Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shivani Srivastava, Harsh Pandey, Surya Kumar Singh et al. · 2019 · Advanced Pharmaceutical Bulletin
Purpose: Basically insulin is known to be secreted by β cells of the pancreas. Recently, it has also been found to be produced and expressed by intestinal epithelial cells with the help of L cells secreting glucagon like peptide 1 (GLP 1). Here, we have studied the same intestinal insulin expression property in T2D rats. Methods: Following 2 weeks of high fat diet (HFD) consumption, we have been given a single dose of streptozotocin (STZ) (35 mg/kg bw). Rats were then sacrificed after 1, 7 and 21 days. The GLP 1 analogue, liraglutide was also given to one group of diabetic rats, upto their res
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
M Dadvand Sarab, H Naghdi Badi, M Nasri et al. · 2008 · Journal of Medicinal Plants
Background: Basil (Ocimum basilicum L.) is a valuable medicinal and aromatic plant which is cultivated throughout the world. Therefore, it is necessary to determine effect of important agronomical factors on quality and quantity of its volatile oil. Objective: To determine plant density and nitrogen fertilization effects on quality and quantity yield of basil. Method: This study was done in Research farm of ACECR, Institute of Medicinal Plants & Natural Products Research in 2006 on the base of factorial experiment in randomized complete block design with four replications. All possible combina
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Alan J. Weaver, Timothy R. Borgogna, Galen O’Shea-Stone et al. · 2022 · Antibiotics
The rise in bacterial resistance to common antibiotics has raised an increased need for alternative treatment strategies. The natural antibacterial product, 18β-glycyrrhetinic acid (GRA) has shown efficacy against community-associated methicillin-resistant Staphylococcus aureus (MRSA), although its interactions against planktonic and biofilm modes of growth remain poorly understood. This investigation utilized biochemical and metabolic approaches to further elucidate the effects of GRA on MRSA. Prolonged exposure of planktonic MRSA cell cultures to GRA resulted in increased production of staph
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Joanna Hajduk, Cyrill Brunner, Sebastian Malik et al. · 2020 · mAbs
Minor changes in the quality of biologically manufactured monoclonal antibodies (mAbs) can affect their bioactivity and efficacy. One of the most important variations concerns the N-glycosylation pattern, which directly affects an anti-tumor mechanism called antibody-dependent cell-meditated cytotoxicity (ADCC). Thus, careful engineering of mAbs is expected to enhance both protein-receptor binding and ADCC. The specific aim of this study is to evaluate the influence of terminal carbohydrates within the Fc region on the interaction with the FcγRIIIa/CD16a receptor in native and label-free condi
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Wang J, Lu S, Zhang C et al. · 2025 · Drug Design, Development and Therapy
Jinglong Wang, Shijia Lu, Chenxiao Zhang, Junjie Wang, Huiru Wu, Guofei Li Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of ChinaCorrespondence: Guofei Li, Department of Pharmacy, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Shenyang, 110004, People’s Republic of China, Tel/Fax +86-24-23925108, Email sylgf2009@163.comPropose: The co-treatment of ulcerative colitis with berberine hydrochloride (BBR), the Janus kinase(JAK) inhibitor Tofacitinib (TOFA), and Fligotinib (FIGA) is feasible and sophisti
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
David P. Burns, Sarah E. Drummond, Stefanie Wölfel et al. · 2024 · Antioxidants
Obstructive sleep apnoea (OSA) involves impaired upper airway muscle function and is linked to several pathologies including systemic hypertension, daytime somnolence and cognitive decline. Selenium is an essential micronutrient that exerts many of its effects through selenoproteins. Evidence indicates that either deficient or excessive dietary selenium intake can result in impaired muscle function, termed nutritional myopathy. To investigate the effects of selenium on an upper airway muscle, the sternohyoid, rats were fed on diets containing deficient, normal (0.5 ppm sodium selenite) or exce
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Sun D, Han M, Huang X et al. · 2026 · Drug Design, Development and Therapy
Dandan Sun,1,* Mingming Han,1,* Xiang Huang,1 Danjun Lu,1 Bingqing Zhu,1 Daoying Zhou,2 Muzi Hua,3 Fang Kang,1 Juan Li1 1Department of Anesthesiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230036, People’s Republic of China; 2Department of Anesthesiology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310005, People’s Republic of China; 3Department of Public Health Sciences,University of Connecticut School, Farmington, CT, USA*These authors contributed equally to this workCorrespond
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Hongping Hou, Tengfei Chen, Ziying Xu et al. · 2022 · Frontiers in Pharmacology
Tibetan medicine is one of the oldest traditional medicine systems in the world. Taking the Ruyi Zhenbao tablet (RYZB) as an example, which is a widely used classic oral Tibetan medicine, this article discusses the pharmacokinetics of single administration and long-term treatment and analyzed its metabolic properties and tissue distribution in vivo. After single administration, blood samples were collected before administration and at different time points after administration in different groups of rats. In the study of long-term treatment effects, blood samples were collected from the animal
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Reza Baghbanian, Mohsen Savaie, Farhad Soltani et al. · 2023 · Journal of Nephropharmacology
Introduction: Effective antiviral medications with minimal side effects has received scholarly attention since the start of the COVID-19 pandemic. Ivermectin, a long-time anti-parasitic drug, has been proven through laboratory tests to have anti-COVID-19 effects. Objectives: This study investigated the effects of inclusion of ivermectin to the standard treatment of mechanically ventilated patients. Patients and Methods: This study is a double-blinded, randomized, placebo-controlled clinical trial that was conducted on COVID-19 patients, in Ahvaz, Iran, from March 2020 to September 2021. Intuba
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Yulu Miao, Bin Wang, Jing Hu et al. · 2022 · Frontiers in Pharmacology
Lung infection is a common complication induced by stroke and seriously affects the prognosis and life quality of patients. However, effective therapeutic strategies are still lacking. In the present study, the herb formula GCis was confirmed to prevent pulmonary infection induced by intracerebral hemorrhage (ICH). The animal model of lung infection induced by ICH, GCis (Ginseng Radix et Rhizoma, Aconiti Lateralis Radix Praeparata, and Cistanches Herba) was orally administrated every day for 7 days. Lung microbial biomass and pathological results showed that the GCis formula pretreatment signi
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Tanja Elnaz Hassanzadeh, Tanja Elnaz Hassanzadeh, Carina Hohmann et al. · 2024 · Frontiers in Pharmacology
Polypharmacy is common among patients with antithrombotic medication, giving rise to concerns about Drug-Related Problems (DRPs). Therefore, these patients would benefit from a Medication Review (MR) along with pharmacist counselling to reduce the risks accompanying polymedication. This prospective study presents a concept for MRs that are applicable in German community pharmacies and can efficiently support pharmacist counselling and improve the safety of drug therapy. As this is a major challenge in everyday pharmacy practice, we used a Decision Support System (DSS) to evaluate its ability t
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
O. A. Saygina, T. S. Sukhinina, M. A. Terenicheva et al. · 2026 · Рациональная фармакотерапия в кардиологии
Aim. To study the safety of using the intravenous beta-blocker (BB) esmolol in the early stages of ST-segment elevation myocardial infarction (STEMI) before primary percutaneous coronary intervention (PCI) based on an analysis of the incidence and clinical significance of adverse events (acute heart failure, hypotension, bradycardia, disorders of atrioventricular conduction (AV conduction), etc.) compared with the control group.Material and methods. The presented study is part of the randomized controlled trial ESMO-VASCMI (ClinicalTrials.gov NCT number 06376630) on the study of the cardioprot
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Chanchal Katariya, Arvina Rajasekar · 2022 · Journal of Advanced Pharmaceutical Technology & Research
Microsurgery is a minimally invasive procedure that uses a surgical microscope, specially designed equipment, and suture materials. Even though this equipment and expertise of numerous surgeries are required to meet patient esthetic reckoning, doctors must be ready to invest time and effort into becoming familiar with novel surgical methods and devices. The ambition of this case series is to compare conventional macro surgery and microsurgery in terms of clinical approach. This study included four cases, two flap surgery, and two root coverage. Clinical parameters for root coverage, increase i
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
L Elhampour, MA Azarbayjani, M Nasehi et al. · 2017 · Journal of Medicinal Plants
Introduction: There is need to more research because of extent drug trade in country and diversity of proposal cures such as non pharmacological ways including exercise and herbal medicine. The aim of the study: The aim of this study was study of synchronic effect of Curcumin and swimming training on depression in morphine addicted male mice. Methods: In an experimental research, 40 Albino NMRI male mice with 19- 21 gr were selected as subjects and they were divide randomly to care groups of control, morphine, swim training, Curcumin, swim training+ Curcumin. Subjects swam 60 min/day, 5 days/w
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Nilsson KF, Goździk W, Frostell C et al. · 2018 · Drug Design, Development and Therapy
Kristofer F Nilsson,1,2 Waldemar Goździk,3 Claes Frostell,4 Stanisław Zieliński,3 Marzena Zielińska,3 Kornel Ratajczak,5 Piotr Skrzypczak,5 Sylwia Rodziewicz,5 Johanna Albert,6 Lars E Gustafsson1,† 1Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; 2Department of Cardiothoracic and Vascular Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden; 3Department of Anaesthesiology and Intensive Therapy, Wroclaw Medical University, Wroclaw, Poland; 4Department of Anesthesia and Intensive Care, Danderyd Hospital, Stockholm, Swede
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ju Chen, Faming Zhao, Faming Zhao et al. · 2023 · Frontiers in Pharmacology
Background and Purpose: The aim of this study was to explore the effect of half a year of evolocumab plus moderate-intensity statin treatment on carotid intraplaque neovascularization (IPN) and blood lipid levels.Methods: A total of 31 patients with 33 carotid plaques who received evolocumab plus statin treatment were included. Blood lipid levels, B-mode ultrasound and contrast-enhanced ultrasonography (CEUS) at baseline and after half a year of evolocumab plus statin therapy were collected. The area under the curve (AUC) reflected the total amount of acoustic developer entering the plaque or
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Minou Kalantari, Madineh Hassani, Kazem Hassani et al. · 2013 · Journal of Rehabilitation
Objective: One of the most prevalent sensory problems in cerebral palsy is Astereognosis which has special importance in daily manual functions. The purpose of this study was to determine the level of hand stereognosis using common objects and geometric shapes in children with spastic hemiplegia and diplegia. Materials & Methods: In this cross sectional study, 20 children with cerebral palsy between 3-6 years old (9 males, 11 females) with mean age (hemiplegya: 55months, diplegya: 57months) were selected through nonrandomized convinience sampling referd to Occupational Therapy centers of Shahi
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ghasem Rahmatpour Rokni, Massoud Golpour, Alimorad Heidari Gorji et al. · 2017 · Journal of Advanced Pharmaceutical Technology & Research
Vitiligo is one of the most primitive well-known dermatoid disorders with different suggested therapies. Therefore, this study investigated the efficiency and safety of topical tacrolimus in treatment of patients with vitiligo. This study was a clinical randomized designed study pre- post-test method, has been conducted on thirty cases with vitiligo who have referred to polyclinic and dermatology clinic. Participant′s evaluated and demographic information recorded in designed checklist. In the next stage, the disease activity scored by vitiligo index disease activity system. Photography and de
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mudit Agarwal, Piyush Ranjan, Upendra Baitha et al. · 2020 · Frontiers in Pharmacology
Hydroxychloroquine has gained much attention as one of the candidate drugs that can be repurposed as a prophylactic agent against SARS-CoV-2, the agent responsible for the COVID-19 pandemic. Due to high transmissibility and presence of asymptomatic carriers and presymptomatic transmission, there is need for a chemoprophylactic agent to protect the high-risk population. In this review, we dissect the currently available evidence on hydroxychloroquine prophylaxis from a clinical and pharmacological point of view. In vitro studies on Vero cells show that hydroxychloroquine effectively inhibits SA
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Alina Nussbaumer-Pröll, Bela Hausmann, Maria Weber et al. · 2025 · Antibiotics
Background : The collection of microorganisms that colonize the human genital and urinary tract is referred to as the genitourinary microbiome. Urinary tract infections (UTIs), which predominantly affect women, are linked to alterations in the genitourinary microbiome. Cranberries ( Vaccinium oxycoccos ), rich in proanthocyanidins, and ascorbic acid (vitamin C), known for their urinary acidification properties, are commonly used for UTI prevention. However, their effects on the genitourinary microbiome remain inadequately characterized. This pilot study assesses the genitourinary microbiome co
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Rudra Paul, Arijit Ghosh, Nilanjan Sengupta et al. · 2022 · National Journal of Physiology, Pharmacy and Pharmacology
Background: Type 2 diabetes mellitus (DM) is mainly due to multifactorial of which insulin resistance and deficiency in the incretion are two important pathophysiological factors. Vildagliptin, an oral hypoglycemic agent, acts by inhibiting dipeptidyl peptidase-4 enzyme, often uses as a first line drug along with metformin to enhance outcome. Aim and Objective: The aim of this study was to compare the effectiveness and safety of vildagliptin 50 mg twice daily dose with vildagliptin 100 mg sustained release tablet (SR) once daily in Type 2 DM patients and uncontrolled with metformin monotherapy
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Jing Long, Yan Huang, Gang Wang et al. · 2023 · Antioxidants
Increased maternal glucocorticoid levels have been implicated as a risk factor for preeclampsia (PE) development. We found that pregnant rats exposed to dexamethasone (DEX) showed hallmarks of PE features, impaired spiral artery (SA) remodeling, and elevated circulatory levels of sFlt1, sEng IL-1β, and TNFα. Abnormal mitochondrial morphology and mitochondrial dysfunction in placentas occurred in DEX rats. Omics showed that a large spectrum of placental signaling pathways, including oxidative phosphorylation (OXPHOS), energy metabolism, inflammation, and insulin-like growth factor (IGF) system
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Ophélie Vacca, Amel Saoudi, Mathilde Doisy et al. · 2025 · Molecular Therapy: Nucleic Acids
The mdx52 mouse model exhibits a common mutation profile associated with brain involvement in Duchenne muscular dystrophy (DMD), characterized by heightened anxiety, fearfulness, and impaired associative fear learning. Deletion of exon 52 disrupts the expression of two dystrophins found in the brain (Dp427 and Dp140) and is eligible for therapeutic exon-skipping strategies. We previously demonstrated that a single intracerebroventricular administration of an antisense oligonucleotide (ASO) targeting exon 51 of the Dmd gene could restore 5%–15% of Dp427 expression. This treatment reduced anxiet
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Tina Taule, Ole-Bjørn Tysnes, Jörg Aßmus et al. · 2025 · Journal of Rehabilitation Medicine
Objective: To determine whether early cognitive function in amyotrophic lateral sclerosis patients predicts future cognitive function and the decision to cease driving. Design: Observational study. Subjects: Patients with amyotrophic lateral sclerosis. Methods: Subjects underwent baseline assessments of cognitive function and driving ability within 4 months of diagnosis, with follow-up evaluation conducted 4 months thereafter. Two hypotheses were tested: (H1) cognitive status remains stable between baseline and follow-up, (H2) patients with baseline cognitive impairment cease driving earlier t
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Maha M. AlRasheed · 2022 · Saudi Pharmaceutical Journal
Background: The role of thyroid-stimulating hormone in the pathogenesis of thyroid cancer is not yet fully explored. This study aimed to evaluate the role of the TSH-β polymorphism in thyroid cancer in a Saudi cohort. Methods: A prospective case-control study was conducted on 507 patients with differentiated thyroid carcinoma and compared them with 560 controls of Saudi origin. The association of two variants, the rs201857310, and rs7530810, in the TSH-β gene with thyroid cancer risk as well as thyroxine dose, were evaluated. Results: The rs201857310_A > G [OR: 0.50 (95 % CI: 0.35–0.71); P < 0
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Priyadharshini Mohan, Karthika Priyadharshini Udayakumar, Hiramath PB · 2020 · National Journal of Physiology, Pharmacy and Pharmacology
Back ground: In addition to the imbalance in the cardiac autonomic function, deficiency of micronutrients such as zinc (Zn), magnesium, and copper (Cu) was also found to be one of the cause of hypertensive disorders of pregnancy. Although there are number of studies done to know the autonomic balance and serum trace elements among preeclamptic women, none of the studies were done among the gestational hypertensives, hence, we have chosen this study on association between the level of micronutrients and frequency domain parameters of heart rate variability (HRV) among newly diagnosed gestationa
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Asher Shafrir, Asher Shafrir, Asher Shafrir et al. · 2022 · Frontiers in Pharmacology
Background and Aims: There is conflicting evidence regarding the association between proton pump inhibitors (PPI) and the risk of acquisition and severity of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.Aim: To evaluate the association between PPI exposure and infection and development of severe disease in patients infected with SARS-CoV2in a large population-based historical cohort.Methods: Data were extracted from a health maintenance organization database in Israel that insures over 1,200,000 individuals from across the country. All patients who underwent SARS-CoV-2 testi
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Shih-Wei Lai, Shih-Wei Lai, Cheng-Li Lin et al. · 2017 · Frontiers in Pharmacology
Background/Objectives: Previous studies showed that zolpidem use could be associated with increased cancer risk, but the role of zolpidem on hepatocellular carcinoma (HCC) risk remains undetermined. The study purpose was to examine the association between HCC risk and zolpidem use in Taiwan.Methods: Using the database from the Taiwan National Health Insurance Program, we designed a case-control study which consisted of 77986 subjects aged 20 years or older with newly diagnosed HCC as the case group, and 77986 subjects without HCC as the control group, from 2000 to 2011. Ever use of zolpidem wa
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Mansour S Almetwazi, Ahmad O Noor, Diena M Almasri et al. · 2017 · Saudi Pharmaceutical Journal
Objective: To evaluate the association between the level of vitamin D and glycemic control among patients with diabetes. Research design and method: We analyzed data collected from NHANES 2003–2006. We included only non-pregnant adult diabetic persons 18 years or older. Participants who had vitamin D level less than 20 ng/ml were considered as having vitamin D deficiency. Participants were considered to have a glucose control if the HbA1c level was less than 7% [53 mmol/L]. We used student’s t test to compare the difference in HbA1c means between people with Diabetes with and without a vitamin
View details →Negative / Null Result ReportOpen accessTherapeutics. Pharmacology
Kun Wang, Yuanyuan Shen, Chen Hu et al. · 2025 · Clinical and Translational Science
ABSTRACT While PD‐L1 antibodies have demonstrated efficacy in small cell lung cancer, the therapeutic benefits remain limited. To address this unmet medical need, serplulimab was developed as an innovative monoclonal antibody targeting PD‐1. This study evaluated the pharmacokinetic (PK) properties of serplulimab and their relationship with efficacy and safety in patients with extensive‐stage small cell lung cancer (ES‐SCLC), using population pharmacokinetics (PopPK) and exposure–response (E–R) analysis to inform dose selection. Data from 1144 patients across eight Phase I–III clinical trials s
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