A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20201 results in Negative / Null Result Report · page 89 of 674
Prayut Jain, Shashi Jain · 2019 · Risks
The Hierarchical risk parity (HRP) approach of portfolio allocation, introduced by Lopez de Prado (2016), applies graph theory and machine learning to build a diversified portfolio. Like the traditional risk-based allocation methods, HRP…
Janna N. Vrijsen, Ben Grafton, Ernst H. W. Koster et al. · 2024 · Behaviour Research and Therapy
Cognitive bias modification (CBM) has evolved from an experimental method testing cognitive mechanisms of psychopathology to a promising tool for accessible digital mental health care. While we are still discovering the conditions under which clinically relevant effects occur, the dire need for accessible, effective, and low-cost mental health tools underscores the need for implementation where such tools are available. Providing our expert opinion as Association for Cognitive Bias Modification members, we first discuss the readiness of different CBM approaches for clinical implementation, the
Felix Chopra, Ingar Haaland, Christopher Roth et al. · 2023 · The Economic Journal
Abstract We examine how the evaluation of research studies in economics depends on whether a study yielded a null result. Studies with null results are perceived to be less publishable, of lower quality, less important and less precisely…
Urko M. Marigorta, Óscar Lao, Ferrán Casals et al. · 2011 · BMC Genomics
BACKGROUND: Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a figure that keeps increasing, especially with the recent explosion of array-based Genome-Wide Association Studies. Even if the number of true associations described so far is high, many of the putative risk variants detected so far have failed to be consistently replicated and are widely considered false positives. Here, we focus on the world-wide patterns of replicability of
Hazem Aboaid, Taimur Khalid, Abbas Hussain et al. · 2025 · Frontiers in Immunology
Head and neck squamous cell carcinoma (HNSCC) remains a challenging malignancy with suboptimal survival outcomes despite advances in surgery, radiotherapy, and chemotherapy. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1), has transformed treatment paradigms, yet its full potential in HNSCC is still being explored. This review evaluates the current landscape of immunotherapy in both locally advanced (LA) and recurrent/metastatic (R/M) HNSCC, discussing key clinical trials, emerging biomarker
Murray G. Efford · 2026 · Ecology
Spatially explicit capture-recapture (SECR) methods are used widely to estimate animal population density and related parameters. Maximum likelihood has been applied to two flavors of the SECR model-a full model that includes absolute…
Iacopo Morchio, Christian Moser · 2026 · American Economic Review
Using linked employer-employee data from Brazil, we document a significant gender pay gap, which is largely attributed to women working at lower-paying employers. To interpret this fact, we develop an equilibrium search model with…
Nanike Esterhuizen, Susana Clusella‐Trullas, Corné E. van Daalen et al. · 2014 · Journal of Experimental Biology
The influence of thermal history on temperature-dependent flight performance was investigated in an invasive agricultural pest insect, Ceratitis capitata (Diptera: Tephritidae). Flies were exposed to one of four developmental acclimation…
Rebecca Treiman, Brett Kessler, Tatiana Cury Pollo et al. · 2016 · Scientific Studies of Reading
Learning the orthographic forms of words is important for both spelling and reading. To determine whether some methods of scoring children's early spellings predict later spelling performance better than do other methods, we analyzed data…
Guy E. Blelloch, Girija Narlikar · 2018 · Figshare
This work compares three algorithms for the three dimensional N-body problem, the Barnes-Hut algorithm, Greengard's Fast Multipole Method(FMM), and the Parallel Multipole Tree Algorithm (PMTA) to determine which of the algorithms performs…
Gerlig Widmann, Alexander Bischel, Andreas Stratis et al. · 2017 · Dentomaxillofacial Radiology
OBJECTIVES: The objective of this study was to determine how iterative reconstruction technology (IRT) influences contrast and spatial resolution in ultralow-dose dentomaxillofacial CT imaging. METHODS: A polymethyl methacrylate phantom with various inserts was scanned using a reference protocol (RP) at CT dose index volume 36.56 mGy, a sinus protocol at 18.28 mGy and ultralow-dose protocols (LD) at 4.17 mGy, 2.36 mGy, 0.99 mGy and 0.53 mGy. All data sets were reconstructed using filtered back projection (FBP) and the following IRTs: adaptive statistical iterative reconstructions (ASIRs) (ASIR
Imad Bou Akl, Fatima Ghaddar, Ramzi Sabra et al. · 2011 · The Journal of Clinical Pharmacology
The purpose of this study was to formulate evidence-based recommendations on whether to deliver the team-based learning (TBL)-designed clinical pharmacology course at the American University of Beirut Faculty of Medicine (AUBFM) during the…
Marika Fallenius, Markus B. Skrifvars, Matti Reinikainen et al. · 2017 · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine
BACKGROUND: Intensive care scoring systems are widely used in intensive care units (ICU) around the world for case-mix adjustment in research and benchmarking. The aim of our study was to investigate the usefulness of common intensive care scoring systems in predicting mid-term mortality in patients with spontaneous intracerebral hemorrhage (ICH) treated in intensive care units (ICU). METHODS: We performed a retrospective observational study including adult patients with spontaneous ICH treated in Finnish ICUs during 2003-2012. We used six-month mortality as the primary outcome of interest. We
S. Heirbaut, Xiaoping Jing, Barbara Stefańska et al. · 2022 · Journal of Dairy Science
Data on metabolic profiles of blood sampled at d 3, 6, 9, and 21 in lactation from 117 lactations (99 cows) were used for unsupervised k-means clustering. Blood metabolic parameters included -hydroxybutyrate (BHB), nonesterified fatty acids, glucose, insulin-like growth factor-1 (IGF-1) and insulin. Clustering relied on the average and range of the 5 blood parameters of all 4 sampling days. The clusters were labeled as imbalanced (n = 42) and balanced (n = 72) metabolic status based on the values of the blood parameters. Various random forest models were built to predict the metabolic cluster
Chia Wen Tsai, Wen Shin Chang, Kuo Cheng Lin et al. · 2014 · PubMed
Interleukin-10 (IL10) is an immunosuppressive cytokine which may facilitate carcinogenesis by down-regulating interferon-gamma production and supporting tumor escape from the immune response. Polymorphisms within the promoter of IL10 gene…
Davide Ferrari, Massimo Locatelli · 2020 · International Journal for Vitamin and Nutrition Research
Abstract. The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies…
J. B. Warren · 2020 · BMJ
Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes John Warren
Tracie C. Rosser, Jamie O. Edgin, George T. Capone et al. · 2018 · American Journal on Intellectual and Developmental Disabilities
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and…
Felix Kwame Aveh, Dadson Awunyo‐Vitor · 2017 · Cogent Economics & Finance
This study seeks to examine the influence of firm-specific determinants of stock prices in an emerging market with particular reference to firms listed on the Ghana Stock Exchange. The study employs a data-set from all listed firms on the Ghana Stock Exchange from 2008 to 2014. The study used panel regression analysis to analyse the data. In general, the study found that accounting information, specifically earning per share, return on equity, book value and market capitalization of the firms, is relevant in explaining stock prices after the adoption of International Financial Reporting Standa
Rebecca Kanive, Peter M. Nelson, Matthew K. Burns et al. · 2013 · The Journal of Educational Research
ABSTRACT The authors’ purpose was to determine the effects of computer-based practice and conceptual interventions on computational fluency and word-problem solving of fourth- and fifth-grade students with mathematics difficulties. A…
Jason E. Strickhouser, Ethan Zell, Kara Harris · 2018 · Social Psychological and Personality Science
Why do White Americans perceive less racism than Black Americans? Two provocative studies on the Marley hypothesis suggest that White Americans are more ignorant of historical instances of racism than Black Americans and that ignorance of…
Ngan T.K. Tran, Stella Aslibekyan, Hemant K. Tiwari et al. · 2015 · Frontiers in Genetics
Proprotein convertase subtilisin/kexin type 9 (encoded by PCSK9) plays a well-known role in the regulation of low-density lipoprotein (LDL) receptors, and an inhibitor of this enzyme is a promising new therapeutic for hyperlipidemia. Recently, animal and human studies also implicate PCSK9 genetic variation in the regulation of blood pressure. The goal of this study was to examine if common and rare polymorphisms in PCSK9 are associated with blood pressure in an African-American population at high risk for cardiovascular disease. Using genomic data assayed on the Affymetrix 6.0 array (n = 1199)
José‐Antonio Daròs, Verónica Aragonés, Teresa Cordero · 2018 · Scientific Reports
Viruses have been engineered into useful biotechnological tools for gene therapy or to induce the synthesis of products of interest, such as therapeutic proteins and vaccines, in animal and fungal cells, bacteria or plants. Viroids are a particular class of infectious agents of higher plants that exclusively consist of a small non-protein-coding circular RNA molecule. In the same way as viruses have been transformed into useful biotechnological devices, can viroids be converted into beneficial tools? We show herein that, by expressing Eggplant latent viroid (ELVd) derived RNAs in Escherichia c
Kateřina Hotová Svádová, Alice Exnerová, Michala Kopečková et al. · 2013 · Ethology
Abstract We tested the importance of innate wariness, avoidance learning, memory and generalization for the formation of predatory behaviour in naive great tits ( P arus major ) towards mimetic complex of four aposematic species of true…
Owen M. Peters, Tatyana A. Shelkovnikova, Tatiana Tarasova et al. · 2013 · Journal of Alzheimer s Disease
Dimebon has been tested as a potential modifier of Alzheimer's disease (AD), resulting in mixed clinical trial outcomes. Originally utilized as an antihistamine, Dimebon was later found to ameliorate AD symptoms in initial human trials.…
Yolandi Swart, Caitlin Uren, Paul D. van Helden et al. · 2021 · Frontiers in Genetics
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis , is a complex disease. The risk of developing active TB is in part determined by host genetic factors. Most genetic studies investigating TB susceptibility fail to replicate association signals particularly across diverse populations. South African populations arose because of multi-wave genetic admixture from the indigenous KhoeSan, Bantu-speaking Africans, Europeans, Southeast Asian-and East Asian populations. This has led to complex genetic admixture with heterogenous patterns of linkage disequilibrium and associated traits.
Matthew S. Clement, Nathan A. Kaib, John E. Chambers · 2019 · The Astronomical Journal
Abstract Of the solar system’s four terrestrial planets, the origin of Mercury is perhaps the most mysterious. Modern numerical simulations designed to model the dynamics of terrestrial planet formation systematically fail to replicate…
Yun‐Young Lee, Robert X. Black · 2013 · Journal of Geophysical Research Atmospheres
Abstract This study assesses the capability of CMIP5 models in representing primary modes of boreal winter extratropical low‐frequency variability. Rotated principal component analysis is applied to monthly mean output from historical…
Michael Talledo, Giovanni López, Jeroen R. Huyghe et al. · 2010 · Journal of Medical Virology
Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the…
Anja Achtziger, Carlos Alós‐Ferrer, Sabine Hügelschäfer et al. · 2015 · Social Cognitive and Affective Neuroscience
Standard economic thinking postulates that increased monetary incentives should increase performance. Human decision makers, however, frequently focus on past performance, a form of reinforcement learning occasionally at odds with rational…