Negative / Null Result ReportMedicine
Zhang J, Pan Q, Jin L et al. · 2026 · The British journal of ophthalmology
Aims To investigate the effect of switching to a different type of myopia control spectacles on myopia progression. Methods This retrospective matched-cohort study involved 1012 children or adolescents who were prescribed myopia control…
View details →DOI: 10.1136/bjo-2025-329403 Negative / Null Result ReportOpen accessMedicine
Nagai T, Kuwaki A, Kodama K · 2026 · Nanoscale advances
Developing oxygen reduction reaction (ORR) catalysts with both high catalytic activity and durability is essential for the commercialization of polymer electrolyte fuel cells (PEFCs). One promising strategy to simultaneously enhance the…
View details →DOI: 10.1039/d5na01009h Negative / Null Result ReportMedicine
Gažarová M, Lenártová P, Kopčeková J et al. · 2026 · Nutrients
Background/Objectives: The aim of the study was to assess the metabolic response of women to a six-week consumption of full-fat sheep milk yogurt, with a focus on cardiovascular risk markers, lipid profile, and subfractions of low-density…
View details →DOI: 10.3390/nu18121933 Negative / Null Result Report
Majewska A, J NW, Chambers J et al. · 2026 · Preprint
Abstract Objective: To evaluate the association between metformin treatment in gestational diabetes mellitus and severity of intrahepatic cholestasis of pregnancy (ICP). Design: Retrospective multicentre cohort study. Setting: Six…
View details →DOI: 10.22541/authorea.15003138/v1 Negative / Null Result Report
Starowicz M, Domínguez-Soberanes J, Garcia-Gutierrez E et al. · 2026 · Preprint
Bread is an important source of energy and is ubiquitous in human diets. As a carbohydrate-rich food, it is often considered to impair glycaemic homeostasis; however, clinical and molecular evidence suggests that its effects may vary…
View details →DOI: 10.20944/preprints202606.0657.v1 Failed Experiment ReportMedicine
Guinard P, Pécaut J, Le-Goff A et al. · 2026 · Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
In order to mitigate superoxide-induced damage, cells rely on superoxide dismutases (SODs), a family of metalloenzymes that catalyze the dismutation of superoxide. These enzymes display a positively-charged substrate entrance channel for…
View details →DOI: 10.1007/s00775-026-02150-3 Negative / Null Result ReportMedicine
Vogel MJ, Hacker K, Herting J et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Electrical cardioversion (ECV) is an effective treatment for restoring sinus rhythm in supraventricular tachycardias such as atrial fibrillation (AFib) and atrial flutter (AFlu). In clinical practice, serum potassium is often…
View details →DOI: 10.1007/s00392-026-02944-0 Negative / Null Result ReportOpen accessMedicine
Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology
Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…
View details →DOI: 10.1002/jper.24-0847 Negative / Null Result ReportMedicine
Abapolnikova M, Coyne AE, Glushka L et al. · 2026 · Psychotherapy research : journal of the Society for Psychotherapy Research
Objective Although interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT) for depression are comparably efficacious, less is known about the respective patient-level processes that help transmit their beneficial effect.…
View details →DOI: 10.1080/10503307.2026.2656698 Negative / Null Result ReportMedicine
Ersoy O, Kizilay G · 2026 · Biotechnic & histochemistry : official publication of the Biological Stain Commission
Clinical and experimental studies have shown that sitagliptin regulates blood glucose levels. This study was designed because it is thought that sitagliptin may reduce diabetes-induced apoptosis in testes by affecting blood glucose levels…
View details →DOI: 10.1080/10520295.2025.2583963 Negative / Null Result ReportOpen accessMedicine
Sosnówka-Czajka E, Skomorucha I, Wojtysiak D et al. · 2026 · Animals : an open access journal from MDPI
The growing greenhouse gas emissions from agricultural production are increasing the pressure on poultry producers to use practices that reduce the environmental impact of farms, mainly by reducing ammonia emissions. The study evaluated…
View details →DOI: 10.3390/ani16060911 Negative / Null Result ReportOpen accessMedicine
Adeva-Andany MM · 2025 · World journal of nephrology
Sodium-glucose cotransporter-2 (SGLT2) inhibitors suppress glucose reabsorption in the kidney proximal tubule through the SGLT2 protein, leading to glucosuria and osmotic diuresis. Randomized placebo-controlled clinical trials show that…
View details →DOI: 10.5527/wjn.v14.i4.110990 Negative / Null Result ReportMedicine
Chommaux T, Renault PO, Godard P et al. · 2026 · ACS applied materials & interfaces
The electrical and mechanical behaviors of 400 nm thick indium tin oxide (ITO) thin films on polyimide substrates were investigated by means of electrical resistivity and synchrotron X-ray diffraction (XRD) measurements during equibiaxial…
View details →DOI: 10.1021/acsami.5c21501 Negative / Null Result ReportMedicine
Vaidie J, Demiselle J, Gabriel A et al. · 2025 · Intensive care medicine
Purpose Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of…
View details →DOI: 10.1007/s00134-025-08024-7 Negative / Null Result ReportMedicine
Gröning M, Smerup MH, Nissen H et al. · 2026 · Pediatric cardiology
To assess temporal changes in the timing of pulmonary valve replacement (PVR) among patients with tetralogy of Fallot and to determine whether temporal shifts toward earlier PVR were accompanied by differences in ventricular volumes,…
View details →DOI: 10.1007/s00246-026-04294-0 Negative / Null Result ReportMedicine
Pascoe B, Cocks K, Clarke N et al. · 2026 · Schizophrenia research
Cognitive impairment associated with schizophrenia (CIAS) is a fundamental symptom of the disorder, which significantly affects individuals' daily functioning and overall quality of life. Currently available antipsychotic drugs have little…
View details →DOI: 10.1016/j.schres.2026.03.028 Negative / Null Result ReportMedicine
Thimmesch M, Cheping Simo C, Boulay M et al. · 2026 · Revue medicale de Liege
Cystic fibrosis, the most common genetic disorder in Caucasian populations, is caused by mutations in the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator), which disrupts chloride ion transport and leads to the production of…
Negative / Null Result ReportMedicine
Kloura C, Jensen MM, Ekblond TS et al. · 2026 · Diabetes research and clinical practice
Aim The aim of this exploratory analysis was to investigate effects of time-restricted eating (TRE) on glycemic control and variability in adults with prediabetes. Methods This study utilized data from the Restricted Eating Time (RESET)…
View details →DOI: 10.1016/j.diabres.2026.113276 Negative / Null Result ReportOpen accessMedicine
Mommers I, Mubarik S, van Boven JFM et al. · 2025 · BMJ open respiratory research
Background Antibiotics are widely used to manage acute asthma exacerbations, despite little evidence for their effectiveness. This study assesses the added value of antibiotics alongside oral corticosteroids (OCSs) in treating asthma…
View details →DOI: 10.1136/bmjresp-2025-003506 Negative / Null Result Report
Lee BJ, Kim R · 2026 · Preprint
Background: There is a growing interest in the effects of coffee consumption on the human health. This study was conducted to identify a causal relationship between the coffee consumption and the risk of metabolic syndrome (MetS). Methods:…
View details →DOI: 10.20944/preprints202601.0373.v1 Negative / Null Result ReportMedicine
Toraño P, Balmaseda A, Bordons A et al. · 2025 · Food Microbiology.
Oenococcus oeni is the main species of lactic acid bacteria (LAB) responsible for malolactic fermentation (MLF) in winemaking. MLF development can present difficulties because of the harsh, stressful conditions of wine. Yeast mannoproteins…
Negative / Null Result ReportMedicine
Holzhauer CG, Bickar L · 2026 · Alcohol, clinical & experimental research
Background The associations of stress and negative emotion with alcohol use are well established. These associations are mediated by cognitive and psychological mechanisms that may be sex-dependent. This pilot study examined sex…
View details →DOI: 10.1111/acer.70268 Negative / Null Result ReportMedicine
Kobayashi Y, Hosoda C, Kohda M et al. · 2026 · Journal of ethology
Parental care has a direct and beneficial effect on parental fitness. An important question regarding the evolution of parental care is why parental roles and the amount of care invested are characterized by sexual bias. In species that…
Negative / Null Result ReportMedicine
Bourgeois J, Domange C, Celie B · 2026 · International journal of environmental research and public health
Sleep is a fundamental aspect of physiological and psychological functioning, and the beneficial effect of exercise on sleep quality and quantity, depending on training modality, remains underexplored. This study compared the effects of…
View details →DOI: 10.3390/ijerph23020202 Replication Failure
Lan T, Ming J, Liu J et al. · 2026 · Preprint
Objective: Evidence on the stress–fecundability relationship is mixed, and both the population heterogeneity and the effects of moderate stress remain understudied. We aimed to investigate the association of stress with fecundability in…
View details →DOI: 10.22541/au.177095736.68250416/v1 Failed Experiment ReportOpen accessMedicine
Okon-Rocha E, Taylor D · 2026 · Therapeutic advances in psychopharmacology
Cariprazine is effective in a number of conditions and has shown efficacy in the treatment of negative symptoms. Data on its use as an adjunct to other antipsychotics is growing. To evaluate the effectiveness of add-on cariprazine in…
View details →DOI: 10.1177/20451253261456389 Negative / Null Result ReportMedicine
Kolli RD, Kasireddy B, Iuspa MA et al. · 2026 · British poultry science
1. This 42 d study further examined the physiological mechanisms underlying responses to a precision biotic (PB) on growth performance and ileal amino acid digestibility. It focussed on fermentation profile, caecal soluble protein levels,…
View details →DOI: 10.1080/00071668.2026.2630726 Negative / Null Result ReportOpen accessMedicine
Fransisca S, Sitepu BRE, Delfi · 2026 · Frontiers in medicine
Background Visual disturbances are a common and often debilitating complication following stroke, significantly impairing patients' functional independence and quality of life. Among various neuroprotective agents, Citicoline…
View details →DOI: 10.3389/fmed.2026.1769632 Negative / Null Result ReportMedicine
Omae K, Luo Y, Sahker E et al. · 2026 · World journal of urology
PURPOSE: The smallest worthwhile difference (SWD) represents the minimal beneficial effect of an intervention that patients consider valuable when weighed against its burdens, including potential harms, costs, and inconveniences. We aimed…
View details →DOI: 10.1007/s00345-026-06274-8 Negative / Null Result ReportMedicine
Zhiping N, Yuanyuan Y, Qichun Z et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
With the acceleration of China's aging society, how to enhance the subjective well-being of older adults has become a core issue of concern. This study aims to explore the influence mechanisms of socioeconomic status, health, recreation,…
View details →DOI: 10.1177/07334648251409958 