Negative / Null Result ReportOpen accessMedicine
Başeğmez M, Eryavuz A, Demirel HH · 2025 · Journal of biochemical and molecular toxicology
This study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were…
View details →DOI: 10.1002/jbt.70324 Negative / Null Result Report
Ehinger BV, Bonasch H · 2023 · Preprint
Abstract 1 Some participants consistently show large, and others small activations in Electroencephalography (EEG) and other neuroimaging studies. Similarly, decoding accuracies in Brain-Computer-Interface (BCI) vary between subjects, in…
View details →DOI: 10.1101/2023.05.21.541632 Negative / Null Result ReportOpen accessMedicine
Scott MB, Kammermeier PJ · 2024 · Pharmaceuticals (Basel, Switzerland)
The gabapentenoids such as gabapentin (GP) and pregabalin are approved for the treatment of chronic pain, but their utility is limited by persistent side effects. These adverse effects result from GPs affecting many types of neurons and…
View details →DOI: 10.3390/ph17091237 Negative / Null Result ReportOpen accessMedicine
Choneva M, Delchev S, Hrischev P et al. · 2024 · International journal of molecular sciences
Diabetic cardiomyopathy is a major etiological factor in heart failure in diabetic patients, characterized by mitochondrial oxidative metabolism dysfunction, myocardial fibrosis, and marked glycogen elevation. The aim of the present study…
View details →DOI: 10.3390/ijms251810027 Negative / Null Result ReportMedicine
Ebrahimi F, Kangari H, Akbarzadeh-Bagheban A et al. · 2025 · International journal of ophthalmology
Aim To evaluate the effects of polarized and non-polarized sunglasses on visual functions, including distance and near visual acuity, phoria, stereopsis and contrast sensitivity across five spatial frequencies (1.5, 3, 6, 12, 18…
View details →DOI: 10.18240/ijo.2025.12.14 Negative / Null Result ReportOpen accessMedicine
Zeng X, Chen Y, Lin S et al. · 2026 · Frontiers in surgery
Purpose This study aimed to investigate the influence of previous percutaneous renal procedures on the outcome of ultrasound (US)-guided percutaneous nephrolithotomy (PCNL) in patients with upper urinary tract stones. Patients and methods…
View details →DOI: 10.3389/fsurg.2026.1721410 Negative / Null Result Report
Lartey NL, Nyarko ENY, Asare-Anane H et al. · 2023 · Preprint
ABSTRACT Background and aim The lack of standardization and scientific validation of the use of most plant extracts leads to toxicity problems. The stem bark extract of Annickia polycarpa has been shown to possess antioxidant,…
View details →DOI: 10.1101/2023.09.14.557718 Negative / Null Result ReportOpen accessMedicine
Kazmi S, Sanford E, Rammaha ZA et al. · 2025 · International journal of molecular sciences
Oral squamous cell carcinoma (OSCC) is marked by profound differences in survival between the localized and disseminated disease, estimated to result in a 70% and less than a 40% five-year survival rate with surgical and/or radiation…
View details →DOI: 10.3390/ijms262110651 Negative / Null Result ReportMedicine
Dicker D, Tamir O, Lieberman-Segal G et al. · 2023 · The Israel Medical Association journal : IMAJ
Background In 2019, 1 mg subcutaneous semaglutide was registered for the treatment of diabetes in Israel. Recognition of its effect on weight has led to its use as a treatment for obesity. Objectives To explore physicians' pre-therapy…
Negative / Null Result ReportMedicine
Goldschmied N, Lambrecht J, Castro A et al. · 2023 · Scandinavian journal of medicine & science in sports
Hockey is a sport known for its violent nature. Specifically, hockey fights have consistently been an integral part of the National Hockey League. Past research has demonstrated that players are likely to be involved in fighting as a…
View details →DOI: 10.1111/sms.14432 Negative / Null Result ReportOpen accessMedicine
Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
View details →DOI: 10.1111/head.70061 Negative / Null Result ReportOpen accessMedicine
Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
View details →DOI: 10.1186/s13014-026-02833-w Negative / Null Result ReportOpen accessMedicine
Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
View details →DOI: 10.1007/s00394-026-03994-w Negative / Null Result ReportOpen accessMedicine
Kreko-Pierce T, Chen L, Qu G et al. · 2026 · Membranes
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex…
View details →DOI: 10.3390/membranes16040115 Negative / Null Result Report
Bracci EL, Barnett AG, Brown C et al. · 2023 · Preprint
Background: Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for Appropriate Care…
View details →DOI: 10.21203/rs.3.rs-3268081/v1 Negative / Null Result ReportOpen accessMedicine
Krittaphol W, Martin LW, Walker GF et al. · 2025 · Pathogens (Basel, Switzerland)
Chronic infections of Pseudomonas aeruginosa are commonly treated with tobramycin. During infections, the bacteria can exist under conditions of oxygen deprivation that render them less susceptible to this antibiotic. The aims of this…
View details →DOI: 10.3390/pathogens14020187 Negative / Null Result ReportOpen accessMedicine
Newman MS, Smeaton J · 2025 · Menopause (New York, N.Y.)
Objectives 3,3'-diindolylmethane (DIM) is a supplement, investigational drug, and the primary in vivo product of indole-3-carbinol. DIM is sometimes recommended to postmenopausal women by functional or integrative medicine providers. Some…
View details →DOI: 10.1097/gme.0000000000002542 Negative / Null Result ReportOpen accessMedicine
Vega-Trejo R, Sanghvi K, Todorova B et al. · 2024 · Scientific reports
Mate availability and social information can influence mating behaviour in both males and females. Social information obtained from conspecifics can influence mate choice, particularly shown by studies on mate choice copying. However, the…
View details →DOI: 10.1038/s41598-024-83465-6 Negative / Null Result ReportOpen accessMedicine
Hemmingsen MG, Zhang GF, Ma Y et al. · 2025 · JCI insight
Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during…
View details →DOI: 10.1172/jci.insight.187758 Negative / Null Result ReportOpen accessMedicine
Rolig AS, Ziglari T, McGee GH et al. · 2026 · Scientific reports
The tumor microenvironment (TME), which heavily influences immune checkpoint blockade (ICB) efficacy, is shaped by host-microbe interactions. Endogenous intratumoral bacteria have been implicated in efficacy of ICB, such as anti-PD-1…
View details →DOI: 10.1038/s41598-026-39758-z Negative / Null Result ReportOpen accessMedicine
Hauber MM, Nordahl O, Todisco V et al. · 2026 · PloS one
Many coregonine species have declined drastically across the Northern Hemisphere, including populations of Coregonus maraena (whitefish) in the Baltic Sea, and the mechanisms leading to these declines are not well investigated. An abrupt…
View details →DOI: 10.1371/journal.pone.0344576 Negative / Null Result ReportOpen accessMedicine
Marquis-Gravel G, Tong G, Dodd M et al. · 2025 · Journal of the Society for Cardiovascular Angiography & Interventions
Background Coronary artery bypass grafting (CABG) improves survival compared with optimal medical therapy (OMT) alone in patients with ischemic left ventricular systolic dysfunction (iLVSD), but percutaneous coronary intervention (PCI) did…
View details →DOI: 10.1016/j.jscai.2025.103820 Negative / Null Result ReportOpen accessMedicine
Shahid N, Kim CH, Jabilona KB et al. · 2026 · PloS one
Tyrosine kinase inhibitors (TKI) are often used in combination with other chemotherapeutic nucleoside/nucleobase analogues, such as gemcitabine and 6-mercaptopurine, in the treatment of various cancers. Past studies have shown that several…
View details →DOI: 10.1371/journal.pone.0348426 Negative / Null Result ReportOpen accessMedicine
Lubineau M, Watkins CP, Glasel H et al. · 2023 · Proceedings. Biological sciences
Does word flickering facilitate reading? Despite a lack of scientific evidence, flickering glasses and lamps for dyslexia are being marketed in various countries. We conducted four experiments to assess their efficacy. Two experiments…
View details →DOI: 10.1098/rspb.2023.1665 Negative / Null Result ReportOpen accessMedicine
Salerno JW, Xu S, Rainforth M et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Cardiovascular disease (CVD) is the leading cause of death globally. The World Health Organization has called for investigations into traditional systems of medicine for CVD prevention. Ayurveda includes a…
View details →DOI: 10.3390/medicina62050972 Negative / Null Result ReportMedicine
Stark R, Zigman JM, Andrews ZB · 2025 · Journal of neuroendocrinology
The olfactory bulb (OB) is an emerging neuroendocrine centre regulating appetite, metabolism, and behaviours such as those linked to anxiety, motivation and spatial navigation. These processes are likely mediated by one or more of the many…
View details →DOI: 10.1111/jne.70096 Negative / Null Result ReportOpen accessMedicine
Liu S, Hu S, Chen J et al. · 2025 · Psychological research
Previous research has shown that the addition of happy or angry expressions to other-race faces can assist infants in overcoming the perceptual narrowing of face race and reinstating their recognition of other-race faces. In the present…
View details →DOI: 10.1007/s00426-025-02098-0 Abandoned HypothesisOpen accessMedicine
Yata S, Takatani Y, Sato Y et al. · 2025 · Cureus
Sodium zirconium cyclosilicate (SZC) is a novel potassium-binding agent used to treat hyperkalemia. Although SZC is generally considered safe, its efficacy and safety in critically ill patients remain unclear. We report a novel adverse…
View details →DOI: 10.7759/cureus.93726 Negative / Null Result ReportOpen accessMedicine
Draper B, Wand APF · 2025 · Current opinion in psychiatry
Purpose of review Depression and physical illnesses have long been recognized as risk factors for suicidal behaviour in late life. Qualitative studies have previously identified frailty as being an issue in late life suicidal behaviour,…
View details →DOI: 10.1097/yco.0000000000001009 Failed Experiment ReportOpen accessMedicine
McCloskey NS, Li C, Kirby LG · 2025 · Psychopharmacology
Rationale Our laboratory has demonstrated that stressors regulate the 5-HT system with consequences in behavioral models of psychiatric disorders including addiction. We have employed behavioral pharmacology methods to show that stressors…
View details →DOI: 10.1007/s00213-025-06947-z 