Negative / Null Result ReportOpen accessMedicine
Yasuhiro Koh, Manabu Aoki, Matthew Danish et al. · 2011 · Journal of Virology
Dimerization of HIV protease is essential for the acquisition of protease's proteolytic activity. We previously identified a group of HIV protease dimerization inhibitors, including darunavir (DRV). In the present work, we examine whether…
View details →DOI: 10.1128/jvi.05121-11Cited by 44 Negative / Null Result ReportOpen accessEngineering
Yexin Gu, Wenting Zhang, Qiaoling Sun et al. · 2015 · Journal of Materials Chemistry B
Osteocytes reside as 3-dimensionally networked cells in the lacunocanalicular structure of bones, and function as the master regulators of homeostatic bone remodeling. We report here, for the first time to our best knowledge, the use of a…
View details →DOI: 10.1039/c5tb00421gCited by 44 Negative / Null Result ReportOpen accessMedicine
Xiaoyan Zhang, Sufang Shi, Yan Ouyang et al. · 2018 · Journal of Translational Medicine
BACKGROUND: A working group on the Oxford classification of IgA nephropathy (IgAN) recently reported that crescents detected in kidney tissue predicted a worse renal outcome. However, this finding must be validated in independent cohorts before it can be widely applied to clinical practice. METHODS: Biopsy-proven IgAN patients were continuously recruited from two large renal centers in China from 1989 to 2014. All patients were followed for more than 1 year unless end stage renal disease (ESRD) occurred within 12 months. Crescents were defined as focal cellular or fibrocellular crescent format
View details →DOI: 10.1186/s12967-018-1488-5Cited by 44 Negative / Null Result ReportEarth and Planetary Sciences
Yoshihiro Nakayama, Dimitris Menemenlis, Michael Schodlok et al. · 2017 · Journal of Geophysical Research Oceans
Abstract Recent studies suggest that the thickness of Winter Water (WW), that is, water with potential temperature below ∼−1°C located below Antarctic Surface Water and above Circumpolar Deep Water (CDW) is critical in determining the ice…
View details →DOI: 10.1002/2016jc012538Cited by 44 Negative / Null Result ReportOpen accessHealth Professions
Jonathan B. Dingwell, Joseph P. Cusumano · 2019 · PLoS Computational Biology
A fundamental question in human motor neuroscience is to determine how the nervous system generates goal-directed movements despite inherent physiological noise and redundancy. Walking exhibits considerable variability and equifinality of task solutions. Existing models of bipedal walking do not yet achieve both continuous dynamic balance control and the equifinality of foot placement humans exhibit. Appropriate computational models are critical to disambiguate the numerous possibilities of how to regulate stepping movements to achieve different walking goals. Here, we extend a theoretical and
View details →DOI: 10.1371/journal.pcbi.1006850Cited by 44 Negative / Null Result ReportOpen accessPhysics and Astronomy
Sheehan H. Ahmed, Alyson Brooks, Charlotte Christensen · 2016 · Monthly Notices of the Royal Astronomical Society
We investigate whether the inclusion of baryonic physics influences the formation of thin, coherently rotating planes of satellites such as those seen around the Milky Way and Andromeda. For four Milky Way-mass simulations, each run both…
View details →DOI: 10.1093/mnras/stw3271Cited by 44 Negative / Null Result ReportOpen accessEnvironmental Science
Morgan Hardy, Jamie McCasland · 2019 · The World Bank Economic Review
Abstract Entrepreneurs in developing countries report that unreliable electricity imposes a serious constraint, yet little evidence exists on how blackouts impact the micro-firms that account for the majority of employment. This article…
View details →DOI: 10.1093/wber/lhz028Cited by 44 Negative / Null Result ReportPsychology
Judith Gere, Geoff MacDonald, Samantha Joel et al. · 2013 · Journal of Personality and Social Psychology
Although separate literatures have emerged on effects of social threats (i.e., rejection and negative evaluation) and rewards (i.e., connection and intimacy) on the process of commitment to a romantic relationship, no research has examined…
View details →DOI: 10.1037/a0033874Cited by 44 Negative / Null Result ReportOpen accessNeuroscience
Peter E. Clayson, Ann Clawson, Michael J. Larson · 2011 · Social Cognitive and Affective Neuroscience
Previous research suggests that performance-monitoring processes are related to personality traits; relationships with affective states, however, remain unclear. The purpose of this study was to replicate and extend previous findings that…
View details →DOI: 10.1093/scan/nsr040Cited by 44 Negative / Null Result Report
Brooke E Crowley, Karen E Samonds · 2013 · The Holocene
Madagascar is home to some of the world’s most unique plants and animals. Unfortunately, anthropogenic forest loss has had a dramatic impact on both floral and faunal communities. In many regions the scale and timing of this loss remains…
View details →DOI: 10.1177/0959683613484675Cited by 44 Negative / Null Result Report
Liang Fang, Pierre Martre, Kaining Jin et al. · 2022 · Global Change Biology
Abstract Extreme climatic events, such as heat waves, cold snaps and drought spells, related to global climate change, have become more frequent and intense in recent years. Acclimation of plant physiological processes to changes in…
View details →DOI: 10.1111/gcb.16488Cited by 44 Negative / Null Result ReportOpen accessMedicine
Brian W. Timmons · 2026 · PubMed
Considerable advances have been made in exercise immunology over the last two decades, and it is becoming evident that many of the health benefits of regular physical activity may be directly related to activation of the immune system. The…
View details →DOI: 10.22029/eir.2005.1619Cited by 44 Negative / Null Result ReportOpen accessComputer Science
Νικόλαος Πέλλας · 2025 · Education Sciences
Artificial Intelligence (AI) has gained significant prominence in science education, yet its practical applications, particularly in teacher training, remain underexplored. Specifically, there is a lack of research on AI’s potential to support personalized professional development through automated analysis of classroom interactions and tailored feedback. As science teacher education requires skill development in complex scientific concepts within problem-based learning (PBL) contexts, there is a growing need for innovative, technology-driven instructional tools. AI-generated instructional vid
View details →DOI: 10.3390/educsci15010102Cited by 44 Negative / Null Result ReportOpen accessMedicine
Rabie Adel El Arab, Omayma Abdulaziz Al Moosa, Mette Sagbakken et al. · 2025 · Frontiers in Public Health
Background: Artificial Intelligence (AI) is rapidly transforming the nursing profession, presenting significant opportunities and challenges. Despite its promising potential in enhancing nursing education, clinical practice, and operational efficiency, critical barriers related to ethics, workforce adaptation, and humanistic care persist. Aim: This integrative review systematically evaluates the integration of AI in nursing practice, with a specific focus on nursing education, clinical care, workload management, and professional perceptions. Methods: Guided by PRISMA 2020 and the SPIDER framew
View details →DOI: 10.3389/fpubh.2025.1619378Cited by 44 Negative / Null Result ReportOpen accessHealth Professions
Francesco Savino, Andrea Quartieri, Angela De Marco et al. · 2016 · Acta Paediatrica
AIM: This study compared the faecal microbial composition of formula-fed infants who did and did not have colic. METHODS: Faecal samples from formula-fed infants under 16 weeks of age with (n = 38) and without (n = 39) colic were collected at Department of Pediatrics in Turin, Italy, between February 2014 and October 2015. The pH and faecal ammonia were determined and total bacteria, bifidobacteria, lactic acid bacteria and coliforms were quantified by fluorescent in situ hybridisation (FISH). RESULTS: Faecal ammonia was significantly higher in the colicky infants than in the controls (483 vs.
View details →DOI: 10.1111/apa.13642Cited by 44 Negative / Null Result Report
Richard J. Smith · 2020 · American Journal of Physical Anthropology
Abstract Statistically nonsignificant ( p > .05) results from a null hypothesis significance test (NHST) are often mistakenly interpreted as evidence that the null hypothesis is true—that there is “no effect” or “no difference.” However,…
View details →DOI: 10.1002/ajpa.24092Cited by 43 Negative / Null Result ReportOpen accessNeuroscience
Aine Ito, Andrea E. Martin, Mante S. Nieuwland · 2017 · Language Cognition and Neuroscience
In our recent publication “How robust are prediction effects in language comprehension? Failure to replicate article-elicited N400 effects” (Ito, Martin, & Nieuwland, 2016a), we report two experiments which failed to replicate existing…
View details →DOI: 10.1080/23273798.2017.1323112Cited by 43 Negative / Null Result ReportOpen accessMedicine
Ricardo Parreira, Shelley Cook, Ângela Celis de Almeida Lopes et al. · 2012 · Virus Research
We describe the full genetic characterization of an insect-specific flavivirus (ISF) from Culex theileri (Theobald) mosquitoes collected in Portugal. This represents the first isolation and full characterization of an ISF from Portuguese mosquitoes. The virus, designated CTFV, for Culex theileri flavivirus, was isolated in the C6/36 Stegomyia albopicta (=Aedes albopictus) cell line, and failed to replicate in vertebrate (Vero) cells in common with other ISFs. The CTFV genome encodes a single polyprotein with 3357 residues showing all the features expected for those of flaviviruses. Phylogeneti
View details →DOI: 10.1016/j.virusres.2012.04.010Cited by 43 Negative / Null Result ReportOpen accessMedicine
Andrew M. Bean, Rebecca Payne, Guy Parsons et al. · 2026 · Nature Medicine
Global healthcare providers are exploring the use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly perfect scores on medical licensing exams, but this does not necessarily translate to accurate performance in real-world settings. We tested whether LLMs can assist members of the public in identifying underlying conditions and choosing a course of action (disposition) in ten medical scenarios in a controlled study with 1,298 participants. Participants were randomly assigned to receive assistance from an LLM (GPT-4o, Llama 3, Command R+) or a source
View details →DOI: 10.1038/s41591-025-04074-yCited by 43 Negative / Null Result Report
Aymen Ben Rejeb, Mongi Arfaoui · 2019 · European Journal of Management and Business Economics
Purpose The purpose of this paper is to investigate whether Islamic stock indexes outperform conventional stock indexes, in terms of informational efficiency and risk, during the recent financial instability period.…
View details →DOI: 10.1108/ejmbe-08-2018-0088Cited by 43 Negative / Null Result Report
Zhijian Wang, Yanran Zhou, Jaimie W. Lien et al. · 2016 · Nature Communications
Abstract Zero-determinant (ZD) strategies, as discovered by Press and Dyson, can enforce a linear relationship between a pair of players’ scores in the iterated prisoner’s dilemma. Particularly, the extortionate ZD strategies can enforce…
View details →DOI: 10.1038/ncomms11125Cited by 43 Negative / Null Result Report
M. Wojcieszak, L. Wadley · 2018 · Archaeometry
Micro‐residue analysis of stone tools is generally performed with optical light microscopy and the visual observations are then compared with experimental, replicated pieces. This paper complements such archaeological research by providing…
View details →DOI: 10.1111/arcm.12369Cited by 43 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Shun‐Long Weng, Wenjun Wu, Yi‐Hsuan Hsiao et al. · 2018 · International Journal of Medical Sciences
Up to date, no study explores the relationship of single nucleotide polymorphisms (SNPs) of long non-coding RNAs HOTAIR (lncRNAs HOTAIR) with cancer recurrence and patient survival in uterine cervical cancer for Taiwanese women. We…
View details →DOI: 10.7150/ijms.27505Cited by 43 Negative / Null Result ReportMedicine
Grazia Crescimanno, Oreste Marrone, Andrea Vianello · 2011 · Respirology
BACKGROUND AND OBJECTIVE: Although non-invasive ventilation is widely used for the management of patients with neuromuscular disease, it remains unclear which ventilatory mode is associated with optimal patient-ventilator interaction and…
View details →DOI: 10.1111/j.1440-1843.2011.01962.xCited by 43 Negative / Null Result ReportOpen accessMedicine
Anouk Wouters, Gerda Croiset, Nienke R. Schripsema et al. · 2017 · Advances in Health Sciences Education
Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct admission based on top pre-university grade point averages (≥8 out of 10; top-pu-GPA). We also considered whether students had participated in selection, prior to being admitted through weighted lottery. Year-1 (pre-clinical) and Year-4 (clinical) stude
View details →DOI: 10.1007/s10459-016-9745-yCited by 43 Negative / Null Result ReportMedicine
John T. Kanegaye, Jennifer M. Jacob, Denise Malicki · 2014 · PEDIATRICS
OBJECTIVE: The performance of automated flow cytometric urinalysis is not well described in pediatric urinary tract infection. We sought to determine the diagnostic performance of automated cell counts and emergency department…
View details →DOI: 10.1542/peds.2013-4222Cited by 43 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mariama Jaiteh, Ismael Rodríguez‐Espigares, Jana Selent et al. · 2020 · PLoS Computational Biology
Rational drug design for G protein-coupled receptors (GPCRs) is limited by the small number of available atomic resolution structures. We assessed the use of homology modeling to predict the structures of two therapeutically relevant GPCRs and strategies to improve the performance of virtual screening against modeled binding sites. Homology models of the D2 dopamine (D2R) and serotonin 5-HT2A receptors (5-HT2AR) were generated based on crystal structures of 16 different GPCRs. Comparison of the homology models to D2R and 5-HT2AR crystal structures showed that accurate predictions could be obta
View details →DOI: 10.1371/journal.pcbi.1007680Cited by 43 Negative / Null Result ReportOpen accessMedicine
Catarina Dinis Fernandes, Cuong V. Dinh, Iris Walraven et al. · 2018 · Physics and Imaging in Radiation Oncology
BACKGROUND AND PURPOSE: High-risk prostate cancer patients are frequently treated with external-beam radiotherapy (EBRT). Of all patients receiving EBRT, 15-35% will experience biochemical recurrence (BCR) within five years. Magnetic…
View details →DOI: 10.1016/j.phro.2018.06.005Cited by 43 Negative / Null Result ReportOpen accessMedicine
Ivo M.B. Francischetti, Emile B. Gordon, Bruna Bizzarro et al. · 2014 · PLoS ONE
BACKGROUND: The role of intracellular radical oxygen species (ROS) in pathogenesis of cerebral malaria (CM) remains incompletely understood. METHODS AND FINDINGS: We undertook testing Tempol--a superoxide dismutase (SOD) mimetic and pleiotropic intracellular antioxidant--in cells relevant to malaria pathogenesis in the context of coagulation and inflammation. Tempol was also tested in a murine model of CM induced by Plasmodium berghei Anka infection. Tempol was found to prevent transcription and functional expression of procoagulant tissue factor in endothelial cells (ECs) stimulated by lipopo
View details →DOI: 10.1371/journal.pone.0087140Cited by 43 Negative / Null Result ReportBusiness, Management and Accounting
Olenka Kacperczyk, Peter Younkin · 2021 · Organization Science
There is both widespread interest in encouraging entrepreneurship and universal recognition that the vast majority of these founders will fail, which raises an important unanswered question: What happens to ex-founders when they apply for…
View details →DOI: 10.1287/orsc.2021.1456Cited by 43 