Negative / Null Result ReportOpen accessMedicine
Bruna Cassia Dal Vesco, Ana Carolina de Miranda, Fernanda do Carmo De Stefani et al. · 2026 · Einstein (São Paulo)
ABSTRACT Objective: The causal mechanisms of peripheral hypoperfusion in sepsis have not yet been fully elucidated. Therefore, this study aimed to investigate whether peripheral hypoperfusion in septic patients is associated with serum levels of damage-associated molecular patterns. Methods: A retrospective cohort study was conducted to compare serum levels of damage-associated molecular patterns - histone H3, histone H4, and high-mobility group box-1 protein (HMGB1) - with markers of tissue hypoperfusion - the peripheral perfusion index and the capillary refill time, using a single measuremen
View details →Negative / Null Result ReportOpen accessPublic aspects of medicine
Maria Henström, Christine Delisle Nyström, Susanne Andermo et al. · 2025 · BMC Public Health
Abstract Background Early-life interventions are essential for improving public health since lifestyle behaviours are established already in childhood. Child healthcare (CHC) plays a crucial role in this context. The ‘Saga Stories in health talk’ (SSiHT) material includes a flipchart with colourful illustrations to facilitate CHC nurses’ routine health talks with parents and their children, and a hand-out material kit to support healthy lifestyle behaviours in the families. Our aim was to evaluate the effectiveness of the SSiHT intervention at the 5-year routine visit at CHC on parental self-e
View details →Negative / Null Result ReportOpen accessPhilology. Linguistics
Tatiane Maria Pelitero, Alessandra Kerli da Silva Manfredi, Andrea Pires Corrêa Schneck · 2010 · Revista CEFAC
OBJETIVO: comparar o desempenho na Avaliação Simplificada do Processamento Auditivo (ASPA) e no Pediatric Speech Intelligibility Test (PSI), de crianças com alteração de Aprendizagem da Leitura e Escrita e sem este tipo de alteração. MÉTODOS: participaram da pesquisa 28 crianças na faixa etária de 8 a 12 anos, do sexo masculino e feminino. Os participantes foram submetidos ao Teste de Desempenho Escolar (TDE) para a categorização dos grupos de estudo e controle, e, para avaliação das habilidades auditivas foram aplicados a ASPA e o Teste PSI. RESULTADOS: não foi observada associação estatistic
View details →Negative / Null Result ReportOpen accessMedicine (General)
Yanyuan Wu, Yedie He, Jun Qi et al. · 2024 · Journal of Men's Health
This study was aimed to retrospectively analyze the potential of non-invasive serum biomarkers in clinically predicting the detrusor underactivity (DU) in benign prostatic hyperplasia (BPH) patients with lower urinary tract symptoms (LUTS) and low prostate volume (PV). The study enrolled 196 patients with BPH and LUTS at our hospital in the period from January 2018 to October 2023. The patients were divided into two groups based on the projected isovolumetric pressure (PIP): the DU and the control groups. The patients included in the study had PV of less than 50 mL. A total of 93 and 103 cases
View details →Negative / Null Result ReportMedicine
Anderson RE, Dolney NA · 2026 · Journal of child sexual abuse
The Sexual Experiences Survey (SES) is a widely used measure of sexual victimization. The most recent version of the SES, the Sexual Experiences Survey-Victimization (SES-V), released in 2024 is longer than prior versions. This raises…
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Zhaoying Li, Shanyu Liu, Yuling Shen et al. · 2025 · Frontiers in Neuroscience
BackgroundAbnormalities in brain activity patterns during episodic memory tasks have been inconsistently reported in amnestic mild cognitive impairment (aMCI) patients using functional magnetic resonance imaging (fMRI). This study applied traditional Chinese medicine (TCM) syndrome differentiation to categorize aMCI patients into distinct subgroups, aiming to clarify the neural mechanisms underlying their cognitive profiles.MethodsParticipants included aMCI patients categorized into the turbid phlegm clouding the orifices (PCO) or spleen-kidney deficiency (SKD) syndrome subgroups, alongside co
View details →Negative / Null Result ReportOpen accessMedicine
Alexandre Almeida, Vinícius Atti, Daniel Cecconi Agostini et al. · 2015 · Revista Brasileira de Ortopedia
OBJECTIVE: To analyze the results from arthroscopic suturing of large and extensive rotator cuff injuries, according to the patient's degree of osteopenia.METHOD: 138 patients who underwent arthroscopic suturing of large and extensive rotator cuff injuries between 2003 and 2011 were analyzed. Those operated from October 2008 onwards formed a prospective cohort, while the remainder formed a retrospective cohort. Also from October 2008 onwards, bone densitometry evaluation was requested at the time of the surgical treatment. For the patients operated before this date, densitometry examinations p
View details →Negative / Null Result ReportOpen accessMedicine (General)
Joseph Choi, Rajesh Bhayana, Chenhan D Wang et al. · 2020 · BMJ Open Quality
Ordering and protocolling CT scans after-hours from the emergency department (ED) at our institution previously required discussion between the ED physician and radiology resident, which led to workflow inefficiency. Our intervention consisted of creating an electronic list of CT requests that radiology residents would monitor. Radiology protocolled straightforward requests and contacted the ordering physician for more details when required. We aimed to improve workflow efficiency, increase provider satisfaction and reduce CT turnaround time without significantly affecting CT utilisation. Plan
View details →Negative / Null Result ReportOpen accessMedicine
Hsin-Hua Lee, Ming-Feng Hou, Shu-Yi Wei et al. · 2016 · PLoS ONE
To compare the long-term clinical outcomes of postmastectomy radiotherapy (PMRT) between breast cancer patients with and without immediate transverse rectus abdominis myocutaneous (TRAM) flap reconstruction.The study included 492 patients with stage II or III breast cancer who underwent modified radical mastectomy (MRM) and chemotherapy followed by PMRT between 1997 and 2011. Cox regression model and Kaplan-Meier curves were calculated, and the log-rank test was used to evaluate the differences between overall and disease-free survival rates in the 2 groups.Among 492 patients, 213 patients had
View details →Negative / Null Result ReportOpen accessMedicine
Abbas Abbaszadegan, Zeinab Rafiee, Bahar Asheghi et al. · 2025 · PLoS ONE
Tooth discoloration caused by intracanal medicaments and irrigants presents a significant aesthetic challenge in dentistry. This study aimed to investigate the discoloration effects on tooth of nanographene oxide and positively charged silver nanoparticles and compares them with other commonly used materials in endodontic treatment. A total of 108 single-rooted, single-canal anterior mandibular and maxillary premolar teeth, extracted for orthodontic or periodontal reasons, were selected and prepared. The specimens were randomly divided into seven experimental groups and two control groups, eac
View details →Negative / Null Result ReportOpen accessMedicine (General)
Dumitru-Dragos Chitca, Octavian Mihalache, Florin Bobircă et al. · 2026 · Diagnostics
Background : Anastomotic leakage (AL) remains one of the most feared complications after colorectal surgery. This study aimed to identify preoperative risk factors for AL using a five-year dataset from two Romanian surgical clinics. Materials and Methods : A retrospective cohort of 155 patients undergoing colorectal resection with primary anastomosis (105 from “Colentina” Hospital and 50 from “Dr. I. Cantacuzino” Hospital) was analyzed. Preoperative demographic, clinical, and laboratory data were extracted and assessed using univariate and multivariable logistic regression. Statistical analyse
View details →Negative / Null Result ReportOpen accessMedicine
Serpi M, Çakan A, Akpınar A · 2026 · Medical science monitor : international medical journal of experimental and clinical research
BACKGROUND Vertebral fractures result from degenerative, osteoporotic, or traumatic spinal loading. Treatment options include conservative management, segmental fusion, and percutaneous vertebroplasty/kyphoplasty (PVP/BKP) performed using…
View details →Negative / Null Result ReportOpen accessPharmacy and materia medica
Mohammad Jalaluddin, Saurabh Sathe, Joyce Thomas et al. · 2021 · Journal of Pharmacy and Bioallied Sciences
Aim: The aim of the present study was to assess the implant stability in immediate implant placement using different bone grafting materials. Materials and Methods: Twelve patients (5 males, 7 females, range of 40–58 years) were included in the study. All patients were divided into two groups based on the graft material used. For Group 1, Xenograft bone grafting material was used, and for Group 2, Freeze-dried bone allograft was used. The patients were suggested to rinse with 0.2% chlorhexidine mouth wash for 1 min. Periotome was used for atraumatic tooth extraction, and necessary care was tak
View details →Negative / Null Result ReportOpen accessGenetics
Tug E., Sengül N., Aydin H. et al. · 2012 · Balkan Journal of Medical Genetics
Interactions between individual genetic and environ- mental factors determine the onset of the multi nodular goiter (MNG). The thyroid-stimulating hormone receptor (TSHR) gene is a convincing candidate gene in the pathogenesis of certain thyroid diseases including MNG. We investigated the codon 727 polymorphism (p.Asp727Glu, p.D727E) of the human TSHR gene using the polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP) methods in 31 Turkish patients with MNG and in 30 control subjects, aiming to evaluate the relationship between this polymorphism and MNG. After genomic D
View details →Negative / Null Result ReportOpen accessMedicine
Đorđević Dragan, Lović Branko, Deljanin-Ilić Marina et al. · 2008 · Srpski Arhiv za Celokupno Lekarstvo
INTRODUCTION The prognostic significance of QTc dispersion changes during exercise testing (ET) in patients with left ventricular hypertrophy is not clear. OBJECTIVE The aim was to study the dynamics of QTc interval dispersion (QTcd) in patients (pts) with left ventricular hypertrophy (LVH) during the exercise testing and its prognostic significance. METHOD In the study we included 55 men (aged 53 years) with hypertensive left ventricular hypertrophy and a negative ET (LVH group), 20 men (aged 58 years) with a positive ET and 20 healthy men (aged 55 years). There was no statistically significa
View details →Negative / Null Result ReportOpen accessEducation (General)
Sasmita Tarihoran, Jufrizal Jufrizal · 2024 · English Review: Journal of English Education
This study examines the impact of a language program on the speaking skills of students at UIN SYAHADA Padangsidimpuan. With English proficiency being crucial for global communication, the research aimed to assess the program's effectiveness in improving students' speaking abilities. Using an ex post facto research design, 43 English department students were assessed. Speaking tests were administered at the start and end of the semester, and the data were analyzed using the Wilcoxon test. Findings showed a modest increase in mean scores, indicating some positive effect of the program. However,
View details →Negative / Null Result ReportOpen accessDiseases of the endocrine glands. Clinical endocrinology
Pei Wang, Pei Wang, Zhizhong Dong et al. · 2024 · Frontiers in Endocrinology
BackgroundActive surveillance has been an option for patients with low-risk papillary thyroid carcinoma (PTC). However, whether delayed surgery leads to an increased risk of local tumor metastasis remain unclear. We sought to investigate the impact of observation time on central lymph node metastasis (CLNM) and multifocal disease in patients with low-risk PTC.MethodsPatients who were diagnosed with asymptomatic low-risk PTC, and with a pathological maximum tumor size ≤1.5 cm by were included. The patients were classified into observation group and immediate surgery group, and subgroup analyses
View details →Negative / Null Result ReportOpen accessDentistry
Ada Njokanma, Olayinka Otuyemi, Kikelomo Kolawole · 2023 · Nigerian Dental Journal
Background: Digit sucking habit (DSH) generates functional forces that can influence craniofacial morphology. Although the dental effects have been widely reported, its influence on the masseter muscle thickness (MMT) and upper airway (UA) dimensions is not well known. Methods: Thirty (30) children selected from the orthodontic clinic (OAUTHC), with a DSH were matched with a group of 30 children without a DSH. Each group comprised of 16 males and 14 females. Ultrasonographic evaluation of the masseter muscle (MM) was performed to measure the left and right MMT in the relaxed and contracted sta
View details →Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
A. Guermazi, G. Kalsi, J. Niu et al. · 2017 · BMC Musculoskeletal Disorders
Abstract Background To determine effects of allogeneic human chondrocytes expressing TGF-β1 (TG-C) on structural progression of MRI features of knee osteoarthritis over a 1 year period. Methods This phase II randomized controlled trial of TG-C included patients with moderate to advanced osteoarthritis. Patients were randomized to receive an intraarticular 3:1 mixture of non-transduced allogeneic human chondrocytes and TG-C or placebo. 3 T MRI was acquired for all patients at baseline and follow-up (3, 6 and 12 months). MRIs were assessed using the WORMS system including cartilage damage, bone
View details →Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
Hakan Demirci, Yildirim Cinar, Nazan Bilgel · 2021 · Psychiatry and Clinical Psychopharmacology
Background: The possible association between depressive symptoms and metabolic syndrome (MetS) has recently become an important topic of discussion. There is some limited and inconsistent evidence in the literature concerning whether or not depression and metabolic syndrome are associated. The aim of this study was to examine the association between depressive symptoms and metabolic syndrome. Methods: This is a cross-sectional community-based study. The setting is a family practice unit in an urban area which serves about 3,600 people. The participants were 250 individuals aged 18 and over, se
View details →Negative / Null Result ReportOpen accessMedicine
Kričković Zoran, Simatović Milan, Lukić Darko et al. · 2020 · Scripta Medica
Background/Aim: Benign prostatic hyperplasia (BPH) is a very common disease in older men. BPH involves the presence of signs of hyperplasia of the stromal and epithelial elements in the prostate with consequent enlargement of its volume. The aim of this study is to analyse the frequency of typical complications in the treatment of patients with benign prostatic hyperplasia and the effect of medicamentous treatment. Method: Patients diagnosed BPH were included in the prospective, one-year study. They were divided into 2 groups. The first group (30 patients) consisted of those ones, whose prosta
View details →Negative / Null Result ReportOpen accessScience (General)
Nury Tatiana Jiménez, Juan Carlos Munévar, José Manuel González et al. · 2018 · Heliyon
Three-dimensional-porous scaffolds of bone graft substitutes play a critical role in both cell targeting and transplantation strategies. These scaffolds provide surfaces that facilitate the response of stem cells related to attachment, survival, migration, proliferation, and differentiation. Objective: The aim of this study was to evaluate the in vitro behavior of human dental pulp mesenchymal stem cells cultured on scaffolds of polylactic/polyglycolic acid with and without hydroxyapatite. Method: We performed an in vitro experimental study using dental pulp stem cells obtained from samples of
View details →Negative / Null Result ReportOpen accessNutrition. Foods and food supply
Md Khairul Islam, Ivan Lozada Lawag, Kathryn J. Green et al. · 2022 · Current Research in Food Science
This study reports on the analysis of eleven Jarrah (Eucalyptus marginata) honeys, of which nearly half (n = 5) were re-classified as Blackbutt (E. patens) honey on the grounds of the predominant flower pollen identified by melissopalynology. Based on a comprehensive analysis of the honeys' physico- and phytochemical characteristics and antioxidant activity data, taking into account pH, electrical conductivity, refractive index and Brix values as well as moisture content, individual fructose and glucose content and derived fructose to glucose ratio alongside total phenolic content and antioxid
View details →Negative / Null Result ReportOpen accessBiochemistry
Carlotta Peticone, David De Silva Thompson, Nikolay Dimov et al. · 2020 · Journal of Tissue Engineering
Using microspherical scaffolds as building blocks to repair bone defects of specific size and shape has been proposed as a tissue engineering strategy. Here, phosphate glass (PG) microcarriers doped with 5 mol % TiO 2 and either 0 mol % CoO (CoO 0%) or 2 mol % CoO (CoO 2%) were investigated for their ability to support osteogenic and vascular responses of human mesenchymal stem cells (hMSCs). Together with standard culture techniques, cell-material interactions were studied using a novel perfusion microfluidic bioreactor that enabled cell culture on microspheres, along with automated processin
View details →Negative / Null Result ReportOpen accessTechnology
Jolanta Grochowska, Renata Tandyrak · 2021 · Applied Sciences
A study was carried out in the Kartuzy lake complex, which has been a receiver of raw domestic sewage since the 1950s. In 2018, the city’s sewage system of Kartuzy was modernized. An analysis of the water quality prior to the modernization of the sewage system revealed that the total phosphorus (TP) load that was introduced to the individual lakes from external sources substantially exceeded the dangerous load concentration (defined by Vollenweider) that causes accelerated eutrophication. The annual TP load introduced to the analyzed lakes in 2017 exceeded the critical load by 200% (Mielenko)
View details →Negative / Null Result ReportOpen accessMedicine
Rokaya D, Al Jaghsi A, Masri M et al. · 2026 · Frontiers in dental medicine
Objectives This study aimed to investigate the accuracy of two intraoral scanners at different post space preparation depths and widths for CAD/CAM fabricated post and core fabrication. Methods A total of 36 extracted anterior teeth were…
View details →Negative / Null Result ReportMedicine
Malvandi H, Shamabadi MH, Vaezi I · 2026 · Bulletin of environmental contamination and toxicology
In the present study, thirteen urban bird species were used as bioindicators to monitor metal concentrations in the metropolis of Mashhad. The concentrations of lead (Pb), zinc (Zn), and copper (Cu) ranged from 0.004 to 0.073, 0.750 to…
View details →Negative / Null Result ReportOpen accessMedicine
Zaharovs V, Pilmane M · 2026 · Journal of molecular histology
The anti-apoptotic genes DAD-1 and HAX-1 and the pro-apoptotic GZMB gene have a significant role in the regulation of apoptosis in heart tissue. However, investigation into these genes and their proteins in the pathogenesis of…
View details →Negative / Null Result ReportMedicine
Clukey J, Locascio J, Semler J et al. · 2026 · Journal of clinical gastroenterology
Goals We aimed to evaluate the efficacy and safety of IFT for the treatment of CC in a pilot randomized controlled trial (RCT). Background Subjects with refractory chronic constipation (CC) have limited treatment options. Interferential…
View details →Negative / Null Result ReportOpen accessMedicine
Vatan A, Karabay O, Moralı H et al. · 2026 · BMC infectious diseases
Background Tenofovir alafenamide (TAF) is widely used in antiretroviral therapy due to its improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF). However, concerns remain regarding its potential metabolic effects…
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