A Low Glycaemic Index Diet in Pregnancy Induces DNA Methylation Variation in Blood of Newborns: Results from the ROLO Randomised Controlled Trial
Aisling A. Geraghty; Alexandra Sexton‐Oates; Eileen C. O’Brien; Goiuri Alberdi; Peter Fransquet; Richard Saffery; Fionnuala M. McAuliffe · 2018 · Nutrients
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
The epigenetic profile of the developing fetus is sensitive to environmental influence. Maternal diet has been shown to influence DNA methylation patterns in offspring, but research in humans is limited. We investigated the impact of a low glycaemic index dietary intervention during pregnancy on offspring DNA methylation patterns using a genome-wide methylation approach. Sixty neonates were selected from the ROLO (Randomised cOntrol trial of LOw glycaemic index diet to prevent macrosomia) study: 30 neonates from the low glycaemic index intervention arm and 30 from the control, whose mothers re
Abstract by Aisling A. Geraghty; Alexandra Sexton‐Oates; Eileen C. O’Brien; Goiuri Alberdi; Peter Fransquet; Richard Saffery; Fionnuala M. McAuliffe, Nutrients (2018) — licensed CC BY 4.0.
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Metadata source: OpenAlex · DOI 10.3390/nu10040455