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Failure-mode index

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A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

444 results in Replication Failure · page 7 of 15

Replication FailureOpen accessPsychology

Belief Bias in Individual and Collective Reasoning

Alba Massolo, Mariel Traversi, Matías Alfonso · 2024 · Europe's Journal of Psychology

In this paper, we investigate whether collaborative group performance is better than individual performance in solving a syllogism evaluation task. We hypothesise that collaborative group settings will outperform individual settings and that the belief bias effect will be mitigated in a group setting. Two empirical studies were conducted with Argentinian undergraduate students. Study 1 (N = 239) used a between-subjects design with two conditions: individual resolution and interactive group resolution. Overall, the group condition performed better than the individual condition, but there were n

View details →DOI: 10.5964/ejop.12041
Replication FailureOpen accessMedicine

Effect of 10-minute oropharyngeal exercise on the apnoea–hypopnoea index

Tatsuya Nagano, Masashi Hashimoto, Shintaro Izumi et al. · 2024 · Scientific Reports

Abstract Previously reported oropharyngeal exercises are long and difficult to perform. Therefore, we created a 10-min daily oropharyngeal exercise program and conducted a study to confirm its effectiveness. Twenty-five participants whose apnoea–hypopnoea index (AHI) values were greater than 5 were enrolled. All of the participants performed 10 min of exercise per day for 12 weeks and were evaluated for AHI values, tongue pressure, lip closure pressure, snoring, and Mallampati scores before and after the exercise. Twenty-two participants (88% of all participants) completed the oropharyngeal ex

View details →DOI: 10.1038/s41598-024-79884-0
Replication FailureOpen accessMedicine

Is a combined proximal femoral osteotomy necessary when performing open reduction and Dega acetabuloplasty in walking-age children with developmental dysplasia of the hip.

Yu J, Li L, Shi L et al. · 2026 · SICOT-J

Purpose To determine the necessity of simultaneous proximal femoral osteotomy (PFO) during open reduction (OR) and Dega acetabuloplasty (DA) in patients with developmental dysplasia of the hip (DDH) by comparing the clinical and…

View details →DOI: 10.1051/sicotj/2026031
Replication FailureOpen accessSpecialties of internal medicine

Reassessing Simultaneous Pancreas-Kidney Vs. Kidney Transplant Alone: A Propensity-Weighted Analysis of Survival and Morbidity

Pooja Budhiraja, Rocio Lopez, Rocio Lopez et al. · 2025 · Transplant International

This study compares outcomes between Simultaneous Pancreas-Kidney Transplantation (SPKT) and Deceased Donor Kidney Transplantation (DDKT) in recipients with diabetes, assessing survival benefits against surgical and immunological risks. We analyzed Scientific Registry of Transplant Recipients data (2014–2023) to assess patient and kidney graft survival. Overlap propensity score weighting was applied to adjust for group differences. Kaplan-Meier and Cox proportional hazards models were used to estimate survival outcomes in unadjusted, covariate-adjusted, and weighted analyses. Among 22,545 reci

View details →DOI: 10.3389/ti.2025.14934
Replication Failure

Vickers Hardness and Microleakage of Coated Glass-Hybrid and High-Viscosity Glass-Ionomer Systems in Thermocycled Conservative Class II Cavities: An In Vitro Study

Ho CB, Tran TT, Ngo LT · 2026 · Preprint

Background: /Objectives: Glass-hybrid and high-viscosity glass-ionomer systems aim to improve conventional glass-ionomer performance. This in vitro study compared Vickers hardness and microleakage of a coated glass-hybrid system and a…

View details →DOI: 10.20944/preprints202606.0957.v1
Replication FailureMedicine

Diagnostic value of inguinal ultrasound for predicting histological lymph node status in vulvar cancer.

Hartmann S, Wenk N, Mann E et al. · 2026 · Ultraschall in der Medizin (Stuttgart, Germany : 1980)

Purpose As part of the pretherapeutic diagnostic workup for vulvar cancer, the inguinal lymph node status should be assessed. The diagnostic value of structured inguinal sonography for predicting the histological lymph node status in…

View details →DOI: 10.1055/a-2830-7606
Replication FailureOpen accessMedicine (General)

EEffect of Chloroquine on Hyoscine-Induced Memory Impairment in Mice: Possible Involvement of Opioids and Nitric Oxide

Parsa Mohammadi, Elaheh Karimi, Adeleh Maleki et al. · 2022 · Acta Medica Iranica

Accumulating evidence suggests the potential use of chloroquine, an anti-malaria medication, as a neuroprotective agent. Moreover, several studies have reported that the endogenous opioids and nitric oxide (NO) may mediate the chloroquine’s effects. In the present study, effects of chloroquine on hyoscine-induced memory impairment were assessed. Furthermore, the possible involvements of opioids and NO were evaluated. Chloroquine was administered intraperitonially (i.p.) at doses of 0.1, 0.5, 1, 3, 10, and 20 mg/kg to hyoscine-treated (1mg/kg, i.p.) mice, and the spatial and fear memories were

View details →DOI: 10.18502/acta.v60i2.8819
Replication FailureOpen accessDiseases of the endocrine glands. Clinical endocrinology

Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial

Quoc Huy Hoang, Hung Sy Ho, Huong Thuy Do et al. · 2021 · Reproductive Medicine and Biology

Abstract Purpose This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregna

View details →DOI: 10.1002/rmb2.12383
Replication FailureMedicine

Effects of reducing sedentary behaviour on heart rate variability and cardio-metabolic biomarkers in desk workers with untreated high blood pressure.

Alansare AB, Muldoon MF, Perera S et al. · 2026 · Experimental physiology

Lower sedentary behaviour (SB) has been associated with reduced cardiovascular disease and mortality. Yet, few trials have evaluated cardiovascular mechanisms of benefit. We examined the effects of a SB reduction intervention on heart rate…

View details →DOI: 10.1113/ep093468
Replication FailureMedicine

Patient Characteristics Associated With Speech Recognition and Quality of Life Improvement After Cochlear Implantation.

Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…

View details →DOI: 10.1097/mao.0000000000004755
Replication FailureMedicine

Randomised three-armed trial investigation of the Copenhagen Achilles tendon Rupture Treatment Algorithm (CARTA) for individualised treatment of acute Achilles tendon rupture.

Toft M, Hansen MS, Vestergaard JD et al. · 2026 · British journal of sports medicine

Objective To evaluate whether individualised treatment using the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) is superior to default operative or non-operative strategies. Methods We conducted a multicentre, three-arm,…

View details →DOI: 10.1136/bjsports-2025-110210
Replication FailureMedicine

Impact of prevention of postoperative pulmonary complications with penehyclidine inhalation on long-term outcomes in high-risk patients: follow-up of a randomized trial.

Liang XQ, Han L, Yan T et al. · 2026 · Journal of anesthesia

Purpose Postoperative pulmonary complications are common and associated with worse long-term outcomes. In our previous trial, prophylactic penehyclidine inhalation reduced pulmonary complications in high-risk patients. Herein, we tested…

View details →DOI: 10.1007/s00540-026-03735-7
Replication FailureOpen accessMedicine

Subject-Wise Depression Screening from Eight-Channel Resting-State EEG Using Asymmetry-Aware Spectral Features and Connectivity Ablation.

Ugail H, Howard N, Elmahmudi AA et al. · 2026 · Sensors (Basel, Switzerland)

Major depressive disorder remains difficult to diagnose objectively, as routine assessment is still largely dependent on clinical interview and rating scales. Resting-state electroencephalography (EEG) is an attractive complementary…

View details →DOI: 10.3390/s26103065
Replication FailureMedicine

Enhancing patient education in cataract surgery using a conversational artificial intelligence chatbot: pilot randomized controlled trial.

Cardon de Lichtbuer P, Declerck W, Rosseel Q et al. · 2026 · Journal of cataract and refractive surgery

Purpose To evaluate the effectiveness and usability of a safety-first, clinician-validated conversational artificial intelligence (AI) chatbot for cataract surgery education compared with standard brochures. Setting University Hospital (UZ…

View details →DOI: 10.1097/j.jcrs.0000000000001856
Replication FailureOpen accessMedicine

The Effect of Milk Thistle Extract in the Treatment of Diabetic Nephropathy

Hassan Rezvanian, Ali Kachuei, Ali Mirzapour · 2011 · مجله دانشکده پزشکی اصفهان

Background: Milk thistle has antioxidative effects and may improve renal performance. Our study investigated whether Milk thistle improve renal performance in patients with type II diabetes mellitus nephropathy. Methods: In this clinical trial study, after ethics committee approval, 65 Patients with type II diabetes mellitus were enrolled into a randomized simple sampling, prospective, double-blinded study. In the case group, was gave Milk thistle and control group was given placebo. We measured urine albumin/cratinine (A/C) ratio and eGFR before and after intervention. The gathered data were

Replication FailureOpen accessDiseases of the digestive system. Gastroenterology

Ten-day vonoprazan–amoxicillin dual therapy versus 14-day esomeprazole–amoxicillin dual therapy for first-line eradication: a prospective multicenter randomized controlled trial

Ben-Gang Zhou, Ming-Wen Guo, Li-Juan Zhang et al. · 2024 · Therapeutic Advances in Gastroenterology

Background: The efficacy of the 14-day esomeprazole–amoxicillin (EA) dual therapy in eradicating Helicobacter pylori ( H. pylori ) has been widely discussed previously. Vonoprazan, a novel potassium-competitive acid blocker, presents rapid, potent, and long-lasting acid inhibitory effects compared to esomeprazole. However, there is currently a scarcity of direct comparisons between the 10-day vonoprazan–amoxicillin (VA) and the 14-day EA dual therapy for H. pylori eradication. Objectives: This study aimed to compare the efficacy and safety of the 10-day VA and the 14-day EA dual therapy for H.

View details →DOI: 10.1177/17562848241309870
Replication FailureMedicine

Diacerein for Knee Osteoarthritis: A Randomized Clinical Trial.

Aitken D, Cai G, Hill CL et al. · 2026 · JAMA internal medicine

Importance Knee osteoarthritis (OA) is disabling, with few effective treatments. Anti-inflammatory treatments may be effective for patients with an inflammatory phenotype. Objectives To evaluate the efficacy of the interleukin-1β blocker…

View details →DOI: 10.1001/jamainternmed.2025.8237
Replication FailureOpen accessNeoplasms. Tumors. Oncology. Including cancer and carcinogens

Nosocomial infections causedby Pseudomonas aeruginosa in cancer clinics

N. V. Dmitrieva, M. V. Eidelshtein, V. V. Aginova et al. · 2019 · Сибирский онкологический журнал

The purpose of the study was to evaluate the frequency of isolation of multi-resistant Pseudomonas aeruginosa and identify the mechanisms of resistance to carbapenems.Material and methods. We analyzed 866 strains of Pseudomonos aeruginosaisolated from clinical samples from cancer patients in the period 2014–2016. the level of resistance to piperacillin/tazobactam, ceftazidime, cefepime, imipenem, meropenem, ciprofloxacin, amikacin in dynamics was determined. carbapenem-resistant (car-R) strains were examined for the presence of enzymes.Results. Between 2014 and 2016, the number of strains resi

View details →DOI: 10.21294/1814-4861-2019-18-2-28-34
Replication FailureMedicine

HPV status fully mediates sex-related survival differences in oropharyngeal cancer: a population-based analysis with formal interaction testing.

Hoenle A, Rickert D, Steinhart H et al. · 2026 · The Journal of laryngology and otology

Objectives. To determine whether sex independently predicts survival in oropharyngeal squamous cell carcinoma and whether human papillomavirus status mediates apparent sex-related survival differences at the population level. Methods.…

View details →DOI: 10.1017/s002221512610512x
Replication FailureOpen accessAstrophysics

Deep Einstein@Home Search for Continuous Gravitational Waves from the Central Compact Objects in the Supernova Remnants Vela Jr. and G347.3-0.5 Using LIGO Public Data

J. Ming, M. A. Papa, H.-B. Eggenstein et al. · 2024 · The Astrophysical Journal

We perform a search for continuous nearly monochromatic gravitational waves from the central compact objects associated with the supernova remnants Vela Jr. and G347.3. Over 10 ^18 different waveforms are considered, covering signal frequencies between 20 and 1300 Hz (20 and 400 Hz) for G347.3-0.5 (Vela Jr.) and a very broad range of frequency derivatives. The data set used for this first search is from the second observing run of LIGO (O2). Thousands of volunteers donating compute cycles through the computing project Einstein@Home have made this endeavor possible. Following the Einstein@Home

View details →DOI: 10.3847/1538-4357/ad8b9e
Replication Failure

Exploring Factors That Influence Green Space Engagement in Florida

Suhendy CCV, Koeser AK, Klein RW et al. · 2026 · Preprint

Urban parks are widely recognized for their mental health benefits, especially among frequent visitors. However, the factors underlying regular park use among older urban residents remain poorly understood. This study examined park…

View details →DOI: 10.20944/preprints202606.1589.v1
Replication FailureMedicine

Effect of Lidocaine as an Adjuvant to Clove Essential Oil on Anaesthetic Induction and Recovery in Nile Tilapia.

Franco-Ortega JA, Albertos-Alpuche PJ, Mora-Medina P et al. · 2026 · Journal of fish diseases

Immersion anaesthesia is widely used in fish handling and research, yet optimization of protocols requires not only effective immobilization but also consideration of internal physiological responses. This study evaluated the effects of…

View details →DOI: 10.1111/jfd.70186
Replication FailureMedicine

Is Combined Tranexamic Acid Administration Superior to Single-Route Protocols in Primary Total Knee Arthroplasty? A Prospective Cohort Study.

Stepanovic Z, Ristic B, Matic A et al. · 2026 · Journal of clinical medicine

Background : The optimal route of tranexamic acid (TXA) administration remains one of the most debated topics in total knee arthroplasty. This study aimed to compare the effects of intravenous (IV), intra-articular (IA), and combined TXA…

View details →DOI: 10.3390/jcm15124776
Replication FailureMedicine

Comparison Between Eccentric-Concentric and Eccentric-Only Dumbbell Arm Curl Exercise for the Number of Repetitions to Failure Over Five Sets.

Shibata K, Yamaguchi T, Takizawa K et al. · 2026 · Journal of strength and conditioning research

Abstract Shibata, K, Yamaguchi, T, Takizawa, K, and Nosaka, K. Comparison between eccentric-concentric and eccentric-only (ECC-only) dumbbell arm curl exercise for the number of repetitions to failure over five sets. J Strength Cond Res…

View details →DOI: 10.1519/jsc.0000000000005432
Replication FailureMedicine

Relapse risk after glucocorticoid withdrawal in stable Sjögren's disease-associated interstitial lung disease: a retrospective cohort study in China.

Li N, Huang H, Jia Y et al. · 2026 · Clinical rheumatology

Objectives To explore the risk of relapse after glucocorticoids (GCs) withdrawal in patients with stable Sjögren's disease-associated interstitial lung disease (SjD-ILD). Methods This was a single-center, retrospective cohort study…

View details →DOI: 10.1007/s10067-025-07916-9
Replication FailureMedicine

Clinical advantages of robotic gastrectomy for gastric cancer over conventional laparoscopic approach: a retrospective cohort study using a nationwide registry database in Japan.

Shibasaki S, Endo H, Yamamoto H et al. · 2026 · Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association

Objective To evaluate contemporary short-term outcomes of robotic gastrectomy (RG) approximately 5 years after its widespread implementation, compared with laparoscopic gastrectomy (LG) using a nationwide Japanese database. Background RG…

View details →DOI: 10.1007/s10120-026-01764-5
Replication FailureOpen accessNuclear and particle physics. Atomic energy. Radioactivity

Search for excited tau leptons in the ττγ final state in proton-proton collisions at $$\sqrt{\text{s}}$$ = 13 TeV

The CMS collaboration, A. Hayrapetyan, A. Tumasyan et al. · 2025 · Journal of High Energy Physics

Abstract Results are presented for a test of the compositeness of the heaviest charged lepton, τ, using data collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 13 TeV at the CERN LHC. The data were collected in 2016–2018 and correspond to an integrated luminosity of 138 fb −1. This analysis searches for tau lepton pair production in which one of the tau leptons is produced in an excited state and decays to a ground state tau lepton and a photon. The event selection consists of two isolated tau lepton decay candidates and a high-energy photon. The mass of

View details →DOI: 10.1007/jhep06(2025)006
Replication FailureMedicine

[High expression of low-risk hpv in nasal inverted papilloma and its response to interferon therapy].

He Z, Lyu S, Huang M et al. · 2026 · Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery

Objective: To investigate the expression of HPV 6/11 in NIP tissues and evaluate the adjuvant therapeutic effect of interferon-α gel on HPV-positive NIP patients. Methods: Forty-two newly diagnosed Nasal Inverted Papilloma(NIP) patients…

View details →DOI: 10.13201/j.issn.2096-7993.2026.05.011
Replication FailureMedicine

Incisional Infiltration of Liposomal Bupivacaine in Geriatric Hip Fracture Surgery: A Randomized Parallel-Group Trial.

Yu X, Yuan Y, Zhao S et al. · 2026 · The Journal of bone and joint surgery. American volume

Background Hip fracture volumes are rising with population aging, and inadequate analgesia following hip fracture surgery has been shown to impede early mobilization and recovery. Liposomal bupivacaine (LB) may extend analgesia, but…

View details →DOI: 10.2106/jbjs.25.01498