The Impact of the D727e Polymorphism has no Significant Role in Multi Nodular Goiter
Tug E.; Sengül N.; Aydin H.; Yilmaz E.E. · 2012 · Balkan Journal of Medical Genetics
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Abstract
Interactions between individual genetic and environ- mental factors determine the onset of the multi nodular goiter (MNG). The thyroid-stimulating hormone receptor (TSHR) gene is a convincing candidate gene in the pathogenesis of certain thyroid diseases including MNG. We investigated the codon 727 polymorphism (p.Asp727Glu, p.D727E) of the human TSHR gene using the polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP) methods in 31 Turkish patients with MNG and in 30 control subjects, aiming to evaluate the relationship between this polymorphism and MNG. After genomic D
Abstract by Tug E.; Sengül N.; Aydin H.; Yilmaz E.E., Balkan Journal of Medical Genetics (2012) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.2478/bjmg-2013-0009