A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 77 of 660
Janet H. Hsiao, Jeehye An, Yueyuan Zheng et al. · 2021 · Cognition
Recent research has suggested the importance of part-based information in face recognition in addition to global, whole-face information. Nevertheless, face drawing experience was reported to enhance selective attention to the eyes but did…
Susanne R. Youngren-Ortiz, David B. Hill, Peter Hoffmann et al. · 2017 · Journal of Aerosol Medicine and Pulmonary Drug Delivery
BACKGROUND: Aerosol delivery of chemotherapeutic nanocarriers represents a promising alternative for lung cancer therapy. This study optimized gemcitabine (Gem)-loaded gelatin nanocarriers (GNCs) cross-linked with genipin (Gem-GNCs) to…
Matthew A. Thomas, Benjamin B. Mirus, Joel B. Smith · 2020 · Hydrological Processes
Abstract The devastating impacts of the widespread flooding and landsliding in Puerto Rico following the September 2017 landfall of Hurricane Maria highlight the increasingly extreme atmospheric disturbances and enhanced hazard potential…
Marcos S. Lopes, H. Bovenhuis, Maren van Son et al. · 2017 · Journal of Animal Science
The first attempts of applying marker-assisted selection (MAS) in animal breeding were not very successful because the identification of markers closely linked to QTL using low-density microsatellite panels was difficult. More recently,…
Daisuke Hamada, Masataka Nakayama, Jun Saiki · 2020 · Cognitive Research Principles and Implications
BACKGROUND: The wisdom of crowds and collective decision-making are important tools for integrating information between individuals, which can exceed the capacity of individual judgments. They are based on different forms of information integration. The wisdom of crowds refers to the aggregation of many independent judgments without deliberation and consensus, while collective decision-making is aggregation with deliberation and consensus. Recent research has shown that collective decision-making outperforms the wisdom of crowds. Additionally, many studies have shown that metacognitive knowled
Yue Du, Ying‐Ping Wang, Dafeng Hui et al. · 2022 · Global Change Biology
Abstract Global warming intensifies the hydrological cycle, which results in changes in precipitation regime (frequency and amount), and will likely have significant impacts on soil respiration ( R s ). Although the responses of R s to…
Peter C. Banacos, Michael L. Ekster · 2010 · Weather and Forecasting
Abstract The occurrence of rare but significant severe weather events associated with elevated mixed-layer (EML) air in the northeastern United States is investigated herein. A total of 447 convective event days with one or more…
Ji‐Feng Feng, Liang Wang, Xun Yang et al. · 2019 · Cancer Management and Research
Background: We firstly identified a combination of lactate dehydrogenase (LDH) along with albumin (ALB), which was defined as LAR (LDH/ALB ratio). The purpose of our study here was initially to explore the prognostic role of LAR in…
Kalijn F. Bol, Gerty Schreibelt, Martine Bloemendal et al. · 2024 · Nature Communications
Autologous natural dendritic cells (nDCs) treatment can induce tumor-specific immune responses and clinical responses in cancer patients. In this phase III clinical trial (NCT02993315), 148 patients with resected stage IIIB/C melanoma were randomized to adjuvant treatment with nDCs (n = 99) or placebo (n = 49). Active treatment consisted of intranodally injected autologous CD1c+ conventional and plasmacytoid DCs loaded with tumor antigens. The primary endpoint was the 2-year recurrence-free survival (RFS) rate, whereas the secondary endpoints included median RFS, 2-year and median overall surv
Bertrand Sauneuf, Benoît Champigneulle, Alexis Soummer et al. · 2013 · Critical Care
INTRODUCTION: The overall outcome of septic shock has been recently improved. We sought to determine whether this survival gain extends to the high-risk subgroup of patients with cirrhosis. METHODS: Cirrhotic patients with septic shock admitted to a medical intensive care unit (ICU) during two consecutive periods (1997-2004 and 2005-2010) were retrospectively studied. RESULTS: Forty-seven and 42 cirrhotic patients presented with septic shock in 1997-2004 and 2005-2010, respectively. The recent period differed from the previous one by implementation of adjuvant treatments of septic shock includ
Fengling Zhang, Xingjia Xiang, Yuanqiu Dong et al. · 2020 · Animals
Intestinal bacterial communities form an integral component of the organism. Many factors influence gut bacterial community composition and diversity, including diet, environment and seasonality. During seasonal migration, birds use many habitats and food resources, which may influence their intestinal bacterial community structure. Hooded crane (Grus monacha) is a migrant waterbird that traverses long distances and occupies varied habitats. In this study, we investigated the diversity and differences in intestinal bacterial communities of hooded cranes over the migratory seasons. Fecal sample
Mats Enlund, Anders Berglund, Anna Enlund et al. · 2023 · EClinicalMedicine
Background: Anaesthesia may impact long-term cancer survival. In the Cancer and Anaesthesia study, we hypothesised that the hypnotic drug propofol will have an advantage of at least five percentage points in five-year survival over the inhalational anaesthetic sevoflurane for breast cancer surgery. Methods: From 2118 eligible breast cancer patients scheduled for primary curable, invasive breast cancer surgery, 1764 were recruited after ethical approval and individual informed consent to this open label, single-blind, randomised trial at four county- and three university hospitals in Sweden and
Joji Suzuki, Jeffrey DeVido, Inder Kalra et al. · 2015 · American Journal on Addictions
BACKGROUND AND OBJECTIVES: Opioid dependent patients are hospitalized frequently. We aimed to determine if initiation of buprenorphine treatment during hospitalization facilitates entry into treatment following discharge. METHODS:…
Hasan Akın, Aysun Ölçmen, Özgür İşgörücü et al. · 2011 · The Thoracic and Cardiovascular Surgeon
Mediastinal lymph node dissection, an important part of surgery for non-small cell lung cancer, is associated with a risk of chylothorax. Although mortality has significantly decreased in recent years, it still worries thoracic surgeons.…
Koji Matsuo, Muneaki Shimada, Harushige Yokota et al. · 2017 · Oncotarget
// Koji Matsuo 1, 2, * , Muneaki Shimada 3, 4, * , Harushige Yokota 5 , Toyomi Satoh 6 , Hidetaka Katabuchi 7 , Shoji Kodama 8, 9 , Hiroshi Sasaki 10, 11 , Noriomi Matsumura 12, 13 , Mikio Mikami 14 and Toru Sugiyama 15 1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA, USA 2 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA 3 Department of Obstetrics and Gynecology, Tottori University, Tottori, Japan 4 Current affiliation: Department of Obstetrics and Gynecology, Tohoku Univ
Anwaar Saeed, Robin Park, Harsh B. Pathak et al. · 2024 · Nature Communications
CAMILLA is a basket trial (NCT03539822) evaluating cabozantinib plus the ICI durvalumab in chemorefractory gastrointestinal cancer. Herein, are the phase II colorectal cohort results. 29 patients were evaluable. 100% had confirmed pMMR/MSS tumors. Primary endpoint was met with ORR of 27.6% (95% CI 12.7-47.2%). Secondary endpoints of 4-month PFS rate was 44.83% (95% CI 26.5-64.3%); and median OS was 9.1 months (95% CI 5.8-20.2). Grade≥3 TRAE occurred in 39%. In post-hoc analysis of patients with RAS wild type tumors, ORR was 50% and median PFS and OS were 6.3 and 21.5 months respectively. Explo
Jing Wang, Ting Xu, Lirong Wu et al. · 2022 · JTO Clinical and Research Reports
IntroductionDurvalumab after concurrent chemoradiation (CCRT) for NSCLC improves survival, but only in a subset of patients. We investigated the effect of severe radiation-induced lymphopenia (sRIL) on survival in these…
Kyle J. Bednar, Elena Shanina, Romain Ballet et al. · 2017 · The Journal of Immunology
Abstract CD22, a sialic acid–binding Ig-type lectin (Siglec) family member, is an inhibitory coreceptor of the BCR with established roles in health and disease. The restricted expression pattern of CD22 on B cells and most B cell lymphomas…
Subin Park, Ki Kyoung Yi, Riji Na et al. · 2013 · Behavioral and Brain Functions
BACKGROUND: Previous research on serum total cholesterol and suicidality has yielded conflicting results. Several studies have reported a link between low serum total cholesterol and suicidality, whereas others have failed to replicate these findings, particularly in patients with major affective disorders. These discordant findings may reflect the fact that studies often do not distinguish between patients with bipolar and unipolar depression; moreover, definitions and classification schemes for suicide attempts in the literature vary widely. METHODS: Subjects were patients with one of the th
Maximilian J. Mair, Barbara Kiesel, Katharina Feldmann et al. · 2021 · Journal of Neuro-Oncology
PURPOSE: Immune modulatory therapies including immune checkpoint inhibitors have so far failed to result in clinically meaningful efficacy in glioma. We aimed to investigate lymphocyte activation gene 3 (LAG-3), an inhibitory receptor on immune cells and target of second-generation immune checkpoint inhibitors, in glioma. METHODS: 97 patients with diffuse glioma (68 with glioblastoma, 29 with WHO grade II-III glioma) were identified from the Neuro-Biobank of the Medical University of Vienna. LAG-3 expression in the inflammatory microenvironment was assessed by immunohistochemistry (monoclonal
Vanessa Pitz, Mary B. Makarious, Sara Bandrés‐Ciga et al. · 2024 · npj Parkinson s Disease
Although many rare variants have been reportedly associated with Parkinson's disease (PD), many have not been replicated or have failed to replicate. Here, we conduct a large-scale replication of rare PD variants. We assessed a total of 27,590 PD cases, 6701 PD proxies, and 3,106,080 controls from three data sets: 23andMe, Inc., UK Biobank, and AMP-PD. Based on well-known PD genes, 834 variants of interest were selected from the ClinVar annotated 23andMe dataset. We performed a meta-analysis using summary statistics of all three studies. The meta-analysis resulted in five significant variants
Yoon‐Koo Kang, Yung‐Jue Bang, Shunsuke Kondo et al. · 2020 · Clinical Cancer Research
Abstract Purpose: Patients with advanced gastric/gastroesophageal junction cancer (GC/GEJC) have limited treatment options after first-line therapy. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the…
Tia Stevens Andersen · 2015 · Criminal Justice and Behavior
Missing from the considerable body of literature on disproportionate minority contact is an examination of the factors that influence risk of juvenile arrest. Using the National Longitudinal Survey of Youth 1997, the author examines…
Wenshu Tang, Cario W. S. Lo, Wei Ma et al. · 2024 · Cell & Bioscience
BACKGROUND: Glioma is a highly heterogeneous brain tumor categorized into World Health Organization (WHO) grades 1-4 based on its malignancy. The suppressive immune microenvironment of glioma contributes significantly to unfavourable patient outcomes. However, the cellular composition and their complex interplays within the glioma environment remain poorly understood, and reliable prognostic markers remain elusive. Therefore, in-depth exploration of the tumor microenvironment (TME) and identification of predictive markers are crucial for improving the clinical management of glioma patients. RE
Chetan Shenoy, Judy Boura, Pamela Orshaw et al. · 2010 · PLoS ONE
BACKGROUND: Chronic kidney disease (CKD) is strongly associated with adverse outcomes after percutaneous coronary intervention (PCI). There are limited data on the effectiveness of drug-eluting stents (DES) in patients with CKD. METHODOLOGY/PRINCIPAL FINDINGS: Of 3,752 consecutive patients enrolled in the Guthrie PCI Registry between 2001 and 2006, 436 patients with CKD - defined as a creatinine clearance <60 mL/min - were included in this study. Patients who received DES were compared to those who received bare metal stents (BMS). Patients were followed for a mean duration of 3 years after th
Robert Z. Tashjian, Rahul Banerjee, Michael P. Bradley et al. · 2010 · The Journal of Knee Surgery
Sixty-eight patients undergoing outpatient knee arthroscopy for treatment of meniscal tears or loose bodies were divided into three treatment groups (zolpidem [24 patients], control [24 patients], and placebo [20 patients]). All groups…
Henrik Falconer, Ulrika Joneborg, Kamilla Krawiec et al. · 2020 · Gynecologic Oncology
OBJECTIVE: Ultra-radical surgery to achieve complete resection in advanced epithelial ovarian cancer (EOC) has been widely accepted without strong supporting data. Our objective was to assess overall survival after a structured shift to an ultra-radical upfront surgical treatment algorithm and to investigate changes in the distribution of primary treatments after this shift. PATIENTS AND METHODS: In this population-based cohort study, all women with suspected EOC in the Stockholm-Gotland region of Sweden reported to the Swedish Quality Registry for Gynecologic Cancer (SQRGC) and National Cance
Kanan Patel, Gregg C. Fonarow, Dalane W. Kitzman et al. · 2012 · European Journal of Heart Failure
AIMS: To examine the clinical effectiveness of angiotensin receptor blockers (ARBs) in older patients with heart failure and preserved ejection fraction (HF-PEF). METHODS AND RESULTS: Of the 10 570 hospitalized HF-PEF patients, aged ≥ 65…
Rishikesh Kankesh Patel, James Brouner, Owen Spendiff · 2015 · Journal of the International Society of Sports Nutrition
BACKGROUND: Dark chocolate (DC) is abundant in flavanols which have been reported to increase the bioavailability and bioactivity of nitric oxide (NO). Increasing NO bioavailability has often demonstrated reduced oxygen cost and performance enhancement during submaximal exercise. METHODS: Nine moderately-trained male participants volunteered to undertake baseline (BL) measurements that comprised a cycle V̇O(2max) test followed by cycling at 80% of their established gas exchange threshold (GET) for 20-min and then immediately followed by a two-minute time-trial (TT). Using a randomised crossove
Zhiyong Liu, Weitao Yao, Yao Zhao et al. · 2021 · Cancer Management and Research
PURPOSE: Anlotinib is a novel tyrosine kinase inhibitor with promising anti-tumor activity in patients with advanced soft tissue sarcomas (STS) in China. Liposomal doxorubicin monotherapy showed an encouraging effect on this disease. The…