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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20211 results in Negative / Null Result Report · page 97 of 674

Negative / Null Result ReportOpen accessPsychology

“Can You Remember What Was in Your Pocket When You Were Stung by a Bee?”: Eliciting Cues to Deception by Asking the Unanticipated

Meiling Liu, Pär Anders Granhag, Sara Landström et al. · 2010 · The Open Criminology Journal

In this paper we focused on children's deception (10-12 years, Experiment 1), and adult's ability detect deception in children (Experiment 2). The self-presentational perspective By asking unanticipated questions we put the liars in the…

View details →DOI: 10.2174/1874917801003010031Cited by 25
Negative / Null Result ReportOpen accessMedicine

Voxel-based 18F-FET PET segmentation and automatic clustering of tumor voxels: A significant association with IDH1 mutation status and survival in patients with gliomas

Paul Blanc‐Durand, Axel Van Der Gucht, Antoine Verger et al. · 2018 · PLoS ONE

INTRODUCTION: Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. METHODS: Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-sco

View details →DOI: 10.1371/journal.pone.0199379Cited by 25
Negative / Null Result ReportOpen accessEnvironmental Science

Spatial prediction of soil properties in two contrasting physiographic regions in Brazil

Michele Duarte de Menezes, Sérgio Henrique Godinho Silva, Carlos Rogério de Mello et al. · 2016 · Scientia Agricola

This study compared the performance of ordinary kriging (OK) and regression kriging (RK) to predict soil physical-chemical properties in topsoil (0-15 cm). Mean prediction of error and root mean square of prediction error were used to assess the prediction methods. Two watersheds with contrasting soil-landscape features were studied, for which the prediction methods were performed differently. A multiple linear stepwise regression model was performed with RK using digital terrain models (DTMs) and remote sensing images in order to choose the best auxiliary covariates. Different pedogenic facto

View details →DOI: 10.1590/0103-9016-2015-0071Cited by 25
Negative / Null Result ReportOpen accessEnvironmental Science

Using Silviculture to Influence Carbon Sequestration in Southern Appalachian Spruce-Fir Forests

Patrick Moore, R. Justin DeRose, James N. Long et al. · 2012 · Forests

Enhancement of forest growth through silvicultural modification of stand density is one strategy for increasing carbon (C) sequestration. Using the Fire and Fuels Extension of the Forest Vegetation Simulator, the effects of even-aged, uneven-aged and no-action management scenarios on C sequestration in a southern Appalachian red spruce-Fraser fir forest were modeled. We explicitly considered C stored in standing forest stocks and the fate of forest products derived from harvesting. Over a 100-year simulation period the even-aged scenario (250 Mg C ha−1) outperformed the no-action scenario (241

View details →DOI: 10.3390/f3020300Cited by 25
Negative / Null Result ReportPsychology

Multimodal, Multiparty Modeling of Collaborative Problem Solving Performance

Shree Krishna Subburaj, Angela Stewart, Arjun Rao et al. · 2020

Modeling team phenomena from multiparty interactions inherently requires combining signals from multiple teammates, often by weighting strategies. Here, we explored the hypothesis that strategic weighting signals from individual teammates…

View details →DOI: 10.1145/3382507.3418877Cited by 25
Negative / Null Result ReportMedicine

Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study

Andrew M. Penn, Maximilian B. Bibok, Viera Saly et al. · 2018 · Biomarkers

OBJECTIVE: To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients.METHOD: Two consecutive cohorts of ED…

View details →DOI: 10.1080/1354750x.2018.1499130Cited by 25
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Laboratory divergence of Methylobacterium extorquens AM1 through unintended domestication and past selection for antibiotic resistance

Sean M. Carroll, Katherine S. Xue, Christopher J. Marx · 2014 · BMC Microbiology

BACKGROUND: A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discovery in 1960, a stock of Methylobacterium extorquens AM1 ("AM1") has remained in the lab, propagated across numerous growth and storage conditions, researchers, and facilities. To explore the extent to which this lineage has diverged, we compared our own "Modern" stock of AM1 to a

View details →DOI: 10.1186/1471-2180-14-2Cited by 25
Negative / Null Result ReportOpen accessEnvironmental Science

Variation in tree mortality and regeneration affect forest carbon recovery following fuel treatments and wildfire in the Lake Tahoe Basin, California, USA

Chris H. Carlson, Solomon Z. Dobrowski, Hugh D. Safford · 2012 · Carbon Balance and Management

BACKGROUND: Forest fuel treatments have been proposed as tools to stabilize carbon stocks in fire-prone forests in the Western U.S.A. Although fuel treatments such as thinning and burning are known to immediately reduce forest carbon stocks, there are suggestions that these losses may be paid back over the long-term if treatments sufficiently reduce future wildfire severity, or prevent deforestation. Although fire severity and post-fire tree regeneration have been indicated as important influences on long-term carbon dynamics, it remains unclear how natural variability in these processes might

View details →DOI: 10.1186/1750-0680-7-7Cited by 25
Negative / Null Result ReportOpen accessMedicine

Could Ovarian Cancer Prediction Models Improve the Triage of Symptomatic Women in Primary Care? A Modelling Study Using Routinely Collected Data

Garth Funston, Gary Abel, Emma J. Crosbie et al. · 2021 · Cancers

CA125 is widely used as an initial investigation in women presenting with symptoms of possible ovarian cancer. We sought to develop CA125-based diagnostic prediction models and to explore potential implications of implementing model-based thresholds for further investigation in primary care. This retrospective cohort study used routinely collected primary care and cancer registry data from symptomatic, CA125-tested women in England (2011-2014). A total of 29,962 women were included, of whom 279 were diagnosed with ovarian cancer. Logistic regression was used to develop two models to estimate o

View details →DOI: 10.3390/cancers13122886Cited by 25
Negative / Null Result ReportOpen accessMedicine

Randomized Phase IIb Study of Brimonidine Drug Delivery System Generation 2 for Geographic Atrophy in Age-Related Macular Degeneration

William R. Freeman, Francesco Bandello, Eric H. Souied et al. · 2023 · Ophthalmology Retina

To evaluate the safety and efficacy of repeat injections of Brimonidine Drug Delivery System (Brimo DDS) Generation 2 (Gen 2) containing 400-μg brimonidine in patients with geographic atrophy (GA) secondary to age-related macular…

View details →DOI: 10.1016/j.oret.2023.03.001Cited by 25
Negative / Null Result ReportOpen accessMedicine

Effect of calcium vs. placebo on long-term outcomes in patients with out-of-hospital cardiac arrest

Mikael Fink Vallentin, Asger Granfeldt, Carsten Meilandt et al. · 2022 · Resuscitation

OBJECTIVE: The Calcium for Out-of-hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium for out-of-hospital cardiac arrest. The primary and secondary outcomes have been reported previously. This article describes the long-term outcomes of the trial. METHODS: Patients aged ≥18 years were included if they had a non-traumatic out-of-hospital cardiac arrest during which they received adrenaline. The trial drug consisted of calcium chloride (5 mmol) or saline placebo given after the first dose of adrenaline and again after the second dose of adrena

View details →DOI: 10.1016/j.resuscitation.2022.07.034Cited by 25
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Local-scale virome depiction in Medellín, Colombia, supports significant differences between Aedes aegypti and Aedes albopictus

Arley Calle-Tobón, Juliana Pérez-Pérez, Nicolás Forero-Pineda et al. · 2022 · PLoS ONE

Aedes spp. comprise the primary group of mosquitoes that transmit arboviruses such as dengue, Zika, and chikungunya viruses to humans, and thus these insects pose a significant burden on public health worldwide. Advancements in next-generation sequencing and metagenomics have expanded our knowledge on the richness of RNA viruses harbored by arthropods such as Ae. aegypti and Ae. albopictus. Increasing evidence suggests that vector competence can be modified by the microbiome (comprising both bacteriome and virome) of mosquitoes present in endemic zones. Using an RNA-seq-based metataxonomic app

View details →DOI: 10.1371/journal.pone.0263143Cited by 25
Negative / Null Result ReportOpen accessMedicine

Significant differences in the cell‐wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity

S. Takahashi, Atsushi Kudoh, Yoshio Okawa et al. · 2012 · FEBS Journal

Candida glabrata is often the second or third most common cause of candidiasis after Candida albicans. C. glabrata infections are difficult to treat, often resistant to many azole antifungal agents and are associated with a high mortality…

View details →DOI: 10.1111/j.1742-4658.2012.08564.xCited by 25
Negative / Null Result ReportMedicine

Influence of In-House Attending Presence on Trauma Outcomes and Hospital Efficiency

Jessica Cox, Andrew C. Bernard, Anthony J. Bottiggi et al. · 2014 · Journal of the American College of Surgeons

BACKGROUND: The influence of in-house (IH) attendings on trauma patient survival and efficiency measures, such as emergency department length of stay (LOS), ICU LOS, and hospital LOS, has been debated for more than 20 years. No study has…

View details →DOI: 10.1016/j.jamcollsurg.2013.12.027Cited by 25
Negative / Null Result ReportEarth and Planetary Sciences

Contrasting Air Mass Advection Explains Significant Differences in Boundary Layer Depth Seasonal Cycles Under Onshore Versus Offshore Flows

Sandip Pal, Temple R. Lee · 2019 · Geophysical Research Letters

Abstract The complexities in the atmospheric boundary layer depth (BLD) features over coastal regions pose challenges for meteorological forecasts, air quality, greenhouse gas mixing and transport, and wind energy production. Here, for the…

View details →DOI: 10.1029/2018gl081699Cited by 25
Negative / Null Result ReportOpen accessMedicine

Outcomes of Induction Chemotherapy for Head and Neck Cancer Patients

Jinhua Chen, Yu‐Chun Yen, Shing‐Hwa Liu et al. · 2016 · Medicine

The use of induction chemotherapy (CT) is controversial. We compared the survival of head and neck cancer patients receiving docetaxel- or platinum-based induction CT before concomitant chemoradiotherapy (CCRT) with the survival of those receiving upfront CCRT alone. Data from the National Health Insurance and cancer registry databases in Taiwan were linked and analyzed. We enrolled patients who had head and neck cancer between January 1, 2002 and December 31, 2011. Follow-up was from the index date to December 31, 2013. We included head and neck patients diagnosed according to the Internation

View details →DOI: 10.1097/md.0000000000002845Cited by 25
Negative / Null Result Report

US line-ups outperform UK line-ups

Travis M. Seale-Carlisle, Laura Mickes · 2016 · Royal Society Open Science

In the USA and the UK, many thousands of police suspects are identified by eyewitnesses every year. Unfortunately, many of those suspects are innocent, which becomes evident when they are exonerated by DNA testing, often after having been…

View details →DOI: 10.1098/rsos.160300Cited by 25
Negative / Null Result Report

Aerial Observations and Numerical Simulations Confirm Density‐Driven Streamwise Vortices at a River Confluence

J. Duguay, P. M. Biron, J. Lacey · 2022 · Water Resources Research

Abstract When rivers collide, complex three‐dimensional coherent flow structures are generated along the confluence's mixing interface. These structures mix streamborne pollutants and suspended sediment and have considerable bearing on the…

View details →DOI: 10.1029/2021wr031527Cited by 25
Negative / Null Result ReportOpen accessPsychology

Limited generalisation of changes in attentional bias following attentional bias modification with the visual probe task

Bram Van Bockstaele, Elske Salemink, Susan M. Bögels et al. · 2015 · Cognition & Emotion

Although attentional bias modification (ABM) can change anxiety, recent studies failed to replicate such effects, possibly because the visual probe ABM failed to induce changes in attentional bias (AB). We investigated whether visual probe…

View details →DOI: 10.1080/02699931.2015.1092418Cited by 25
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Unmanned Ground Vehicles for Continuous Crop Monitoring in Agriculture: Assessing the Readiness of Current ICT Technology

Maurizio Agelli, Nicola Corona, Fabio Maggio et al. · 2024 · Machines

Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports auton

View details →DOI: 10.3390/machines12110750Cited by 25
Negative / Null Result ReportOpen accessMedicine

ChatGPT Health performance in a structured test of triage recommendations

Ashwin Ramaswamy, Alvira Tyagi, Hannah Hugo et al. · 2026 · Nature Medicine

ChatGPT Health was launched in January 2026 as OpenAI's consumer health tool and has reached millions of users. Here we conducted a structured stress test of triage recommendations using 60 clinician-authored vignettes across 21 clinical domains under 16 factorial conditions, yielding 960 total responses. Performance followed an inverted U-shaped pattern, with the most dangerous failures concentrated at clinical extremes-nonurgent presentations (35%) and emergency conditions (48%). Among gold-standard emergencies, the system undertriaged 52% of cases, directing patients with diabetic ketoacido

View details →DOI: 10.1038/s41591-026-04297-7Cited by 24
Negative / Null Result ReportOpen accessSocial Sciences

No effect of ‘watching eyes’: An attempted replication and extension investigating individual differences

Amanda Rotella, Adam Maxwell Sparks, Sandeep Mishra et al. · 2021 · PLoS ONE

Some evidence suggests that people behave more cooperatively and generously when observed or in the presence of images of eyes (termed the 'watching eyes' effect). Eye images are thought to trigger feelings of observation, which in turn motivate people to behave more cooperatively to earn a good reputation. However, several recent studies have failed to find evidence of the eyes effect. One possibility is that inconsistent evidence in support of the eyes effect is a product of individual differences in sensitivity or susceptibility to the cue. In fact, some evidence suggests that people who ar

View details →DOI: 10.1371/journal.pone.0255531Cited by 24
Negative / Null Result ReportOpen accessSocial Sciences

Strategic Inclusion Without Transformation: How Populist Radical Right Parties Engage With Women’s Interests

Bonnie M. Meguid, Hilde Coffé, Ana Catalano Weeks et al. · 2025 · Comparative Political Studies

Despite their Männerparteien reputation, populist radical right (PRR) parties have recently expanded their agendas to include women’s interests. When do they embrace these interests, and what shapes their stance? We propose a theory of…

View details →DOI: 10.1177/00104140251381760Cited by 24
Negative / Null Result Report

Significant change events in psychodynamic psychotherapy: Is cognition or emotion more important?

Kye L. McCarthy, Peter Caputi, Brin F.S. Grenyer · 2017 · Psychology and Psychotherapy: Theory, Research and Practice

Objective Significant change events are helpful moments within a psychotherapy session that have been shown in previous research to relate strongly to outcome. They are special moments and therefore provide rich data for research into…

View details →DOI: 10.1111/papt.12116Cited by 24
Negative / Null Result Report

Significant Associations of Neurological Complications of Herpes Zoster With Stroke in Rheumatoid Arthritis Patients

Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association

Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…

View details →DOI: 10.1161/jaha.117.006304Cited by 24
Negative / Null Result Report

Replicate sequencing libraries are important for quantification of allelic imbalance

Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta et al. · 2021 · Nature Communications

Abstract A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and…

View details →DOI: 10.1038/s41467-021-23544-8Cited by 24
Negative / Null Result ReportOpen accessEnergy

Ecological Stoichiometry Meets Ecological Engineering: Using Polycultures to Enhance the Multifunctionality of Algal Biocrude Systems

Casey M. Godwin, David C. Hietala, Aubrey R. Lashaway et al. · 2017 · Environmental Science & Technology

For algal biofuels to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and processing must maximize rates of biofuel production while simultaneously minimizing the consumption of nitrogen (N) and…

View details →DOI: 10.1021/acs.est.7b02137Cited by 24
Negative / Null Result Report

Stenotrophomonas maltophilia strains replicate and persist in the murine lung, but to significantly different degrees

Ruella Rouf, Sara M. Karaba, Jenny Dao et al. · 2011 · Microbiology

The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of…

View details →DOI: 10.1099/mic.0.048157-0Cited by 24
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Human essential hypertension: no significant association of polygenic risk scores with antihypertensive drug responses

Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars et al. · 2020 · Scientific Reports

Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four

View details →DOI: 10.1038/s41598-020-68878-3Cited by 24