e-ISSN: Pending
Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21770 results · page 698 of 726

Negative / Null Result ReportOpen accessMedicine

Performance of Early Therapeutic Paracentesis in Spontaneous Bacterial Peritonitis and Its Effect on Clinical Outcomes.

Wentworth BJ, Shwetar M, Mallawaarachchi I et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology

Background and aims Spontaneous bacterial peritonitis (SBP) is common in decompensated cirrhosis and often accompanied by large volume ascites. However, the safety of early therapeutic paracentesis is unknown and may lead to unnecessary…

View details →DOI: 10.1002/jgh3.70339
Negative / Null Result ReportMedicine

How plant composition in margins influences the assemblage of pests and predators and its effect on biocontrol in melon fields.

Sanchez JA, de Pedro L, López-Gallego E et al. · 2024 · Scientific reports

Many agricultural landscapes offer few resources for maintaining natural enemy populations and floral plantings have frequently been adopted to enhance biological pest control in crops. However, restored margins may harbour both pests and…

View details →DOI: 10.1038/s41598-024-63985-x
Negative / Null Result ReportMedicine

Assessment of the impact of microplastic ingestion in striped red mullets from an Eastern Mediterranean coastal area (Zakynthos Island, Ionian Sea).

Patsiou D, Digka N, Galli M et al. · 2024 · Marine environmental research

Monitoring microplastics (MPs) in the marine environment is an ongoing process, and our understanding of their impact on marine organisms is limited. The present study evaluates the effects of ingested MPs on the marine MP pollution…

View details →DOI: 10.1016/j.marenvres.2024.106438
Negative / Null Result ReportOpen accessMedicine

Stable bloodstream infection rates despite rising colonization: insights from a hospital system using in-house polymerase chain reaction screening for <i>Candidozyma auris</i>.

Rosa R, Rosello G, Manzanillo K et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE

Following the implementation of in-house Candidozyma auris ( C. auris ) polymerase chain reaction as part of our surveillance strategy, we observed increasing incidence rates of colonization with C. auris already present at hospital…

View details →DOI: 10.1017/ash.2025.10076
Negative / Null Result ReportOpen accessMedicine

Ki67 and Lymphovascular Invasion as Histopathological Predictors of Residual Cancer Burden After Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Study.

Carabas BA, Țǎpoi DA, Costache M · 2026 · Diagnostics (Basel, Switzerland)

Background: Neoadjuvant chemotherapy (NAC) is widely used in the management of stage I-III breast cancer, with tumor regression serving as an important surrogate for long-term outcome. Identifying reliable pathological biomarkers…

View details →DOI: 10.3390/diagnostics16081213
Negative / Null Result ReportOpen accessMedicine

Helicobacter pylori in the Philippines: Social and Ecological Determinants of Seropositivity and Lack of Association With Systemic Inflammation.

Lee CC, Miller AA, Tallman PS et al. · 2025 · American journal of human biology : the official journal of the Human Biology Council

Helicobacter pylori (H. pylori) is a bacterium that infects the stomach and is associated with various gastrointestinal outcomes and increased cardiovascular disease risk. We examined the role of sex in and the social and ecological…

View details →DOI: 10.1002/ajhb.70069
Negative / Null Result ReportOpen accessMedicine

Circulating Levels of Soluble α-Klotho and FGF23 in Childhood Cancer Survivors: Lack of Association with Nephro- and Cardiotoxicity-A Preliminary Study.

Kozłowski K, Konończuk K, Muszyńska-Rosłan K et al. · 2024 · Journal of clinical medicine

Background/Objectives: The survival rate among pediatric cancer patients has reached 80%; however, these childhood cancer survivors (CCSs) are at a heightened risk of developing chronic conditions in adulthood, particularly kidney and…

View details →DOI: 10.3390/jcm13102968
Negative / Null Result ReportOpen accessMedicine

Correlation of Mean Platelet Volume With Angiographic Severity in Diabetic Coronary Artery Disease: A Cross-Sectional Study.

Agarwal Y, Metgudmath A, Metgudmath V · 2026 · Cureus

Aim To evaluate the association of mean platelet volume (MPV) and immature platelet fraction (IPF) with coronary angiographic severity, categorised by the number of significantly diseased epicardial vessels (single, double or triple vessel…

View details →DOI: 10.7759/cureus.102326
Negative / Null Result ReportOpen accessMedicine

Dietary Fiber Intake Was Inversely Associated with All-Cause Mortality but Not with Cancer and Cardiovascular Disease Mortalities in the US.

Akbar Z, Fituri S, Shi Z et al. · 2025 · Diseases (Basel, Switzerland)

Background Evidence linking dietary fiber intake with cancer risk and mortality is equivocal. Objective We investigated the relationship between dietary fiber intake and all-cause, cancer, and cardiovascular disease (CVD) mortalities in US…

View details →DOI: 10.3390/diseases13080272
Negative / Null Result ReportMedicine

PICU Admission of Children for Status Epilepticus: Is There a Different Approach Between Referral and Second-Level Hospitals in an Italian Region?

Bonardi CM, Nosadini M, Lorenzoni G et al. · 2024 · Clinical pediatrics

Appropriate status epilepticus (SE) management is key to minimize admission to the pediatric intensive care unit (PICU). We retrospectively describe 115 children admitted to the PICU of the tertiary-care referral hospital of Padova for…

View details →DOI: 10.1177/00099228231220174
Negative / Null Result ReportOpen accessMedicine

Could MOTS-c Levels in Children with Type 1 Diabetes Mellitus Be an Indicator for Early Diabetic Kidney Disease?

Girişgen İ, Altıncık SA, Avcı E et al. · 2025 · Journal of clinical research in pediatric endocrinology

Objective To compare serum mitochondrial open reading frame of 12S rRNA-c (MOTS-c) levels, a new potential biomarker for oxidative stress, in children with type 1 diabetes mellitus (T1DM) and healthy children. A further aim was to…

View details →DOI: 10.4274/jcrpe.galenos.2024.2024-5-6
Negative / Null Result ReportOpen accessMedicine

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study.

Tristani-Firouzi B, Pappas L, Joseph M et al. · 2026 · BJOG : an international journal of obstetrics and gynaecology

Objective Maternal genotypes may be useful to customise foetal growth assessment, but generalisability across diverse racial and ancestral groups remains uncertain. We assessed the generalisability of a genetic risk score for birth weight…

View details →DOI: 10.1111/1471-0528.70088
Negative / Null Result ReportMedicine

Lack of association between periodontitis and rheumatoid arthritis.

Posada-López A, Duque JD, Pineda-Tamayo RA et al. · 2023 · Reumatologia clinica

Background and objective Periodontitis and rheumatoid arthritis (RA) have been associated in a bidirectional way. The objective of this study was to determine the association between clinical parameters of periodontitis and RA. Materials…

View details →DOI: 10.1016/j.reumae.2022.03.006
Negative / Null Result ReportMedicine

Association of machine-learning-rated supportive counseling skills with psychotherapy outcome.

Zhang X, Goldberg SB, Baldwin SA et al. · 2025 · Journal of consulting and clinical psychology

Objective This study applied a machine-learning-based skill assessment system to investigate the association between supportive counseling skills (empathy, open questions, and reflections) and treatment outcomes. We hypothesized that…

View details →DOI: 10.1037/ccp0000935
Negative / Null Result ReportMedicine

Opioid and healthcare service use in medical cannabis patients with chronic pain: a prospective study.

Sznitman S, Mabouk C, Said Z et al. · 2023 · BMJ supportive & palliative care

Background Various jurisdictions have legalised medical cannabis (MC) for use in chronic pain treatment. The objective of this study was to determine if the use of MC is related to a reduction in the use of prescription opioids and other…

View details →DOI: 10.1136/bmjspcare-2020-002661
Negative / Null Result ReportMedicine

Lack of association of superoxide dismutase I/D variant with osteopenia/osteoporosis in Turkish postmenopausal women.

Nacar MC, Yigit S · 2023 · Nucleosides, nucleotides & nucleic acids

Background Osteoporosis (OP) is a common systemic, metabolic bone disease that affects 40% of postmenopausal women. Oxidative stress (OS) ìs caused by reactive oxygen species (ROS), inhibits osteoblast differentiation and causes apoptosis…

View details →DOI: 10.1080/15257770.2023.2185785
Negative / Null Result ReportMedicine

Movement-evoked pain is not associated with pain at rest or physical function in knee osteoarthritis.

Lozano-Meca JA, Gacto-Sánchez M, Montilla-Herrador J · 2024 · European journal of pain (London, England)

Introduction Knee Osteoarthritis (KOA) is mainly characterized by pain. The assessment of KOA-related pain frequently focuses on different constructs subject to sources of bias or drawbacks, as the classical Pain at Rest (PAR).…

View details →DOI: 10.1002/ejp.2236
Negative / Null Result ReportOpen accessMedicine

C-reactive protein and fatigue after subarachnoid haemorrhage.

Daniel S, Hou R, Galea I et al. · 2025 · Brain, behavior, & immunity - health

Background Subarachnoid haemorrhage (SAH) is a severe type of intracranial bleed that causes significant morbidity. One of the most overlooked yet commonly reported symptom is persistent fatigue. Fatigue in the general population has been…

View details →DOI: 10.1016/j.bbih.2025.101046
Negative / Null Result ReportOpen accessMedicine

Anthropometric indicators and dental caries in the pediatric population of rural communities in the peruvian amazon: a cross-sectional study.

Aquino-Canchari CR, Parraga Camayo EF, Ambrosio Huaman EN et al. · 2025 · Revista cientifica odontologica (Universidad Cientifica del Sur)

Introduction Dental caries and nutritional alterations are common in childhood, particularly in rural communities with limited access to health services. Objective To determine the association between anthropometric indicators and the…

View details →DOI: 10.21142/2523-2754-1304-2025-264
Negative / Null Result ReportOpen accessMedicine

Investigating the association between demographic factors and patient satisfaction with recovery in the early phase after non-catastrophic musculoskeletal injuries: a cross-sectional study.

Maleki M, Modarresi S · 2025 · BMC research notes

Background Orthopedic injuries can negatively impact both the physical and mental health of patients. Ensuring patient satisfaction with their recovery is crucial for meeting patient-centered goals and enhancing overall health outcomes.…

View details →DOI: 10.1186/s13104-025-07210-6
Negative / Null Result ReportMedicine

Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary syndrome.

Bogari NM, Naffadi HM, Babalghith AO et al. · 2024 · Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

Background Ischemic injury is a common mechanism in both ischemic stroke (IS) and acute coronary syndrome (ACS). Matrix metalloproteinase 9 (MMP-9), an endopeptidase that degrades extracellular matrix, is important in the pathogenesis of…

View details →DOI: 10.1016/j.jstrokecerebrovasdis.2024.107824
Negative / Null Result ReportOpen accessMedicine

Combined Prognostic Value of Nutritional and Inflammatory Indices for Predicting Functionally Significant Coronary Stenosis Verified by FFR: The PNI-SII-GINI Study.

Aydın MZ, Arin CB, Teber MK et al. · 2026 · Journal of inflammation research

Background Systemic inflammatory and nutritional indices have been associated with coronary artery disease burden and prognosis; however, their ability to predict lesion-level functional ischemia remains uncertain. This study evaluated…

View details →DOI: 10.2147/jir.s585010
Negative / Null Result ReportOpen accessMedicine

Immunosuppressive Medications and Nonserious Infections in People With Rheumatoid Arthritis: A Prospective Cohort Study.

George MD, Gavigan K, Venkatachalam S et al. · 2026 · ACR open rheumatology

Objective People with rheumatoid arthritis (RA) are at increased risk of serious infection, but less is known about nonserious infections. Our prospective cohort study evaluated associations between medications for RA and the risk of…

View details →DOI: 10.1002/acr2.90050
Negative / Null Result ReportOpen accessMedicine

Social norm intervention in real-world supermarkets in the Netherlands: A quasi-experimental evaluation of effects on perceived social norms and meat substitute purchases.

Wolfswinkel SMM, Raghoebar S, de Vet E et al. · 2026 · Applied psychology. Health and well-being

Social norm perceptions are implicit rules of conduct that describe what is normal and acceptable behavior. Changing social norm perceptions through textual and physical social norm communications can be a promising approach to changing…

View details →DOI: 10.1111/aphw.70159