Structural effects of intra-articular TGF-β1 in moderate to advanced knee osteoarthritis: MRI-based assessment in a randomized controlled trial
A. Guermazi; G. Kalsi; J. Niu; M. D. Crema; R. O. Copeland; A. Orlando; M. J. Noh; F. W. Roemer · 2017 · BMC Musculoskeletal Disorders
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background To determine effects of allogeneic human chondrocytes expressing TGF-β1 (TG-C) on structural progression of MRI features of knee osteoarthritis over a 1 year period. Methods This phase II randomized controlled trial of TG-C included patients with moderate to advanced osteoarthritis. Patients were randomized to receive an intraarticular 3:1 mixture of non-transduced allogeneic human chondrocytes and TG-C or placebo. 3 T MRI was acquired for all patients at baseline and follow-up (3, 6 and 12 months). MRIs were assessed using the WORMS system including cartilage damage, bone
Abstract by A. Guermazi; G. Kalsi; J. Niu; M. D. Crema; R. O. Copeland; A. Orlando; M. J. Noh; F. W. Roemer, BMC Musculoskeletal Disorders (2017) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1186/s12891-017-1830-8