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19,866 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Exploring the clinical application value of peripheral blood T lymphocyte subset in patients with asymptomatic omicron infection

Tuantuan Li, Jing Xu, Yong Gao et al. · 2023 · European Journal of Medical Research

Abstract Objective To investigate the clinical significance and value of peripheral blood T lymphocyte subset in patients with asymptomatic novel coronavirus variant strains infection (OMICRON). Methods A retrospective analysis of 281 patients with asymptomatic OMICRON infection who were admitted and isolated to the Fuyang Second People's Hospital from March to April 2022 was conducted. With 32 normal people as the control group, T lymphocytes of the two groups (CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T) were analyzed and the differences between the two groups were analyzed. CD4 + T lymphocytes be

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Negative / Null Result ReportOpen accessDentistry

Influence of resin cement shade on the color and translucency of ceramic veneers

Daiana Kelly Lopes HERNANDES, Cesar Augusto Galvão ARRAIS, Erick de LIMA et al. · Journal of Applied Oral Science

ABSTRACT Objective This in vitro study evaluated the effect of two different shades of resin cement (RC- A1 and A3) layer on color change, translucency parameter (TP), and chroma of low (LT) and high (HT) translucent reinforced lithium disilicate ceramic laminates. Material and Methods One dual-cured RC (Variolink II, A1- and A3-shade, Ivoclar Vivadent) was applied to 1-mm thick ceramic discs to create thin RC films (100 µm thick) under the ceramics. The RC was exposed to light from a LED curing unit. Color change (ΔE) of ceramic discs was measured according to CIEL*a*b* system with a standard

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Negative / Null Result ReportOpen accessSports medicine

The Incidence of Chronic Opioid Use Following Arthroscopic Rotator Cuff Repair and Patient Opioid Education

Danielle G. Weekes MD, Jenna A. Feldman, Richard E. Campbell BS et al. · 2019 · Orthopaedic Journal of Sports Medicine

Objectives: Opioids are commonly prescribed for pain management following Arthroscopic Rotator Cuff Repair (ARCR). While their efficacy outweighs their risks in the short term, chronic opioid use is associated with significant adverse effects, such as dependence, endocrine imbalance or respiratory depression. The rate of chronic opioid use and dependence following ARCR is unknown. The purpose of this study is to determine the rate of chronic opioid use following ARCR and establish the effect of preoperative opioid education on reducing chronic consumption. A secondary aim is to determine if an

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Negative / Null Result ReportOpen accessDentistry

An In Vitro Comparison of Microleakage of White Pro Root MTA and Root MTA in Retro Grade Cavity

L Safi, A Adl, T Ebrahimi Moghadam · 2007 · مجله دانشکده دندانپزشکی اصفهان

Introduction: This study was aimed to evaluate and compare the amount of microleakage of two types of root end filling materials, white Pro Root MTA (Dentsply) and Iranian MTA (Root MTA).Methods and Materials: In this laboratory study, 34 extracted single root and canal human teeth were selected. Root canals were cleaned, shaped and obdurate. Experimental samples were divided randomly in to 2 groups of 15 specimens. Root tips were sectioned in perpendicular angel and root end cavities were prepared. In first group, white Pro Root MTA and in second group, Root MTA was used as root end filling m

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Negative / Null Result ReportOpen accessMedicine

Microablative Erbium: YAG Laser Therapy for Vulvodynia – A Report on Efficacy, Safety, and Treatment Satisfaction

Gerda Trutnovsky, MD, Brigitte Bliem, MD, Elfriede Greimel, PhD et al. · 2021 · Sexual Medicine

ABSTRACT: Introduction: Treatment for vulvodynia is challenging and a multidisciplinary approach is recommended. Aim: To examine the effectiveness, safety and treatment satisfaction of vulvovaginal microablative laser treatment for vulvodynia. Methods: Case study of women who received laser treatment as part of a multidisciplinary treatment program for vulvodynia. Subjective improvement was compared to a retrospective cohort of women treated for vulvodynia without LASER therapy. LASER treatment was offered to women with vulvodynia presenting to a gynecologic pain clinic of a tertiary universit

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Negative / Null Result ReportOpen accessMedicine

Efeito do Hólmio YAG laser (Ho: YAG) sobre o tendão patelar de ratos após 12 e 24 semanas de seguimento The effects of Holmium YAG laser (Ho:YAG) on the patellar tendon of rats after 12 and 24 weeks of follow up

Waldo Lino Júnior, William Dias Belangero · 2005 · Acta Ortopédica Brasileira

Os autores estudaram os efeitos do laser Hólmio:Ítrio-Alumínio-Granada (Ho: YAG) sobre as dimensões do tendão (comprimento e largura proximal e distal) e sobre a celularidade e arranjo das fibras de colágeno em 20 ratos adultos, machos, brancos (Ratus Novergicus) da varidade Wistar. Os animais foram divididos em dois grupos de acordo com o tempo de seguimento (12 e 24 semanas) e de acordo com a forma de aplicação do laser (contínua e em dois pontos). Utilizou-se aparelho de laser de Hólmio (pulsátil, estado sólido, com ondas de 2,1 microns, com potência de 40 watts, ponteira OmniTip de 30º) .

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Negative / Null Result ReportOpen accessOphthalmology

Influence of bar reader colour and contrast when reading

Fiona J. Rowe, Laura Tremarco · 2010 · British and Irish Orthoptic Journal

Aim: To identify the effect of using different coloured bars on reading time for the bar reading task, along with an assessment of subject experience with different colour bars. Methods: Inclusion criteria were: visual acuity better than 0.5 logMAR, presence of binocular single vision, and ability to understand and perform bar reading. Measurements were taken of visual acuity, near point of convergence, interpupillary distance, Bagolini glasses and prism fusion range. Bar reading was timed and undertaken with and without five coloured bars for N5 and N12 print. Results: Forty subjects were rec

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Negative / Null Result ReportOpen accessMedicine

The effects of a non-school setting on quantity and quality of biology knowledge of primary students-A pilot study.

Ludmila Malariková, Kristýna Machová, Ivona Svobodová et al. · 2023 · PLoS ONE

To increase the effectiveness of education is appropriate to incorporate varied teaching methods with multisensory stimulation and with an emphasis on personal and emotional experiences. This study aims to compare the knowledge of biology subject matter acquired by second and fourth-grade primary students. The lesson occurred at a farm in the experimental group and at school in the control group. Students' knowledge levels were assessed before the lesson, after the lesson, after 14 days, after a month, and after six months. When the levels of knowledge after the lesson were compared between th

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Negative / Null Result ReportOpen accessMedicine

Frozen vs. fresh cycles IVF outcomes: retrospective study from an Indonesian IVF centre

Wiryawan Permadi, Hartanto Bayuaji, Kevin Dominique Tjandraprawira et al. · 2021 · BMC Research Notes

Abstract Objective To compare the live birth rates (LBR) and neonatal outcomes of frozen cycle in vitro fertilization (IVF) with fresh cycle IVF in the Indonesian population. Results This was retrospective study using secondary data of IVF patients at a private fertility centre. Study recruitment was between 3/8/2018 and 31/12/2019. Total sampling included all patients undergoing oocyte retrieval and embryo transfer within recruitment period. Patients undergoing fresh IVF cycles and frozen IVF cycles were compared. 351 patients were recruited: 68.1% (239/351) underwent fresh cycles and 31.9% (

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Negative / Null Result ReportOpen accessMedicine

Association between chemotherapy and prognostic factors of survival in hepatocellular carcinoma: a SEER population-based cohort study

Meiqi Liu, Mengying Xu, Tiantian Tang · 2021 · Scientific Reports

Abstract Hepatectomy and transplantation are the main surgical therapies for HCC patients, and radiotherapy or chemotherapy is often used as adjuvant treatment. Researches have evaluated the independent predictors of HCC, but evidence for factors predicting the efficacy of chemotherapy is rare. Patients diagnosed with HCC between 2010 and 2015 from the SEER database were included and randomly divided into non-chemotherapy and chemotherapy groups. The predictors of CSS and OS were analyzed with the Cox proportional-hazards regression model and Fine and Gray’s competing risk model. Although ther

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Negative / Null Result ReportOpen accessSurgery

Polypropylene and polypropylene/polyglecaprone (Ultrapro(r)) meshes in the repair of incisional hernia in rats

Edivaldo Massazo Utiyama, Maria Beatriz Sartor de Faria Rosa, Marina de Paula Andres et al. · 2015 · Acta Cirúrgica Brasileira

PURPOSE: To compare the inflammatory response of three different meshes on abdominal hernia repair in an experimental model of incisional hernia.METHODS: Median fascial incision and skin synthesis was performed on 30 Wistar rats. After 21 days, abdominal hernia developed was corrected as follows: 1) No mesh; 2) Polypropylene mesh; and, 3) Ultrapro(r) mesh. After 21 days, the mesh and surrounding tissue were submitted to macroscopic (presence of adhesions, mesh retraction), microscopic analysis to identify and quantify the inflammatory and fibrotic response using a score based on a predefined s

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Negative / Null Result ReportOpen accessSurgery

The value of blood and urine metabolomics in differential diagnosis of cholestasis in infants

Samah Abdelfatah Eshiaty, Shimaa Abdelsattar, Dina Sweed et al. · 2023 · Egyptian Liver Journal

Abstract Background Early detection of biliary atresia (BA) is a great challenge providing the main useful way to improve its clinical consequence. Promising metabolomics provides an effective method for determining innovative biomarkers and biochemical ways for improving early diagnosis. This study aimed to determine the benefit of serum and urinary potential bile acid metabolites in the differentiation of BA from non-biliary atresia (non-BA) cases using tandem mass spectrometry (MS/MS). Fourteen bile acids metabolites were measured quantitively by MS/MS in serum and urine samples from 102 ch

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Negative / Null Result ReportOpen accessDemography. Population. Vital events

Adult children's union type and contact with mothers: A replication

Martin Kreidl, Zuzana Žilinčíková · 2023 · Demographic Research

Background : Several studies show that cohabiting adult children have less frequent contact with their mothers than married adult children. We argue that these findings might be spurious due to confounding. Objective : Our aim is to replicate earlier research using more robust statistical instruments from the family of multi-level models with fixed effects, which are known to offer better control of omitted-variable bias. We also want to show the extent to which union-type effects vary across countries and by parenthood status. Methods : We use data from the SHARE survey. Mothers are the prima

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Negative / Null Result ReportOpen accessOrthopedic surgery

Radiation Exposure and Safety in Minimally Invasive Foot and Ankle Surgery: A Comparative Analysis Between Minimally Invasive Distal First Metatarsal Transverse Osteotomy and Akin Osteotomy vs. Open Modified Lapidus Procedure

Preston Harrison BS, Sarah Kiriluk MD, Kevin Lee et al. · 2026 · Foot & Ankle Orthopaedics

Category: Midfoot/Forefoot, Bunion Diabetes Keywords: Ankle, Degenerative, Hindfoot Deformity Introduction/Purpose: Intraoperative fluoroscopy has become essential in orthopedic surgery, particularly with the rise of minimally invasive surgery (MIS) techniques. Despite the advantages of minimally invasive foot and ankle surgery, it raises concerns about radiation exposure to both patients and surgical staff. The purpose of this study was to evaluate fluoroscopy time and radiation dose (cumulative air kerma) associated with open versus MIS bunion correction, comparing the open modified Lapidus

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Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Laparoscopic radical gastrectomy for gastric cancer: an anatomical approach to right mesogastrium excision and its clinical significance

Guofeng Pan, Guofeng Pan, Guofeng Pan et al. · 2025 · Frontiers in Oncology

ObjectiveRadical gastrectomy for gastric cancer involves the en-bloc resection of the primary tumor and complete excision of the mesogastrium. However, the surgical boundaries and techniques for removing lymph nodes above the pylorus during gastric cancer surgery remain unclear. We aimed to investigate a novel, standardized approach for excising the right mesogastrium in gastric cancer patients undergoing suprapyloric lymphadenectomy, focusing on surgical techniques and outcomes.MethodsOur surgical technique includes identifying three key elements of the mesogastrium: the encircling portion, t

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Negative / Null Result ReportOpen accessOrthopedic surgery

Accuracy of pedicle screw placement based on preoperative computed tomography versus intraoperative data set acquisition for spinal navigation system

Hao Liu, Weikai Chen, Tao Liu et al. · 2017 · Journal of Orthopaedic Surgery

Aim: To investigate the accuracy of pedicle screw placement based on preoperative computed tomography in comparison with intraoperative data set acquisition for spinal navigation system. Methods: The PubMed (MEDLINE), EMBASE, and Web of Science were systematically searched for the literature published up to September 2015. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-analysis guidelines. Statistical analysis was performed using the Review Manager 5.3. The dichotomous data for the pedicle violation rate was summarized using relative risk (RR) and 95% confid

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Negative / Null Result ReportOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Effect of liposome binding antisense oligonucleotide BP1003 on albumin-bound paclitaxel sensitivity in pancreatic cancer cells by inhibiting STAT3

FU Hua, ZHOU Guochao, CAI Rongmin, SONG Xin, YANG Dinghua · 2025 · Zhongguo aizheng zazhi

Background and purpose: The resistance of pancreatic cancer to albumin-bound paclitaxel affects the therapeutic effect and prognosis. Signal transducer and activator of transcription 3 (STAT3) is one of the important molecules regulating the chemotherapy sensitivity of cancer cells. The liposome BP1003 targeting the antisense oligonucleotide of STAT3 mRNA can inhibit the expression of STAT3 and increase the chemotherapy sensitivity. However, the effect of BP1003 on the sensitivity of pancreatic cancer cells to albumin-bound paclitaxel remains unclear. The purpose of this study was to investiga

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Negative / Null Result ReportOpen accessVeterinary medicine

Toxicity of standing milkvetch infected with Alternaria gansuense in white mice

Bo Yang, Zhi Biao Nan, Yan Zhong Li · 2025 · Frontiers in Veterinary Science

IntroductionStanding milkvetch (Astragalus adsurgens) is widely distributed in the wild in Eurasia and North America and has been bred for cultivated forage in China. Yellow stunt and root rot disease caused by Alternaria gansuense is the primary disease of standing milkvetch. A. gansuense promotes the production of swainsonine in the plant. This study aimed to determine the safety of standing milkvetch that is infected with A. gansuense as forage for animals.MethodsTwo-week-old specific pathogen-free (SPF) male white mice were fed a commercial mouse feed (CMF), healthy plant feed (HPF) and di

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Negative / Null Result ReportOpen accessMedicine

Construction and confirmatory factor analysis of the core cognitive ability index system of ship C2 system operators.

Ning Li, Jincai Huang, Yanghe Feng · 2020 · PLoS ONE

Background Cognitive ability refers to the ability to receive, process, store, and extract information. It is the most important psychological condition for people to successfully complete activities. Previous studies have shown that the design of the human-computer interface of the command and control system cannot exceed the cognitive ability of the operator of the command and control system, and it must match the cognitive ability of the operator in order to reduce the mental load intensity, and improve the accuracy, timeliness and work efficiency. However, previous researchers in the field

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Negative / Null Result ReportOpen accessSports

The Effect of Self-Movement on Distance Perception: An Examination of Perception-Action Coupling

Atefe Eftekhari, Jalal Dehghanizade · 2022 · رشد و یادگیری حرکتی ورزشی

The aim of this study was to investigate the effect of self-movement on distance perception. The method of the present study is quasi-experimental. The statistical population of the present study was the students of Urmia University who were randomly selected as a sample of 60 students who were eligible to participate in the study and were randomly divided into three groups of 20 people including static group, dynamic group with treadmill speed 4 Km/h and the dynamic group were divided at a speed of 8 km/h. The test of walking blindfolded in a straight line to a previously observed target was

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Negative / Null Result ReportOpen accessMedicine

The correlation between serum sex hormone levels and clear cell renal cell carcinoma in male patients

Zhongwei Yu, Chenhui Zhao, Anqing Yang et al. · 2025 · Scientific Reports

Abstract To investigate the correlation between serum sex hormone levels and clear cell renal cell carcinoma(ccRCC). The clinical data of male patients diagnosed with ccRCC and with simple renal cysts in our hospital from 2017 to 2023 were collected. The basic clinical data and serum sex hormone levels, including luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol(E2), prolactin (PRL), progesterone(P), and testosterone (T), were compared between patients with ccRCC and patients with simple renal cysts. A total of 56 male patients with ccRCC and 82 male patients with simple

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Negative / Null Result ReportOpen accessMedical technology

Clinical Study on the Application of Ultrasound-guided Quadratus Lumborum Block Combined with Ilioinguinal/Iliohypogastric Nerve Block in Inguinal Surgery in the Elderly

Jian Zhang, Guohai Sun, Lei Zhang et al. · 2025 · Journal of Medical Ultrasound

Background: This study aimed to investigate the effects of combining an ilioinguinal/iliohypogastric nerve block with an ultrasound-guided quadratus lumborum block during inguinal surgery in older patients. Methods: Between December 2020 and June 2023, 300 elderly patients who underwent inguinal surgery at our institution were randomly divided into an observation group (n = 150) and a control group (n = 150). The observation group received ultrasound-guided quadratus lumborum block in addition to ilioinguinal/iliohypogastric nerve block, whereas the control group received only ultrasound-guide

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Negative / Null Result ReportOpen accessEconomic theory. Demography

Y és Z generációs fiatal közgazdászok vélekedése a mesterséges intelligenciáról

Kitti Dióssy · 2024 · Köz-gazdaság

Hungarian Életünk és mindennapjaink egyre nagyobb részére van befolyása a mesterséges intelligenciának (MI). A munkaerőpiacon már jelenlévő Y és Z generáció motivációja és attitűdje hatással van hosszú távon a vállalatok versenyképességére. Az MI előnyeinek felismerése mellett annak alkalmazása és az esetleges hátrányaihoz való alkalmazkodás is jelentős feladat. Kutatásomban arra fókuszálok, hogy feltárjam a fiatal közgazdászok gondolkodásmódját az MI-vel kapcsolatban, anonim kérdőívek segítségével (147 magyar, 105 amerikai válaszadó). Ennek érdekében amerikai (fejlett gazdaság és élen járó az

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Negative / Null Result ReportOpen accessAgriculture

The role of dietary nucleotide on energy sources and growth function of common carp, Cyprinus carpio

B. Falahatkar email ; H. Abdi; N. Mahmoudi · 2012 · ‬‭Majallah-i ̒Ilmī-i Shīlāt-i Īrān

Considering the effects of dietary nucleotides on growth and metabolism, this study was conducted to determine the effect of different levels of this nutrient on the sources of the body needed energy, and growth performance of common carp. Fish with average (±SD) weight of 7.5±0.2g were fed to five levels of dietary nucleotides containing 0, 0.1, 0.2, 0.3 and 0.4 percent for 8 weeks. Fish were fed 5 times daily according the satiation. After 56 days, the results showed that the level 0.2% nucleotide had the highest growth rate in terms of weight and length, but other parameters such as body

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Negative / Null Result ReportOpen accessDentistry

Tooth-Implant-Supported Prosthetic Structures Versus Implant-Supported Restorations

Marieta Bujak, Ivan Brakus, Ratka Borić · 2023 · Acta Stomatologica Croatica

Objectives: The primary aim was to compare the amount of bone height change that occurs around the tooth and the implant when having tooth-implant-supported prosthetic restorations versus bone height change that appears around implants in only implant-supported prosthetic restorations. The secondary aim was to examine the influence of various factors such as the number of teeth involved in the construction, their endodontic treatment, number of implants, the type of implantology construction, the jaw in which the construction is located, the condition of the opposite jaw, gender, age, and work

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Negative / Null Result ReportOpen accessBiology (General)

PROFILE OF EPILEPSY PATIENTS IN PEDIATRIC WARD AT DR. SOETOMO GENERAL ACADEMIC HOSPITAL, SURABAYA, INDONESIA IN THE PERIOD OF JANUARY-DECEMBER 2017

Dewi Sekarsari, Viskasari P. Kalanjati, Abdulloh Machin et al. · 2020 · Majalah Biomorfologi

Background: Various risk factors of epilepsy in children had been reported although differences were found amongst regions. Objective: To identify the profile of epilepsy patients and previous febrile seizure history in children aged 0-17 years at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indonesia, in 2017. Materials and Methods: This was a cross-sectional retrospective study, using secondary data from medical records of epilepsy patients with febrile seizure history in children aged 0-17 years old at Pediatric Ward, Dr. Soetomo General Academic Hospital, Surabaya, Indo

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Negative / Null Result ReportOpen accessNursing

External application with Traditional Chinese Medicine in prevention of postoperative fever in patient undergoing surgery for obstructive sleep apnea-hypopnea syndrome (中药敷贴预防阻塞性睡眠呼吸暂停低通气综合征患者术后发热的效果)

YE Yuquan (叶玉泉) · 2021 · 中西医结合护理

Objective To observe the effect of external application with Traditional Chinese Medicine in prevention of postoperative fever (>38 ℃) in patient undergoing surgery for obstructive sleep apnea-hypopnea syndrome. Methods Totally 118 patients undergoing bilateral tonsillectomy/adenoidectomy were randomly divided into the study group and the control group, with 59 cases in each group. All patients received routine care after surgery, and those in the study group were given external application with Traditional Chinese Medicine. The incidence of postoperative fever (>38 ℃) was compared between two

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Negative / Null Result ReportOpen accessDiseases of the blood and blood-forming organs

Preparation quality control and clinical application observation of pooled platelets with leukocytes reduced

Min GUO, Jianmin LI, Jianhui LIU et al. · 2023 · Zhongguo shuxue zazhi

Objective To investigate the preparation quality and clinical application effect of pooled platelets with leukocytes reduced. Methods The quality and clinical effect of the buffy-coated method prepared pooled platelets leukocytes reduced (experimental group, n=40) and apheresis platelets leukocytes reduced (control group, n=40) were compared. Results The platelet volume (mL), platelet count (×1011), red blood cell contamination (×108) and residual white blood cell (×106) of the experimental group and control group were 278.90±7.92 vs 276.52±8.01, 2.66±0.09 vs 2.66±0.83, 0.54±0.42 vs 0.83±0.84,

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Negative / Null Result ReportOpen accessPublic aspects of medicine

Can Prostate Specific Antigen Be Used as New Biomarker for Early Diagnosis of Breast Cancer?

Seyed Mostafa Shiryazdi, Mohammad Dehestani, Mohammad forat yazdi et al. · 2015 · Journal of Community Health Research

Introduction: As a glycoprotein, Plasma Prostate-Specific Antigen (PSA) is mainly produced by prostate epithelial cells and is used as a major diagnostic tool for prostate cancer. A group of researchers relate the elevated number of estrogen receptors in breast cancer samples to the over-production of PSA in this type of cancer. Therefore, the present study aimed to determine the participants' plasma PSA level as a new biomarker for the primary diagnosis of breast cancer. Methods: Employing a historical cohort design, this study was conducted on 95 patients suffering from breast masses. The pa

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Negative / Null Result ReportOpen accessVeterinary medicine

Coconut water combined with purebred chicken egg yolk as an alternative semen extender for Madura Pote bucks semen preservation

Tatik Hernawati, Suherni Susilowati, Tri Wahyu Suprayogi et al. · 2024 · Ovozoa: Journal of Animal Reproduction

One of the many efforts to increase the quality of livestock genetics is through artificial insemination (AI). Other than increasing it, AI can be conducted to preserve semen. A successful AI is determined by seminal quality, therefore, a method to preserve semen for a longer storage time is needed. The method used is adding an extender that fulfills prerequisites for a semen extender such as coconut water combined with egg yolk citrate extender. Coconut water is rich in carbohydrates, protein, vitamins, and antioxidants while egg yolk contains lecithin. This study aims to find out the Pote bu

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