A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19792 results in Negative / Null Result Report · page 74 of 660
Lauren A. Stutts, Kerstin K. Blomquist · 2018 · International Journal of Eating Disorders
OBJECTIVE: The present study employed a longitudinal design to examine the moderating role of self-compassion in the relationship between weight/shape concerns and the outcomes of eating pathology and stress in a diverse college student…
John Keane, Wei Zhang, Chris H. Kim · 2011 · IEEE Journal of Solid-State Circuits
Variations in the number and characteristics of charges or traps contributing to transistor degradation lead to a distribution of device “ages” at any given time. This issue is well understood in the study of time dependent dielectric…
Chung-Young Lee, Se-Hee An, Il Hwan Kim et al. · 2017 · Scientific Reports
The polymerase of avian influenza A virus (AIV) is a heterotrimer composed of PB2, PB1, and PA. PB2 plays a role in overcoming the host barrier; however, the genetic prerequisites for avian PB2 to acquire mammalian pathogenic mutations have not been well elucidated. Previously, we identified a prototypic avian PB2 that conferred non-replicative and non-pathogenic traits to a PR8-derived recombinant virus when it was used to infect mice. Here, we demonstrated that key amino acid mutations (I66M, I109V, and I133V, collectively referred to as MVV) of this prototypic avian PB2 increase the replica
Priya Landa, Ann‐Marie Differ, Kaukab Rajput et al. · 2013 · BMC Medical Genetics
BACKGROUND: Pendred syndrome is a common autosomal recessive disorder causing deafness. Features include sensorineural hearing impairment, goitre, enlarged vestibular aqueducts (EVA) and occasionally Mondini dysplasia. Hearing impairment and EVA may occur in the absence of goitre or thyroid dyshormonogensis in a condition known as non-syndromic EVA. A significant number of patients with Pendred syndrome and non-syndromic EVA show only one mutation in SLC26A4. Two genes, KCNJ10, encoding an inwardly rectifying potassium channel and FOXI1, a transcriptional factor gene, are thought to play a rol
Douglas K. Rex, Indira Bhavsar-Burke, Daniel Buckles et al. · 2024 · Annals of Internal Medicine
BACKGROUND: Real-time prediction of histologic features of small colorectal polyps may prevent resection and/or pathologic evaluation and therefore decrease colonoscopy costs. Previous studies showed that computer-aided diagnosis (CADx)…
Arthur Caye, Jessica Agnew‐Blais, Louise Arseneault et al. · 2019 · Epidemiology and Psychiatric Sciences
AIM: Few personalised medicine investigations have been conducted for mental health. We aimed to generate and validate a risk tool that predicts adult attention-deficit/hyperactivity disorder (ADHD). METHODS: Using logistic regression models, we generated a risk tool in a representative population cohort (ALSPAC - UK, 5113 participants, followed from birth to age 17) using childhood clinical and sociodemographic data with internal validation. Predictors included sex, socioeconomic status, single-parent family, ADHD symptoms, comorbid disruptive disorders, childhood maltreatment, ADHD symptoms,
James B. Adams, Daniel P. Howsmon, Uwe Krüger et al. · 2017 · PLoS ONE
INTRODUCTION: A number of previous studies examined a possible association of toxic metals and autism, and over half of those studies suggest that toxic metal levels are different in individuals with Autism Spectrum Disorders (ASD). Additionally, several studies found that those levels correlate with the severity of ASD. METHODS: In order to further investigate these points, this paper performs the most detailed statistical analysis to date of a data set in this field. First morning urine samples were collected from 67 children and adults with ASD and 50 neurotypical controls of similar age an
R Kelly Garrett, Shannon Poulsen · 2019 · Journal of Computer-Mediated Communication
Abstract We present two studies evaluating the effectiveness of flagging inaccurate political posts on social media. In Study 1, we tested fact-checker flags, peer-generated flags, and a flag indicating that the publisher self-identified…
Raffaele Di Fenza, Naman S. Shetty, Stefano Gianni et al. · 2023 · American Journal of Respiratory and Critical Care Medicine
Abstract Rationale The effects of high-dose inhaled nitric oxide on hypoxemia in coronavirus disease (COVID-19) acute respiratory failure are unknown. Objectives The primary outcome was the change in arterial oxygenation (PaO2/Fi O2) at 48…
Yan Sun, Ying Cheng, Xuezhi Hao et al. · 2016 · BMC Cancer
BACKGROUND: Extensive-disease small-cell lung cancer (ED-SCLC) is characterized by rapid progression and relapse, despite high initial response rates to chemotherapy. The primary objective of this trial was to demonstrate the non-inferiority of amrubicin and cisplatin (AP) combination therapy compared with the standard first-line regimen of etoposide and cisplatin (EP) for previously untreated ED-SCLC in a Chinese population. When non-inferiority was verified, the objective was switched from non-inferiority to superiority. METHODS: From June 2008 to July 2010, 300 patients were enrolled and ra
Mauro Giovanni Carta, Maria Efisia Lecca, Luca Saba et al. · 2015 · BMC Psychiatry
BACKGROUND: To compare the six-month outcome on mood, cognition and quality of life (QoL) in patients with severe carotid atherosclerosis (CA) who underwent carotid endarterectomy (CEA) with subjects who refused treatment. METHODS: Cohort study on consecutive inpatients with CA (stenosis ≥ 50 %) (N = 46; age 72.56 ± 7.26; male 65.2 %). Intervention cohort: subjects who decided to undergo CEA (N = 35); Control cohort patients who refused CEA (N = 11). DSM-IV-Psychiatric diagnosis made by clinicians using interviews, QoL measured by Short Form Health Survey (SF-12); cognitive performance by WAIS
Abigail T. Berman, Leslie A. Litzky, Virginia A. LiVolsi et al. · 2011 · Cancer
BACKGROUND: The clinical benefit of postoperative mediastinal radiation for completely resected Masaoka stage 2 thymoma remains controversial. Due to its indolent nature and infrequent recurrences, no study has definitively determined the…
Junko Ueshima, Akio Shimizu, Keisuke Maeda et al. · 2022 · Journal of the American Medical Directors Association
This position paper prepared by the Japanese Working Group on Integrated Nutrition for Dysphagic People (JWIND) aims to summarize the need for nutritional management in adult patients with dysphagia, the issues that nutrition professionals should address, and the promising approaches as well as to propose a vision for the future of nutritional care for adult patients with dysphagia. JWIND is a joint certification system recognized by the Japan Dietetic Association and the Japanese Society of Dysphagia Rehabilitation; its members are mostly experts known as "Certified Specialist of Registered D
Youlu Chen, Yong Zeng, Xiaowei Zhu et al. · 2020 · Bioactive Materials
Compared with paclitaxel, sirolimus has been more used in the treatment of vascular restenosis gradually as an anti-proliferative drug, but few basic studies have elucidated its mechanism. The anti-proliferative effects of sirolimus or…
Hao Chen, Donghang Zheng, Jeff Abbott et al. · 2013 · Antimicrobial Agents and Chemotherapy
Lethal viral infections produce widespread inflammation with vascular leak, clotting, and bleeding (disseminated intravascular coagulation [DIC]), organ failure, and high mortality. Serine proteases in clot-forming (thrombotic) and…
Shuang-Jie Cao, Yue Zhang, Yuxiu Zhang et al. · 2023 · British Journal of Anaesthesia
BACKGROUND: Experimental evidence indicates that i.v. anaesthesia might reduce cancer recurrence compared with volatile anaesthesia, but clinical information is observational only. We therefore tested the primary hypothesis that…
Koichi Araki, Shivaprakash Gangappa, Dirck L. Dillehay et al. · 2010 · The Journal of Experimental Medicine
Recently, several cases of fatal lymphocytic choriomeningitis virus (LCMV) infection occurred in transplant recipients being treated with the immunosuppressive calcineurin inhibitor FK506. These findings were surprising because LCMV is a…
Ilaria Salvato, Antonio Marchini · 2024 · Cancers
Despite decades of research and the best up-to-date treatments, grade 4 Glioblastoma (GBM) remains uniformly fatal with a patient median overall survival of less than 2 years. Recent advances in immunotherapy have reignited interest in utilizing immunological approaches to fight cancer. However, current immunotherapies have so far not met the anticipated expectations, achieving modest results in their journey from bench to bedside for the treatment of GBM. Understanding the intrinsic features of GBM is of crucial importance for the development of effective antitumoral strategies to improve pat
Kai Zhu, Manya Tu, Yingcheng Li · 2022 · Land
Curbing carbon emissions by restricting economic growth could decrease human well-being across the world and especially in developing countries, suggesting that we need to find alternative approaches to reducing carbon emissions. Against…
Eyad Atalah, C.M Hernández-Cruz, T. Benítez-Santana et al. · 2010 · Aquaculture Research
The effect of different arachidonic acid (ARA) dietary contents at several dietary eicosapentaenoic acid (EPA) levels on the growth, survival and biochemical composition of gilthead seabream larvae was studied to better define the…
Marco R. Oggioni, Joana Rosado Coelho, Leonardo Furi et al. · 2015 · Current Pharmaceutical Design
There is a growing concern by regulatory authorities for the selection of antibiotic resistance caused by the use of biocidal products. We aimed to complete the detailed information on large surveys by investigating the relationship…
Frederick F. Lang, Nam Tran, Vinay K. Puduvalli et al. · 2017 · Journal of Clinical Oncology
2002 Background: DNX-2401 is a replication-competent, tumor-selective, oncolytic adenovirus with enhanced infectivity that causes durable tumor control by killing tumor cells and eliciting antitumor immunity. To increase immune activation,…
Joshua T. Kantrowitz, Christoph U. Correll, Rakesh Jain et al. · 2023 · The International Journal of Neuropsychopharmacology
BACKGROUND: Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective for negative and cognitive symptoms and are associated with a range of troublesome side effects. A significant unmet medical need for more effective and better-tolerated therapies remains. METHODS: A roundtable consisting of 4 experts in the treatment of patients with schizophrenia convened to discuss the current treatment landscape, unmet needs from patient and societal
Shigeki Nanjo, Tadaaki Yamada, Hiroshi Nishihara et al. · 2013 · PLoS ONE
PURPOSE: Although EGF receptor tyrosine kinase inhibitors (EGFR-TKI) have shown dramatic effects against EGFR mutant lung cancer, patients ultimately develop resistance by multiple mechanisms. We therefore assessed the ability of combined treatment with the Met inhibitor crizotinib and new generation EGFR-TKIs to overcome resistance to first-generation EGFR-TKIs. EXPERIMENTAL DESIGN: Lung cancer cell lines made resistant to EGFR-TKIs by the gatekeeper EGFR-T790M mutation, Met amplification, and HGF overexpression and mice with tumors induced by these cells were treated with crizotinib and a ne
Seung-Kwan Lim, Sang‐Oh Lee, Seong-Ho Choi et al. · 2011 · Journal of Korean Medical Science
Despite the identification of Acinetobacter baumannii isolates that demonstrate susceptibility to only colistin, this antimicrobial agent was not available in Korea until 2006. The present study examined the outcomes of patients with…
Daniel V.T. Catenacci, Agnes Ang, Wei‐Li Liao et al. · 2016 · Cancer
BACKGROUND: MET gene amplification and Met protein overexpression may be associated with a poor prognosis. The MET/Met status is typically determined with fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC),…
Daniel T.I. Bayley, Andrew O.M. Mogg, Heather Koldewey et al. · 2019 · PeerJ
Reef structural complexity provides important refuge habitat for a range of marine organisms, and is a useful indicator of the health and resilience of reefs as a whole. Marine scientists have recently begun to use ‘Structure from Motion’…
Ahmed M. Abdel‐Khalek · 2012 · Mental Health Religion & Culture
The present study sought to test for an association between, and sex-related differences in, happiness, health, and religiosity. A sample (N = 239) of Lebanese adolescents was recruited (111 boys and 128 girls). They responded to the…
Adele Wang, S. Katherine Nelson, Kristin Layous et al. · 2017 · PLoS ONE
Interventions rarely have a universal effect on all individuals. Reasons ranging from participant characteristics, context and fidelity of intervention completion could cause some people to respond more positively than others. Understanding these individual differences in intervention response may provide clues to the mechanisms behind the intervention, as well as inform future designs to make interventions maximally beneficial for all. Here we focus on an intervention designed to improve adolescent wellbeing, and explore potential moderators using a representative and well-powered sample. 16-
Robert A. Comley, Simon Červenka, Sven Pålhagen et al. · 2010 · Journal of Neuroimaging
BACKGROUND: Restless legs syndrome (RLS) is a common neurological disorder the pathophysiology of which is incompletely understood. Four studies have examined structural differences between the brains of RLS patients and healthy controls,…