A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20211 results in Negative / Null Result Report · page 102 of 674
Matthew R. Pearson, Mark A. Prince, Adrián J. Bravo · 2017 · Substance Use & Misuse
BACKGROUND: Protective behavioral strategies (PBS) can be used to reduce alcohol-related harm when drinking. Despite much research demonstrating that use of protective behavioral strategies (PBS) is associated with decreased alcohol…
Donghyok Kwon, Kyeong‐Cheol Shin, Seungtae Kim et al. · 2010 · The Journal of Microbiology
This study aimed to characterize the replication and pathogenic properties of a Korean pandemic (H1N1) 2009 influenza virus isolate in ferrets and mice. Ferrets infected with A/Korea/01/2009 (H1N1) virus showed mild clinical signs. The…
TM Barber, Stephen Franks · 2010 · Expert Review of Endocrinology & Metabolism
Polycystic ovary syndrome (PCOS) is associated with obesity and manifests with reproductive, hyperandrogenic and metabolic features. Although the etiology of PCOS is complex and incompletely understood, genetics plays an important role…
Adrienne L. Romer, Diego A. Pizzagalli · 2021 · Biological Psychiatry Global Open Science
A general psychopathology factor (p factor) captures shared variance across mental disorders in diverse samples and may partly reflect executive dysfunction. Higher p factor scores have been related to structural alterations within the…
Amir Arastehfar, Farnaz Daneshnia, Hrant Hovhannisyan et al. · 2023 · mBio
ABSTRACT Small colony variants are relatively common among some bacterial species and are associated with poor prognosis and recalcitrant infections. Similarly, Candida glabrata— a major intracellular fungal pathogen—produces small and slow-growing respiratory-deficient colonies, termed “petite.” Despite reports of clinical petite C. glabrata strains, our understanding of petite behavior in the host remains obscure. Moreover, controversies exist regarding in-host petite fitness and its clinical relevance. Herein, we employed whole-genome sequencing (WGS), dual-RNAseq, and extensive ex vivo and
Michał Król, Magdalena Ewa Król · 2019 · Journal of Neuroscience Psychology and Economics
Recent studies reported that the attraction effect, whereby inferior decoys cause choice reversals, fails to replicate if the choice options are presented in a pictorial rather than abstract numerical form. We argue that the pictorial…
Andreas Ketterer, Satoya Imai, Nikolai Wyderka et al. · 2022 · Physical review. A/Physical review, A
We consider statistical methods based on finite samples of locally randomized measurements in order to certify different degrees of multiparticle entanglement in intermediate-scale quantum systems. We first introduce hierarchies of…
Waldemar Siemens, Joerg J. Meerpohl, Miriam S. Rohe et al. · 2022 · Research Synthesis Methods
Abstract Using the Hartung–Knapp method and 95% prediction intervals (PIs) in random‐effects meta‐analyses is recommended by experts but rarely applied. Therefore, we aimed to reevaluate statistically significant meta‐analyses using the…
Michael A. Mooney, Peter Ryabinin, Hannah E. Morton et al. · 2023 · JCPP Advances
Abstract Background attention‐deficit/hyperactivity disorder (ADHD) is associated with both polygenic liability and environmental exposures, both intrinsic to the family, such as family conflict, and extrinsic, such as air pollution. However, much less is known about the interplay between environmental and genetic risks relevant to ADHD—a better understanding of which could inform both mechanistic models and clinical prediction algorithms. Methods Two independent data sets, the population‐based Adolescent Brain Cognitive Development Study (ABCD) ( N = 11,876) and the case‐control Oregon‐ADHD‐1
André Luiz Souza, Arthur B. Markman · 2013 · eScholarship (California Digital Library)
A recent paper by Lev-Ari and Keysar (2010) reported that the processing fluency associated with non-native speech causes non-native speakers to sound less credible.The authors found that the same trivia statements were rated as less…
Veronika V. Odintsova, Fiona A. Hagenbeek, Matthew Suderman et al. · 2019 · Nutrients
Breastfeeding has long-term benefits for children that may be mediated via the epigenome. This pathway has been hypothesized, but the number of empirical studies in humans is small and mostly done by using peripheral blood as the DNA source. We performed an epigenome-wide association study (EWAS) in buccal cells collected around age nine (mean = 9.5) from 1006 twins recruited by the Netherlands Twin Register (NTR). An age-stratified analysis examined if effects attenuate with age (median split at 10 years; n<10 = 517, mean age = 7.9; n>10 = 489, mean age = 11.2). We performed replication
Mark O. Goodarzi, Nicholette D Palmer, Jinrui Cui et al. · 2019 · The Journal of Clinical Endocrinology & Metabolism
CONTEXT: Genome-wide association studies have identified more than 450 single nucleotide polymorphisms (SNPs) for type 2 diabetes (T2D). OBJECTIVE: To facilitate use of these SNPs in future genetic risk score (GRS)-based analyses, we aimed…
Paul A. Gilbert, Scott D. Rhodes · 2012 · Hispanic Journal of Behavioral Sciences
Social support is protective for a variety of health outcomes, and individuals living outside their country of origin ("sojourners") might use social support in distinctive ways. The authors performed a confirmatory factor analysis of the…
Sarah Kunkle, Manny Yip, Justin Hunt et al. · 2020 · JMIR Formative Research
BACKGROUND: Anxiety is an extremely prevalent condition, and yet, it has received notably less attention than depression and other mental health conditions from a research, clinical, and public health perspective. The COVID-19 pandemic has only exacerbated growing concerns about the burden of anxiety due to the confluence of physical health risks, economic stressors, social isolation, and general disruption of daily activities. OBJECTIVE: This study examines differences in anxiety outcomes by care modality (coaching, teletherapy and telepsychiatry, and combined care) within an on-demand mental
C. M. Chang, Victoria M. Chia, Marc J. Gunter et al. · 2013 · Carcinogenesis
Inherited variation in genes that regulate innate immunity and inflammation may contribute to colorectal neoplasia risk. To evaluate this association, we conducted a nested case-control study of 451 colorectal cancer cases, 694 colorectal…
Magnus Bergquist, Andréas Nilsson, Emma Ejelöv · 2019 · Sustainability
Setting up a contest is a popular means to promote pro-environmental behaviors. Yet, research on contest-based interventions is scarce while norm-based interventions have gained much attention. In two field experiments, we randomly assigned 79 apartments to either a contest-based or a norm-based electricity conservation intervention and measured kWh usage for 2 and 4 weeks, respectively. Results from both studies showed that contest-based interventions promote intensive but short-lived electricity saving. In Study 1 apartments assigned to a norm-based intervention showed more stable electricit
Ángel Herráiz-Adillo, Viktor H. Ahlqvist, Sara Higueras‐Fresnillo et al. · 2023 · Frontiers in Cardiovascular Medicine
Background To quantify cardiovascular health (CVH), the American Heart Association (AHA) recently launched an updated construct of the “Life's Simple 7” (LS7) score, the “Life's Essential 8” (LE8) score. This study aims to analyse the association between both CVH scores and carotid artery plaques and to compare the predictive capacity of such scores for carotid plaques. Methods Randomly recruited participants aged 50–64 years from the Swedish CArdioPulmonary bioImage Study (SCAPIS) were analysed. According to the AHA definitions, two CVH scores were calculated: i) the LE8 score (0, worst CVH;
Sergio Garnica-Galvez, Stefanie Korntner, Ioannis Skoufos et al. · 2021 · Cells
The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering. Despite the significant advancements in the field, the optimal macromolecular crowder still remains elusive. Herein, the physicochemical properties of different concentrations of different molecular weights hyaluronic acid (HA) and their influence on equine adipose-derived stem cell cultures were assessed. Within the different concentrations and molecular weight HAs, the 10 mg/mL 100 kDa and 500 kDa HAs exhibited the high
Kiana Christensen, Keegan M. Melstrom · 2021 · PLOS ONE
Squamates are ideal subjects for investigating relationships between diet and dental patterns because they exhibit wide dietary diversity, marked variation in dental shape, and are taxonomically abundant. Despite this, well-established…
HELENA FORSMAN · 2021 · International Journal of Innovation Management
While innovation is an attractive path, it is also a rocky path made up of numerous challenges, even failures. This study provides new knowledge for understanding innovation failure. It seeks answers to the question: What are the perceived…
John Guenther, Samuel Osborne · 2020 · The Australian Journal of Indigenous Education
Abstract Over the 10 years of ‘Closing the Gap’, several interventions designed to improve outcomes for Aboriginal and Torres Strait Islander students have been trialled. In 2014 the Australian Government announced the ‘Flexible Literacy…
Joy Leopold, Jason R. Lambert, Ifeyimika O. Ogunyomi et al. · 2019 · Equality, Diversity and Inclusion: An International Journal
Purpose The purpose of this paper is to propose that #MeToo is a social movement which has been more effective in changing norms around and increasing understanding about the prevalence and destructiveness of sexual harassment than decades…
Stephanie K. Courtney Jones, Adam J. Munn, Phillip G. Byrne · 2018 · Royal Society Open Science
Captive breeding programmes are increasingly relied upon for threatened species management. Changes in morphology can occur in captivity, often with unknown consequences for reintroductions. Few studies have examined the morphological…
Sheeva Bhattarai, Tore Framstad, Jens Peter Nielsen · 2019 · Acta Veterinaria Scandinavica
Abstract Background Anemia characterized by low hemoglobin concentration (HbC) is common in indoor housed pregnant sows. Iron is essential for hemoglobin synthesis and a number of metabolic processes including DNA synthesis and regulation…
Maarten Korrel, Sanne Lof, Jony van Hilst et al. · 2020 · Annals of Surgical Oncology
BACKGROUND: Surgical factors, including resection of Gerota's fascia, R0-resection, and lymph node yield, may be associated with survival after distal pancreatectomy (DP) for pancreatic ductal adenocarcinoma (PDAC), but evidence from large multicenter studies is lacking. This study aimed to identify predictors for overall survival after DP for PDAC, especially those related to surgical technique. PATIENTS AND METHODS: Data from an international retrospective cohort including patients from 11 European countries and the USA who underwent DP for PDAC (2007-2015) were analyzed. Cox proportional ha
Antonella Ferro, Michela Campora, A. Caldara et al. · 2024 · Journal of Clinical Medicine
Estrogen receptor (ER)-positive breast cancer (BC) is the most common BC subtype. Endocrine therapy (ET) targeting ER signaling still remains the mainstay treatment option for hormone receptor (HR)-positive BC either in the early or in advanced setting, including different strategies, such as the suppression of estrogen production or directly blocking the ER pathway through SERMs—selective estrogen receptor modulators—or SERDs—selective estrogen receptor degraders. Nevertheless, the development of de novo or acquired endocrine resistance still remains challenging for oncologists. The use of no
Ronak G Gandhi, Camille N Kotton · 2022 · Therapeutics and Clinical Risk Management
Purpose of Review: Cytomegalovirus (CMV) infections are a common complication in solid organ (SOT) and hematopoietic stem cell transplant (HSCT) recipients, leading to increased morbidity and mortality. Currently available treatment…
Haiming Liu, Jiaohua Luo, Bobby Guillory et al. · 2020 · Oncotarget
// Haiming Liu 1 , 2 , * , Jiaohua Luo 3 , 4 , * , Bobby Guillory 3 , Ji-an Chen 3 , 5 , Pu Zang 3 , 6 , Jordan K. Yoeli 3 , Yamileth Hernandez 3 , Ian (In-gi) Lee 1 , 2 , Barbara Anderson 1 , 2 , Mackenzie Storie 1 , 2 , Alison Tewnion 1 and Jose M. Garcia 1 , 2 , 3 1 Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA 2 Gerontology and Geriatric Medicine, University of Washington Department of Medicine, Seattle, WA, USA 3 Division of Endocrinology, Diabetes and Metabolism, MCL, Center for Translational Research on Inflammatory
Berna Harmse, Herculina S. Kruger · 2011 · PubMed
Low-grade systemic inflammation is emerging as a component of the metabolic syndrome. The purpose of this study was to assess the association between serum C-reactive protein (CRP), physical activity and body composition in 193 black children aged 13 to 18 years from a South African township. Demographic information and anthropometric measurements were taken, and fasting blood samples were analysed for high-sensitivity serum CRP. Body fat was measured by air displacement plethysmography. There was a trend towards higher serum CRP in the boys with a higher percentage body fat. After multiple re
Annalisa Petrelli, Sabrina Rizzolio, Filippo Pietrantonio et al. · 2023 · Cancer Research
Despite negative results of clinical trials conducted on the overall population of patients with gastric cancer, PARP inhibitor (PARPi) therapeutic strategy still might represent a window of opportunity for a subpopulation of patients with…