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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19803 results in Negative / Null Result Report · page 96 of 661

Negative / Null Result ReportOpen accessComputer Science

Comparing conventional statistical models and machine learning in a small cohort of South African cardiac patients

Preesha Premsagar, Colleen Aldous, Tonya M. Esterhuizen et al. · 2022 · Informatics in Medicine Unlocked

Machine learning is used to process big data volumes with complex non-linear relationships between predictive variables and predictions. Research into the usefulness of machine learning in small data volumes remains limited. To compare…

View details →DOI: 10.1016/j.imu.2022.101103Cited by 25
Negative / Null Result ReportOpen accessNeuroscience

Long-Term Survival and Differentiation of Human Neural Stem Cells in Nonhuman Primate Brain with no Immunosuppression

Sang‐Rae Lee, Hong J. Lee, Sang-Hoon Cha et al. · 2015 · Cell Transplantation

Cellular fate of human neural stem cells (hNSCs) transplanted in the brain of nonhuman primates (NHPs) with no immunosuppression was determined at 22 and 24 months posttransplantation (PTx) regarding survival, differentiation, and tumorigenesis. Survival of hNSCs labeled with magnetic nanoparticles was successfully detected around injection sites in the brain at 22 months PTx by MRI. Histological examination of brain sections with H&E and Prussian blue staining at 24 months revealed that most of the grafted hNSCs were found located along the injection tract. Grafted hNSCs were found to differe

View details →DOI: 10.3727/096368914x678526Cited by 25
Negative / Null Result ReportOpen accessVeterinary

Not statistically significant, but still scientific

Rachael L. Brown · 2017 · Animal Sentience

Birch’s formulation is persuasive but not nuanced enough to capture at least one situation where it is reasonable to invoke the precautionary principle (PP): when we have multiple, weak, but convergent, lines of evidence that a species is…

View details →DOI: 10.51291/2377-7478.1247Cited by 25
Negative / Null Result ReportChemistry

Intrinsic Optical Activity and Conformational Flexibility: The Role of Size-Dependent Ring Morphology in Model Cycloketones

Priyanka Lahiri, Kenneth B. Wiberg, Patrick H. Vaccaro · 2013 · The Journal of Physical Chemistry A

The optical rotatory dispersion of two monocyclic ketones, (R)-3-methylcyclopentanone [R-3MCP] and (R)-3-methylcyclohexanone [R-3MCH], has been investigated under isolated and solvated conditions to explore the role of ring size/morphology…

View details →DOI: 10.1021/jp4089194Cited by 25
Negative / Null Result ReportOpen accessBusiness, Management and Accounting

The Effect of Money Supply, Exchange Rate, and Interest Spread toward the Performance of Stock Market in Malaysia

Yeoh Kai Qing, Suhal Kusairi · 2019 · WIDYAKALA JOURNAL OF PEMBANGUNAN JAYA UNIVERSITY

The stock market has become a significant role in the economy and has attracted investor's attention, as it is to generate funds and make an investment decision for companies and investors as well. Therefore, the objective of this study is…

View details →DOI: 10.36262/widyakala.v6i2.217Cited by 25
Negative / Null Result ReportOpen accessEngineering

Generation and characterisation of gallium titanate surfaces through hydrothermal ion-exchange processes

Matthew D. Wadge, Bryan W. Stuart, Kathryn G. Thomas et al. · 2018 · Materials & Design

Infection negation and biofilm prevention are necessary developments needed for implant materials. Furthermore, an increase in publications regarding gallium (Ga) as an antimicrobial ion has resulted in bacterial-inhibitory surfaces incorporating gallium as opposed to silver (Ag). The authors present the production of novel gallium titanate surfaces through hydrothermal ion-exchange reactions. Commercially-pure Ti (S0: Cp-Ti) was initially suspended in NaOH solutions to obtain sodium titanate (S1: Na2TiO3) layers ca. 0.5–1 μm in depth (2.4 at.% Na). Subsequent suspension in Ga(NO3)3 (S2: Ga2(T

View details →DOI: 10.1016/j.matdes.2018.05.060Cited by 25
Negative / Null Result ReportOpen accessEarth and Planetary Sciences

Melt addition to mid-ocean ridge peridotites increases spinel Cr# with no significant effect on recorded oxygen fugacity

Suzanne Birner, Elizabeth Cottrell, J. M. Warren et al. · 2021 · Earth and Planetary Science Letters

Mid-ocean ridge peridotites record significantly greater variability in major and trace elements, isotopic compositions, and thermodynamic properties such as oxygen fugacity (fO2) than do their basaltic counterparts. This variability may derive from modern ridge processes related to melting and melt-rock interaction or from long-lived source heterogeneity related to recycled material or ancient melting events. In this study, we investigate variations in spinel geochemistry as well as silicate major and trace element chemistry and oxygen fugacity of a suite of peridotites from a single segment

View details →DOI: 10.1016/j.epsl.2021.116951Cited by 25
Negative / Null Result ReportOpen accessHealth Professions

Occupational exposure to extremely low-frequency magnetic fields and cardiovascular disease mortality in a prospective cohort study

Tom Koeman, Pauline Slottje, Hans Kromhout et al. · 2013 · Occupational and Environmental Medicine

OBJECTIVES: Although a study among utility workers found an increased risk for acute myocardial infarction and arrhythmia-related deaths associated with occupational extremely low-frequency magnetic fields (ELF-MF) exposure, later studies…

View details →DOI: 10.1136/oemed-2012-100889Cited by 25
Negative / Null Result ReportMedicine

No significant effect of cannabis use on the count and percentage of circulating CD4 T‐cells in HIV‐HCV co‐infected patients (ANRS CO13‐HEPAVIH French cohort)

Fabienne Marcellin, C. Lions, Éric Rosenthal et al. · 2016 · Drug and Alcohol Review

INTRODUCTION AND AIMS: Despite cannabis use being very common in patients co-infected with HIV and hepatitis C virus (HCV), its effect on these patients' immune systems remains undocumented. Documenting the potential effect of cannabis use…

View details →DOI: 10.1111/dar.12398Cited by 25
Negative / Null Result ReportOpen accessPsychology

Sequential Bayes Factor designs in developmental research: Studies on early word learning

Nivedita Mani, Melanie S. Schreiner, Julia Brase et al. · 2021 · Developmental Science

Developmental research, like many fields, is plagued by low sample sizes and inconclusive findings. The problem is amplified by the difficulties associated with recruiting infant participants for research as well as the increased variability in infant responses. With sequential testing designs providing a viable alternative to paradigms facing such issues, the current study implemented a Sequential Bayes Factor (SBF) design on three findings in the developmental literature. In particular, using the framework described by Schönbrödt and colleagues (2017), we examined infants' sensitivity to mis

View details →DOI: 10.1111/desc.13097Cited by 25
Negative / Null Result ReportMathematics

Priming Mathematics Word Problem Structures in a Rural Elementary Classroom

Cynthia C. Griffin, Joseph Calvin Gagnon, Maggie H. Jossi et al. · 2018 · Rural Special Education Quarterly

This study examined mathematics strategy instruction that primes the common underlying structures of word problems using explicit instruction in a rural elementary classroom with fourth- and fifth-grade students with and without…

View details →DOI: 10.1177/8756870518772164Cited by 25
Negative / Null Result ReportOpen accessSocial Sciences

Academic Performance of Students with Disabilities in Higher Education: Insights from a Study of One Catholic College

Laura M. Wasielewski · 2016 · Journal of Catholic Education

The purpose of this study was to determine if students with disabilities perform comparably to students without disabilities academically at a small liberal arts college. Quantitative results were gathered through the comparison of end of semester and cumulative grade point averages for students with disabilities and students without disabilities (n=56). The t test for independent means and a 2-way analysis of variance were used to test hypotheses. Students without disabilities had significantly higher academic performances than students with disabilities as measured by grade point averages. F

View details →DOI: 10.15365/joce.2001062016Cited by 25
Negative / Null Result ReportOpen accessMedicine

Detecting Corticospinal Tract Impairment in Tumor Patients With Fiber Density and Tensor-Based Metrics

Lucius S. Fekonja, Ziqian Wang, Dogu Baran Aydogan et al. · 2021 · Frontiers in Oncology

Tumors infiltrating the motor system lead to significant disability, often caused by corticospinal tract injury. The delineation of the healthy-pathological white matter (WM) interface area, for which diffusion magnetic resonance imaging (dMRI) has shown promising potential, may improve treatment outcome. However, up to 90% of white matter (WM) voxels include multiple fiber populations, which cannot be correctly described with traditional metrics such as fractional anisotropy (FA) or apparent diffusion coefficient (ADC). Here, we used a novel fixel-based along-tract analysis consisting of cons

View details →DOI: 10.3389/fonc.2020.622358Cited by 25
Negative / Null Result ReportOpen accessMedicine

No Significant Association Between the Fecal Microbiome and the Presence of Irritable Bowel Syndrome-type Symptoms in Patients with Quiescent Inflammatory Bowel Disease

Oliver Shutkever, David J. Gracie, Caroline Young et al. · 2018 · Inflammatory Bowel Diseases

Background: The microbiome is implicated in the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Whether a distinct microbiome profile is associated with the reporting of IBS-type symptoms in IBD…

View details →DOI: 10.1093/ibd/izy052Cited by 25
Negative / Null Result ReportOpen accessPsychology

“Can You Remember What Was in Your Pocket When You Were Stung by a Bee?”: Eliciting Cues to Deception by Asking the Unanticipated

Meiling Liu, Pär Anders Granhag, Sara Landström et al. · 2010 · The Open Criminology Journal

In this paper we focused on children's deception (10-12 years, Experiment 1), and adult's ability detect deception in children (Experiment 2). The self-presentational perspective By asking unanticipated questions we put the liars in the…

View details →DOI: 10.2174/1874917801003010031Cited by 25
Negative / Null Result ReportOpen accessMedicine

Voxel-based 18F-FET PET segmentation and automatic clustering of tumor voxels: A significant association with IDH1 mutation status and survival in patients with gliomas

Paul Blanc‐Durand, Axel Van Der Gucht, Antoine Verger et al. · 2018 · PLoS ONE

INTRODUCTION: Aim was to develop a full automatic clustering approach of the time-activity curves (TAC) from dynamic 18F-FET PET and evaluate its association with IDH1 mutation status and survival in patients with gliomas. METHODS: Thirty-seven patients (mean age: 45±13 y) with newly diagnosed gliomas and dynamic 18F-FET PET before any histopathologic investigation or treatment were retrospectively included. Each dynamic 18F-FET PET was realigned to the first image and spatially normalized in the Montreal Neurological Institute template. A tumor mask was semi-automatically generated from Z-sco

View details →DOI: 10.1371/journal.pone.0199379Cited by 25
Negative / Null Result ReportOpen accessEnvironmental Science

Spatial prediction of soil properties in two contrasting physiographic regions in Brazil

Michele Duarte de Menezes, Sérgio Henrique Godinho Silva, Carlos Rogério de Mello et al. · 2016 · Scientia Agricola

This study compared the performance of ordinary kriging (OK) and regression kriging (RK) to predict soil physical-chemical properties in topsoil (0-15 cm). Mean prediction of error and root mean square of prediction error were used to assess the prediction methods. Two watersheds with contrasting soil-landscape features were studied, for which the prediction methods were performed differently. A multiple linear stepwise regression model was performed with RK using digital terrain models (DTMs) and remote sensing images in order to choose the best auxiliary covariates. Different pedogenic facto

View details →DOI: 10.1590/0103-9016-2015-0071Cited by 25
Negative / Null Result ReportOpen accessEnvironmental Science

Using Silviculture to Influence Carbon Sequestration in Southern Appalachian Spruce-Fir Forests

Patrick Moore, R. Justin DeRose, James N. Long et al. · 2012 · Forests

Enhancement of forest growth through silvicultural modification of stand density is one strategy for increasing carbon (C) sequestration. Using the Fire and Fuels Extension of the Forest Vegetation Simulator, the effects of even-aged, uneven-aged and no-action management scenarios on C sequestration in a southern Appalachian red spruce-Fraser fir forest were modeled. We explicitly considered C stored in standing forest stocks and the fate of forest products derived from harvesting. Over a 100-year simulation period the even-aged scenario (250 Mg C ha−1) outperformed the no-action scenario (241

View details →DOI: 10.3390/f3020300Cited by 25
Negative / Null Result ReportPsychology

Multimodal, Multiparty Modeling of Collaborative Problem Solving Performance

Shree Krishna Subburaj, Angela Stewart, Arjun Rao et al. · 2020

Modeling team phenomena from multiparty interactions inherently requires combining signals from multiple teammates, often by weighting strategies. Here, we explored the hypothesis that strategic weighting signals from individual teammates…

View details →DOI: 10.1145/3382507.3418877Cited by 25
Negative / Null Result ReportMedicine

Validation of a proteomic biomarker panel to diagnose minor-stroke and transient ischaemic attack: phase 2 of SpecTRA, a large scale translational study

Andrew M. Penn, Maximilian B. Bibok, Viera Saly et al. · 2018 · Biomarkers

OBJECTIVE: To validate our previously developed 16 plasma-protein biomarker panel to differentiate between transient ischaemic attack (TIA) and non-cerebrovascular emergency department (ED) patients.METHOD: Two consecutive cohorts of ED…

View details →DOI: 10.1080/1354750x.2018.1499130Cited by 25
Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology

Laboratory divergence of Methylobacterium extorquens AM1 through unintended domestication and past selection for antibiotic resistance

Sean M. Carroll, Katherine S. Xue, Christopher J. Marx · 2014 · BMC Microbiology

BACKGROUND: A common assumption of microorganisms is that laboratory stocks will remain genetically and phenotypically constant over time, and across laboratories. It is becoming increasingly clear, however, that mutations can ruin strain integrity and drive the divergence or "domestication" of stocks. Since its discovery in 1960, a stock of Methylobacterium extorquens AM1 ("AM1") has remained in the lab, propagated across numerous growth and storage conditions, researchers, and facilities. To explore the extent to which this lineage has diverged, we compared our own "Modern" stock of AM1 to a

View details →DOI: 10.1186/1471-2180-14-2Cited by 25
Negative / Null Result ReportOpen accessEnvironmental Science

Variation in tree mortality and regeneration affect forest carbon recovery following fuel treatments and wildfire in the Lake Tahoe Basin, California, USA

Chris H. Carlson, Solomon Z. Dobrowski, Hugh D. Safford · 2012 · Carbon Balance and Management

BACKGROUND: Forest fuel treatments have been proposed as tools to stabilize carbon stocks in fire-prone forests in the Western U.S.A. Although fuel treatments such as thinning and burning are known to immediately reduce forest carbon stocks, there are suggestions that these losses may be paid back over the long-term if treatments sufficiently reduce future wildfire severity, or prevent deforestation. Although fire severity and post-fire tree regeneration have been indicated as important influences on long-term carbon dynamics, it remains unclear how natural variability in these processes might

View details →DOI: 10.1186/1750-0680-7-7Cited by 25
Negative / Null Result ReportOpen accessMedicine

Could Ovarian Cancer Prediction Models Improve the Triage of Symptomatic Women in Primary Care? A Modelling Study Using Routinely Collected Data

Garth Funston, Gary Abel, Emma J. Crosbie et al. · 2021 · Cancers

CA125 is widely used as an initial investigation in women presenting with symptoms of possible ovarian cancer. We sought to develop CA125-based diagnostic prediction models and to explore potential implications of implementing model-based thresholds for further investigation in primary care. This retrospective cohort study used routinely collected primary care and cancer registry data from symptomatic, CA125-tested women in England (2011-2014). A total of 29,962 women were included, of whom 279 were diagnosed with ovarian cancer. Logistic regression was used to develop two models to estimate o

View details →DOI: 10.3390/cancers13122886Cited by 25
Negative / Null Result ReportOpen accessMedicine

Randomized Phase IIb Study of Brimonidine Drug Delivery System Generation 2 for Geographic Atrophy in Age-Related Macular Degeneration

William R. Freeman, Francesco Bandello, Eric H. Souied et al. · 2023 · Ophthalmology Retina

To evaluate the safety and efficacy of repeat injections of Brimonidine Drug Delivery System (Brimo DDS) Generation 2 (Gen 2) containing 400-μg brimonidine in patients with geographic atrophy (GA) secondary to age-related macular…

View details →DOI: 10.1016/j.oret.2023.03.001Cited by 25
Negative / Null Result ReportOpen accessMedicine

Effect of calcium vs. placebo on long-term outcomes in patients with out-of-hospital cardiac arrest

Mikael Fink Vallentin, Asger Granfeldt, Carsten Meilandt et al. · 2022 · Resuscitation

OBJECTIVE: The Calcium for Out-of-hospital Cardiac Arrest (COCA) trial was a randomized, placebo-controlled, double-blind trial of calcium for out-of-hospital cardiac arrest. The primary and secondary outcomes have been reported previously. This article describes the long-term outcomes of the trial. METHODS: Patients aged ≥18 years were included if they had a non-traumatic out-of-hospital cardiac arrest during which they received adrenaline. The trial drug consisted of calcium chloride (5 mmol) or saline placebo given after the first dose of adrenaline and again after the second dose of adrena

View details →DOI: 10.1016/j.resuscitation.2022.07.034Cited by 25
Negative / Null Result ReportOpen accessAgricultural and Biological Sciences

Local-scale virome depiction in Medellín, Colombia, supports significant differences between Aedes aegypti and Aedes albopictus

Arley Calle-Tobón, Juliana Pérez-Pérez, Nicolás Forero-Pineda et al. · 2022 · PLoS ONE

Aedes spp. comprise the primary group of mosquitoes that transmit arboviruses such as dengue, Zika, and chikungunya viruses to humans, and thus these insects pose a significant burden on public health worldwide. Advancements in next-generation sequencing and metagenomics have expanded our knowledge on the richness of RNA viruses harbored by arthropods such as Ae. aegypti and Ae. albopictus. Increasing evidence suggests that vector competence can be modified by the microbiome (comprising both bacteriome and virome) of mosquitoes present in endemic zones. Using an RNA-seq-based metataxonomic app

View details →DOI: 10.1371/journal.pone.0263143Cited by 25
Negative / Null Result ReportOpen accessMedicine

Significant differences in the cell‐wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity

S. Takahashi, Atsushi Kudoh, Yoshio Okawa et al. · 2012 · FEBS Journal

Candida glabrata is often the second or third most common cause of candidiasis after Candida albicans. C. glabrata infections are difficult to treat, often resistant to many azole antifungal agents and are associated with a high mortality…

View details →DOI: 10.1111/j.1742-4658.2012.08564.xCited by 25
Negative / Null Result ReportMedicine

Influence of In-House Attending Presence on Trauma Outcomes and Hospital Efficiency

Jessica Cox, Andrew C. Bernard, Anthony J. Bottiggi et al. · 2014 · Journal of the American College of Surgeons

BACKGROUND: The influence of in-house (IH) attendings on trauma patient survival and efficiency measures, such as emergency department length of stay (LOS), ICU LOS, and hospital LOS, has been debated for more than 20 years. No study has…

View details →DOI: 10.1016/j.jamcollsurg.2013.12.027Cited by 25
Negative / Null Result ReportEarth and Planetary Sciences

Contrasting Air Mass Advection Explains Significant Differences in Boundary Layer Depth Seasonal Cycles Under Onshore Versus Offshore Flows

Sandip Pal, Temple R. Lee · 2019 · Geophysical Research Letters

Abstract The complexities in the atmospheric boundary layer depth (BLD) features over coastal regions pose challenges for meteorological forecasts, air quality, greenhouse gas mixing and transport, and wind energy production. Here, for the…

View details →DOI: 10.1029/2018gl081699Cited by 25