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20,233 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBiochemistry

Characterisation of osteogenic and vascular responses of hMSCs to Ti-Co doped phosphate glass microspheres using a microfluidic perfusion platform

Carlotta Peticone, David De Silva Thompson, Nikolay Dimov et al. · 2020 · Journal of Tissue Engineering

Using microspherical scaffolds as building blocks to repair bone defects of specific size and shape has been proposed as a tissue engineering strategy. Here, phosphate glass (PG) microcarriers doped with 5 mol % TiO 2 and either 0 mol % CoO (CoO 0%) or 2 mol % CoO (CoO 2%) were investigated for their ability to support osteogenic and vascular responses of human mesenchymal stem cells (hMSCs). Together with standard culture techniques, cell-material interactions were studied using a novel perfusion microfluidic bioreactor that enabled cell culture on microspheres, along with automated processin

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Negative / Null Result ReportOpen accessTechnology

The Influence of the Modernization of the City Sewage System on the External Load and Trophic State of the Kartuzy Lake Complex

Jolanta Grochowska, Renata Tandyrak · 2021 · Applied Sciences

A study was carried out in the Kartuzy lake complex, which has been a receiver of raw domestic sewage since the 1950s. In 2018, the city’s sewage system of Kartuzy was modernized. An analysis of the water quality prior to the modernization of the sewage system revealed that the total phosphorus (TP) load that was introduced to the individual lakes from external sources substantially exceeded the dangerous load concentration (defined by Vollenweider) that causes accelerated eutrophication. The annual TP load introduced to the analyzed lakes in 2017 exceeded the critical load by 200% (Mielenko)

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Negative / Null Result ReportOpen accessMedicine

The pro-apoptotic GZMB and anti-apoptotic HAX-1 and DAD-1 genes and gene proteins in human right auricular tissue affected by coronary heart disease and aortic valve stenosis: a pilot study.

Zaharovs V, Pilmane M · 2026 · Journal of molecular histology

The anti-apoptotic genes DAD-1 and HAX-1 and the pro-apoptotic GZMB gene have a significant role in the regulation of apoptosis in heart tissue. However, investigation into these genes and their proteins in the pathogenesis of…

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Negative / Null Result ReportMedicine

A Multicenter, Sham-Controlled, Pilot, Randomized Controlled Trial of Interferential Therapy for the Treatment of Chronic Constipation.

Clukey J, Locascio J, Semler J et al. · 2026 · Journal of clinical gastroenterology

Goals We aimed to evaluate the efficacy and safety of IFT for the treatment of CC in a pilot randomized controlled trial (RCT). Background Subjects with refractory chronic constipation (CC) have limited treatment options. Interferential…

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Negative / Null Result ReportOpen accessMedicine

Subclinical atherosclerosis assessed by cardio-ankle vascular index and carotid intima-media thickness in people living with HIV receiving integrase inhibitor-based tenofovir regimens.

Vatan A, Karabay O, Moralı H et al. · 2026 · BMC infectious diseases

Background Tenofovir alafenamide (TAF) is widely used in antiretroviral therapy due to its improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF). However, concerns remain regarding its potential metabolic effects…

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Negative / Null Result ReportMedicine

The Drug-Coated Balloon and Primary Patency in Endovascular Therapy for Femoropopliteal Lesions With "Black Rock" Nodular Calcification.

Shikama T, Otaki Y, Kinoshita D et al. · 2026 · Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists

Objective Nodular calcifications occupying the lumen in the femoropopliteal artery, known as "Black Rock (BR)" lesions, are associated with poor patency. We focused on the drug-coated balloon (DCB) and examined whether the impact of final…

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Negative / Null Result ReportOpen accessMedicine

No-touch versus conventional radiofrequency ablation for treating solitary recurrent hepatocellular carcinoma ≤ 3 cm: a retrospective cohort study.

Wu G, Ou X, Zou M et al. · 2026 · Journal of cancer research and clinical oncology

OBJECTIVE: This study aimed to compare the outcomes of no-touch radiofrequency ablation (NT-RFA) and conventional RFA (C-RFA) in the treatment of solitary recurrent hepatocellular carcinoma (rHCC) ≤ 3 cm. METHODS: 255 patients with rHCC…

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Negative / Null Result ReportMedicine

[Comparison of Imaging Efficacy and Patient Tolerability Between a Novel Cellulose-Based anda Conventional Starch-Based Oral Contrast Agent: A Prospective Randomized Controlled Trial].

Liang H, Gui Y, Lv K et al. · 2026 · Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

Objective To compare the imaging efficacy and patient tolerability of a novel cellulose-based oral contrast agent with a conventional starch-based agent in gastric contrast-enhanced ultrasound,thus providing evidence-based support for…

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Negative / Null Result ReportOpen accessMedicine

Consequences of the 2022 Intravenous Contrast Shortage on Emergency Department Care: A Retrospective Study.

Bellew S, Tjiattas-Saleski L, Butz D et al. · 2026 · The western journal of emergency medicine

Introduction Computed tomography (CT) is an essential diagnostic tool for evaluating emergency department (ED) patients. Between 15-20% of patients who present to the ED in the United States (US) undergo CT imaging. CT imaging with the use…

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Negative / Null Result ReportOpen accessMedicine

Urolithin A improves motility, antioxidant defense, and mitochondrial function of chilled canine spermatozoa during 72-h liquid storage.

Mirzaei R, Soleimanzadeh A, Asri-Rezaei S · 2026 · Scientific reports

Dog semen conservation at cold temperatures (5 °C) is a valuable reproductive management tool, but it is bedeviled by issues of oxidative stress and mitochondrial damage that reduce sperm quality and viability. Urolithin A (UA), a natural…

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Negative / Null Result Report

Enhancing Port Performance through Digital Transformation: The Role of Networking Capability and Organizational transformation in Indonesian Container Ports

Pramitra B, Al Musadieq M, Afrianty TW et al. · 2026 · Preprint

Although digital transformation in port management has been widely discussed, previous studies have not extensively examined how organizational capabilities translate into performance through digital adoption at ports. This study addresses…

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Negative / Null Result ReportMedicine

[Effects of repeated controlled ovarian stimulation on the expression of aerobic glycolysis-related enzymes at various stages of early embryo development in mice].

Shen LL, Shi BB, Xiong WY et al. · 2026 · Sheng li xue bao : [Acta physiologica Sinica]

This study aims to investigate whether the reduction in early embryonic development due to repeated controlled ovarian stimulation (COS) is associated with the expression levels of enzymes related to aerobic glycolysis. A repeated COS…

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Negative / Null Result ReportOpen accessMedicine

A Standardized Onion Peel-Derived Bioactive Ingredient Attenuates Palmitate-Induced Steatosis and Oxidative Stress by Modulating Mitochondrial Dynamics and Autophagy in HepG2 Cells.

Di Gregorio I, Migliaccio V, D'Elia M et al. · 2026 · Antioxidants (Basel, Switzerland)

Onion peel represents a valuable food by-product rich in bioactive phenolic compounds. Building on previous phytochemical investigations, an onion peel extract from the Rossa di Tropea variety was developed as a standardized bioactive…

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Negative / Null Result ReportMedicine

The effect of sesame, canola, and sesame-canola oils on oxidative stress markers in patients with type 2 diabetes: A three-way randomized crossover clinical trial.

Moghtaderi F, Zimorovat A, Raeisi-Dehkordi H et al. · 2026 · Nutrition and health

BackgroundOxidative stress plays a critical role in the pathogenesis of chronic diseases. Canola oil (CO) and sesame oil (SO), due to their antioxidant constituents, may differentially influence oxidative stress biomarkers.AimThis study…

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Negative / Null Result ReportMedicine

Depression and cognition: is there a bidirectional relationship?

Glei DA, Weinstein M · 2026 · Aging & mental health

Objectives The association between depression and cognition is well-established, but there is uncertainty regarding the direction of causation. We evaluated the relationship between depression and poor cognition in both directions. Method…

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Negative / Null Result ReportMedicine

Beyond Conventional Care: The use of Alternative Medicine by Head and Neck Cancer Patients in Pakistan - A Retrospective study.

Akhtar, Ghaloo, Pasha et al. · 2026 · JPMA. The Journal of the Pakistan Medical Association

To investigate the prevalence, utilisation and association of diagnostic delay, tumour stage and recurrence with alternative medicine among head and neck cancer patients having undergone surgical resection. The retrospective,…

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