Negative / Null Result ReportOpen accessMedicine
Sahir Javed, Stéphane Benoist, Patrick Devos et al. · 2022 · World Journal of Surgical Oncology
BACKGROUND: BRAF V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than BRAF wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains difficult due to the scarce literature. The aim was to study a large cohort of BRAF V600E-mutant CRLM patients in order to see if surgery extend overall survival among others prognostic factors. METHODS: BRAF V600E-mutant CRCs diagnosed with liver-only metastases, resected or not, were retrospectively identified between April 2008 and December 2017, in 25 French centers. Clinic
View details →DOI: 10.1186/s12957-022-02594-2Cited by 33 Negative / Null Result ReportOpen accessMedicine
John Ly, David Minarik, Lars Edenbrandt et al. · 2019 · EJNMMI Research
The Deauville score (DS) is a clinical tool, based on the comparison between lesion and reference organ uptake of 18F-fluorodeoxyglucose (FDG), used to stratify patients with lymphoma into categories reflecting their disease status. With a plethora of positron emission tomography with computed tomography (PET-CT) hard- and software algorithms, standard uptake value (SUV) in lesions and reference organs may differ which affects DS classification and therefore medical treatment. The EANM Research Ltd. (EARL) harmonization program from the European Association of Nuclear Medicine (EANM) partly mi
View details →DOI: 10.1186/s13550-019-0536-3Cited by 33 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Simran Thakkar, Aditi Chopra, Lakshmi Nagendra et al. · 2023 · touchREVIEWS in Endocrinology
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune condition characterized by the irreversible destruction of the β cells of the pancreas, which leads to a lifelong dependency on exogenous insulin. Despite the advancements in insulin…
View details →DOI: 10.17925/ee.2023.19.2.7Cited by 33 Negative / Null Result ReportOpen accessMedicine
Péter Kupó, T Riesz, László Sághy et al. · 2023 · Journal of Cardiovascular Electrophysiology
INTRODUCTION: Routine ultrasound (US) guidance for femoral venous access to decrease vascular complications of atrial fibrillation (AF) ablation procedures has been advocated. However, the benefit has not been unequivocally demonstrated by randomized-trial data. METHODS: Consecutive patients undergoing pulmonary vein isolation (PVI) on uninterrupted anticoagulant treatment were included. A quasi-random allocation to either US-guided or conventional puncture group was based on which of the two procedure rooms the patient was scheduled in, with only one of the rooms equipped with a US machine in
View details →DOI: 10.1111/jce.15893Cited by 33 Negative / Null Result ReportOpen accessMedicine
Deborah Ayeni, Braden Miller, Alexandra Kuhlmann et al. · 2019 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitors (TKIs) like erlotinib are effective for treating patients with EGFR mutant lung cancer; however, drug resistance inevitably emerges. Approaches to combine immunotherapies and targeted therapies to overcome or delay drug resistance have been hindered by limited knowledge of the effect of erlotinib on tumor-infiltrating immune cells. METHODS: Using mouse models, we studied the immunological profile of mutant EGFR-driven lung tumors before and after erlotinib treatment. RESULTS: We found that erlotinib triggered the re
View details →DOI: 10.1186/s40425-019-0643-8Cited by 33 Negative / Null Result ReportOpen accessMedicine
Miklós Lipcsey, Mia Furebring, Sten Rubertsson et al. · 2010 · Upsala Journal of Medical Sciences
BACKGROUND: Renal dysfunction is associated with increased morbidity and mortality in intensive care patients. In most cases the glomerular filtration rate (GFR) is estimated based on serum creatinine and the Modification of Diet in Renal Disease (MDRD) formula, but cystatin C-estimated GFR is being used increasingly. The aim of this study was to compare creatinine and MDRD and cystatin C-estimated GFR in intensive care patients. METHODS: Retrospective observational study was performed, on patients treated within the general intensive care unit (ICU) during 2004-2006, in a Swedish university h
View details →DOI: 10.3109/03009734.2010.526724Cited by 33 Negative / Null Result ReportOpen accessMedicine
Narendra Kumar, Pankaj Kumar, Shabab Angurana et al. · 2013 · Journal of Neurosciences in Rural Practice
AIMS: We present retrospective analysis of patients of glioblastoma multiforme (GBM) and discuss clinical characteristics, various treatment protocols, survival outcomes, and prognostic factors influencing survival. MATERIALS AND METHODS:…
View details →DOI: 10.4103/0976-3147.116455Cited by 33 Negative / Null Result ReportOpen accessMedicine
Shruti Agashe, David B. Burkholder, Keith Starnes et al. · 2022 · Frontiers in Human Neuroscience
There is a paucity of treatment options for cognitively normal individuals with drug resistant genetic generalized epilepsy (GGE). Centromedian nucleus of the thalamus (CM) deep brain stimulation (DBS) may be a viable treatment for GGE. Here, we present the case of a 27-year-old cognitively normal woman with drug resistant GGE, with childhood onset. Seizure semiology are absence seizures and generalized onset tonic clonic (GTC) seizures. At baseline she had 4-8 GTC seizures per month and weekly absence seizures despite three antiseizure medications and vagus nerve stimulation. A multidisciplin
View details →DOI: 10.3389/fnhum.2022.858413Cited by 33 Negative / Null Result ReportOpen accessMedicine
Bradford L. McRae, Alon D. Levin, Manon E. Wildenberg et al. · 2015 · Journal of Crohn s and Colitis
BACKGROUND AND AIMS: Anti-tumour necrosis factor [TNF] monoclonal antibodies [infliximab, adalimumab] induce complete mucosal healing in a proportion of patients with Crohn's disease whereas a TNF receptor fusion protein [etanercept] is…
View details →DOI: 10.1093/ecco-jcc/jjv179Cited by 32 Negative / Null Result ReportOpen accessMedicine
Valérie Fonteyne, Piet Dirix, Charles Van Praet et al. · 2021 · European Urology Focus
BACKGROUND: High-risk muscle-invasive bladder cancer (MIBC) has a poor prognosis. Old trials showed that external beam radiotherapy (EBRT) after radical cystectomy (RC) decreases the incidence of local recurrences but induces severe…
View details →DOI: 10.1016/j.euf.2021.11.004Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Jie Shen, Gary N. Landis, John Tower · 2016 · The Journals of Gerontology Series A
The Gompertz equation describes survival in terms of initial mortality rate (parameter a), indicative of health, and age-dependent acceleration in mortality rate (parameter b), indicative of aging. Gompertz parameters were analyzed for…
View details →DOI: 10.1093/gerona/glw005Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Sindrila Dutta Banik, Nilashis Nandi · 2012 · Journal of Biomolecular Structure and Dynamics
In the present work we report, for the first time, a novel difference in the molecular mechanism of the activation step of aminoacylation reaction between the class I and class II aminoacyl tRNA synthetases (aaRSs). The observed difference is in the mode of nucleophilic attack by the oxygen atom of the carboxylic group of the substrate amino acid (AA) to the αP atom of adenosine triphosphate (ATP). The syn oxygen atom of the carboxylic group attacks the α-phosphorous atom (αP) of ATP in all class I aaRSs (except TrpRS) investigated, while the anti oxygen atom attacks in the case of class II aa
View details →DOI: 10.1080/07391102.2012.689701Cited by 32 Negative / Null Result ReportOpen accessNursing
Todd W. Rice, D. Clark Files, Peter E. Morris et al. · 2018 · Journal of Parenteral and Enteral Nutrition
BACKGROUND: Enteral nutrition (EN) increases hyperglycemia due to high carbohydrate concentrations while providing insufficient protein. The study tested whether an EN formula with very high-protein- and low-carbohydrate-facilitated…
View details →DOI: 10.1002/jpen.1447Cited by 32 Negative / Null Result ReportOpen accessMedicine
Lindsay Rosenbeck, Patrick J. Kiel, Iftekhar Kalsekar et al. · 2010 · Biology of Blood and Marrow Transplantation
Methotrexate (MTX) is a standard agent used in combination with calcineurin inhibitors for graft-versus-host disease (GVHD) prophylaxis in patients undergoing allogeneic hematopoietic cell (HCT) transplantation. We retrospectively compared…
View details →DOI: 10.1016/j.bbmt.2010.09.017Cited by 32 Negative / Null Result ReportOpen accessMedicine
Ian Roberts · 2016 · Transfusion
Administration of tranexamic acid (TXA) to bleeding trauma patients who are within 3 hours of injury has been shown to safely reduce mortality in bleeding trauma patients. However, some believe that thromboelastography (TEG or ROTEM) can…
View details →DOI: 10.1111/trf.13490Cited by 32 Negative / Null Result ReportOpen accessMedicine
Arjan Kol, Anton Terwisscha van Scheltinga, Martin Pool et al. · 2017 · Oncotarget
// Arjan Kol 1 , Anton Terwisscha van Scheltinga 2 , Martin Pool 1 , Christian Gerdes 3 , Elisabeth de Vries 1 , Steven de Jong 1 1 Department of Medical Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 2 Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands 3 Roche Pharma Research & Early Development, Roche Innovation Center Zürich, Schlieren, Switzerland Correspondence to: Steven de Jong, email: s.de.jong@umcg.nl Keywords: non-small cell lung cancer,
View details →DOI: 10.18632/oncotarget.17139Cited by 32 Negative / Null Result ReportMedicine
Mauro Cignarelli, Ettore Cicinelli, Mónica Corso et al. · 2010 · Gynecologic and Obstetric Investigation
Thermocutaneous, vascular, metabolic and hormonal changes were investigated during 11 hot flashes from 6 postmenopausal women. The first detectable change was an increase in finger blood flow with a concomitant enhancement of skin…
View details →DOI: 10.1159/000293612Cited by 32 Negative / Null Result ReportMedicine
Daisuke Nakamura, Tomohiro Suzuki, Mikinobu Yasumatsu et al. · 2011 · The Journal of Strength and Conditioning Research
Several investigators have reported the effects of reduced training and interrupted training on athletic performance, but few reports are available for soccer players. The purpose of this study was to examine, using the Yo-Yo intermittent…
View details →DOI: 10.1519/jsc.0b013e3182474356Cited by 32 Negative / Null Result ReportOpen accessSocial Sciences
Elizabeth Ty Wilde, Zohn Rosen, Kenneth A. Couch et al. · 2013 · American Journal of Public Health
OBJECTIVES: We examined whether Jobs First, a multicenter randomized trial of a welfare reform program conducted in Connecticut, demonstrated increases in employment, income, and health insurance relative to traditional welfare (Aid to…
View details →DOI: 10.2105/ajph.2012.301072Cited by 32 Negative / Null Result ReportOpen accessMedicine
Sonia Tejada, Ricardo Díez-Valle, Guillermo Aldave et al. · 2013 · Journal of Neuro-Oncology
Our purpose was to analyze the pattern of failure in glioblastoma (GBM) patients at first recurrence after radiotherapy and temozolomide and its relationship with different factors. From 77 consecutive GBM patients treated at our institution with fluorescence guided surgery and standard radiochemotherapy, 58 first recurrences were identified and included in a retrospective review. Clinical data including age, Karnofsky performance score, preoperative tumor volume and location, extend of resection, MGMT promoter methylation status, time to progression (PFS), overall survival (OS) and adjuvant t
View details →DOI: 10.1007/s11060-013-1279-zCited by 32 Negative / Null Result ReportOpen accessMedicine
Romelia Barba Bernal, Bryan W. Ferrigno, Esli Medina Morales et al. · 2023 · The Turkish Journal of Gastroenterology
Primary biliary cholangitis is an autoimmune cholestatic liver disease characterized by progressive destruction of bile ducts, which can ultimately progress to chronic liver disease and cirrhosis. Ursodeoxycholic acid and obeticholic acid are the only 2 Food and Drug Administration (FDA)-approved medications for primary biliary cholangitis. Unfortunately, up to 40% of patients with primary biliary cholangitis have an incomplete response to ursodeoxycholic acid, warranting an essential need for additional therapeutics. Peroxisome proliferator-activated receptor agonists have shown promising dat
View details →DOI: 10.5152/tjg.2023.22239Cited by 32 Negative / Null Result ReportMedicine
Gonçalo N. Petrucci, Joaquim Henriques, Luís Lobo et al. · 2020 · Veterinary and Comparative Oncology
This study aims to evaluate the efficacy and side effects of low dose cyclophosphamide chemotherapy plus meloxicam as an adjuvant treatment, compared with high dose doxorubicin or surgery alone in cats with mammary carcinoma. Medical…
View details →DOI: 10.1111/vco.12660Cited by 32 Negative / Null Result Report
Timothy J. Layton, Andrew M. Ryan · 2015 · Health Services Research
Objective To evaluate the effects of the size of financial bonuses on quality of care and the number of plan offerings in the Medicare Advantage Quality Bonus Payment Demonstration. Data Sources Publicly available data from CMS from 2009…
View details →DOI: 10.1111/1475-6773.12409Cited by 32 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Satoru Sugie, Shoichiro Mukai, Koji Yamasaki et al. · 2016 · PubMed
BACKGROUND/AIM: Up-regulation of caveolin (CAV)-1 is associated with aggressive prostate cancer. Recently, it has been inferred that CAV2, a co-factor sub-type of CAV1, cross-talks with CAV1 and promotes tumor growth. We previously…
Negative / Null Result ReportOpen accessMedicine
Jawed Alam, Sankar Maiti, Prachetash Ghosh et al. · 2012 · Journal of Medical Microbiology
A novel virulence factor, duodenal ulcer-promoting gene A (dupA), in Helicobacter pylori has been found to be associated with disease in certain populations but not in others. This study analysed a South-east Indian population as part of…
View details →DOI: 10.1099/jmm.0.038398-0Cited by 32 Negative / Null Result ReportPsychology
Chung-Yuan Hsu, Chin‐Chung Tsai · 2012 · Interactive Learning Environments
Abstract Educational researchers have indicated that although computer games have the potential to promote students' motivation and engagement, the work on how to design effective games that fulfil educational purposes is still in its…
View details →DOI: 10.1080/10494820.2012.705850Cited by 32 Negative / Null Result ReportNeuroscience
Fanxing Meng, Cristy Ho, Rob Gray et al. · 2014 · Ergonomics
Three experiments were conducted to assess the effectiveness of dynamic vibrotactile warning signals with different spatial patterns and to compare dynamic towards-torso and towards-head vibrotactile warnings in a simulated driving task.…
View details →DOI: 10.1080/00140139.2014.976278Cited by 32 Negative / Null Result Report
André S. Pereira, Eithne Kavanagh, Catherine Hobaiter et al. · 2020 · Biology Letters
Abstract Speech is a human hallmark, but its evolutionary origins continue to defy scientific explanation. Recently, the open–close mouth rhythm of 2–7 Hz (cycles/second) characteristic of all spoken languages has been identified in the…
View details →DOI: 10.1098/rsbl.2020.0232Cited by 32 Negative / Null Result Report
Karen Cristine Gonçalves dos Santos, Isabel Desgagné-Penix, Hugo Germain · 2020 · BMC Genomics
Abstract Background RNA sequencing allows the measuring of gene expression at a resolution unmet by expression arrays or RT-qPCR. It is however necessary to normalize sequencing data by library size, transcript size and composition, among…
View details →DOI: 10.1186/s12864-019-6426-2Cited by 32 Negative / Null Result Report
Mikhail Ponomarenko, Dmitry Rasskazov, Olga Arkova et al. · 2015 · BioMed Research International
The use of biomedical SNP markers of diseases can improve effectiveness of treatment. Genotyping of patients with subsequent searching for SNPs more frequent than in norm is the only commonly accepted method for identification of SNP…
View details →DOI: 10.1155/2015/359835Cited by 32 