A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
1757 results in Negative / Null Result Report for "Mpro" · page 1 of 59
Bertram Pitt, Marc A. Pfeffer, Susan F. Assmann et al. · 2014 · New England Journal of Medicine
BACKGROUND: Mineralocorticoid-receptor antagonists improve the prognosis for patients with heart failure and a reduced left ventricular ejection fraction. We evaluated the effects of spironolactone in patients with heart failure and a…
Russell Fulmer, Angela Joerin, Breanna Gentile et al. · 2018 · JMIR Mental Health
BACKGROUND: Students in need of mental health care face many barriers including cost, location, availability, and stigma. Studies show that computer-assisted therapy and 1 conversational chatbot delivering cognitive behavioral therapy (CBT) offer a less-intensive and more cost-effective alternative for treating depression and anxiety. Although CBT is one of the most effective treatment methods, applying an integrative approach has been linked to equally effective posttreatment improvement. Integrative psychological artificial intelligence (AI) offers a scalable solution as the demand for affor
Bart L. Scott, Marcelo C. Pasquini, Brent R. Logan et al. · 2017 · Journal of Clinical Oncology
Purpose The optimal regimen intensity before allogeneic hematopoietic cell transplantation (HCT) is unknown. We hypothesized that lower treatment-related mortality (TRM) with reduced-intensity conditioning (RIC) would result in improved…
Francis Kim, Graham Nichol, Charles Maynard et al. · 2013 · JAMA
IMPORTANCE: Hospital cooling improves outcome after cardiac arrest, but prehospital cooling immediately after return of spontaneous circulation may result in better outcomes. OBJECTIVE: To determine whether prehospital cooling improves…
Fabrice André, Eva Ciruelos, Dejan Juric et al. · 2020 · Annals of Oncology
•In SOLAR-1, the key secondary endpoint of OS was evaluated in patients with HR+, HER2−, PIK3CA-mutated ABC.•Adding alpelisib to fulvestrant numerically improved mOS by 7.9 months, though the result was not statistically significant.•OS…
Naihui Zhou, Yuxiang Jiang, Timothy Bergquist et al. · 2019 · Genome biology
BACKGROUND: The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. RESULTS: Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. S
Siliang Tong, Nan Jia, Xueming Luo et al. · 2021 · Strategic Management Journal
Abstract Companies are increasingly using artificial intelligence (AI) to provide performance feedback to employees, by tracking employee behavior at work, automating performance evaluations, and recommending job improvements. However,…
Daniel J. Wilson · 2019 · Proceedings of the National Academy of Sciences
-value (HMP), which controls the FWER while greatly improving statistical power by combining dependent tests using generalized central limit theorem. I show that the HMP effortlessly combines information to detect statistically significant signals among groups of individually nonsignificant hypotheses in examples of a human GWAS for neuroticism and a joint human-pathogen GWAS for hepatitis C viral load. The HMP simultaneously tests all ways to group hypotheses, allowing the smallest groups of hypotheses that retain significance to be sought. The power of the HMP to detect significant hypothesi
Lei Wu, Lin Liu, Bin Gao et al. · 2013 · Langmuir
Although graphene oxide (GO) has been used in many applications to improve human life quality, its environmental fate and behavior are still largely unknown. In this work, a novel approach that combines experimental measurements and…
Elhadi Adam, Onisimo Mutanga, John Odindi et al. · 2014 · International Journal of Remote Sensing
Mapping of patterns and spatial distribution of land-use/cover (LULC) has long been based on remotely sensed data. In the recent past, efforts to improve the reliability of LULC maps have seen a proliferation of image classification…
Charles E. Geyer, Judy E. Garber, Richard D. Gelber et al. · 2022 · Annals of Oncology
BACKGROUND: The randomized, double-blind OlympiA trial compared 1 year of the oral poly(adenosine diphosphate-ribose) polymerase inhibitor, olaparib, to matching placebo as adjuvant therapy for patients with pathogenic or likely pathogenic variants in germline BRCA1 or BRCA2 (gBRCA1/2pv) and high-risk, human epidermal growth factor receptor 2-negative, early breast cancer (EBC). The first pre-specified interim analysis (IA) previously demonstrated statistically significant improvement in invasive disease-free survival (IDFS) and distant disease-free survival (DDFS). The olaparib group had fewe
Rameshwar Dubey, Angappa Gunasekaran, Stephen J. Childe · 2018 · Management Decision
Purpose The purpose of this paper is to examine when and how organizations build big data analytics capability (BDAC) to improve supply chain agility (SCA) and gain competitive advantage. Design/methodology/approach The authors grounded…
Daniël B.F. Saris, Andrew Price, Wojciech Widuchowski et al. · 2014 · The American Journal of Sports Medicine
BACKGROUND: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured…
Kai Liu, Ying Chen, Duozhi Wu et al. · 2020 · Complementary Therapies in Clinical Practice
BACKGROUND: Patients with Coronavirus Disease 2019(COVID-19) will experience high levels of anxiety and low sleep quality due to isolation treatment. Some sleep-improving drugs may inhibit the respiratory system and worsen the condition.…
Amélie C. M. Gaudin, Tor N. Tolhurst, Alan P. Ker et al. · 2015 · PLoS ONE
Cropping sequence diversification provides a systems approach to reduce yield variations and improve resilience to multiple environmental stresses. Yield advantages of more diverse crop rotations and their synergistic effects with reduced tillage are well documented, but few studies have quantified the impact of these management practices on yields and their stability when soil moisture is limiting or in excess. Using yield and weather data obtained from a 31-year long term rotation and tillage trial in Ontario, we tested whether crop rotation diversity is associated with greater yield stabili
Damon Jones, David Molitor, Julian Reif · 2019 · The Quarterly Journal of Economics
Workplace wellness programs cover over 50 million U.S. workers and are intended to reduce medical spending, increase productivity, and improve well-being. Yet limited evidence exists to support these claims. We designed and implemented a…
Matthew J. Ward, Stephen M. Thirdborough, Toby Mellows et al. · 2013 · British Journal of Cancer
BACKGROUND: Human papillomavirus (HPV)-positive oropharyngeal cancer (OPSCC) is associated with improved survival compared with HPV-negative disease. However, a minority of HPV-positive patients have poor prognosis. Currently, there is no…
Humira Sonah, Louise S. O’Donoughue, Elroy R. Cober et al. · 2014 · Plant Biotechnology Journal
Soya bean is a major source of edible oil and protein for human consumption as well as animal feed. Understanding the genetic basis of different traits in soya bean will provide important insights for improving breeding strategies for this…
Jens‐Ulrik Stæhr Jensen, Lars Hein, Bettina Lundgren et al. · 2011 · Critical Care Medicine
OBJECTIVE: For patients in intensive care units, sepsis is a common and potentially deadly complication and prompt initiation of appropriate antimicrobial therapy improves prognosis. The objective of this trial was to determine whether a…
Amy R. Romijn, Julia J. Rucklidge, Roeline G. Kuijer et al. · 2017 · Australian & New Zealand Journal of Psychiatry
OBJECTIVES: This trial investigated whether probiotics improved mood, stress and anxiety in a sample selected for low mood. We also tested whether the presence or severity of irritable bowel syndrome symptoms, and levels of proinflammatory…
Arjan J. Houtepen, Zeger Hens, Jonathan S. Owen et al. · 2016 · Chemistry of Materials
One of the greatest challenges in the field of semiconductor nanomaterials is to make trap-free nanocrystalline structures to attain a remarkable improvement of their optoelectronic performances. In semiconductor nanomaterials, a very high…
Biren B. Kamdar, Lauren M. King, Nancy A. Collop et al. · 2013 · Critical Care Medicine
OBJECTIVES: To determine if a quality improvement intervention improves sleep and delirium/cognition. DESIGN: Observational, pre-post design. SETTING: A tertiary academic hospital in the United States. PATIENTS: 300 medical ICU patients.…
Scott Freeman, David C. Haak, Mary Pat Wenderoth · 2011 · CBE—Life Sciences Education
We tested the hypothesis that highly structured course designs, which implement reading quizzes and/or extensive in-class active-learning activities and weekly practice exams, can lower failure rates in an introductory biology course for…
Ashish K. Jha, Karen E. Joynt, E. John Orav et al. · 2012 · New England Journal of Medicine
BACKGROUND: Pay for performance has become a central strategy in the drive to improve health care. We assessed the long-term effect of the Medicare Premier Hospital Quality Incentive Demonstration (HQID) on patient outcomes. METHODS: We…
Marc-André Schulz, B.T. Thomas Yeo, Joshua T Vogelstein et al. · 2020 · Nature Communications
Recently, deep learning has unlocked unprecedented success in various domains, especially using images, text, and speech. However, deep learning is only beneficial if the data have nonlinear relationships and if they are exploitable at available sample sizes. We systematically profiled the performance of deep, kernel, and linear models as a function of sample size on UKBiobank brain images against established machine learning references. On MNIST and Zalando Fashion, prediction accuracy consistently improves when escalating from linear models to shallow-nonlinear models, and further improves w
Doo Hun Lim, Michael L. Morris, Virginia W. Kupritz · 2019 · Online Learning
This study investigates differences in instructional and learner factors between two groups of learners exposed to online only and blended delivery formats, respectively, in an effort to compare learning outcomes and other instructional variables between online and blended delivery methods. Findings indicated that no significant differences existed in learning outcomes; however, significant differences existed in several instructional and learner factors between the two delivery format groups. Discussions about improving online or blended delivery method are presented based upon the research f
Kathleen N. Moore, Amit M. Oza, Nicoletta Colombo et al. · 2021 · Annals of Oncology
•In platinum-resistant EOC MIRV did not significantly improve PFS over chemotherapy.•No unexpected toxicities were observed, and tolerability profiles were consistent with those observed in previous studies.•The most promising signals of…
Manjit Mehat, Venki Sundaram, Caterina Ripamonti et al. · 2018 · Ophthalmology
PURPOSE: Transplantation of human embryonic stem cell (hESC)-derived retinal pigment epithelial (RPE) cells offers the potential for benefit in macular degeneration. Previous trials have reported improved visual acuity (VA), but lacked detailed analysis of retinal structure and function in the treated area. DESIGN: Phase 1/2 open-label dose-escalation trial to evaluate safety and potential efficacy (clinicaltrials.gov identifier, NCT01469832). PARTICIPANTS: Twelve participants with advanced Stargardt disease (STGD1), the most common cause of macular degeneration in children and young adults. M
Joris D. Veltman, Margaretha Lambers, Menno van Nimwegen et al. · 2010 · BMC Cancer
BACKGROUND: Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in immune suppression. MDSC suppress T and NK cell function via increased expression of arginase I and production of reactive oxygen species (ROS) and nitric oxide (NO). Immune suppression by MDSC was found to be one of the main factors for immunotherapy insufficiency. Here we investigate if the in vivo immunoregulatory function of MDSC can be reversed by in
Mats Brittberg, David P. Recker, John Ilgenfritz et al. · 2018 · The American Journal of Sports Medicine
Background: Matrix-based cell therapy improves surgical handling, increases patient comfort, and allows for expanded indications with better reliability within the knee joint. Five-year efficacy and safety of autologous cultured…