Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Benjamin L. Rambo‐Martin, Jennifer G. Mulle, David J. Cutler et al. · 2017 · G3 Genes Genomes Genetics
One in five people with Down syndrome (DS) are born with an atrioventricular septal defect (AVSD), an incidence 2000 times higher than in the euploid population. The genetic loci that contribute to this risk are poorly understood. In this study, we tested two hypotheses: (1) individuals with DS carrying chromosome 21 copy number variants (CNVs) that interrupt exons may be protected from AVSD, because these CNVs return AVSD susceptibility loci back to disomy, and (2) individuals with DS carrying chromosome 21 genes spanned by microduplications are at greater risk for AVSD because these microdup
View details →DOI: 10.1534/g3.117.300366Cited by 21 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Matthijs J. H. M. van der Loos, Philipp Koellinger, Patrick J. F. Groenen et al. · 2011 · Small Business Economics
Candidate gene studies of human behavior are gaining interest in economics and entrepreneurship research. Performing and interpreting these studies is not straightforward because the selection of candidates influences the interpretation of…
View details →DOI: 10.1007/s11187-011-9339-2Cited by 21 Negative / Null Result ReportOpen accessNeuroscience
Adam Maxwell Sparks, Pat Barclay · 2015 · Letters on Evolutionary Behavioral Science
The effect of exposure to eye images on various behaviors has been explained as a response to an invalid cue of observation. This interpretation has been supported by an experiment showing that a short exposure to eye images increased…
View details →DOI: 10.5178/lebs.2015.35Cited by 21 Negative / Null Result ReportOpen accessPhysics and Astronomy
Wei Hu · 2013 · Social Networking
Various networks exist in the world today including biological, social, information, and communication networks with the Internet as the largest network of all. One salient structural feature of these networks is the formation of groups or communities of vertices that tend to be more connected to each other within the same group than to those outside. Therefore, the detection of these communities is a topic of great interest and importance in many applications and different algorithms including label propagation have been developed for such purpose. Speaker-listener label propagation algorithm
View details →DOI: 10.4236/sn.2013.23012Cited by 21 Negative / Null Result ReportOpen accessMaterials Science
Kimberly M. Sogi, Zev J. Gartner, Mark A. Breidenbach et al. · 2013 · PLoS ONE
The genome of Mycobacterium tuberculosis (Mtb) encodes nine putative sulfatases, none of which have a known function or substrate. Here, we characterize Mtb's single putative type II sulfatase, Rv3406, as a non-heme iron (II) and α-ketoglutarate-dependent dioxygenase that catalyzes the oxidation and subsequent cleavage of alkyl sulfate esters. Rv3406 was identified based on its homology to the alkyl sulfatase AtsK from Pseudomonas putida. Using an in vitro biochemical assay, we confirmed that Rv3406 is a sulfatase with a preference for alkyl sulfate substrates similar to those processed by Ats
View details →DOI: 10.1371/journal.pone.0065080Cited by 21 Negative / Null Result ReportOpen accessImmunology and Microbiology
John F. Krisko, Nurjahan Begum, Caroline E. Baker et al. · 2016 · Journal of Virology
UNLABELLED: The multifunctional HIV-1 accessory protein Vif counters the antiviral activities of APOBEC3G (A3G) and APOBEC3F (A3F), and some Vifs counter stable alleles of APOBEC3H (A3H). Studies in humanized mice have shown that HIV-1…
View details →DOI: 10.1128/jvi.03275-15Cited by 21 Negative / Null Result ReportPsychology
Valeriia V. Vlasenko, Emma G. Rogers, Christian E. Waugh · 2021 · Cognition & Emotion
Although affect labelling has been widely reported to decrease negative emotions, it is less clear whether affect labelling also decreases positive emotions. In four studies, we explored how affect labelling (choosing the emotion that best…
View details →DOI: 10.1080/02699931.2021.1959302Cited by 21 Negative / Null Result ReportMedicine
Valerie A. Smith, Joan E. Cunningham, Eric J. Lentsch · 2012 · Otolaryngology
OBJECTIVE: Determine if completion lymph node dissection (CLND) is associated with improved survival in sentinel lymph node (SLN)-positive cutaneous melanoma of the head and neck (CMHN) patients. STUDY DESIGN: Retrospective analysis of…
View details →DOI: 10.1177/0194599811432672Cited by 21 Negative / Null Result ReportOpen accessMedicine
Junyi Chen, Jiao Li, Chuanliang Xu et al. · 2012 · BMC Cancer
BACKGROUND: Gamma-synuclein (SNCG) has previously been demonstrated to be significantly correlated with metastatic malignancies; however, in-depth investigation of SNCG in prostate cancer is still lacking. In the present study, we evaluated the role of SNCG in prostate cancer progression and explored the underlying mechanisms. METHODS: First, alteration of SNCG expression in LNCaP cell line to test the ability of SNCG on cellular properties in vitro and vivo whenever exposing with androgen or not. Subsequently, the Dual-luciferase reporter assays were performed to evaluate whether the role of
View details →DOI: 10.1186/1471-2407-12-593Cited by 21 Negative / Null Result ReportOpen accessMedicine
Thiago Pereira Diniz, Wilson Luiz da Costa, Victor Hugo Fonseca de Jesus et al. · 2019 · Journal of Surgical Oncology
BACKGROUND: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been associated with improved survival when compared with surgery alone for non-metastatic gastric cancer patients in randomized trials and meta-analyses. However, little evidence is available regarding the use of HIPEC in nonmetastatic patients who are treated with perioperative chemotherapy and radical surgery. The aim of this study was to investigate the putative survival benefit of HIPEC in the subgroup of gastric cancer patients treated with perioperative chemotherapy and surgery. PATIENTS AND METHODS: This was a retrospect
View details →DOI: 10.1002/jso.25823Cited by 21 Negative / Null Result ReportOpen accessSocial Sciences
Dafina Petrova, Edward T. Cokely, Agata Sobków et al. · 2022 · Risk Analysis
We introduce a brief instrument specifically validated for measuring positive and negative feelings about risks-the Berlin Emotional Responses to Risk Instrument (BERRI). Based on seven studies involving diverse adults from three countries…
View details →DOI: 10.1111/risa.13946Cited by 21 Negative / Null Result Report
Qing Miao · 2018 · Risk Analysis
Abstract There has been a growing interest in understanding whether and how people adapt to extreme weather events in a changing climate. This article presents one of the first empirical analyses of adaptation to flooding on a global…
View details →DOI: 10.1111/risa.13245Cited by 21 Negative / Null Result Report
Evrim Bostankolu, Hilal Ayoglu, Serhan Yurtlu et al. · 2012 · The Kaohsiung Journal of Medical Sciences
Abstract Ischemia reperfusion injury causes the release of free oxygen radicals. Free oxygen radicals initiate the production of toxic metabolites, such as malondialdehyde (MDA), through the lipid peroxidation of cellular membranes.…
View details →DOI: 10.1016/j.kjms.2012.08.013Cited by 21 Negative / Null Result ReportOpen accessImmunology and Microbiology
Daniel Doyle, Gerald McDonald, Claire Pratt et al. · 2021 · PLoS ONE
OBJECTIVES: Inappropriate antibiotic use contributes to antimicrobial resistance. The SpectrumTM app provides antibiotic decision support, based on local antimicrobial resistance rates. We determined the impact of regional implementation of the app on inpatient antimicrobial appropriateness, inpatient antimicrobial usage (AMU), population-based Clostridioides difficile infection (CDI) rates and cost, using a retrospective, before and after quasi-experimental design, including a one-year study period. METHODS: The SpectrumTM app was released to prescribers in February, 2019. We performed two on
View details →DOI: 10.1371/journal.pone.0252407Cited by 21 Negative / Null Result ReportOpen accessMedicine
Toshiki Kuno, Takahisa Mikami, Yuki Sahashi et al. · 2022 · Scientific Reports
Acute kidney injury (AKI) after percutaneous coronary intervention (PCI) is associated with a significant risk of morbidity and mortality. The traditional risk model provided by the National Cardiovascular Data Registry (NCDR) is useful for predicting the preprocedural risk of AKI, although the scoring system requires a number of clinical contents. We sought to examine whether machine learning (ML) techniques could predict AKI with fewer NCDR-AKI risk model variables within a comparable PCI database in Japan. We evaluated 19,222 consecutive patients undergoing PCI between 2008 and 2019 in a Ja
View details →DOI: 10.1038/s41598-021-04372-8Cited by 21 Negative / Null Result ReportOpen accessMedicine
Alexander Filatenkov, Jeanette Baker, Antonia Müller et al. · 2014 · Radiation Research
The goal of this study was to determine whether a combination of local tumor irradiation and autologous T-cell transplantation can effectively treat metastatic 4T1 breast cancer in mice. BALB/c mice were injected subcutaneously with…
View details →DOI: 10.1667/rr13471.1Cited by 21 Negative / Null Result Report
Bo Christiansen · 2013 · Journal of Climate
Abstract The author investigates whether the increasing numbers of warm records and warm extremes in the extratropical Northern Hemisphere over the last decade are statistically significant. For the extremes, the focus is on summer mean…
View details →DOI: 10.1175/jcli-d-12-00814.1Cited by 21 Negative / Null Result ReportOpen accessMedicine
Manjusha Kulkarni, Sanjay Varikuti, César Terrazas et al. · 2014 · Immunology
The control of Trypanosoma cruzi infection is related to interferon-γ (IFN-γ) activation leading to intracellular clearance of parasites. The transcription factor signal transducer and activator of transcription 1 (STAT-1) is a key…
View details →DOI: 10.1111/imm.12438Cited by 21 Negative / Null Result ReportOpen accessMedicine
Stefanie G. Beesems, Jocelyn Berdowski, Michiel Hulleman et al. · 2016 · Resuscitation
BACKGROUND: Previous large retrospective analyses have found an association between duration of peri-shock pauses in cardiopulmonary resuscitation (CPR) and survival. In a randomized trial, we tested whether shortening these pauses…
View details →DOI: 10.1016/j.resuscitation.2016.06.009Cited by 21 Negative / Null Result ReportArts and Humanities
Loren Kajikawa · 2020 · twentieth-century music
Abstract The last two decades have witnessed a dramatic rise in dissertations, theses, and other academic publications exploring hip-hop music, while college courses on hip-hop history have become commonplace. The growing prominence of…
View details →DOI: 10.1017/s1478572220000262Cited by 21 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Kamala Krishnaswamy · 2016 · Revista de Fomento Social
Worldwide non-communicable diseases (NCDs) occur due to multiple etiological factors impacting development and economic progress. Developing countries have dual burden of diseases viz., under and over nutrition, which are critical public…
View details →DOI: 10.16943/ptinsa/2016/48881Cited by 21 Negative / Null Result ReportOpen accessMedicine
Jonathan Tucci, Waseem Alhushki, Ting Chen et al. · 2018 · Cancer & Metabolism
BACKGROUND: It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. METHODS: Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL cells. Some DIO mice were switched to the low-fat control diet. Survival from A
View details →DOI: 10.1186/s40170-018-0189-0Cited by 21 Negative / Null Result ReportOpen accessMedicine
Wanzhu Tu, Samer Gawrieh, Srinivasan Dasarathy et al. · 2023 · Contemporary Clinical Trials Communications
Background: Mortality is high for severe alcohol-associated hepatitis (AH). Corticosteroids are the standard of care for patients without contraindications. Recent data showed that interleukin-1β receptor antagonist anakinra attenuated…
View details →DOI: 10.1016/j.conctc.2023.101074Cited by 21 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Martin Boegemann, Katrin Schlack, Ann-Kathrin Fischer et al. · 2016 · PLoS ONE
OBJECTIVE: Even though the exact mechanism is largely unknown until now, statins are supposed to improve survival outcomes in various malignancies. For prostate cancer however, statins are known to compete with dehydroepiandrosterone (DHEAS) for the transport into the cytosol both using the cell by the Solute Carrier Transporter and thus diminish the cellular uptake of DHEAS as a precursor of androgens. Abiraterone inhibits CYP17A1 and thus effectively decreases the production of all relevant androgens including DHEAS. In this study we examined whether statins still affect survival outcome in
View details →DOI: 10.1371/journal.pone.0161959Cited by 21 Negative / Null Result ReportOpen accessMedicine
Herbert S. B. Baraf, Puja Khanna, Alan Kivitz et al. · 2023 · Lara D. Veeken
OBJECTIVES: Serum urate (SU) lowering with PEGylated uricases in gout can reduce flares and tophi. However, treatment-emergent anti-drug antibodies adversely affect safety and efficacy and the currently approved PEGylated uricase…
View details →DOI: 10.1093/rheumatology/kead333Cited by 21 Negative / Null Result ReportOpen accessMedicine
Eisaku Miyauchi, Tatsuo Matsuda, Kazuma Kiyotani et al. · 2018 · Cancer Science
Recent clinical trials of non-small cell lung cancer with immune checkpoint inhibitors revealed that patients with epidermal growth factor receptor (EGFR) mutations had more unfavorable outcomes compared with those with wild-type EGFR.…
View details →DOI: 10.1111/cas.13919Cited by 21 Negative / Null Result ReportMedicine
Sebastian Richards-Taylor, Charles Tilley, Eleanor Jaynes et al. · 2017 · Pancreas
OBJECTIVE: Pancreatic neuroendocrine tumors (NETs) (pNETs) have a varied prognosis according to their grade. The European Neuroendocrine Tumor Society grading system uses assessment of the proliferation index via Ki-67 immunohistochemistry…
View details →DOI: 10.1097/mpa.0000000000000933Cited by 21 Negative / Null Result ReportOpen accessMedicine
Hidehiko Okazawa, Tetsuya Tsujikawa, Yoshifumi Higashino et al. · 2019 · EJNMMI Research
Accurate attenuation correction (AC) is one of the most important issues to be addressed in quantitative brain PET/MRI imaging. Atlas-based MRI AC (AB-MRAC), one of the representative MRAC methods, has been used to estimate the skull attenuation in brain scans. The zero echo time (ZTE) pulse sequence is also expected to provide a better MRAC estimation in brain PET scans. The difference in quantitative measurements of cerebral blood flow (CBF) using H215O-PET/MRI was compared between the two MRAC methods, AB and ZTE. Twelve patients with cerebrovascular disease (4 males, 43.2 ± 11.7 years) und
View details →DOI: 10.1186/s13550-019-0494-9Cited by 21 Negative / Null Result Report
S. L. Matheson, A. M. Shepherd, V. J. Carr · 2014 · Psychological Medicine
Background. True findings about schizophrenia remain elusive; many findings are not replicated and conflicting results are common. Well-conducted systematic reviews have the ability to make robust, generalizable conclusions, with good…
View details →DOI: 10.1017/s0033291714000166Cited by 21 Negative / Null Result ReportOpen accessMedicine
Anna Katri, Aneta Dąbrowska, Henrik Löfvall et al. · 2019 · Arthritis Research & Therapy
BACKGROUND: Pain is a debilitating symptom of rheumatoid arthritis (RA), caused by joint inflammation and cartilage and bone destruction. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation in RA, but are not disease-modifying and do not prevent joint destruction when administered alone. KBPs (Key Bioscience peptides) are synthetic peptides based on salmon calcitonin and are expected to inhibit bone resorption and to be chondroprotective. In this study, we investigated if combining a standard of care NSAID (naproxen) with a KBP resulted in improvement in pain
View details →DOI: 10.1186/s13075-019-1819-9Cited by 21 