expected viability bene
View details →DOI: 10.5281/zenodo.21168072Cited by 21 Negative / Null Result ReportOpen accessSocial Sciences
Ahmet Jeyhunov, Jong Dae Kim, Seong Mi Bae · 2025 · Sustainability
This paper explores the effect of board diversity on environmental, social, and governance (ESG) performance in Korean-listed firms using regression analysis. Our findings reveal that an increased board size significantly correlates with higher ESG scores when combined with other board diversity dimensions. The presence of female directors on boards was found to have a significant effect on environmental and social components of ESG performance. Age diversity exhibits a negative association with ESG scores, emphasizing potential disruptions from intergenerational differences. Foreign directors
View details →DOI: 10.3390/su17020787Cited by 21 Negative / Null Result ReportOpen accessMedicine
Xiaodong Wang, Jing He, Gouping Ding et al. · 2025 · Frontiers in Immunology
Immune checkpoint inhibitors (ICIs) targeting PD-1 and CTLA-4 have achieved groundbreaking clinical success in multiple cancers; however, a large proportion of patients experience primary or acquired resistance. This review synthesizes the complex mechanisms underlying resistance to PD-1/CTLA-4 blockade and surveys emerging strategies to overcome them. Resistance arises from multifaceted interactions among tumor-intrinsic alterations (e.g., epigenetic silencing of antigen presentation machinery via EZH2/PRC2, oncogenic pathway-driven upregulation of PD-L1, genetic loss of IFNγ pathway componen
View details →DOI: 10.3389/fimmu.2025.1688699Cited by 21 Negative / Null Result ReportOpen accessMedicine
Simon Bowman, Raphaèle Séror, Raphaël Porcher et al. · 2025 · Annals of the Rheumatic Diseases
Primary Sjögren's disease (pSjD) is an autoimmune rheumatic disease involving exocrine glands and associated with high symptom burden (dryness, fatigue, pain), systemic features and salivary gland dysfunction. B-cell hyperactivity is common, with an increased risk of mucosa-associated lymphoid tissue lymphoma. This review describes the unmet need, scientific validity of outcome measures, optimisation of clinical trial design, therapeutic advances and how clinical improvement relates to health-related quality of life, additional quality-adjusted life years and economic benefit in pSjD. It deriv
View details →DOI: 10.1016/j.ard.2025.05.004Cited by 20 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Ryan Zenhausern, Bora Jang, Elisa Schrader Echeverri et al. · 2025 · Nature Biotechnology
Understanding how well delivery in mice predicts delivery in nonhuman primates (NHPs) could make lipid nanoparticle (LNP) discovery more efficient. Yet, few LNP-mRNA drug candidates are tested in NHPs, in part because the experiments…
View details →DOI: 10.1038/s41587-025-02711-yCited by 20 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Christos Mavrommatis, Daniel W. Belsky, Kejun Ying et al. · 2025 · Nature Communications
Epigenetic Clocks have been trained to predict chronological age, healthspan and lifespan. Such clocks are often analysed in relation to disease outcomes - typically using small datasets and a limited number of clocks. Here, we present a large-scale (n = 18,859), unbiased comparison of 14 widely used clocks as predictors of 174 incident disease outcomes and all-cause mortality over 10-years of follow up. Second- and third-generation clocks significantly outperform first-generation clocks, which have limited applications in disease settings. Of the 176 Bonferroni significant (P 1%. However, the
View details →DOI: 10.1038/s41467-025-66106-yCited by 20 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Tiasha Islam, Murugesh Arunachalum, Nirosha Hewa Wellalage et al. · 2025 · Business Strategy and the Environment
ABSTRACT This study examines the interplay between social media sentiment (SMS) and corporate reputation (CR) in shaping the relationship between corporate environmental performance (CEP) and corporate financial performance (CFP). Using a…
View details →DOI: 10.1002/bse.4201Cited by 20 Negative / Null Result ReportOpen accessMedicine
Alejandro Borrego-Ruiz, Juan J. Borrego · 2024 · Nutrients
BACKGROUND/OBJECTIVES: Diet is one of the major determinants of the composition and function of the gut microbiome, and diverse studies have established directional connections between gut microbiome dysbiosis and skin dyshomeostasis. Furthermore, a significant link between the gut and certain skin-related disorders has been reported. This work reviews the mechanisms underlying the relationship between nutritional factors, gut microbiome, and certain skin diseases such as acne vulgaris, alopecia, and atopic dermatitis. In addition, it explores how the modulation of the gut microbiome and human
View details →DOI: 10.3390/nu16203559Cited by 20 Negative / Null Result ReportOpen accessEnvironmental Science
Kyle Lesinger, Di Tian · 2025 · Nature Communications
Deep neural networks that learn from climate reanalysis data have produced skillful weather forecasts within ten days. However, it is still a great challenge for dynamic models to predict soil moisture, droughts, and other extreme events…
View details →DOI: 10.1038/s41467-025-62761-3Cited by 20 Negative / Null Result ReportOpen accessPsychology
R. Chris Fraley, Jia Y. Chong, Kyle A. Baacke et al. · 2022 · Advances in Methods and Practices in Psychological Science
Scholars and institutions commonly use impact factors to evaluate the quality of empirical research. However, a number of findings published in journals with high impact factors have failed to replicate, suggesting that impact alone may…
View details →DOI: 10.1177/25152459221120217Cited by 20 Negative / Null Result ReportOpen accessImmunology and Microbiology
Clara Young, Mandeep Singh, Katherine Jackson et al. · 2025 · Immunity
The unexplained association between infection and autoimmune disease is strongest for hepatitis C virus-induced cryoglobulinemic vasculitis (HCV-cryovas). To analyze its origins, we traced the evolution of pathogenic rheumatoid factor (RF) autoantibodies in four HCV-cryovas patients by deep single-cell multi-omic analysis, revealing three sources of B cell somatic mutation converged to drive the accumulation of a large disease-causing clone. A method for quantifying low-affinity binding revealed recurring antibody variable domain combinations created by V(D)J recombination that bound self-immu
View details →DOI: 10.1016/j.immuni.2024.12.011Cited by 20 Negative / Null Result ReportOpen accessMedicine
Harriet Lampe, Laura Tam, Aaron R. Hansen · 2024 · Frontiers in Pharmacology
Metastatic castrate resistant prostate cancer (mCRPC) continues to have poor survival rates due to limited treatment options. Bi-specific T cell engagers (BiTEs) are a promising class of novel immunotherapies with demonstrated success in haematological malignancies and melanoma. BiTEs developed for tumour associated antigens in prostate cancer have entered clinical testing. These trials have been hampered by high rates of treatment related adverse events, minimal or transient anti-tumour efficacy and generation of high titres of anti-drug antibodies. This paper aims to analyse the challenges f
View details →DOI: 10.3389/fphar.2024.1399802Cited by 20 Negative / Null Result ReportOpen accessMedicine
Catherine Gutierrez, Anthony S. Stein, Amir T. Fathi et al. · 2025 · American Journal of Hematology
Acute myeloid leukemia is a molecularly heterogenous disease caused by the rapid expansion and impaired differentiation of malignant myeloid progenitors. Overall, outcomes remain poor, and more than half of patients develop relapsed or…
View details →DOI: 10.1002/ajh.27584Cited by 20 Negative / Null Result ReportOpen accessMedicine
Oluwamayokun Oshinowo, Renee Copeland, Yumiko Sakurai et al. · 2021 · Blood Advances
Key Points Human, canine, ovine, and porcine platelets exhibit disparate biophysical signatures, whereas human and murine platelets are similar. Multiple biophysical parameters integrate during clot formation, measured by bulk clot…
View details →DOI: 10.1182/bloodadvances.2020003755Cited by 20 Negative / Null Result ReportOpen accessMedicine
Tanguy Y. Seiwert, Sara Kochanny, Kevin Wood et al. · 2020 · Cancer
BACKGROUND: Patients with cetuximab-resistant, recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) have poor outcomes. This study hypothesized that dual blockade of mammalian target of rapamycin and epidermal growth factor…
View details →DOI: 10.1002/cncr.32929Cited by 20 Negative / Null Result ReportOpen accessEnvironmental Science
Lingling Rong, Ligui Wu, Tiao Zhang et al. · 2023 · Molecules
To improve the adsorption efficiency of pollutants by biochar, preparing graphene-like biochar (GBC) or nitrogen-doped biochar are two commonly used methods. However, the difference in the nitrogen doping (N-doping) effects upon the adsorption of pollutants by pristine biochar (PBC) and GBC, as well as the underlying mechanisms, are still unclear. Take the tetracycline (TC) as an example, the present study analyzed the characteristics of the adsorption of TCs on biochars (PBC, GBC, N-PBC, N-GBC), and significant differences in the effects of N-doping on the adsorption of TCs by PBC and GBC wer
View details →DOI: 10.3390/molecules29010173Cited by 20 Negative / Null Result Report
Greg Campbell, Andrew Coffey, Heather Miller et al. · 2018 · Animal Production Science
Beef cattle production is the major agricultural pursuit in the arid rangelands of Australia. Dingo predation is often considered a significant threat to production in rangeland beef herds, but there is a need for improved understanding of…
View details →DOI: 10.1071/an17008Cited by 20 Negative / Null Result ReportOpen accessMedicine
Malin Assarsson, Jan Söderman, Olaf Dienus et al. · 2020 · Acta Dermato Venereologica
Studies have shown differences in the skin and gut bacterial microbiomes in patients with psoriasis, but the pharyngeal microbiome has not been studied previously. The aim of this study was to investigate differences in the bacterial…
View details →DOI: 10.2340/00015555-3619Cited by 20 Negative / Null Result ReportOpen accessMedicine
Muhammad Furqan, Yu-Yu Tien, Mary C. Schroeder et al. · 2018 · Journal of Thoracic Disease
Background: The optimal surgery for resectable pulmonary typical carcinoid (TC), e.g., lobar resection (L-R) vs. sub-lobar resection (SL-R), is controversial. This is further explored in this population-based study. Methods: The…
View details →DOI: 10.21037/jtd.2018.09.141Cited by 20 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
April R. Giles, Martin Lock, Shu‐Jen Chen et al. · 2023 · Human Gene Therapy
For successful vector-based gene therapy manufacturing, the selected adeno-associated virus (AAV) vector production system must produce vector at sufficient scale. However, concerns have arisen regarding the quality of vector produced…
View details →DOI: 10.1089/hum.2022.116Cited by 20 