Negative / Null Result ReportOpen accessMedicine
James D. Doecke, Giovanni Bellomo, Lisa Vermunt et al. · 2025 · Alzheimer s & Dementia
INTRODUCTION: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aβ42/40) may have diagnostic and prognostic value in Alzheimer's disease (AD). Here we assess which markers can best identify AD from controls and other non-AD dementias in a large international multi-center study. METHODS: Plasma samples (n = 1298) were collected from six international centers. Aβ40, Aβ42, GFAP, NfL, and p-tau181 were measured using single molecule array. In each group, AD diagnosis/co-pathology was defined according to cerebrosp
View details →DOI: 10.1002/alz.14573Cited by 25 Negative / Null Result ReportOpen accessMedicine
Hezixian Guo, L.-T. Pan, Qiuyi Wu et al. · 2025 · Nutrients
Type 2 diabetes (T2D) is a complex metabolic disease characterized by chronic hyperglycemia due to insulin resistance and inadequate insulin secretion. Beyond the classically implicated organs, emerging evidence highlights the gut as a central player in T2D pathophysiology through its interactions with metabolic organs. The gut hosts trillions of microbes and enteroendocrine cells that influence inflammation, energy homeostasis, and hormone regulation. Disruptions in gut homeostasis (dysbiosis and increased permeability) have been linked to obesity, insulin resistance, and β-cell dysfunction,
View details →DOI: 10.3390/nu17162708Cited by 25 Negative / Null Result ReportOpen accessMedicine
Saeede Saadati, Rasoul Godini, Anjana Reddy et al. · 2025 · Frontiers in Immunology
Insulin resistance is a central pathological feature of several chronic metabolic disorders, including obesity, type 2 diabetes, polycystic ovary syndrome, and cardiovascular disease. While its pathogenesis is multifactorial, lipid dysregulation and chronic low-grade inflammation are recognised as two major, interconnected processes that impair insulin action across multiple tissues. This review summarises core mechanistic themes linking these processes, with a focus on three key signalling pathways that are particularly relevant to metabolic regulation and to the interplay between lipid metab
View details →DOI: 10.3389/fimmu.2025.1692742Cited by 25 Negative / Null Result ReportOpen accessNeuroscience
Sophie E. Field, Annabel J. Curle, Roger A. Barker · 2024 · Expert Opinion on Investigational Drugs
INTRODUCTION: Huntington's Disease (HD) is a genetic neurodegenerative disease for which there is currently no disease-modifying treatment. One of several underlying mechanisms proposed to be involved in HD pathogenesis is inflammation;…
View details →DOI: 10.1080/13543784.2024.2348738Cited by 25 Negative / Null Result ReportOpen accessMedicine
Laura Krygere, Povilas Jukna, Kristina Jarienė et al. · 2024 · Biomedicines
Endometriosis is a common gynecological condition affecting approximately 10% of women of reproductive age, characterized by the abnormal presence of endometrial-like tissue outside the uterus. Although endometriosis was first described over 300 years ago, its underlying mechanisms remain poorly understood, and accurate, prompt diagnosis continues to be challenging. Currently, there is a lack of effective, non-invasive diagnostic methods, and available treatments often come with significant side effects and high recurrence rates. This has spurred interest in investigating the role of pro- and
View details →DOI: 10.3390/biomedicines12122867Cited by 24 Negative / Null Result ReportOpen accessMedicine
Meryem A. Yücel, Robert Luke, Rickson C. Mesquita et al. · 2025 · Communications Biology
As data analysis pipelines grow more complex in brain imaging research, understanding how methodological choices affect results is essential for ensuring reproducibility and transparency. This is especially relevant for functional Near-Infrared Spectroscopy (fNIRS), a rapidly growing technique for assessing brain function in naturalistic settings and across the lifespan, yet one that still lacks standardized analysis approaches. In the fNIRS Reproducibility Study Hub (FRESH) initiative, we asked 38 research teams worldwide to independently analyze the same two fNIRS datasets. Despite using dif
View details →DOI: 10.1038/s42003-025-08412-1Cited by 24 Negative / Null Result ReportOpen accessNeuroscience
Yves‐Alain Barde · 2025 · Physiological Reviews
BDNF is synthesized and secreted by excitatory neurons. Decades of work with animal models prepared the ground for interpreting the results of human genome analyses associating polymorphisms with memory deficits, mood disorders and…
View details →DOI: 10.1152/physrev.00038.2024Cited by 24 Negative / Null Result ReportOpen accessHealth Professions
Seunghyeon Wang · 2026 · Scientific Reports
Ensuring consistent compliance with Personal Protective Equipment (PPE) requirements on construction sites is crucial for worker safety. Although deep learning-based methods already perform well in detecting non-PPE cases, there is still…
View details →DOI: 10.1038/s41598-026-35148-7Cited by 24 Negative / Null Result ReportOpen accessSocial Sciences
Sue Lim, Ralf Schmälzle, Gary Bente · 2025 · Computers in Human Behavior Artificial Humans
Interactions with artificial intelligence (AI) based agents can positively influence human behavior and judgment. However, studies to date focus on text-based conversational agents (CA) with limited embodiment, restricting our understanding of how social influence principles, such as physical similarity, apply to AI agents (i.e., artificial social influence). We address this gap by leveraging latest advances in AI (large language models) and combining them with immersive virtual reality (VR). Specifically, we built VR-ECAs, or embodied conversational agents that can engage in turn-taking conve
View details →DOI: 10.1016/j.chbah.2025.100172Cited by 24 Negative / Null Result Report
Kye L. McCarthy, Peter Caputi, Brin F.S. Grenyer · 2017 · Psychology and Psychotherapy: Theory, Research and Practice
Objective Significant change events are helpful moments within a psychotherapy session that have been shown in previous research to relate strongly to outcome. They are special moments and therefore provide rich data for research into…
View details →DOI: 10.1111/papt.12116Cited by 24 Negative / Null Result Report
Tsai‐Ling Liao, Ching‐Heng Lin, Hsin‐Hua Chen et al. · 2017 · Journal of the American Heart Association
Background Accumulating evidence suggests an increased risk of stroke after herpes zoster ( HZ ). This risk is elevated in immunocompromised patients. The incidence of HZ in Asia is higher than in Western countries. However, the…
View details →DOI: 10.1161/jaha.117.006304Cited by 24 Negative / Null Result Report
Asia Mendelevich, Svetlana Vinogradova, Saumya Gupta et al. · 2021 · Nature Communications
Abstract A sensitive approach to quantitative analysis of transcriptional regulation in diploid organisms is analysis of allelic imbalance (AI) in RNA sequencing (RNA-seq) data. A near-universal practice in such studies is to prepare and…
View details →DOI: 10.1038/s41467-021-23544-8Cited by 24 Negative / Null Result ReportOpen accessEnergy
Casey M. Godwin, David C. Hietala, Aubrey R. Lashaway et al. · 2017 · Environmental Science & Technology
For algal biofuels to be economically sustainable and avoid exacerbating nutrient pollution, algal cultivation and processing must maximize rates of biofuel production while simultaneously minimizing the consumption of nitrogen (N) and…
View details →DOI: 10.1021/acs.est.7b02137Cited by 24 Negative / Null Result Report
Ruella Rouf, Sara M. Karaba, Jenny Dao et al. · 2011 · Microbiology
The environmental bacterium Stenotrophomonas maltophilia is increasingly described as a multidrug-resistant pathogen of humans, being associated with pneumonia, among other diseases. But the degree to which S. maltophilia is capable of…
View details →DOI: 10.1099/mic.0.048157-0Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heini Sánez Tähtisalo, Sanni Ruotsalainen, Nina Mars et al. · 2020 · Scientific Reports
Polygenic risk scores (PRSs) for essential hypertension, calculated from > 900 genomic loci, were recently found to explain a significant fraction of hypertension heritability and complications. To investigate whether variation of hypertension PRS also captures variation of antihypertensive drug responsiveness, we calculated two different PRSs for both systolic and diastolic blood pressure: one based on the top 793 independent hypertension-associated single nucleotide polymorphisms and another based on over 1 million genome-wide variants. Using our pharmacogenomic GENRES study comprising four
View details →DOI: 10.1038/s41598-020-68878-3Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Boshu Ru, Dingcheng Li, Yueqi Hu et al. · 2019 · IEEE Transactions on NanoBioscience
Serendipitous drug usage refers to the unexpected relief of comorbid diseases or symptoms when taking medication for a different known indication. Historically, serendipity has contributed significantly to identifying many new drug…
View details →DOI: 10.1109/tnb.2019.2909094Cited by 24 Negative / Null Result ReportOpen accessMedicine
Yen‐Jen Chen, Hsien‐Te Chen, Horng‐Chaung Hsu · 2015 · Journal of Orthopaedic Surgery and Research
BACKGROUND: Survival is a key factor physicians consider when selecting a treatment modality for the treatment of spinal metastases. Various assessment systems can predict length of survival and facilitate selection of the most appropriate treatment. Spinal palsy is a prognostic parameter in the Tokuhashi scoring system but not in the Tomita scoring system. A limitation of these scoring systems is that studies of them have included different tumor types. The aim of this study was to evaluate the usefulness of preoperative neurological status as a prognostic factor in non-small-cell lung cancer
View details →DOI: 10.1186/s13018-015-0291-8Cited by 24 Negative / Null Result Report
Marie R. Johnston, Nick J. Balster, Anita M. Thompson · 2020 · Water
Rain gardens are residential bioretention practices widely used to manage urban runoff, yet their design as plant-soil systems lacks understanding. We hypothesized that vegetative treatment (turfgrass, prairie, and shrubs, plus a…
View details →DOI: 10.3390/w12113151Cited by 24 Negative / Null Result Report
Andrea Riboli, Fabio Esposito, Giuseppe Coratella · 2022 · Journal of Strength & Conditioning Research
Abstract Riboli, A, Esposito, F, and Coratella, G. Small-sided games in elite football: practical solutions to replicate the 4-min match-derived maximal intensities. J Strength Cond Res 37(2): 366–374, 2023—The purpose of the study was to…
View details →DOI: 10.1519/jsc.0000000000004249Cited by 24 Negative / Null Result ReportOpen accessMedicine
Richard A. Brown, Susan E. Ramsey, Christopher W. Kahler et al. · 2011 · Journal of Studies on Alcohol and Drugs
OBJECTIVE: A previous pilot study found positive outcomes among alcohol-dependent individuals with elevated depressive symptoms who received cognitive-behavioral treatment for depression (CBT-D; n = 19) compared with a relaxation training…
View details →DOI: 10.15288/jsad.2011.72.286Cited by 24 Negative / Null Result ReportOpen accessMedicine
Claus Neurohr, Nikolaus Kneidinger, Alessandro Ghiani et al. · 2021 · American Journal of Transplantation
Long-term survival after lung transplantation is limited by chronic allograft dysfunction. The aim of this study was to investigate the effect of locally augmented immunosuppression with liposomal cyclosporine A for inhalation (L-CsA-i)…
View details →DOI: 10.1111/ajt.16858Cited by 24 Negative / Null Result ReportOpen accessEngineering
Shane Esola, Brian Wisner, Prashanth A. Vanniamparambil et al. · 2018 · Applied Sciences
The research presented in this article aims to demonstrate how acoustic emission (AE) monitoring can be implemented in an industrial setting to assist with part qualification, as mandated by related industry standards. The combined structural and nondestructive evaluation method presented departs from the traditional pass/fail criteria used for part qualification, and contributes toward a multi-dimensional assessment by taking advantage of AE data recorded during structural testing. To demonstrate the application of this method, 16 composite fixed-wing-aircraft spars were tested using a struct
View details →DOI: 10.3390/app8091490Cited by 24 Negative / Null Result ReportOpen accessPsychology
Marlou Poppelaars, Anna Lichtwarck‐Aschoff, Roy Otten et al. · 2021 · Frontiers in Psychology
Depressive symptoms and disorders are major public health concerns, affecting many adolescents and young adults. Despite extensive research, depression prevention programs for youth show limited effectiveness. Moreover, the maximal potential of youth psychotherapy — on which depression prevention programs are based — may have been reached. Commercial video games may offer an engaging alternative vehicle for youth to practice emotional and social skills vital to mental health. The current study investigated the potential for the commercial video game Journey to prevent the exacerbation of depre
View details →DOI: 10.3389/fpsyg.2020.575962Cited by 24 Negative / Null Result ReportBiochemistry, Genetics and Molecular Biology
Ying Shen, Yuanlong Yan, Yunqiang Liu et al. · 2013 · Human Molecular Genetics
AZFc deletions cause a significant phenotypic heterogeneity with respect to spermatogenesis; however, the reason for this is poorly understood. Recently, testis-specific protein Y-encoded 1 (TSPY1) copy number variation (CNV) was…
View details →DOI: 10.1093/hmg/ddt004Cited by 24 Negative / Null Result ReportMedicine
Giorgio Aicardi · 2013 · Rejuvenation Research
Despite decades of research, there is no cure for Alzheimer disease (AD), and current pharmacological treatments only partially mask the symptoms while the disease progresses within the brain. AD is associated with impaired clearance of…
View details →DOI: 10.1089/rej.2013.1497Cited by 24 Negative / Null Result ReportOpen accessSocial Sciences
Juliana Abagsonema Abane, Ronald Adamtey, Virceta Owusu Ayim · 2022 · Future Business Journal
Abstract There is mixed evidence that low levels of productivity at the local government level are not common with organizations with strong cultures as these are less prone to any externalities. The paper investigated the link between organizational culture and employee productivity from the perspectives of employees of the Sekondi-Takoradi Metropolitan Assembly (STMA) in Ghana. The study used the quantitative approach with descriptive and cross-sectional designs. The simple random and stratified sampling techniques were used to select 132 respondents from the STMA using a self-administered s
View details →DOI: 10.1186/s43093-022-00145-5Cited by 24 Negative / Null Result ReportOpen accessNeuroscience
Karam Khateeb, Zhaojie Yao, Viktor Kharazia et al. · 2019
Ischemic stroke is a major cause of disability among adults worldwide. Despite its prevalence, few effective treatment options exist to alleviate sensory and motor dysfunctions that result from stroke. In the past, rodent models of stroke…
View details →DOI: 10.1109/embc.2019.8857741Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Masaru Sekijima, Hiroshi Takeda, Katsuaki Yasunaga et al. · 2010 · Journal of Radiation Research
We investigated the mechanisms by which radiofrequency (RF) fields exert their activity, and the changes in both cell proliferation and the gene expression profile in the human cell lines, A172 (glioblastoma), H4 (neuroglioma), and IMR-90…
View details →DOI: 10.1269/jrr.09126Cited by 24 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Eamonn P. Culligan, Julian R. Marchesi, Colin Hill et al. · 2014 · Frontiers in Microbiology
In the current study, a number of salt-tolerant clones previously isolated from a human gut metagenomic library were screened using Phenotype MicroArray (PM) technology to assess their functional capacity. PM's can be used to study gene function, pathogenicity, metabolic capacity and identify drug targets using a series of specialized microtitre plate assays, where each well of the microtitre plate contains a different set of conditions and tests a different phenotype. Cellular respiration is monitored colorimetrically by the reduction of a tetrazolium dye. One clone, SMG 9, was found to be po
View details →DOI: 10.3389/fmicb.2014.00189Cited by 24 Negative / Null Result ReportOpen accessMedicine
Tiffany A. Greenwood, John R. Kelsoe · 2013 · PLoS ONE
The use of clinical features to define subtypes of a disorder may aid in gene identification for complex diseases. In particular, clinical subtypes of mania may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically. To assess this possibility, we performed a genome-wide association study using genotype data from the Bipolar Genome Study (BiGS) and subjects that were categorized as having either irritable or elated mania during their most severe episode. A bipolar case-only analysis in the GAIN bipolar sample identified several genomic regions that differed betwe
View details →DOI: 10.1371/journal.pone.0053804Cited by 24 