Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
S. Heirbaut, Xiaoping Jing, Barbara Stefańska et al. · 2022 · Journal of Dairy Science
Data on metabolic profiles of blood sampled at d 3, 6, 9, and 21 in lactation from 117 lactations (99 cows) were used for unsupervised k-means clustering. Blood metabolic parameters included -hydroxybutyrate (BHB), nonesterified fatty acids, glucose, insulin-like growth factor-1 (IGF-1) and insulin. Clustering relied on the average and range of the 5 blood parameters of all 4 sampling days. The clusters were labeled as imbalanced (n = 42) and balanced (n = 72) metabolic status based on the values of the blood parameters. Various random forest models were built to predict the metabolic cluster
View details →DOI: 10.3168/jds.2022-22217Cited by 30 Negative / Null Result ReportDentistry
Chia Wen Tsai, Wen Shin Chang, Kuo Cheng Lin et al. · 2014 · PubMed
Interleukin-10 (IL10) is an immunosuppressive cytokine which may facilitate carcinogenesis by down-regulating interferon-gamma production and supporting tumor escape from the immune response. Polymorphisms within the promoter of IL10 gene…
Negative / Null Result ReportMedicine
Davide Ferrari, Massimo Locatelli · 2020 · International Journal for Vitamin and Nutrition Research
Abstract. The world is currently overwhelmed by a novel coronavirus disease (COVID-19). Clinically, COVID-19 shows a broad range of manifestations: from asymptomatic to severe and possibly lethal interstitial pneumonia. Several studies…
View details →DOI: 10.1024/0300-9831/a000687Cited by 30 Negative / Null Result ReportMedicine
J. B. Warren · 2020 · BMJ
Widespread prescribing has not reduced mental disability or suicide, raising questions about the assessment of evidence on effectiveness and safety of antidepressants, writes John Warren
View details →DOI: 10.1136/bmj.m3200Cited by 30 Negative / Null Result ReportOpen accessMedicine
Tracie C. Rosser, Jamie O. Edgin, George T. Capone et al. · 2018 · American Journal on Intellectual and Developmental Disabilities
The cause of the high degree of variability in cognition and behavior among individuals with Down syndrome (DS) is unknown. We hypothesized that birth defects requiring surgery in the first years of life (congenital heart defects and…
View details →DOI: 10.1352/1944-7558-123.6.514Cited by 30 Negative / Null Result ReportOpen accessBusiness, Management and Accounting
Felix Kwame Aveh, Dadson Awunyo‐Vitor · 2017 · Cogent Economics & Finance
This study seeks to examine the influence of firm-specific determinants of stock prices in an emerging market with particular reference to firms listed on the Ghana Stock Exchange. The study employs a data-set from all listed firms on the Ghana Stock Exchange from 2008 to 2014. The study used panel regression analysis to analyse the data. In general, the study found that accounting information, specifically earning per share, return on equity, book value and market capitalization of the firms, is relevant in explaining stock prices after the adoption of International Financial Reporting Standa
View details →DOI: 10.1080/23322039.2017.1339385Cited by 30 Negative / Null Result ReportMathematics
Rebecca Kanive, Peter M. Nelson, Matthew K. Burns et al. · 2013 · The Journal of Educational Research
ABSTRACT The authors’ purpose was to determine the effects of computer-based practice and conceptual interventions on computational fluency and word-problem solving of fourth- and fifth-grade students with mathematics difficulties. A…
View details →DOI: 10.1080/00220671.2012.759405Cited by 30 Negative / Null Result ReportSocial Sciences
Jason E. Strickhouser, Ethan Zell, Kara Harris · 2018 · Social Psychological and Personality Science
Why do White Americans perceive less racism than Black Americans? Two provocative studies on the Marley hypothesis suggest that White Americans are more ignorant of historical instances of racism than Black Americans and that ignorance of…
View details →DOI: 10.1177/1948550618808863Cited by 30 Negative / Null Result ReportOpen accessMedicine
Ngan T.K. Tran, Stella Aslibekyan, Hemant K. Tiwari et al. · 2015 · Frontiers in Genetics
Proprotein convertase subtilisin/kexin type 9 (encoded by PCSK9) plays a well-known role in the regulation of low-density lipoprotein (LDL) receptors, and an inhibitor of this enzyme is a promising new therapeutic for hyperlipidemia. Recently, animal and human studies also implicate PCSK9 genetic variation in the regulation of blood pressure. The goal of this study was to examine if common and rare polymorphisms in PCSK9 are associated with blood pressure in an African-American population at high risk for cardiovascular disease. Using genomic data assayed on the Affymetrix 6.0 array (n = 1199)
View details →DOI: 10.3389/fgene.2015.00136Cited by 30 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
José‐Antonio Daròs, Verónica Aragonés, Teresa Cordero · 2018 · Scientific Reports
Viruses have been engineered into useful biotechnological tools for gene therapy or to induce the synthesis of products of interest, such as therapeutic proteins and vaccines, in animal and fungal cells, bacteria or plants. Viroids are a particular class of infectious agents of higher plants that exclusively consist of a small non-protein-coding circular RNA molecule. In the same way as viruses have been transformed into useful biotechnological devices, can viroids be converted into beneficial tools? We show herein that, by expressing Eggplant latent viroid (ELVd) derived RNAs in Escherichia c
View details →DOI: 10.1038/s41598-018-20314-3Cited by 30 Negative / Null Result ReportAgricultural and Biological Sciences
Kateřina Hotová Svádová, Alice Exnerová, Michala Kopečková et al. · 2013 · Ethology
Abstract We tested the importance of innate wariness, avoidance learning, memory and generalization for the formation of predatory behaviour in naive great tits ( P arus major ) towards mimetic complex of four aposematic species of true…
View details →DOI: 10.1111/eth.12121Cited by 30 Negative / Null Result ReportMedicine
Owen M. Peters, Tatyana A. Shelkovnikova, Tatiana Tarasova et al. · 2013 · Journal of Alzheimer s Disease
Dimebon has been tested as a potential modifier of Alzheimer's disease (AD), resulting in mixed clinical trial outcomes. Originally utilized as an antihistamine, Dimebon was later found to ameliorate AD symptoms in initial human trials.…
View details →DOI: 10.3233/jad-130071Cited by 30 Negative / Null Result ReportOpen accessMedicine
Yolandi Swart, Caitlin Uren, Paul D. van Helden et al. · 2021 · Frontiers in Genetics
Pulmonary tuberculosis (TB), caused by Mycobacterium tuberculosis , is a complex disease. The risk of developing active TB is in part determined by host genetic factors. Most genetic studies investigating TB susceptibility fail to replicate association signals particularly across diverse populations. South African populations arose because of multi-wave genetic admixture from the indigenous KhoeSan, Bantu-speaking Africans, Europeans, Southeast Asian-and East Asian populations. This has led to complex genetic admixture with heterogenous patterns of linkage disequilibrium and associated traits.
View details →DOI: 10.3389/fgene.2021.716558Cited by 30 Negative / Null Result ReportOpen accessPhysics and Astronomy
Matthew S. Clement, Nathan A. Kaib, John E. Chambers · 2019 · The Astronomical Journal
Abstract Of the solar system’s four terrestrial planets, the origin of Mercury is perhaps the most mysterious. Modern numerical simulations designed to model the dynamics of terrestrial planet formation systematically fail to replicate…
View details →DOI: 10.3847/1538-3881/ab164fCited by 30 Negative / Null Result ReportOpen accessEnvironmental Science
Yun‐Young Lee, Robert X. Black · 2013 · Journal of Geophysical Research Atmospheres
Abstract This study assesses the capability of CMIP5 models in representing primary modes of boreal winter extratropical low‐frequency variability. Rotated principal component analysis is applied to monthly mean output from historical…
View details →DOI: 10.1002/jgrd.50493Cited by 30 Negative / Null Result ReportOpen accessImmunology and Microbiology
Michael Talledo, Giovanni López, Jeroen R. Huyghe et al. · 2010 · Journal of Medical Virology
Human T-lymphotropic virus 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a complication that affects up to 5% of HTLV-1-infected individuals. Several host genetic and viral factors have been associated with the…
View details →DOI: 10.1002/jmv.21675Cited by 30 Negative / Null Result ReportOpen accessNeuroscience
Anja Achtziger, Carlos Alós‐Ferrer, Sabine Hügelschäfer et al. · 2015 · Social Cognitive and Affective Neuroscience
Standard economic thinking postulates that increased monetary incentives should increase performance. Human decision makers, however, frequently focus on past performance, a form of reinforcement learning occasionally at odds with rational…
View details →DOI: 10.1093/scan/nsv036Cited by 30 Negative / Null Result ReportNeuroscience
So-Yeon Kim, Kelly S. Giovanello · 2011 · Journal of Cognitive Neuroscience
Numerous studies have documented that older adults (OAs) do not perform as well as young adults (YAs) when task demands require the establishment or retrieval of a novel link between previously unrelated information (relational memory:…
View details →DOI: 10.1162/jocn_a_00058Cited by 30 Negative / Null Result ReportOpen accessImmunology and Microbiology
Alexis Dunkle, Ivan Dzhagalov, Y-W He · 2011 · Cell Death and Disease
Myeloid cell leukemia sequence-1 (Mcl-1) is a critical anti-apoptotic factor in T lymphocytes. However, in spite of the many pro-apoptotic proteins with proposed binding to Mcl-1, the specific interactions by which Mcl-1 regulates primary T-cell survival under different conditions have not been fully explored. Further, how different trophic cytokines modulate the specific role(s) of Mcl-1 is unknown. Here, we use genetic mouse models to dissect the roles of Mcl-1 in primary T lymphocytes. Using the inducible Mcl-1-floxed estrogen receptor-Cre fusion protein (Mcl-1(f/f)ERCre) deletion system in
View details →DOI: 10.1038/cddis.2011.95Cited by 30 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sun-Hwa Shin, Won-Seok Choi · 2021 · Food Science of Animal Resources
This study examined the measurement conditions of the texture profile analysis (TPA) experiments that are typically used to measure the physical properties of sausage. As the measurement conditions (compression ratio and cross-head speed)…
View details →DOI: 10.5851/kosfa.2021.e26Cited by 30 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
David H. Howard, Carolyn Kenline, Hillard M. Lazarus et al. · 2011 · Health Services Research
OBJECTIVE: In 1999, three randomized controlled trials concluded that high-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (HDC/HCT) is no better than conventional chemotherapy for women with breast cancer.…
View details →DOI: 10.1111/j.1475-6773.2011.01296.xCited by 30 Negative / Null Result ReportOpen accessMedicine
Marie‐Ève Nadeau, Barbara E. Kitchell · 2011 · PubMed
This retrospective study compared the efficacy of surgery alone versus surgery in combination with chemotherapy in the treatment of canine thyroid carcinoma; potential prognostic factors were evaluated. Forty-four dogs with…
Negative / Null Result ReportOpen accessMedicine
Raquel Ajub Moysés, Rossana Veronica Mendoza López, Patrı́cia Maluf Cury et al. · 2013 · Clinics
OBJECTIVE: As a lifestyle-related disease, social and cultural disparities may influence the features of squamous cell carcinoma of the head and neck in different geographic regions. We describe demographic, clinical, and pathological aspects of squamous cell carcinoma of the head and neck according to the smoking and alcohol consumption habits of patients in a Brazilian cohort. METHODS: We prospectively analyzed the smoking and alcohol consumption habits of 1,633 patients enrolled in five São Paulo hospitals that participated in the Brazilian Head and Neck Genome Project - Gencapo. RESULTS: T
View details →DOI: 10.6061/clinics/2013(06)03Cited by 30 Negative / Null Result ReportNeuroscience
Fabian A. Soto · 2018 · Journal of Experimental Psychology General
In a recent article, Maes et al. (2016) report the results from 15 experiments in the blocking effect, all of which failed to replicate the basic phenomenon. Whereas Maes et al. did not dispute the reality of the blocking effect, they…
View details →DOI: 10.1037/xge0000341Cited by 30 Negative / Null Result ReportOpen accessEngineering
S. M. Abd Elazim, M.H. Elkholy, Abdelrahman Elgarhy et al. · 2025 · Scientific Reports
Growing integration of renewable energy sources (RESs) into power grids has several advantages, including reduced greenhouse gas emissions and improved energy sustainability. Despite the related benefits, RES integration also poses actual…
View details →DOI: 10.1038/s41598-025-14143-4Cited by 29 Negative / Null Result ReportOpen accessNursing
Ana Carolina de Aguiar, Damila Rodrigues de Morais, Leandra P. Santos et al. · 2026 · Archivos Latinoamericanos de Nutrición
This study analyzed the effects of different concentrations of flaxseed oil (FO) on the proximate composition and the contents of alpha-linolenic acid (LNA, 18:3n-3), eicosapentaenoic (EPA, 20:5n-3), and docosahexaenoic (DHA, 22:6n-3)…
View details →DOI: 10.37527/2007.57.3.009Cited by 29 Negative / Null Result ReportOpen accessMedicine
Matthew J. Fisher, Luis A Marcos Raymundo, Melinda Monteforte et al. · 2020 · International Journal of Infectious Diseases
OBJECTIVES: The purpose of this study is to evaluate clinical outcomes in patients with critical COVID-19 pneumonia requiring invasive mechanical ventilation who were treated with tocilizumab DESIGN: Single-center retrospective cohort…
View details →DOI: 10.1016/j.ijid.2020.12.021Cited by 29 Negative / Null Result ReportOpen accessEnergy
Xiaoyu Chen, Dongli Wei, Mårten S. G. Ahlquist · 2021 · Organometallics
A CoPc/CNT system has been only recently reported to transform CO2 to methanol via electrochemical reductions, despite the fact that catalyst has been studied extensively since the 1980s. The explanation of high methanol selectivity lies behind the fact that in the new report CoPc exists mainly as a monomer, while in earlier works aggregates dominate. Here, we have studied the reactivity of monomeric and dimeric CoPc by DFT. The mechanism involves rate-limiting CO2 association, with the C–O cleavage step having very similar activation free energy. Once the Co–CO– intermediate is formed, the re
View details →DOI: 10.1021/acs.organomet.1c00431Cited by 29 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Francesco Giuseppe De Rosa, Silvia Corcione, Giovanni Di Perri et al. · 2015 · PubMed
Tigecycline, the first member of the glycylcyclines, has been approved for complicated skin and soft tissue infections (cSSTIs) and complicated intra-abdominal infections (cIAIs). It has a wide range of activity against Gram-positive and…
Negative / Null Result ReportOpen accessMedicine
Michael Weller, Michael Lim, Ahmed Idbaïh et al. · 2021 · Neuro-Oncology
Abstract BACKGROUND Novel therapies are needed in newly diagnosed glioblastoma as nearly all patients experience recurrence following standard-of-care radiotherapy (RT) + temozolomide (TMZ), including patients with tumors with methylated…
View details →DOI: 10.1093/neuonc/noab196.217Cited by 29 