A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
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Williamson, Hill, Eisenhofer et al. · 2026 · FEMS microbiology letters
The eusocial honey bee is a model for insect microbiome research, with socially transmitted gut communities that play key roles in health and development. In contrast, solitary bees lack social transmission pathways and often have an…
Schmidt, Brühl, Möllers et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia
Sufficient sleep is essential for maintaining both physical and mental health, yet data on sleep health among persons with haemophilia (PwH) remain limited. This study aimed to assess sleep in PwH compared to healthy controls (Con) and…
Vrinzen, Stadhouders, Bloemendal et al. · 2026 · BMJ open
Concentration of care and collaborations between hospitals increasingly reorganise oncological care into Comprehensive Cancer Networks (CCNs), aiming to improve care outcomes and reduce costs. This study aims to evaluate the effect of four…
Pellerito, Dowling, Luke et al. · 2026 · Thrombosis research
Post thrombotic syndrome is a fibrotic disease related to inflammation resolution. There are no direct therapies that can ameliorate this disease. Monocyte/macrophages (Mo/MØ) are the primary leukocyte involved with later venous…
Bregen, de Buhr, Strutzberg-Minder et al. · 2026 · Veterinary sciences
The reasons for disease outbreaks caused by Actinobacillus pleuropneumoniae (APP) in vaccinated pigs are often unknown and remain a challenge for farmers and veterinarians. One hypothesis for APP vaccine failure is the timing of APP…
Wang, Ouyang, Chen et al. · 2026 · Scientific reports
This study aims to explore the impact of wearing Defocus Incorporated Multiple Segments (DIMS) spectacle lenses on astigmatism in myopic children. This study included 396 myopic children and divided the participants into two groups:the…
Ma, Qiu, Liu · 2025 · Frontiers in nutrition
Acute-on-chronic liver failure (ACLF) patients face high risks of nutritional risk and clinical complications, but whether adjuvant nutritional support reduces adverse complications remains unclear. This study included 6,097 hospitalized…
Kır · 2026 · PeerJ
This research compares the yield and quality of barley ( Hordeum vulgare ), rye ( Secale cereale ), triticale (× Triticosecale Wittmack ), and wheat ( Triticum aestivum ) grown in dry conditions in winter and widely used in producing…
Cheng, Wang, Liu et al. · 2026 · PloS one
There has been ongoing debate over whether people are intuitively honest or intuitively dishonest. A recent social harm account was proposed to address this debate: dishonesty is intuitive when cheating inflicts harm on an abstract other…
Li, Wang, Shen et al. · 2026 · International journal of cancer
Gastric carcinoma (GC) with neuroendocrine differentiation (GCNED) is a rare and particular pathological subtype. The survival outcomes and prognosis of patients with GCNED are currently unclear. We conducted a retrospective cohort study…
Pires Marafon, Reuter, Isola et al. · 2026 · Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
The legal shelf life of platelet concentrates (PCs) has been extended from 5 to 7 days in France since 2018. Our study aimed to determine whether this increase in PC storage time has produced a significant impact on…
Akkaya, Kosar · 2026 · Journal of endodontics
To investigate the influence of different types of intracanal medicaments and root canal sealers on root dentine fracture resistance at different time intervals. A total of 180 single-rooted human mandibular premolars were used. Samples…
Liu, Zhang, Yuan et al. · 2026 · Chemical science
Hexafluoropropylene oxide-dimer acid (HFPO-DA) is widely used in food packaging bags, surfactants, lubricants, etc. As a new substitute for the persistent organic pollutant perfluorooctanoic acid (PFOA), it has been proven to have…
Zhuang, Liu, Jia et al. · 2026 · Cardiovascular diabetology
Carotid plaques result from a blockage or narrowing of carotid arteries associated with severe atherosclerotic cardiovascular diseases. We aimed to assess the effect of marine n-3 fatty acid supplementation on carotid plaques among…
Aman, Gencer, Sağlam et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : This study was conducted to investigate the effects of fragment size on clinical and radiological outcomes and the development of complications during the surgical treatment of pediatric lateral condyle…
Chausheva, Shefket, Bocheva et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Individuals with long-standing type 1 diabetes (T1D) remain at elevated cardiovascular risk (CVR). Adiponectin (ADNC) and leptin (LEP) are adipokines involved in metabolic and vascular homeostasis, yet their…
Akler, Gelman, Radomislensky et al. · 2026 · The Israel Medical Association journal : IMAJ
Age is a well-established prognostic factor in civilian trauma, where adverse outcomes increase with ages. Whether this pattern holds true in military trauma, where populations, injury mechanisms, and systems of care differ fundamentally,…
Albayrak · 2026 · Revista da Associacao Medica Brasileira (1992)
Systemic inflammation is closely associated with acute exacerbations of chronic obstructive pulmonary disease and may reflect the risk of future exacerbations. Blood-based inflammatory biomarkers represent simple and practical tools for…
Xiao, Wei, Zhang et al. · 2026 · Journal of visualized experiments : JoVE
Hip fracture is a common and serious condition in elderly individuals, often associated with altered TNF-α signaling. However, few studies have explored whether changes in TNF pathway biomarkers contribute to the risk of hip…
Yoonhee Shin, Bohyun Park, Nam-eun Kim et al. · 2022 · Journal of Preventive Medicine and Public Health
Objectives The aim of this study was to evaluate the subjective level of health-related quality of life of Korean healthcare workers using various quality-of-life instruments. Methods This study included 992 participants, who were doctors and nurses. A survey was conducted between November 28 and December 4, 2019. Data from 954 participants divided into 3 groups (physicians, residents, and nurses) were analyzed. Four measurement tools (29 questions) were used in the survey to evaluate subjective health status and well-being. Results In the Mayo Well-being Index, burnout during work (88.5%) and
Yan-Tao Ma, Yu-Lin Dong, Bo Wang et al. · 2023 · BMC Musculoskeletal Disorders
Abstract Background Latent and active myofascial trigger points (MTrPs) in knee-associated muscles may play a key role in pain management among patients with knee osteoarthritis (KOA). The aim of this study was to investigate the effect of dry needling treatment on pain intensity, disability, and range of motion (ROM) in patients with KOA. Methods This randomized, single-blinded, clinical trial was carried out for 6 weeks of treatment and 6-month follow-up. A total of 98 patients met the entry criteria and were randomly assigned to the dry needling latent and active myofascial trigger point (M
Juan Duchesne, David McGreevy, Kristofer Nilsson et al. · 2020 · Journal of Endovascular Resuscitation and Trauma Management
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is becoming a standardized adjunct in the management of non-compressible hemorrhage. Ultrasound (US)-guided femoral access has been taught as the best practice for femoral artery cannulation. However, there is a lack of evidence to support its use in patients in extremis with severe hemorrhage. We hypothesize that no differences in outcome will exist between US-guided and to blind percutaneous or cutdown access methods. Methods: This was an international, multicenter retrospective review of all patients managed with
Jiaxing Xin, Ying Cui, Jun Yang et al. · 2025 · IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The intensification of the urban heat island (UHI) effect poses a serious threat to public health, particularly in cities. Effectively mitigating UHI has been a focus of national and international academic research over the last decades. However, most contemporary research has focused on land use mitigation measures within urban areas, with less emphasis on suburban land use. To address this research gap and explore spatial characteristics, we analyzed the driving mechanism of suburban land use patterns on UHI intensity (UHII) within the main urban area of Shenyang City based on high spatial r
Bilan Yang, Xiaoli Xi, Hongsheng Yu et al. · 2024 · Cancer Reports
Abstract Background The optimal treatment strategy for early‐stage hepatocellular carcinoma (HCC) remains controversial, specifically in regard to surgical resection (SR) and ablation. The aim of this study was to investigate the impact of SR and ablation on recurrence and prognosis in early‐stage HCC patients, to optimize treatment strategies and improve long‐term survival. Methods A retrospective analysis was conducted on 801 patients diagnosed with Barcelona Clinic Liver Cancer (BCLC) stage 0/A HCC and treated with SR or ablation between January 2015 and December 2019. The effectiveness and
Wade J. Chalker, Anthony J. Shield, David A. Opar et al. · 2018 · PeerJ
Background Hamstring strain injuries (HSI) are one of the most prevalent and serious injuries affecting athletes, particularly those in team ball sports or track and field. Recent evidence demonstrates that eccentric knee flexor weakness and between limb asymmetries are possible risk factors for HSIs. While eccentric hamstring resistance training, e.g. the Nordic hamstring exercise (NHE) significantly increases eccentric hamstring strength and reduces HSI risk, little research has examined whether between limb asymmetries can be reduced with training. As augmented feedback (AF) can produce sig
Wei-Kai Chuang, Skye Hung-Chun Cheng, Chen-Fang Hung et al. · 2022 · Journal of the Formosan Medical Association
Background/purpose: This study aimed to analyze the long-term outcomes of hypofractionated whole-breast irradiation (WBI) (HF-WBI) compared with those of conventionally fractionated WBI (CF-WBI) for early breast cancer treated with breast-conservation surgery (BCS) and adjuvant WBI in Taiwan. Methods: This study included patients treated at our institution between 2012 and 2016. All patients with early breast cancer received BCS (pT1–2, pN0, M0) and adjuvant WBI through one of two treatment schemes. Propensity score matching analysis was conducted to create comparable cohorts. The major result
Hao WANG, Zhitao GU, Jianyong DING et al. · 2016 · Chinese Journal of Lung Cancer
Background and objective Video-assisted thoracoscopic surgery (VATS) theoretically offers advantages over open thymectomy for clinically early-stage (Masaoka-Koga stage I and II) thymic malignancies. However, longterm outcomes have not been well studied. We compared the postoperative outcomes and survival from a cohort study based on the database of the Chinese Alliance for Research in Thymomas (ChART). Methods Between 1994 and 2012, data of 1,117 patients having surgery for clinically early-stage (Masaoka-Koga stage I and II) tumors were enrolled for the study. Among them, 241 cases underwent
Flávio Kapczinski, Jair Mari, Luiz Henrique Junqueira Dieckmann et al. · 2024 · BMJ Open
Objective This study aims to conduct an overview on the comparative efficacy of valproate in acute mania, bipolar depression and maintenance treatment of bipolar disorder (BD).Method We performed an overview of systematic reviews with meta-analyses of randomised controlled trials (RCTs), registered in PROSPERO (CRD42024497749). We searched Medline and Cochrane Database of Systematic Reviews. Summary measures comparing valproate with placebo or other active drugs were described.Results We included 26 systematic reviews. For acute mania (31 RCTs, n=4376), valproate showed a significantly better
Zahra Ojaghi-Haghighi, Atoosa Mostafavi, Hassan Moladoust et al. · 2015 · Journal of Tehran University Heart Center
Background: Left ventricular (LV) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of LV function. We sought to assess the impact of chronic pure mitral regurgitation (MR) on the torsional mechanics of the left human ventricle using tissue Doppler imaging. Methods: Nineteen severe MR patients with a normal LV ejection fraction and 16 non-MR controls underwent conventional echocardiography and apical and basal short-axis color Doppler myocardial imaging (CDMI). LV rotation at the apical and basal short-axis levels was calculated from the
Mohamed Nasr, Moustafa AH El-Nawasany, Haytham E Ali et al. · 2025 · JPRAS Open
Background: Diabetic foot ulcers (DFUs) are a serious complication of diabetes that can lead to significant morbidity. Autologous platelet-rich plasma (PRP), rich in growth factors and cytokines, has emerged as a promising treatment to enhance ulcer healing. This study aimed to compare the clinical and histological efficacy of injected PRP versus topically applied PRP and traditional wound care in the management of DFUs. Methods: Sixty patients with DFUs were randomly assigned to three equal groups (n = 20 each). Group A received locally injected autologous PRP; Group B received topically appl