Negative / Null Result ReportMedicine
Shah S, Kaul A, Pandey P et al. · 2026 · Indian pediatrics
Objectives To evaluate the efficacy of oral Lactobacillus rhamnosus GG (LGG) in reducing neonatal enterocolitis (NEC), sepsis and mortality in very low birth weight (VLBW) infants. Methods This open-label randomized controlled trial…
View details →DOI: 10.1007/s13312-025-00252-w Negative / Null Result Report
Parikh E · 2025 · Preprint
Background: Rheumatoid arthritis (RA) is a chronic inflammatory condition affecting joints. It is managed with pharmacological therapies, but it is speculated that dietary intervention may be of significant benefit to patients in helping…
View details →DOI: 10.20944/preprints202511.0743.v1 Negative / Null Result ReportOpen accessMedicine
Pellegrino N, Eliasziw M, Fortinsky R et al. · 2026 · Scientific reports
Exposure to particulate matter is associated with adverse health outcomes such as cardiovascular and neurological diseases. However, there are few intervention studies that have examined short-term changes in air particulate exposure and…
View details →DOI: 10.1038/s41598-026-48063-8 Negative / Null Result ReportMedicine
Tlili S, Ben Mahfoudh H, Zoudji B · 2025 · Perceptual and motor skills
Generated drawing is a specific instructional approach that has been investigated in academic settings. However, in sports, tactical drawings are often presented based more on coaches' preferences than on empirical evidence. This study…
View details →DOI: 10.1177/00315125251391658 Failed Experiment ReportMedicine
Schmidt ME, Gargano C, Zhou X et al. · 2026 · European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
JNJ-42165279 is a potent, selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for degradation of the endocannabinoid N-arachidonoylethanolamide (anandamide), which plays a role in regulation of fear and anxiety…
View details →DOI: 10.1016/j.euroneuro.2026.112771 Negative / Null Result ReportMedicine
Scherer C, Fung V, Anzellini D et al. · 2026 · Breast cancer (Tokyo, Japan)
Background We report outcomes of patients who received intraoperative radiation therapy (IORT) using 50 kV after lumpectomy and sentinel lymph node biopsy. Methods Women with age > 45 and post-menopausal status, localized, unifocal,…
View details →DOI: 10.1007/s12282-026-01824-9 Negative / Null Result ReportMedicine
Kanthar T, Vatcharavongvan P, Prasert V · 2025 · Journal of evaluation in clinical practice
Rationale The global prevalence rate of glaucoma blindness is extremely high and is a leading cause of irreversible blindness. Despite many advancements in treatment, evaluating glaucoma blindness remains challenging due to the long time…
View details →DOI: 10.1111/jep.70341 Negative / Null Result ReportMedicine
Blin P, Danchin N, Benichou J et al. · 2026 · American journal of cardiovascular drugs : drugs, devices, and other interventions
Introduction Antiplatelet therapy with low-dose aspirin, alone or as dual antiplatelet therapy (DAPT) with a P2Y 12 inhibitor, is used in secondary prevention following myocardial infarction (MI). However, the optimal duration of DAPT is…
View details →DOI: 10.1007/s40256-025-00782-5 Negative / Null Result ReportMedicine
Romagnoli A, Marcellusi A, Lasala R · 2025 · Recenti progressi in medicina
Introduction Rapid access to safe and effective oncological therapies is crucial. In recent years, many expensive drugs have been commercialized, making it essential to prioritize those with significant clinical benefits. For this purpose,…
View details →DOI: 10.1701/4518.45175 Negative / Null Result ReportOpen accessMedicine
Yang M, Yang S, Zhang W et al. · 2026 · BMC cancer
AIM: The role of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) in elderly patients with locally advanced colorectal cancer (LACRC) remains controversial. This study aimed to evaluate the perioperative safety and survival…
View details →DOI: 10.1186/s12885-026-16073-4 Negative / Null Result ReportMedicine
Leggett CL, Plowman RS, Surace L et al. · 2026 · Gastrointestinal endoscopy
Background and aims Computer-aided polyp detection (CADe) systems can enhance polyp detection, although their performance has largely been evaluated at academic rather than community practices. This randomized controlled trial evaluated…
View details →DOI: 10.1016/j.gie.2025.12.290 Negative / Null Result ReportMedicine
Gupta Y, Baranwal M, Chudasama B · 2025 · Biotechnology journal
Despite the challenge in generating adequate immunogenicity, peptide-based vaccines offer a significant benefit in terms of improving immunity when combined with conjugates. In previous studies, three computationally designed immunogenic…
View details →DOI: 10.1002/biot.70140 Negative / Null Result ReportMedicine
Guo Z, Liu X, Yu S et al. · 2025 · Journal of neurointerventional surgery
Background and purpose While endovascular therapy (EVT) is established for acute basilar artery occlusion (BAO), the clinical value of remedial angioplasty or stenting (RAS) is debated. This study investigated the efficacy and safety of…
View details →DOI: 10.1136/jnis-2025-024443 Negative / Null Result ReportMedicine
Mimura T, Moghaddamjou A, Badhiwala JH et al. · 2026 · Spinal cord
Study design Cohort study. Objectives Although the effectiveness of methylprednisolone sodium succinate (MPSS) in spinal cord injury (SCI) is controversial, it is hypothesized that the effectiveness and safety profile of MPSS may vary in…
View details →DOI: 10.1038/s41393-025-01163-0 Negative / Null Result ReportMedicine
Beshr MS, Shembesh RH, Nounou MV et al. · 2026 · Clinical oncology (Royal College of Radiologists (Great Britain))
Aim This study reconstructed patient-level data to provide updated evidence on survival outcomes across PD-L1 expression subgroups. Materials and methods A systematic search was conducted on March 2, 2025, using PubMed, Embase, Web of…
View details →DOI: 10.1016/j.clon.2026.104032 Negative / Null Result ReportMedicine
Yang X, Zhu L, Chen R et al. · 2026 · Human reproduction open
Study question Does adding vaginal estradiol to standard progesterone luteal phase support improve ongoing pregnancy rates in normal-responder IVF/ICSI patients undergoing GnRH antagonist cycles? Summary answer The addition of vaginal…
View details →DOI: 10.1093/hropen/hoag042 Negative / Null Result ReportMedicine
Ortiz-Gutiérrez S, Serralde-Zúñiga AE, González-Salazar LE et al. · 2026 · Scientific reports
Iron deficiency without anemia (IDNA) may be linked to obesity-related inflammation. Weight reduction and heme-iron intake from red meat are proposed to improve iron status. This randomized controlled trial (NCT06104800) assessed the…
View details →DOI: 10.1038/s41598-026-53056-8 Negative / Null Result ReportMedicine
Byun SH, Kim TS, Ahn S et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Background Leptomeningeal carcinomatosis (LMC) is a rare but highly lethal manifestation of gastric cancer. We sought to describe its clinical features and define prognostic factors in a large single-center cohort. Methods We…
View details →DOI: 10.1007/s10120-025-01699-3 Negative / Null Result ReportMedicine
Zeynodini Meimand H, Anbarloui MR, Eslamian M et al. · 2025 · Neurological research
Background Traumatic brain injury (TBI) is one of the most important causes of morbidity and mortality. It is important to have an effective treatment that can improve the quality of life and cognitive functions of these patients.…
View details →DOI: 10.1080/01616412.2025.2578346 Negative / Null Result ReportMedicine
Zeng Z, Ye X, He H et al. · 2025 · Journal of applied gerontology : the official journal of the Southern Gerontological Society
This study examined the associations of tea, coffee, and alcohol consumption with cognitive function in Chinese adults aged ≥45 years ( n = 1326), using data from the China Health and Nutrition Survey (1997-2006). Multiple linear…
View details →DOI: 10.1177/07334648251395359 Negative / Null Result Report
Chen C, Tao Q, Lu C et al. · 2025 · Preprint
Abstract Background: Adjuvant therapy for solitary large hepatocellular carcinoma (SLHCC) remained unclear. Methods: 1292 SLHCC patients treated with hepatectomy between January 2010 and December 2020 were included in this retrospective…
View details →DOI: 10.21203/rs.3.rs-7792877/v1 Negative / Null Result ReportMedicine
Muste JC, Schulgit MJ, Perkins S et al. · 2026 · Ophthalmology. Retina
Objective To evaluate outcomes and complications of pars plana vitrectomy (PPV) for nonclearing vitreous hemorrhage (NCVH) secondary to proliferative diabetic retinopathy (DR) in the small-gauge, anti-VEGF era. Design Retrospective…
View details →DOI: 10.1016/j.oret.2026.01.013 Negative / Null Result ReportMedicine
Marzi Manfroni A, Scaccini OP, Ceccariglia F et al. · 2026 · Head & neck
Background Margin control is a crucial prognostic factor in head and neck oncological surgery. This retrospective case-control study aims to assess the superiority of computer-assisted surgery compared to traditional surgery in achieving…
View details →DOI: 10.1002/hed.70095 Negative / Null Result ReportOpen accessMedicine
Camilli M, Abbate A · 2026 · Cardio-oncology (London, England)
In cardio-oncology, the gap between mechanistic studies and pharmacological trials impedes the delineation of effective cardioprotective strategies. The angiotensin-receptor/neprilysin inhibitor (ARNI) have shown beneficial effects in…
View details →DOI: 10.1186/s40959-025-00423-5 Negative / Null Result ReportMedicine
Lee J, Kim J, Lee K · 2026 · Journal of physical activity & health
Background Although previous studies have identified a positive relationship between physical activity (PA) participation and cognitive function in older adults, further research is needed to determine the level of PA necessary to…
View details →DOI: 10.1123/jpah.2025-0355 Negative / Null Result ReportOpen accessMedicine
Alvey E, Fielding L, Dennis D et al. · 2025 · Open veterinary journal
Background Intranasal lidocaine (LID) administration is a common treatment used to facilitate the passing of endoscopes and nasogastric tubes in horses. However, no research has supported its use in equine practice. Aim To compare patient…
View details →DOI: 10.5455/ovj.2025.v15.i6.62 Negative / Null Result ReportMedicine
Jordan V, Davis JS, Naqvi S · 2026 · Pathology
Optimising laboratory processes is paramount in differentiating prosthetic joint infection (PJI) from non-infectious causes of joint dysfunction. However, the optimal duration of incubation of PJI samples remains unclear in the modern…
View details →DOI: 10.1016/j.pathol.2025.07.004 Negative / Null Result Report
Wang J, He X, Song D et al. · 2025 · Preprint
Abstract Purpose We aimed to evaluate the clinical value of splenectomy as a treatment for Chronic active Epstein-Barr virus disease (CAEBVD). Methods We retrospectively reviewed the clinical data from clinical records of patients received…
View details →DOI: 10.21203/rs.3.rs-7233329/v1 Negative / Null Result ReportMedicine
Zhu J, Ma Y, Xiong Y et al. · 2026 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Background Studies investigating recurrence patterns and adjuvant therapy strategies in patients with esophageal squamous cell carcinoma (ESCC) who achieve pathological complete response (pCR) following neoadjuvant immunochemotherapy…
View details →DOI: 10.1016/j.ejso.2025.111360 Negative / Null Result Report
De Souza Mares G, Bastos Tavares MV, Danieluk MF et al. · 2025 · Preprint
Introduction: Postinfectious hyposmia gained special attention in the postpandemic era, and persistent cases are particularly difficult to treat. Many unproven therapies are used in clinical practice, including corticosteroids, with…
View details →DOI: 10.1590/scielopreprints.13398 