A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 80 of 660
Hongbo Zhou, Jiping Zhu, Jiagang Tu et al. · 2010 · The Journal of Infectious Diseases
To study the effect of NS1 eIF4GI binding domain on virulence and pathogenicity of H5N1 influenza A virus, 5 recombinant H5N1 viruses encoding eIF4GI binding domain-truncated NS1 proteins and parental NS1 (NS1‐wt) were generated by an…
Francesco Bogliacino, Cristiano Codagnone, Felipe Montealegre et al. · 2021 · Scientific Reports
In the context of the current COVID-19 pandemic, households throughout the world have to cope with negative shocks. Previous research has shown that negative shocks impair cognitive function and change risk, time and social preferences. In this study, we analyze the results of a longitudinal multi-country survey conducted in Italy (N = 1652), Spain (N = 1660) and the United Kingdom (N = 1578). We measure cognitive function using the Cognitive Reflection Test and preferences traits (risk, time and social preferences) using an experimentally validated set of questions to assess the differences b
Timo Stein, Deema Awad, Surya Gayet et al. · 2018 · Journal of Experimental Psychology General
Visual stimuli with social-emotional relevance have been claimed to gain preferential access to awareness. For example, recent studies used the breaking continuous flash suppression paradigm (b-CFS) to show that faces that are perceived as less dominant and more trustworthy are prioritized for awareness. Here we asked whether these effects truly reflect differences in social-emotional meaning or whether they can be equally explained by differences in low-level stimulus properties. In Experiment 1, we successfully replicated dominance- and untrustworthiness-related slowing for upright faces. Ho
Camille Lique, Michael Steele · 2012 · Journal of Geophysical Research: Oceans
Recent mooring observations in the Arctic Basin suggest the existence of a seasonality of Atlantic Water (AW) temperature. Here the DRAKKAR global ocean/sea‐ice model is used to examine the seasonal cycle amplitude of AW temperature within…
Rania Magadmi, Judit Mészáros, Zoheir A. Damanhouri et al. · 2019 · Frontiers in Cellular Neuroscience
Neuroimmune interactions are important in the pathophysiology of many chronic inflammatory diseases, particularly those associated with alterations in sensory processing and pain. Mast cells and sensory neuron nerve endings are found in areas of the body exposed to the external environment; both are specialized to sense potential damage by injury or pathogens and signal to the immune system and nervous system respectively, to elicit protective responses. Cell adhesion molecule 1 (CADM1), also known as SynCAM1, has previously been identified as an adhesion molecule which may couple mast cells t
Logan A. Pendergrast, L Lundell, Amy M. Ehrlich et al. · 2023 · Proceedings of the National Academy of Sciences
The circadian clock is a cell-autonomous transcription–translation feedback mechanism that anticipates and adapts physiology and behavior to different phases of the day. A variety of factors including hormones, temperature, food-intake,…
Shengquan Ye, Ting Kin Ng, Kin Hang Yim et al. · 2015 · Journal of Personality Assessment
This study aimed at validating the Curiosity and Exploration Inventory-II (CEI-II; Kashdan et al., 2009 ) in a Chinese context. A total of 294 Chinese first-year undergraduate students in Hong Kong completed the CEI-II and measures of…
Christian Kieling, Mara Helena Hutz, Júlia Pasqualini Genro et al. · 2012 · Journal of Child Psychology and Psychiatry
BACKGROUND: The study of gene-environment interactions (G × E) is one of the most promising strategies to uncover the origins of mental disorders. Replication of initial findings, however, is essential because there is a strong possibility…
Mehraj Ahmad Sheikh, Mushtaq Ahmad Malik, Rana Zehra Masood · 2020 · Asian Journal of Sustainability and Social Responsibility
Abstract Over the years, world market is integrating at much faster pace through increasing trade openness. Not being an unmixed blessing, consistent efforts have been made to examine impact of trade openness on economic, environmental and social welfare. This study is an attempt to empirically examine the implications of trade openness on sustainable development in India since liberalization policy 1991. We used the Autoregressive Distributed Lag (ARDL) model to test the relationship between sustainable development and trade openness along with other control variables that are supposed to aff
Hye-Ryoung Kim, Choi-Ku Park, Jae‐Ku Oem et al. · 2010 · Journal of General Virology
We characterized low pathogenic avian influenza (LPAI) H5N2 and H9N2 viruses isolated in South Korea from 2008 to 2009. Genetic analysis of the H5N2 viruses isolated from wild birds and domestic ducks demonstrated that they were related to…
Stefania Napolitano, Nunzia Matrone, A. L. Muddassir et al. · 2019 · Journal of Experimental & Clinical Cancer Research
BACKGROUND: Molecular mechanisms driving acquired resistance to anti-EGFR therapies in metastatic colorectal cancer (mCRC) are complex but generally involve the activation of the downstream RAS-RAF-MEK-MAPK pathway. Nevertheless, even if inhibition of EGFR and MEK could be a strategy for overcoming anti-EGFR resistance, its use is limited by the development of MEK inhibitor (MEKi) resistance. METHODS: We have generated in vitro and in vivo different CRC models in order to underline the mechanisms of MEKi resistance. RESULTS: The three different in vitro MEKi resistant models, two generated by
Mads Lawaetz, Fatima Birch‐Johansen, Søren Friis et al. · 2016 · Acta Oncologica
Background The study was performed to determine the epidemiological, clinical, and histopathological characteristics and prognosis of primary mucosal melanoma of the head and neck (MMHN) in Denmark. Material and methods This was a national…
Christopher J. Hoffmann, Katherine Fielding, Salome Charalambous et al. · 2010 · AIDS
OBJECTIVE: To assess the effectiveness of cotrimoxazole preventive therapy (CPT) among individuals with CD4 cell count above 200 cells/microl and varying WHO clinical stages in reducing mortality during combination antiretroviral therapy…
Feiyu Niu, Yi‐Long Wu · 2014 · Experimental Hematology and Oncology
Since the recognition of epidermal growth factor receptor (EGFR) as a therapeutic target, EGFR tyrosine kinase inhibitors (TKIs) have been used in lung cancer patients with EGFR mutations, which has been a major breakthrough for lung cancer treatment.. The progression-free survival (PFS) of patients with EGFR mutations treated with EGFR TKIs is significantly prolonged compared with that of patients who underwent standard chemotherapy. However, all patients who initially respond to EGFR TKIs eventually develop acquired resistance (AR). Many small molecule agents and monoclonal antibodies (McAb)
Kian Zarchi, S Latif, Vibeke B. Haugaard et al. · 2014 · Acta Dermato Venereologica
Wounds represent a growing healthcare problem due to an aging population. Nurses play a key role in wound management and their theoretical understanding of basic wound management may be expected to influence the quality of wound therapy…
Cissy Kityo, Alexander J. Szubert, Abraham Siika et al. · 2018 · PLoS Medicine
BACKGROUND: In sub-Saharan Africa, individuals infected with HIV who are severely immunocompromised have high mortality (about 10%) shortly after starting antiretroviral therapy (ART). This group also has the greatest risk of morbidity and mortality associated with immune reconstitution inflammatory syndrome (IRIS), a paradoxical response to successful ART. Integrase inhibitors lead to significantly more rapid declines in HIV viral load (VL) than all other ART classes. We hypothesised that intensifying standard triple-drug ART with the integrase inhibitor, raltegravir, would reduce HIV VL fast
Khrongwong Musikatavorn, Poj Plitawanon, Suthaporn Lumlertgul et al. · 2021 · Western Journal of Emergency Medicine
INTRODUCTION: The ultrasound measurement of inferior vena cava (IVC) diameter change during respiratory phase to guide fluid resuscitation in shock patients is widely performed, but the benefit on reducing the mortality of sepsis patients is questionable. The study objective was to evaluate the 30-day mortality rate of patients with sepsis-induced tissue hypoperfusion (SITH) and septic shock (SS) treated with ultrasound-guided fluid management (UGFM) using ultrasonographic change of the IVC diameter during respiration compared with those treated with the usual-care strategy. METHODS: This was
Kenji Fujiwara, May Tun Saung, Hao Jing et al. · 2020 · Journal for ImmunoTherapy of Cancer
Background Radiation therapy (RT) has the potential to enhance the efficacy of immunotherapy, such as checkpoint inhibitors, which has dramatically altered the landscape of treatments for many cancers, but not yet for pancreatic ductal…
Lisa Eidenschink Brodersen, Robert B. Gerbing, María Laura Pardo et al. · 2020 · Blood Advances
Risk stratification for acute myeloid leukemia (AML) uses molecular and cytogenetic abnormalities identified at diagnosis. Response to therapy informs risk, and morphology continues to be used more frequently than flow cytometry. Herein,…
Zeynep Başağaoğlu Demirekin, Muhammed Hilmi Büyükçavuş · 2022 · BMC Medical Education
BACKGROUND: The long-term psychological effects of COVID-19 on dental students are unclear. The aim of this cross-sectional online study was to investigate the psychological effects of the COVID-19 pandemic on dental students. METHOD: The Quality of Life Scale (WHOQOL-BREF) was sent to all dental students through Google Forms to evaluate their quality of life (QoL), and the DASS-21 scale was used to evaluate their psychosocial status due to distance learning during the COVID-19 pandemic. The answers were analyzed both on the basis of year of education and type of education (online versus class
Toni Weinhage, Timo Wirth, Paula Schütz et al. · 2020 · Frontiers in Immunology
Background. The receptor for advanced glycation end products (RAGE) is a multiligand receptor involved in a number of processes and disorders. While it is known that RAGE-signaling can contribute to toxic liver damage and fibrosis, its role in acute inflammatory liver injury and septic multiorgan failure is yet undefined. We examined RAGE in lipopolysaccharide (LPS) induced acute liver injury of D-galN sensitized mice as a classical model for tumor necrosis factor alpha (TNF-α) dependent inflammatory organ damage. Methods. Mice (Rage-/- and C57BL/6) were intraperitoneally injected with D galN
Yanyan Lu, Ran Meng, Xiangyu Wang et al. · 2019 · Nature Communications
Acute graft-versus-host disease (GVHD) remains a major obstacle for the wider usage of allogeneic hematopoietic stem cell transplantation (allo-HSCT), which is an effective therapy for hematopoietic malignancy. Here we show that caspase-11, the cytosolic receptor for bacterial endotoxin (lipopolysaccharide: LPS), enhances GVHD severity. Allo-HSCT markedly increases the LPS-caspase-11 interaction, leading to the cleavage of gasdermin D (GSDMD). Caspase-11 and GSDMD mediate the release of interleukin-1α (IL-1α) in allo-HSCT. Deletion of Caspase-11 or Gsdmd, inhibition of LPS-caspase-11 interacti
Huan Zhang, Shicheng Zhao, Xin Yu et al. · 2019 · Journal of Polymer Science Part B Polymer Physics
ABSTRACT The physical properties of ultrahigh molecular weight polyethylene (UHMWPE) are generally highly dependent on its molecular weight. However, in our study, it was found that two UHMWPE samples of similar molecular weight, SLL‐5 and…
Dafna Ben Yaakov, Yana Shadkchan, Nathaniel D. Albert et al. · 2017 · Journal of Antimicrobial Chemotherapy
Objectives: Over the last 30 years, the number of invasive fungal infections among immunosuppressed patients has increased significantly, while the number of effective systemic antifungal drugs remains low. The aim of this study was to…
Julia Katharina Schwarze, Jens Tijtgat, Gil Awada et al. · 2022 · Journal for ImmunoTherapy of Cancer
Background Intratumoral (IT) myeloid dendritic cells (myDCs) play a pivotal role in initiating antitumor immune responses and relicensing of anti-tumor cytotoxic T lymphocytes within the tumor microenvironment. Talimogene laherparepvec…
Woo‐Ri Shin, Hyun Tae Lee, Heejin Lim et al. · 2018 · Nature Communications
BAFF, a member of the TNF superfamily, has been recognized as a good target for autoimmune diseases. Belimumab, an anti-BAFF monoclonal antibody, was approved by the FDA for use in treating systemic lupus erythematosus. However, the molecular basis of BAFF neutralization by belimumab remains unclear. Here our crystal structure of the BAFF-belimumab Fab complex shows the precise epitope and the BAFF-neutralizing mechanism of belimumab, and demonstrates that the therapeutic activity of belimumab involves not only antagonizing the BAFF-receptor interaction, but also disrupting the formation of th
E. Gautier, J. Savarino, J. Erbland et al. · 2016 · Climate of the Past
Abstract. Current volcanic reconstructions based on ice core analysis have significantly improved over the past few decades by incorporating multiple-core analyses with a high temporal resolution from different parts of the polar regions…
Kotaro Matsumoto, Katsuya Suzuki, Keiko Yoshimoto et al. · 2019 · Arthritis Research & Therapy
Abstract Background Large vessel vasculitis (LVV) is a type of vasculitis characterized by granulomatous inflammation of medium- and large-sized arteries. Clinical assessment of acute phase reactants has been conventionally used to diagnose and monitor diseases; however, accurate assessment of vascular disease activity status can be difficult. In this study, we investigated comprehensive immuno-phenotyping to explore useful biomarkers associated with clinical characteristics. Methods Consecutive patients with newly diagnosed LVV who visited our institution between May 2016 and May 2019 were en
Klaus‐Holger Knorr, Marcus A. Horn, Werner Borken · 2015 · Global Change Biology
Abstract Nitrogen (N) nutrition in pristine peatlands relies on the natural input of inorganic N through atmospheric deposition or biological dinitrogen (N 2 ) fixation. However, N 2 fixation and its significance for N cycling, plant…
Ahuva Y. Segal, Tracey L. Sletten, Erin E. Flynn-Evans et al. · 2016 · Journal of Biological Rhythms
While previous studies have demonstrated short-wavelength sensitivity to the acute alerting effects of light during the biological night, fewer studies have assessed the alerting effect of light during the daytime. This study assessed the…