Short NoteMedicine
Narimichi, Komaki, Suzuki et al. · 2026 · Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Solar UV comprises UVA and UVB; each exerts distinct biological effects, while their combined impact is not yet fully understood. We previously reported that human keratinocytes exposed to UVA1 followed by UVB irradiation exhibited severe…
View details →DOI: 10.1007/s43630-026-00874-4 Negative / Null Result ReportMedicine
Timothee, Bliss, Blumenthal et al. · 2026 · Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
The primary objective is to determine whether patients undergoing osseous microvascular free flap reconstruction of head and neck defects have higher inpatient pain requirements than those undergoing nonosseous reconstruction. Secondary…
View details →DOI: 10.1002/ohn.70200 Negative / Null Result ReportMedicine
Kacar, Ayaz-Alkaya · 2026 · Journal of pediatric nursing
Internet addiction is a growing problem among children and adolescents. Pathological internet use may lead to psychological and social issues. More effective and innovative interventions are needed to promote the mental health of children.…
View details →DOI: 10.1016/j.pedn.2026.02.035 Negative / Null Result ReportMedicine
Lopes, Costa, Nociti Junior et al. · 2026 · Brazilian oral research
This study investigated the effects of incorporating 3wt% titanium dioxide nanotubes (nTiO2) into calcium hydroxide [Ca(OH)2]-based intracanal medicament (ICM) formulations on the proliferation, viability, and mitochondrial metabolic…
View details →DOI: 10.1590/1807-3107bor-2026.vol40.002 Negative / Null Result ReportMedicine
Linke, Mayer, Suttkus et al. · 2026 · Pediatric research
This study examined parental stress indicators during outpatient pediatric surgery and whether intraoperative text messaging could alleviate stress. This randomized trial assigned parents of children aged 6 months to 6 years undergoing…
View details →DOI: 10.1038/s41390-026-04816-9 Negative / Null Result ReportMedicine
Melnikova · 2025 · Bulletin of experimental biology and medicine
Using in vivo microscopy, changes in the diameter of pial arterial microvessels were studied in rats with modeled moderate acute blood loss followed by whole-body cooling against the background of a single administration of tranexamic acid…
View details →DOI: 10.1007/s10517-026-06603-2 Negative / Null Result ReportMedicine
Nazki, Tennakoon, Reddy et al. · 2026 · The Journal of general virology
Infectious bursal disease virus (IBDV) causes an endemic immunosuppressive disease in chickens. Prior exposure to IBDV influences the pathogenesis and shedding of chicken strains of influenza A virus (IAV), but its effect on waterfowl…
View details →DOI: 10.1099/jgv.0.002235 Negative / Null Result ReportMedicine
Tuncekin, Toprak · 2026 · Iranian journal of immunology : IJI
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are chronic autoimmune inflammatory disorders in which TNF-α plays a key role. Anti-TNF agents are widely used in the management of these diseases. Since TNF-α is also…
View details →DOI: 10.22034/iji.2026.107743.3081 Negative / Null Result ReportMedicine
Xu, Hu, Zhao et al. · 2026 · Obesity (Silver Spring, Md.)
HDM1002, a small-molecule agonist of glucagon-like peptide-1 receptors, was evaluated for safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD). Chinese participants (18-60 years) with…
View details →DOI: 10.1002/oby.70160 Negative / Null Result ReportMedicine
Expósito-Díaz, Medina, Moral · 2026 · Environmental microbiology reports
Olive anthracnose, the most critical disease affecting fruit and oil quality, is caused by Colletotrichum species, with C. godetiae dominant in Italian and Spanish orchards. Climate change could exacerbate its impact, particularly through…
View details →DOI: 10.1111/1758-2229.70276 Failed Experiment ReportMedicine
Balcerac, Cuzzubbo, Bompaire et al. · 2026 · Revue neurologique
Since 2005, the standard treatment for newly diagnosed glioblastoma involves radiotherapy combined with concomitant and adjuvant temozolomide (TMZ), as per the Stupp protocol. A known long-term complication of radiotherapy is…
View details →DOI: 10.1016/j.neurol.2026.01.005 Abandoned HypothesisMedicine
Shakil, Pollestad, Kyaw et al. · 2026 · Journal of environmental management
With European Union initiatives mandating gender quotas on corporate boards, a key question arises: Is greater board gender diversity (BGD) associated with better emissions performance (EP)? To answer this question, we examine the…
View details →DOI: 10.1016/j.jenvman.2026.128776 Negative / Null Result ReportMedicine
Pujol, Minguell, Pijoan et al. · 2025 · Journal of orthopaedics
To determine if maintaining the preoperative CPAK class influences on clinical outcomes when performing a functional aligned robotic assisted TKA (RATKA). This prospective cohort study compared patients who maintained their preoperative…
View details →DOI: 10.1016/j.jor.2025.06.030 Negative / Null Result ReportMedicine
Zhou, Lu, Wang et al. · 2026 · PeerJ
The clinical impact of sperm chromatin condensation defects (SCCD) on in vitro fertilization (IVF) outcomes remains controversial. This study aimed to clarify the effects of SCCD on embryonic development, pregnancy, and neonatal outcomes…
View details →DOI: 10.7717/peerj.20749 Negative / Null Result ReportMedicine
Ergün, Bayraktar Nahir · 2026 · Odontology
Pit and fissure sealants (PFS) are effective in preventing occlusal caries. This randomized split-mouth clinical study aimed to compare the 18-month clinical performance of the bioactive resin-based PFS (BioCoat™) with a…
View details →DOI: 10.1007/s10266-026-01332-4 Negative / Null Result ReportMedicine
Fan, Luo, Zheng et al. · 2026 · Physiology & behavior
The circadian clock genes Per1 and Per2 play a crucial role in regulating circadian rhythms. However, the consequences of their deficiency on motor function and age-related behavioral changes remain poorly understood. This study aimed to…
View details →DOI: 10.1016/j.physbeh.2026.115245 Replication FailureMedicine
Tsoi, Zhu, Wong et al. · 2026 · Health education research
Glaucoma is a chronic eye disease that requires consistent and timely eye drop medication management. However, suboptimal treatment outcomes of glaucoma patients were attributed to poor medication compliance. To address this problem, the…
View details →DOI: 10.1093/her/cyaf051 Negative / Null Result ReportMedicine
Fojcik, Górski, Szulik et al. · 2025 · Frontiers in psychiatry
The aim of this study was to determine the risk of suicidal behavior in patients who were involuntarily hospitalized in forensic psychiatry departments, taking into account demographic variables such as age, level of education and length…
View details →DOI: 10.3389/fpsyt.2025.1752028 Short NoteMedicine
Williamson, Hill, Eisenhofer et al. · 2026 · FEMS microbiology letters
The eusocial honey bee is a model for insect microbiome research, with socially transmitted gut communities that play key roles in health and development. In contrast, solitary bees lack social transmission pathways and often have an…
View details →DOI: 10.1093/femsle/fnag012 Negative / Null Result ReportMedicine
Schmidt, Brühl, Möllers et al. · 2026 · Haemophilia : the official journal of the World Federation of Hemophilia
Sufficient sleep is essential for maintaining both physical and mental health, yet data on sleep health among persons with haemophilia (PwH) remain limited. This study aimed to assess sleep in PwH compared to healthy controls (Con) and…
View details →DOI: 10.1111/hae.70217 Abandoned HypothesisMedicine
Zhuang, Liu, Jia et al. · 2026 · Cardiovascular diabetology
Carotid plaques result from a blockage or narrowing of carotid arteries associated with severe atherosclerotic cardiovascular diseases. We aimed to assess the effect of marine n-3 fatty acid supplementation on carotid plaques among…
View details →DOI: 10.1186/s12933-026-03082-7 Negative / Null Result ReportMedicine
Aman, Gencer, Sağlam et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : This study was conducted to investigate the effects of fragment size on clinical and radiological outcomes and the development of complications during the surgical treatment of pediatric lateral condyle…
View details →DOI: 10.3390/medicina62061123 Negative / Null Result ReportMedicine
Chausheva, Shefket, Bocheva et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives : Individuals with long-standing type 1 diabetes (T1D) remain at elevated cardiovascular risk (CVR). Adiponectin (ADNC) and leptin (LEP) are adipokines involved in metabolic and vascular homeostasis, yet their…
View details →DOI: 10.3390/medicina62061037 Negative / Null Result ReportMedicine
Akler, Gelman, Radomislensky et al. · 2026 · The Israel Medical Association journal : IMAJ
Age is a well-established prognostic factor in civilian trauma, where adverse outcomes increase with ages. Whether this pattern holds true in military trauma, where populations, injury mechanisms, and systems of care differ fundamentally,…
Negative / Null Result ReportMedicine
Albayrak · 2026 · Revista da Associacao Medica Brasileira (1992)
Systemic inflammation is closely associated with acute exacerbations of chronic obstructive pulmonary disease and may reflect the risk of future exacerbations. Blood-based inflammatory biomarkers represent simple and practical tools for…
View details →DOI: 10.1590/1806-9282.20251626 Replication FailureMedicine
Xiao, Wei, Zhang et al. · 2026 · Journal of visualized experiments : JoVE
Hip fracture is a common and serious condition in elderly individuals, often associated with altered TNF-α signaling. However, few studies have explored whether changes in TNF pathway biomarkers contribute to the risk of hip…
View details →DOI: 10.3791/70376 Negative / Null Result ReportOpen accessMedicine
Yoonhee Shin, Bohyun Park, Nam-eun Kim et al. · 2022 · Journal of Preventive Medicine and Public Health
Objectives The aim of this study was to evaluate the subjective level of health-related quality of life of Korean healthcare workers using various quality-of-life instruments. Methods This study included 992 participants, who were doctors and nurses. A survey was conducted between November 28 and December 4, 2019. Data from 954 participants divided into 3 groups (physicians, residents, and nurses) were analyzed. Four measurement tools (29 questions) were used in the survey to evaluate subjective health status and well-being. Results In the Mayo Well-being Index, burnout during work (88.5%) and
View details →DOI: 10.3961/jpmph.22.114 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Yan-Tao Ma, Yu-Lin Dong, Bo Wang et al. · 2023 · BMC Musculoskeletal Disorders
Abstract Background Latent and active myofascial trigger points (MTrPs) in knee-associated muscles may play a key role in pain management among patients with knee osteoarthritis (KOA). The aim of this study was to investigate the effect of dry needling treatment on pain intensity, disability, and range of motion (ROM) in patients with KOA. Methods This randomized, single-blinded, clinical trial was carried out for 6 weeks of treatment and 6-month follow-up. A total of 98 patients met the entry criteria and were randomly assigned to the dry needling latent and active myofascial trigger point (M
View details →DOI: 10.1186/s12891-022-06116-9 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Juan Duchesne, David McGreevy, Kristofer Nilsson et al. · 2020 · Journal of Endovascular Resuscitation and Trauma Management
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is becoming a standardized adjunct in the management of non-compressible hemorrhage. Ultrasound (US)-guided femoral access has been taught as the best practice for femoral artery cannulation. However, there is a lack of evidence to support its use in patients in extremis with severe hemorrhage. We hypothesize that no differences in outcome will exist between US-guided and to blind percutaneous or cutdown access methods. Methods: This was an international, multicenter retrospective review of all patients managed with
View details →DOI: 10.26676/jevtm.v4i2.139 Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Zahra Ojaghi-Haghighi, Atoosa Mostafavi, Hassan Moladoust et al. · 2015 · Journal of Tehran University Heart Center
Background: Left ventricular (LV) twist is due to oppositely directed apical and basal rotation and has been proposed as a sensitive marker of LV function. We sought to assess the impact of chronic pure mitral regurgitation (MR) on the torsional mechanics of the left human ventricle using tissue Doppler imaging. Methods: Nineteen severe MR patients with a normal LV ejection fraction and 16 non-MR controls underwent conventional echocardiography and apical and basal short-axis color Doppler myocardial imaging (CDMI). LV rotation at the apical and basal short-axis levels was calculated from the
