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19,743 real negative results, null findings, and replication failures · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Cholinergic Control over Attention in Rats Prone to Attribute Incentive Salience to Reward Cues

Giovanna Paolone, Christopher C. Angelakos, Paul Meyer et al. · 2013 · Journal of Neuroscience

Some rats [sign-trackers (STs)] are especially prone to attribute incentive salience to reward cues, relative to others [goal-trackers (GTs)]. Thus, reward cues are more likely to promote maladaptive reward-seeking behavior in STs than…

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Negative / Null Result ReportOpen accessEnvironmental Science

Analysis of ecosystem services provision in the Colombian Amazon using participatory research and mapping techniques

Sara O.I. Ramirez-Gomez, Carlos A. Torres-Vitolas, Kate Schreckenberg et al. · 2015 · Ecosystem Services

Over the last two decades indigenous peoples in the lower Caquetá River basin in Colombia have experienced detrimental changes in the provision of important ecosystem services in ways that have significant implications for the maintenance of their traditional livelihoods. To assess these changes we conducted eight participatory mapping activities and convened 22 focus group discussions. We focused the analysis on two types of change: (1) changes in the location of ecosystem services provisioning areas and (2) changes in the stock of ecosystem services. The focal ecosystem services include serv

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Negative / Null Result ReportDecision Sciences

Email Duration, Batching and Self-interruption

Gloria Mark, Shamsi T. Iqbal, Mary Czerwinski et al. · 2016

While email provides numerous benefits in the workplace, it is unclear how patterns of email use might affect key workplace indicators of productivity and stress. We investigate how three email use patterns: duration, interruption habit,…

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Negative / Null Result ReportAgricultural and Biological Sciences

The System of Rice Intensification and its Impacts on Household Income and Child Schooling: Evidence from Rural Indonesia

Kazushi Takahashi, Christopher B. Barrett · 2013 · American Journal of Agricultural Economics

Abstract The yield potential of a set of improved rice management practices, known as the System of Rice Intensification (SRI), has attracted much attention. Yet we know surprisingly little about SRI's socio‐economic impact. Using data…

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Negative / Null Result ReportOpen accessNeuroscience

Functional significance of the emotion-related late positive potential

Stephen B. R. E. Brown, Henk van Steenbergen, Guido P. H. Band et al. · 2012 · Frontiers in Human Neuroscience

The late positive potential (LPP) is an event-related potential (ERP) component over visual cortical areas that is modulated by the emotional intensity of a stimulus. However, the functional significance of this neural modulation remains elusive. We conducted two experiments in which we studied the relation between LPP amplitude, subsequent perceptual sensitivity to a non-emotional stimulus (Experiment 1) and visual cortical excitability, as reflected by P1/N1 components evoked by this stimulus (Experiment 2). During the LPP modulation elicited by unpleasant stimuli, perceptual sensitivity was

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Negative / Null Result ReportEconomics, Econometrics and Finance

The Predictive Content of Commodity Futures

Menzie Chinn, Olivier Coibion · 2013 · Journal of Futures Markets

Abstract This study examines the predictive content of futures prices for energy, agricultural, precious and base metal commodities. In particular, we examine whether futures prices are (1) unbiased and/or (2) accurate predictors of…

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Negative / Null Result ReportOpen accessMedicine

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

Adam C. Naj, Gary W. Beecham, Eden R. Martin et al. · 2010 · PLoS Genetics

Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of association with polymorphisms in APOE. However, until recently, variants at few other loci with statistically significant associations have replicated across studies. The present study combines data on 483,399 single nucleotide polymorphisms (SNPs) from a previously reported GWAS of 492 LOAD cases and 496 controls and from an independent set of 439 LOAD cases and 608 controls to strengthen power to identify novel genetic association signals. Associations exceeding the ex

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Negative / Null Result ReportOpen accessMedicine

Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts

Anja Laschkolnig, Barbara Kollerits, Claudia Lamina et al. · 2014 · Cardiovascular Research

AIMS: The relevance of lipoprotein(a) [Lp(a)] concentrations and low-molecular-weight (LMW) apo(a) phenotypes in peripheral arterial disease (PAD) has only been investigated by few studies. Therefore, we analysed this association in three…

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Negative / Null Result ReportOpen accessMedicine

Subjective Cognitive Decline Correlates With Depression Symptoms and Not With Concurrent Objective Cognition in a Clinic-Based Sample of Older Adults

Zvinka Z. Zlatar, Martha C. Muniz, Douglas Galasko et al. · 2016 · The Journals of Gerontology Series B

Objectives: Subjective cognitive decline (SCD) is common in older adults; however, its utility in clinic-based samples remains controversial given its strong associations with mood symptoms. Methods: Five hundred nineteen individuals aged…

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Negative / Null Result ReportBusiness, Management and Accounting

U.S. Audit Partner Rotations

Henry Laurion, Alastair Lawrence, James Ryans · 2016 · The Accounting Review

ABSTRACT We investigate the effects of audit partner rotation among U.S. publicly listed firms, utilizing the fact that audit partners are periodically copied by name in public correspondence between issuers and the Securities and Exchange…

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Negative / Null Result ReportOpen accessImmunology and Microbiology

Agonistic CD40 therapy induces tertiary lymphoid structures but impairs responses to checkpoint blockade in glioma

Luuk van Hooren, Alessandra Vaccaro, Mohanraj Ramachandran et al. · 2021 · Nature Communications

Abstract Gliomas are brain tumors characterized by an immunosuppressive microenvironment. Immunostimulatory agonistic CD40 antibodies (αCD40) are in clinical development for solid tumors, but are yet to be evaluated for glioma. Here, we demonstrate that systemic delivery of αCD40 in preclinical glioma models induces the formation of tertiary lymphoid structures (TLS) in proximity of meningeal tissue. In treatment-naïve glioma patients, the presence of TLS correlates with increased T cell infiltration. However, systemic delivery of αCD40 induces hypofunctional T cells and impairs the response t

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Negative / Null Result ReportOpen accessSocial Sciences

Media Systems in the Digital Age: An Empirical Comparison of 30 Countries

Edda Humprecht, Laia Castro, Sina Blassnig et al. · 2022 · Journal of Communication

Abstract Media systems have changed significantly as a result of the development of information technologies. However, typologies of media systems that incorporate aspects of digitalization are rare. This study fills this gap by…

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Negative / Null Result ReportOpen accessPhysics and Astronomy

Analysis of Ringdown Overtones in GW150914

R. Cotesta, G. Carullo, Emanuele Berti et al. · 2022 · Physical Review Letters

We analyze GW150914 postmerger data to understand if ringdown overtone detection claims are robust. We find no evidence in favor of an overtone in the data after the waveform peak. Around the peak, the Bayes factor does not indicate the…

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Negative / Null Result ReportOpen accessEnvironmental Science

Susceptibility of amphibians to chytridiomycosis is associated with MHC class II conformation

Arnaud Bataille, Scott D. Cashins, Laura F. Grogan et al. · 2015 · Proceedings of the Royal Society B Biological Sciences

The pathogenic chytrid fungus Batrachochytrium dendrobatidis (Bd) can cause precipitous population declines in its amphibian hosts. Responses of individuals to infection vary greatly with the capacity of their immune system to respond to the pathogen. We used a combination of comparative and experimental approaches to identify major histocompatibility complex class II (MHC-II) alleles encoding molecules that foster the survival of Bd-infected amphibians. We found that Bd-resistant amphibians across four continents share common amino acids in three binding pockets of the MHC-II antigen-binding

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Negative / Null Result ReportOpen accessMedicine

Survival rates and prognostic factors for infiltrating salivary duct carcinoma: Analysis of 228 cases from the Surveillance, Epidemiology, and End Results database

Vijayvel Jayaprakash, Mihai Merzianu, Graham Warren et al. · 2013 · Head & Neck

BACKGROUND: The survival rates and prognostic factors for salivary duct carcinoma (SDC) are not clear. METHODS: Survival estimates and prognostic factors were evaluated for 228 patients with SDC identified from the Surveillance,…

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Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Impacts of the changing climate on agricultural productivity and food security: Evidence from Ethiopia

Ahmed Bouteska, Taimur Sharif, Faruk Bhuiyan et al. · 2024 · Journal of Cleaner Production

This study investigates the influence of climate change on agriculture productivity and food security in the context of Ethiopia. We use 2011–2020 state level data set of four major seasonal crops of Cash and Food in Ethiopia, namely, barley, wheat, maize, and sorghum. Methodologically, we apply the productivity function and the Ricardian approaches in the modelling for simulating the association of climate change with agriculture productivity. This study documents the interconnectedness among changes in climate, security of food and agriculture, indicating how the prior changes bring the latt

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Negative / Null Result ReportOpen accessMedicine

Impact of CFTR Modulation on Intestinal pH, Motility, and Clinical Outcomes in Patients With Cystic Fibrosis and the G551D Mutation

Daniel Gelfond, Sonya L. Heltshe, Chang‐Xing Ma et al. · 2017 · Clinical and Translational Gastroenterology

OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles…

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Negative / Null Result ReportMedicine

Randomized Clinical Trial of Sodium Polystyrene Sulfonate for the Treatment of Mild Hyperkalemia in CKD

Laurence Lepage, A Dufour, Jessica Doiron et al. · 2015 · Clinical Journal of the American Society of Nephrology

BACKGROUND AND OBJECTIVES: Hyperkalemia affects up to 10% of patients with CKD. Sodium polystyrene sulfonate has long been prescribed for this condition, although evidence is lacking on its efficacy for the treatment of mild hyperkalemia…

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Negative / Null Result ReportOpen accessMedicine

An experimental study on the effects of a simulation game on students’ clinical cognitive skills and motivation

Mary Dankbaar, Jelmer Alsma, Els E. H. Jansen et al. · 2015 · Advances in Health Sciences Education

Simulation games are becoming increasingly popular in education, but more insight in their critical design features is needed. This study investigated the effects of fidelity of open patient cases in adjunct to an instructional e-module on students' cognitive skills and motivation. We set up a three-group randomized post-test-only design: a control group working on an e-module; a cases group, combining the e-module with low-fidelity text-based patient cases, and a game group, combining the e-module with a high-fidelity simulation game with the same cases. Participants completed questionnaires

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Negative / Null Result ReportOpen accessComputer Science

Combining Retrieval, Statistics, and Inference to Answer Elementary Science Questions

Peter E. Clark, Oren Etzioni, Tushar Khot et al. · 2016 · Proceedings of the AAAI Conference on Artificial Intelligence

What capabilities are required for an AI system to pass standard 4th Grade Science Tests? Previous work has examined the use of Markov Logic Networks (MLNs) to represent the requisite background knowledge and interpret test questions, but…

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Negative / Null Result ReportOpen accessEnvironmental Science

The role of public and private natural space in children's social, emotional and behavioural development in Scotland: A longitudinal study

Elizabeth Richardson, Jamie Pearce, Niamh Shortt et al. · 2017 · Environmental Research

INTRODUCTION: Poor mental health in childhood has implications for health and wellbeing in later life. Natural space may benefit children's social, emotional and behavioural development. We investigated whether neighbourhood natural space and private garden access were related to children's developmental change over time. We asked whether relationships differed between boys and girls, or by household educational status. METHODS: were modelled to quantify their independent contributions to SDQ score change over time. RESULTS: Private garden access was strongly related to most SDQ domains, while

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Negative / Null Result ReportOpen accessSocial Sciences

Primary Elections and Partisan Polarization in the U.S. Congress

Shigeo Hirano, James M. Snyder, Stephen Ansolabehere et al. · 2010 · Quarterly Journal of Political Science

Many observers and scholars argue that primary elections contribute to ideological polarization in U.S. politics. We test this claim using congressional elections and roll call voting behavior. Many of our findings are null. We find little…

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Negative / Null Result ReportDentistry

Smoking, Diabetes Mellitus, Periodontitis, and Supportive Periodontal Treatment as Factors Associated With Dental Implant Survival: A Long-Term Retrospective Evaluation of Patients Followed for Up to 10 Years

Rachel Anner, Yoav Grossmann, Yael Anner et al. · 2010 · Implant Dentistry

OBJECTIVES: To evaluate the factors associated with long-term implant survival in a large cohort of patients in regular follow-up until data collection. METHODS: The study population consisted of 475 patients who were referred to a private…

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Negative / Null Result ReportOpen accessDecision Sciences

Factors influencing purchase intention towards consumer-to-consumer e-commerce

M. Dachyar, Liska Banjarnahor · 2017 · Intangible Capital

Purpose: This study explores factors that influence consumer’s purchase intention at three consumer-to-consumer (C2C) e-commerce companies in Indonesia.Design/methodology/approach: 5 Expert opinions are used to determine the indicators of each factor and the Structural Equation Modelling (SEM) method is used to analyze the empirical data of 400 respondents for each company.Findings: It is found different significant factors that influence customer’s purchase intention in each company. Trust and risk are found to be significantly effect purchase intention in Company A. Meanwhile, the other two

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