Negative / Null Result ReportOpen accessMathematics
Marlin D Figgins, Trevor Bedford · 2026 · eLife
Accurately estimating relative transmission rates of SARS-CoV-2 variants remains a scientific and public health priority. Recent studies have used the sample proportions of different variants from genetic sequence data to describe variant frequency dynamics and relative transmission rates, but frequencies alone cannot capture the rich epidemiological behavior of SARS-CoV-2. Here, we extend methods for inferring the effective reproduction number of an epidemic using confirmed case data to jointly estimate variant-specific effective reproduction numbers and frequencies of co-circulating variants
View details →DOI: 10.7554/elife.104802.2Cited by 34 Negative / Null Result ReportOpen accessMedicine
Felicia C. Goldstein, Angela F. Caveney, Vicki Hertzberg et al. · 2016 · Journal of Neurotrauma
A Phase III, double-blind, placebo-controlled trial (ProTECT III) found that administration of progesterone did not reduce mortality or improve functional outcome as measured by the Glasgow Outcome Scale Extended (GOSE) in subjects with…
View details →DOI: 10.1089/neu.2015.4313Cited by 34 Negative / Null Result ReportPsychology
Yongliang Wang, Yumeng Guo · 2026 · Journal of Computer Assisted Learning
ABSTRACT Background The rise of artificial intelligence (AI) has reshaped English as Foreign Language (EFL) instruction, offering new opportunities for language learning. While much of the existing research focuses on AI integration in…
View details →DOI: 10.1002/jcal.70189Cited by 33 Negative / Null Result ReportOpen accessMedicine
Christof A. Leicht, Victoria L. Goosey‐Tolfrey, Nicolette C. Bishop · 2026 · PubMed
A spinal cord injury (SCI) can increase the risk of infection by impacting on many aspects of immune function; one particularly well-documented observation is a reduction in lymphocyte numbers. The vast majority of lymphoid cells express…
View details →DOI: 10.22029/eir.2013.1683Cited by 33 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Ahmed Samour, Riza Radmehr, Ernest Baba Ali et al. · 2024 · Heliyon
Given the alarming level of climate change, policymakers across the globe are seeking strategies to mitigate environmental pollution to achieve sustainable development. In this context, renewable energy and technological advancements have…
View details →DOI: 10.1016/j.heliyon.2024.e39970Cited by 33 Negative / Null Result ReportOpen accessMedicine
Chao Gao, Bin Zhu, Fan Ouyang et al. · 2025 · BMJ
Abstract Objectives To investigate whether a less intense antiplatelet regimen could be used for people receiving drug coated balloons. Design Multicentre, randomised, open label, assessor blind, non-inferiority trial (REC-CAGEFREE II).…
View details →DOI: 10.1136/bmj-2024-082945Cited by 33 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Oisín Ryan, Jonas M B Haslbeck, Lourens Waldorp · 2025 · Multivariate Behavioral Research
Time series analysis is increasingly popular across scientific domains. A key concept in time series analysis is stationarity, the stability of statistical properties of a time series. Understanding stationarity is crucial to addressing frequent issues in time series analysis such as the consequences of failing to model non-stationarity, how to determine the mechanisms generating non-stationarity, and consequently how to model those mechanisms (i.e., by differencing or detrending). However, many empirical researchers have a limited understanding of stationarity, which can lead to the use of in
View details →DOI: 10.1080/00273171.2024.2436413Cited by 33 Negative / Null Result ReportOpen accessComputer Science
Anne Lohr, Michael Sailer, Matthias Stadler et al. · 2024 · Teaching and Teacher Education
We investigated factors that are potentially associated with teaching and learning with digital technology, by replicating and extending Sailer, Murböck, and Fischer's (2021) study with a representative sample of 407 German secondary school teachers. In line with the replicated study, teachers' technology-related teaching skills were crucial for different forms of students' active learning, whereas the digital technology equipment available in a school was less important. School support was positively related to successful digital teaching and learning at schools. The success of Bring-Your-Own
View details →DOI: 10.1016/j.tate.2024.104788Cited by 33 Negative / Null Result Report
Mark E. Steiner, L. Ryan Smart · 2012 · Arthroscopy
Purpose This study evaluated the ability of flexible instruments compared with rigid instruments to place anatomic femoral tunnels in anterior cruciate ligament reconstructions by use of both transtibial drilling and anteromedial drilling…
View details →DOI: 10.1016/j.arthro.2011.11.029Cited by 33 Negative / Null Result Report
David Houdoux, Axelle Amon, David Marsan et al. · 2021 · Communications Earth & Environment
Abstract Memory effects in seismology—such as the occurrence of aftershock sequences—are implicitly assumed to be governed by the time since the main event. However, experiments are yet to identify if memory effects are structural or…
View details →DOI: 10.1038/s43247-021-00147-1Cited by 33 Negative / Null Result ReportMedicine
Sarah Moody, Leire Escudero‐Ibarz, Ming Wang et al. · 2017 · The Journal of Pathology
Both antigenic drive and genetic change play critical roles in the development of mucosa-associated lymphoid tissue (MALT) lymphoma, but neither alone is sufficient for malignant transformation, and lymphoma development critically depends…
View details →DOI: 10.1002/path.4933Cited by 33 Negative / Null Result Report
Igor Calzada · 2020 · Smart Cities
This article addresses the problem of replication among smart cities in the European Commission’s Horizon 2020: Smart Cities and Communities (EC-H2020-SCC) framework programme. This article initially sets the general policy context by…
View details →DOI: 10.3390/smartcities3030049Cited by 33 Negative / Null Result ReportOpen accessSocial Sciences
Stefan Stieger, Sabine Wunderl · 2022 · Computers in Human Behavior
In adolescence, smartphone use in general and social media use in particular has often been associated with negative effects, such as higher anxiety levels and body dissatisfaction. Other outcomes – such as fundamental cognitive abilities and skills (e.g., intelligence, information processing, spatial perception) – have rarely been the focus of research. Here, we analysed data from a large sample of adolescents (12–16 years; N > 12,000) who performed a series of psychometric tests ranging from intelligence, spatial perception, and information processing, to practical numeracy, and compared the
View details →DOI: 10.1016/j.chb.2022.107358Cited by 33 Negative / Null Result ReportOpen accessMedicine
Janet M. Boekhout, Brenda Berendsen, Denise A. Peels et al. · 2018 · International Journal of Environmental Research and Public Health
This study explores the effectiveness of the Active Plus65 intervention designed to stimulate physical activity among single older adults with a chronic physical impairment. A quasi-experimental pre-test post-test study was performed. The intervention group (n = 411; mean age = 76.75; SD = 7.75) was assessed at baseline, three months, and six months. Data of comparable older adults who completed the original Active Plus intervention served as reference group (n = 87; mean age = 74.36; SD = 6.26). Multilevel regression analyses were applied: outcome measures were weekly minutes of moderate to v
View details →DOI: 10.3390/ijerph15020346Cited by 33 Negative / Null Result ReportMedicine
Takeo Ishii, Takashi Angata, Emily S. Wan et al. · 2016 · Respirology
BACKGROUND AND OBJECTIVE: The exacerbation-prone phenotype of COPD is particularly important, as exacerbations lead to poor quality of life and disease progression. We previously found that COPD patients who lack Siglec-14, a myeloid cell…
View details →DOI: 10.1111/resp.12952Cited by 33 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Beibei Zhao, Xianghui Li, Yonglun Zeng et al. · 2016 · BMC Microbiology
BACKGROUND: The opportunistic bacterial pathogen Legionella pneumophila uses substrate effectors of Dot/Icm type IVB secretion system (T4BSS) to accomplish survival and replication in amoebae cells and mammalian alveolar macrophages. During the conversion between its highly resistant, infectious dormant form and vigorously growing, uninfectious replicative form, L. pneumophila utilizes a complicated regulatory network in which proteolysis may play a significant role. As a highly conserved core protease, ClpP is involved in various cellular processes as well as virulence in bacteria, and has be
View details →DOI: 10.1186/s12866-016-0790-8Cited by 33 Negative / Null Result Report
Tracy L. Finch, Joan Mackintosh, Alex Petrou et al. · 2022 · PLOS ONE
Autistic children grow to become autistic adults, and autism is increasingly diagnosed in adulthood and later life. This qualitative study aimed to understand experiences of autism throughout adulthood. A national cohort study of autistic…
View details →DOI: 10.1371/journal.pone.0264932Cited by 33 Negative / Null Result ReportMedicine
Jinbo Bi, Jiangwen Sun, Yu‐Wei Wu et al. · 2013 · ACM Transactions on Intelligent Systems and Technology
Alcohol misuse is one of the most serious public health problems facing adolescents and young adults in the United States. National statistics shows that nearly 90% of alcohol consumed by youth under 21 years of age involves binge drinking…
View details →DOI: 10.1145/2508037.2508053Cited by 33 Negative / Null Result ReportMedicine
Laiana Schneider, A C Colar da Silva, Luiz Carlos Werres et al. · 2015 · Lupus
OBJECTIVES: To evaluate the expression of Th1, Th2, and Th17 cytokines in patients with systemic lupus erythematosus (SLE), and verify the association between serum cytokine levels and vitamin D concentration. METHODS: The sample consisted…
View details →DOI: 10.1177/0961203315584811Cited by 33 Negative / Null Result ReportOpen accessMedicine
Leah Wetherill, Manav Kapoor, Arpana Agrawal et al. · 2013 · Alcoholism Clinical and Experimental Research
BACKGROUND: Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes…
View details →DOI: 10.1111/acer.12251Cited by 33 Negative / Null Result ReportOpen accessMedicine
Toru Hashimoto, Vidhya Sivakumaran, Ricardo Carnicer et al. · 2016 · Journal of the American Heart Association
BACKGROUND: Nitric oxide synthase uncoupling occurs under conditions of oxidative stress modifying the enzyme's function so it generates superoxide rather than nitric oxide. Nitric oxide synthase uncoupling occurs with chronic pressure…
View details →DOI: 10.1161/jaha.116.003208Cited by 33 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dan Li, Shu-Gao Yang, Cheng-Wen He et al. · 2020 · BMC Biology
BACKGROUND: When stressed, eukaryotic cells produce triacylglycerol (TAG) to store nutrients and mobilize autophagy to combat internal damage. We and others previously reported that in yeast, elimination of TAG synthesizing enzymes inhibits autophagy under nitrogen starvation, yet the underlying mechanism has remained elusive. RESULTS: Here, we show that disruption of TAG synthesis led to diacylglycerol (DAG) accumulation and its relocation from the vacuolar membrane to the endoplasmic reticulum (ER). We further show that, beyond autophagy, ER-accumulated DAG caused severe defects in the endom
View details →DOI: 10.1186/s12915-020-00837-wCited by 33 Negative / Null Result ReportOpen accessPsychology
Valentina Nachtigall, Katja Serova, Nikol Rummel · 2020 · Instructional Science
Abstract The current work builds on research demonstrating the effectiveness of Productive Failure (PF) for learning. While the effectiveness of PF has been demonstrated for STEM learning, it has not yet been investigated whether PF is also beneficial for learning in non-STEM domains. Given this need to test PF for learning in domains other than mathematics or science, and the assumption that features embodied in a PF design are domain-independent, we investigated the effect of PF on learning social science research methods. We conducted two quasi-experimental studies with 212 and 152 10th gra
View details →DOI: 10.1007/s11251-020-09525-2Cited by 33 Negative / Null Result ReportOpen accessNeuroscience
Kenia Martínez, Sarah K. Madsen, Anand A. Joshi et al. · 2015 · Human Brain Mapping
People differ in their cognitive functioning. This variability has been exhaustively examined at the behavioral, neural and genetic level to uncover the mechanisms by which some individuals are more cognitively efficient than others.…
View details →DOI: 10.1002/hbm.22843Cited by 33 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Nararuk Boonyanam · 2014 · International Journal of Financial Research
Monetary variables contain information to forecast stock price is still controversial. This paper examines the relationship between stock price and monetary variables in Thailand which is an Asian small open emerging economy. Monetary variables are consumer price index, nominal bilateral exchange rate in term of bath per US dollar, narrow money, and 14 days repurchased rate, employing a multivariate cointegration, VECM, variance decomposition and impulse response analysis covering the period of January 1999 to December 2012 with 168 observations. The study found a long run relationship between
View details →DOI: 10.5430/ijfr.v5n1p52Cited by 33 Negative / Null Result ReportOpen accessComputer Science
Jutta R. de Jong, Anouk Keizer, Manja M. Engel et al. · 2017 · Experimental Brain Research
The sense of how we experience our physical body as our own represents a fundamental component of human self-awareness. Body ownership can be studied with bodily illusions which are generated by inducing a visuo-tactile conflict where individuals experience illusionary ownership over a fake body or body part, such as a rubber hand. Previous studies showed that different types of touch modulate the strength of experienced ownership over a rubber hand. Specifically, participants experienced more ownership after the rubber hand illusion was induced through affective touch vs non-affective touch.
View details →DOI: 10.1007/s00221-017-4912-9Cited by 33 Negative / Null Result ReportMedicine
Jeanne E. Barthold, Kaitlin P. McCreery, Jaylene Martinez et al. · 2022 · Biofabrication
Abstract Articular cartilage is a layered tissue with a complex, heterogeneous structure and lubricated surface which is challenging to reproduce using traditional tissue engineering methods. Three-dimensional printing techniques have…
View details →DOI: 10.1088/1758-5090/ac584cCited by 33 Negative / Null Result ReportOpen accessMedicine
Terence Fullerton, Brendon Binneman, William David et al. · 2018 · Alzheimer s Research & Therapy
Symptomatic benefits have been reported for 5-HT6 receptor antagonists in Alzheimer’s disease (AD) trials. SAM-760 is a potent and selective 5-HT6 receptor antagonist that has demonstrated central 5-HT6 receptor saturation in humans at a dose of 30 mg. This was a randomized, double-blind, placebo-controlled, parallel-group, multicenter trial evaluating the efficacy and safety of SAM-760 30 mg once daily (QD) for 12 weeks in subjects with AD on a stable regimen of donepezil 5 to 10 mg QD. The study included an interim analysis with stopping rules for futility or efficacy after 180 subjects comp
View details →DOI: 10.1186/s13195-018-0368-9Cited by 33 Negative / Null Result Report
Lucinda M Hilliard, Katrina M Mirabito, Kate M Denton · 2013 · Clinical and Experimental Pharmacology and Physiology
Summary Major sex differences exist in the development and progression of hypertension and cardiovascular disease. Prior to menopause, women have lower arterial pressure and, furthermore, are protected from hypertension and cardiovascular…
View details →DOI: 10.1111/1440-1681.12067Cited by 33 Negative / Null Result ReportMedicine
Helmut Schoellnast, Ajita Deodhar, Meier Hsu et al. · 2012 · Acta Radiologica
BACKGROUND: Radiofrequency ablation (RFA) is a potential application as a salvage tool after failure of surgery, chemotherapy, or radiotherapy of non-small cell lung cancer (NSCLC). Although several studies have evaluated the use of RFA in…
View details →DOI: 10.1258/ar.2012.110333Cited by 33 