Negative / Null Result ReportOpen accessMedicine
Jai Chand Patel, Meenakshi Shukla, Manish Shukla et al. · 2025 · Frontiers in Bioengineering and Biotechnology
Mesenchymal stem cells (MSCs) are emerging as a powerful tool in regenerative medicine due to their ability to differentiate into mesenchymal lineages, such as bone, cartilage, and fat, along with their low immunogenicity and strong immunomodulatory properties. Unlike traditional cell therapies that rely on engraftment, MSCs primarily function through paracrine signaling-secreting bioactive molecules like vascular endothelial growth factor (VEGF), transforming growth factor-beta (TGF-β), and exosomes. These factors contribute to tissue repair, promote angiogenesis, and modulate immune response
View details →DOI: 10.3389/fbioe.2025.1639439Cited by 38 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
H Neef, Steven R. G. Ongena, Gergana Tsonkova · 2026 · European Financial Management
ABSTRACT This paper studies the development of a firm's Environmental, Social, and Governance (ESG) performance following the issuance of “green loans” earmarked for green projects versus “sustainable loans” benchmarked by ESG criteria. Firms issuing green loans improve environmental performance, particularly by reducing emissions, but experience declines in social performance, suggesting a trade‐off between environmental and social objectives. In contrast, sustainable loans are associated with broader ESG improvements, enhancing environmental and governance outcomes without a comparable socia
View details →DOI: 10.1111/eufm.70101Cited by 37 Negative / Null Result ReportOpen accessMedicine
Cédric Peleman, Stig Hellemans, Geraldine Veeckmans et al. · 2024 · Cell Death and Differentiation
There is an unmet clinical need for pharmacologic treatment for metabolic dysfunction-associated steatotic liver disease (MASLD). Hepatocyte cell death is a hallmark of this highly prevalent chronic liver disease, but the dominant type of cell death remains uncertain. Here we report that ferroptosis, an iron-catalyzed mode of regulated cell death, contributes to MASLD. Unsupervised clustering in a cohort of biopsy-proven MASLD patients revealed a subgroup with hepatic ferroptosis signature and lower glutathione peroxidase 4 (GPX4) levels. Likewise, a subgroup with reduced ferroptosis defenses
View details →DOI: 10.1038/s41418-024-01348-9Cited by 37 Negative / Null Result ReportOpen accessMedicine
Mairi Ziaka, Aristomenis K. Exadaktylos · 2024 · Critical Care
Acute respiratory distress syndrome (ARDS) represents a life-threatening inflammatory reaction marked by refractory hypoxaemia and pulmonary oedema. Despite advancements in treatment perspectives, ARDS still carries a high mortality rate, often due to systemic inflammatory responses leading to multiple organ dysfunction syndrome (MODS). Indeed, the deterioration and associated mortality in patients with acute lung injury (LI)/ARDS is believed to originate alongside respiratory failure mainly from the involvement of extrapulmonary organs, a consequence of the complex interaction between initial
View details →DOI: 10.1186/s13054-024-04966-4Cited by 37 Negative / Null Result ReportOpen accessPhysics and Astronomy
K. Masuda, Joshua N. Winn · 2017 · The Astronomical Journal
Abstract We revisit the null result of the Hubble Space Telescope search for transiting planets in the globular cluster 47 Tucanae, in the light of improved knowledge of planet occurrence from the Kepler mission. Gilliland and co-workers…
View details →DOI: 10.3847/1538-3881/aa647cCited by 37 Negative / Null Result ReportOpen accessEarth and Planetary Sciences
Alexis Rojas, Pedro Patarroyo, Liang Mao et al. · 2017 · Geology
Large-scale biogeographic provinces of Cretaceous ammonoids, as currently defined in the literature, were delimited using qualitative assessments of taxonomic inventories. Using aggregated species occurrences in the Paleobiology Database, we generated a geographic network to quantify connectivity of Albian epicontinental basins and used the flow-based Infomap algorithm to delineate bioprovinces. Despite taxonomic, stratigraphic, and geographic limitations of the data, the Infomap bioprovinces are largely concordant with the traditional, qualitatively derived biogeographic model, including the
View details →DOI: 10.1130/g38944.1Cited by 37 Negative / Null Result ReportOpen accessMedicine
Luciana Mascia, Vito Fanelli, Alice Mistretta et al. · 2024 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale Lung-protective strategies using low Vt and moderate positive end-expiratory pressure (PEEP) are considered best practice in critical care, but interventional trials have never been conducted in patients with acute brain…
View details →DOI: 10.1164/rccm.202402-0375ocCited by 37 Negative / Null Result ReportOpen accessDecision Sciences
Paul Monsarrat, Jean‐Noël Vergnes · 2017 · GigaScience
Background: In medicine, effect sizes (ESs) allow the effects of independent variables (including risk/protective factors or treatment interventions) on dependent variables (e.g., health outcomes) to be quantified. Given that many public health decisions and health care policies are based on ES estimates, it is important to assess how ESs are used in the biomedical literature and to investigate potential trends in their reporting over time. Results: Through a big data approach, the text mining process automatically extracted 814 120 ESs from 13 322 754 PubMed abstracts. Eligible ESs were risk
View details →DOI: 10.1093/gigascience/gix121Cited by 37 Negative / Null Result ReportMedicine
Sergio Leonardi, Pierluigi Tricoci, HD White et al. · 2013 · European Heart Journal
AIMS: The TRA·CER trial compared vorapaxar, a novel platelet protease-activated receptor (PAR)-1 antagonist, with placebo in 12 944 patients with high-risk non-ST-segment elevation acute coronary syndromes (NSTE ACS). In this analysis, we…
View details →DOI: 10.1093/eurheartj/eht104Cited by 37 Negative / Null Result ReportOpen accessMedicine
Sriram Ramgopal, Cameron Dezfulian, Robert W. Hickey et al. · 2019 · JAMA Network Open
Importance: A high Pao2, termed hyperoxemia, is postulated to have deleterious health outcomes. To date, the association between hyperoxemia during the ongoing management of critical illness and mortality has been incompletely evaluated in children. Objective: To examine whether severe hyperoxemia events are associated with mortality among patients admitted to a pediatric intensive care unit (PICU). Design, Setting, and Participants: A retrospective cohort study was conducted over a 10-year period (January 1, 2009, to December 31, 2018); all 23 719 PICU encounters at a quaternary children's ho
View details →DOI: 10.1001/jamanetworkopen.2019.9812Cited by 37 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Inmaculada Martínez‐Zarzoso, Martina Vidovic, Anca M. Voicu · 2016 · The Journal of Environment & Development
The aim of this article is to investigate the relationship between environmental stringency and intra–European Union (EU) trade flows. Two main hypotheses are tested. First, we test whether the stringency of a country's environmental…
View details →DOI: 10.1177/1070496516670196Cited by 37 Negative / Null Result ReportMedicine
Alicia K. Klanecky, Dennis E. McChargue, Lindsay Bruggeman · 2012 · American Journal on Addictions
Alcohol use to replace inadequate dissociative capabilities, or chemical dissociation, has been linked to college students with childhood or adolescent sexual abuse (CASA). Insofar as CASA-exposed persons experience a restricted range of…
View details →DOI: 10.1111/j.1521-0391.2012.00228.xCited by 37 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Hector Roux de Bézieux, Koen Van den Berge, Kelly Street et al. · 2024 · Nature Communications
In single-cell RNA sequencing (scRNA-Seq), gene expression is assessed individually for each cell, allowing the investigation of developmental processes, such as embryogenesis and cellular differentiation and regeneration, at unprecedented resolution. In such dynamic biological systems, cellular states form a continuum, e.g., for the differentiation of stem cells into mature cell types. This process is often represented via a trajectory in a reduced-dimensional representation of the scRNA-Seq dataset. While many methods have been suggested for trajectory inference, it is often unclear how to h
View details →DOI: 10.1038/s41467-024-44823-0Cited by 37 Negative / Null Result ReportOpen accessPsychology
Victoria Whitelock, Suzanne Higgs, Jeffrey M. Brunstrom et al. · 2018 · Appetite
Focusing attention on food during a meal has been shown to reduce later snack consumption. We report the results of two studies that aimed to replicate this effect and to elucidate the underlying mechanisms. We hypothesised that focused attention during a lunchtime meal would improve visual memory and/or memory for the satiating effects of the meal, and that this would reduce later food intake. In Study 1, participants (N = 108, 52.8% female, BMI M = 25.75 kg/m2) were randomly allocated to eat a fixed lunchtime meal while listening to instructions that encouraged them to pay attention to the s
View details →DOI: 10.1016/j.appet.2018.06.002Cited by 37 Null Dataset
Hatice Büşra Lüleci, Alper Yılmaz · 2022 · BioData Mining
Abstract Objectives In this study, we aimed to identify tissue-specific genes for various human tissues/organs more robustly and rigorously by extending the tau score algorithm. Introduction Tissue-specific genes are a class of genes whose…
View details →DOI: 10.1186/s13040-022-00315-9Cited by 37 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Miroslav Petr, Petr Šťastný, Ondřej Pecha et al. · 2014 · PLoS ONE
To date, polymorphisms in several genes have been associated with a strength/power performance including alpha 3 actinin, ciliary neurotrophic factor, vitamin D receptor, or angiotensin I converting enzyme, underlining the importance of genetic component of the multifactorial strength/power-related phenotypes. The single nucleotide variation in peroxisome proliferator-activated receptor alpha gene (PPARA) intron 7 G/C (rs4253778; g.46630634G>C) has been repeatedly found to play a significant role in response to different types of physical activity. We investigated the effect of PPARA intron 7
View details →DOI: 10.1371/journal.pone.0107171Cited by 37 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Clara Collart, Christo P. Christov, James C. Smith et al. · 2011 · Molecular and Cellular Biology
Noncoding Y RNAs are essential for the initiation of chromosomal DNA replication in mammalian cell extracts, but their role in this process during early vertebrate development is unknown. Here, we use antisense morpholino nucleotides (MOs)…
View details →DOI: 10.1128/mcb.05411-11Cited by 37 Negative / Null Result ReportOpen accessMedicine
Michael Scott Doyle, Bethany N. Swope, Jerome A. Hogsette et al. · 2011 · Journal of Medical Entomology
In 2006-2007, stable flies, Stomoxys calcitrans (L.) (Diptera: Muscidae), were suspected of being enzootic vectors of West Nile virus (family Flaviviridae, genus Flavivirus, WNV) during a die-off of American white pelicans (Pelecanus…
View details →DOI: 10.1603/me10167Cited by 37 Negative / Null Result ReportOpen accessEnvironmental Science
Imogen Wadlow, Clare Paton‐Walsh, Hugh Forehead et al. · 2019 · Atmosphere
Motivated by public interest, the Clean Air and Urban Landscapes (CAUL) hub deployed instrumentation to measure air quality at a roadside location in Sydney. The main aim was to compare concentrations of fine particulate matter (PM2.5) measured along a busy road section with ambient regional urban background levels, as measured at nearby regulatory air quality stations. The study also explored spatial and temporal variations in the observed PM2.5 concentrations. The chosen area was Randwick in Sydney, because it was also the subject area for an agent-based traffic model. Over a four-day campai
View details →DOI: 10.3390/atmos10040217Cited by 37 Negative / Null Result ReportOpen accessAgricultural and Biological Sciences
Sophie Q. van Rijssel, Guusje J. Koorneef, G. F. Veen et al. · 2025 · Science
Organic farming is often considered to be more sustainable than conventional farming. However, both farming systems comprise highly variable management practices. In this study, we show that in organic and conventional arable fields, the…
View details →DOI: 10.1126/science.adr0211Cited by 37 Negative / Null Result ReportOpen accessMedicine
Kosuke Kitamura, Toshiyuki China, Mayuko Kanayama et al. · 2018 · Prostate International
To determine the clinical predictive factors affecting the recovery from postoperative urinary incontinence after robot-assisted radical prostatectomy (RARP). We consecutively analyzed 320 patients who underwent RARP between January 2012…
View details →DOI: 10.1016/j.prnil.2018.06.003Cited by 37 Negative / Null Result ReportOpen accessMedicine
Stephen J. Nicholls · 2012 · Cleveland Clinic Journal of Medicine
The AIM-HIGH trial (Atherothrombosis Intervention in Metabolic Syndrome With Low HDL/High Triglycerides: Impact on Global Health Outcomes) found, in an interim analysis, no cardiovascular benefit from taking extended-release niacin…
View details →DOI: 10.3949/ccjm.79a.11166Cited by 37 Negative / Null Result ReportOpen accessImmunology and Microbiology
Duc Tin Tran, Sri Nagarjun Batchu, Andrew Advani · 2024 · Frontiers in Cardiovascular Medicine
Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial infection. However, these processes may also be activated during the pathogenesis of non-infectious diseases, where they may contribute to organ injury, or function in a compensatory manner. In this review, we explore the roles of IFNs and IFN-related pathways in heart disease. We consider the cardiac effects of type I IFNs and IFN-stimulated genes (ISGs); the emerging role of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway; the seemingly paradoxical effects of the type
View details →DOI: 10.3389/fcvm.2024.1357343Cited by 37 Negative / Null Result ReportOpen accessMedicine
Guodong Sun, Yang Zhang, Shanshan Mo et al. · 2021 · International Journal of General Medicine
PURPOSE: To analyze the risk factors of multiple organ dysfunction syndromes (MODS) caused by sepsis. PATIENTS AND METHODS: A total of 180 patients with sepsis admitted to The First Affiliated Hospital of Harbin Medical University (No. 23,…
View details →DOI: 10.2147/ijgm.s328419Cited by 37 Negative / Null Result ReportOpen accessMedicine
Gil Cunha De Santis, Luciana Correa Oliveira de Oliveira, Pedro Manuel Marques Garibaldi et al. · 2022 · Emerging infectious diseases
To assess whether high-dose coronavirus disease (COVID-19) convalescent plasma (CCP) transfusion may benefit patients with severe COVID-19, we conducted a multicenter randomized trial in Brazil. Patients with severe COVID-19 who were within 10 days of initial symptom onset were eligible. Patients in the CCP group received 3 daily doses of CCP (600 mL/d) in addition to standard treatment; control patients received standard treatment only. Primary outcomes were death rates at days 30 and 60 of study randomization. Secondary outcomes were ventilator-free days and hospital-free days. We enrolled 1
View details →DOI: 10.3201/eid2803.212299Cited by 37 Negative / Null Result ReportOpen accessNursing
Tatiana Galvão, Bethany H. Brown, Peter Hecker et al. · 2011 · Cardiovascular Research
AIMS: The impact of a high-fat diet on the failing heart is unclear, and the differences between polyunsaturated fatty acids (PUFA) and saturated fat have not been assessed. Here, we compared a standard low-fat diet to high-fat diets…
View details →DOI: 10.1093/cvr/cvr258Cited by 37 Negative / Null Result ReportOpen accessMedicine
Stefan D. Anker, Javed Butler, Muhammad Usman et al. · 2022 · Nature Medicine
Abstract The EMPEROR-Preserved trial showed that the sodium–glucose co-transporter 2 inhibitor empagliflozin significantly reduces the risk of cardiovascular death or hospitalization for heart failure (HHF) in heart failure patients with left ventricular ejection fraction (LVEF) > 40%. Here, we report the results of a pre-specified analysis that separately evaluates these patients stratified by LVEF: preserved (≥ 50%) ( n = 4,005; 66.9%) or mid-range (41–49%). In patients with LVEF ≥ 50%, empagliflozin reduced the risk of cardiovascular death or HHF (the primary endpoint) by 17% versus plac
View details →DOI: 10.1038/s41591-022-02041-5Cited by 37 Negative / Null Result Report
Karin Isler · 2011 · BioEssays
Abstract Recently, Weisbecker and Goswami presented the first comprehensive comparative analysis of brain size, metabolic rate, and development periods in marsupial mammals. In this paper, a strictly energetic perspective is applied to…
View details →DOI: 10.1002/bies.201000123Cited by 37 Negative / Null Result Report
Manju Dhandapani, Sivashanmugam Dhandapani, Meena Agarwal et al. · 2013 · Journal of Clinical Nursing
Aims and objectives To assess the factors associated with development of pressure ulcer in patients with severe traumatic brain injury ( TBI ) and study its prognostic significance with respect to neurological outcome at three months.…
View details →DOI: 10.1111/jocn.12396Cited by 36 Negative / Null Result Report
Aaron Yerke, Daisy Fry Brumit, Anthony A. Fodor · 2024 · Microbiome
Abstract Background Normalization, as a pre-processing step, can significantly affect the resolution of machine learning analysis for microbiome studies. There are countless options for normalization scheme selection. In this study, we…
View details →DOI: 10.1186/s40168-023-01747-zCited by 36 