Negative / Null Result ReportOpen accessMedicine
Lopez-Alonso V, López-Bermúdez G, Pagaduan JC et al. · 2025 · Sensors (Basel, Switzerland)
Transcranial direct current stimulation (tDCS) modulates cortical excitability, thus inducing improvements in motor learning of simple tasks. In this study, we aimed to evaluate the effect of different tDCS conditions-anodal stimulation…
View details →DOI: 10.3390/s25144297 Negative / Null Result ReportOpen accessMedicine
Lewandowski K, Kaniewska M, Tulewicz-Marti E et al. · 2024 · Journal of clinical medicine
Background : Oncological anxiety associated with biological therapy is a particular challenge in inflammatory bowel disease (IBD), and it has raised questions about the need for the dermatological assessment of the skin before starting…
View details →DOI: 10.3390/jcm13175213 Negative / Null Result ReportOpen accessMedicine
Okada M, Tran TTT · 2024 · IBRO neuroscience reports
We have previously shown that a single dose of a TREK-1 channel activator, ostruthin, exhibited antidepressant and anxiolytic effects in acute behavioral test models in mice. To assess the potential clinical application, it is essential to…
View details →DOI: 10.1016/j.ibneur.2024.05.009 Negative / Null Result ReportMedicine
Strickland JA, Austen JM, Sprengel R et al. · 2024 · Hippocampus
The hippocampus has been implicated in temporal learning. Plasticity within the hippocampus requires NMDA receptor-dependent glutamatergic neurotransmission. We tested the prediction that hippocampal NMDA receptors are required for…
View details →DOI: 10.1002/hipo.23593 Negative / Null Result ReportOpen accessMedicine
Stoddart K, Davies M, Oughton J et al. · 2025 · Addiction biology
Chronic nicotine administration leads to neuroadaptations, an important process in nicotine and tobacco dependence for which treatments are limited. The cysteine pro-drug, N-acetyl-cysteine (NAC), is a promising glutamatergic agent that…
View details →DOI: 10.1111/adb.70051 Negative / Null Result ReportOpen accessMedicine
Bonne TC, Arthemalle V, Doherty CS et al. · 2025 · Physiological reports
Athletes use creatine monohydrate (CM) to enhance high-intensity exercise performance by increasing creatine phosphate availability. While CM supplementation is known to raise muscle creatine levels in vegans and vegetarians, its impact on…
View details →DOI: 10.14814/phy2.70539 Negative / Null Result ReportMedicine
Barranco I, Spinaci M, Nesci S et al. · 2024 · Theriogenology
Porcine seminal plasma (SP) is loaded with a heterogeneous population of extracellular vesicles (sEVs) that modulate several reproductive-related processes. This study investigated the effect of two sEV subsets, small (S-sEVs) and large…
View details →DOI: 10.1016/j.theriogenology.2024.02.024 Negative / Null Result ReportMedicine
Goldschmied N, Lambrecht J, Castro A et al. · 2023 · Scandinavian journal of medicine & science in sports
Hockey is a sport known for its violent nature. Specifically, hockey fights have consistently been an integral part of the National Hockey League. Past research has demonstrated that players are likely to be involved in fighting as a…
View details →DOI: 10.1111/sms.14432 Negative / Null Result ReportOpen accessMedicine
Riise HS, Simpson MR, Espnes KA et al. · 2026 · Headache
Objective To explore the adherence, effectiveness, safety, tolerability, and acceptability of frequently used oral migraine preventive drugs in a real-world setting. Background Oral migraine preventives are previously mainly explored in…
View details →DOI: 10.1111/head.70061 Negative / Null Result ReportOpen accessMedicine
Sonnhoff M, Oyur M, Becker JN et al. · 2026 · Radiation oncology (London, England)
BACKGROUND: Despite the favorable toxicity profiles of whole breast radiotherapy, there are subgroups that tend to experience high toxicity. This study examines anatomical and physiological characteristics that can predict the induction of…
View details →DOI: 10.1186/s13014-026-02833-w Negative / Null Result ReportOpen accessMedicine
Hunter-Cooper SD, Rahimi M, Millet P et al. · 2026 · European journal of nutrition
Introduction High sodium intake has been associated with greater pressor responses in Black compared with White adults. While the acute effects of sodium on BP have been studied in Black adults, to our knowledge, no studies have explored…
View details →DOI: 10.1007/s00394-026-03994-w Negative / Null Result ReportOpen accessMedicine
Kreko-Pierce T, Chen L, Qu G et al. · 2026 · Membranes
HIV-associated neurocognitive disorders (HAND) persist despite combination antiretroviral therapy (cART) and can be exacerbated by repeated cocaine (COC) exposure. Because COC, HAND, and cART independently disrupt medial prefrontal cortex…
View details →DOI: 10.3390/membranes16040115 Negative / Null Result Report
Bracci EL, Barnett AG, Brown C et al. · 2023 · Preprint
Background: Non-beneficial treatment affects a considerable proportion of older people in hospital, and some will choose to decline invasive treatments when they are approaching the end of their life. The Intervention for Appropriate Care…
View details →DOI: 10.21203/rs.3.rs-3268081/v1 Negative / Null Result ReportOpen accessMedicine
Krittaphol W, Martin LW, Walker GF et al. · 2025 · Pathogens (Basel, Switzerland)
Chronic infections of Pseudomonas aeruginosa are commonly treated with tobramycin. During infections, the bacteria can exist under conditions of oxygen deprivation that render them less susceptible to this antibiotic. The aims of this…
View details →DOI: 10.3390/pathogens14020187 Negative / Null Result ReportOpen accessMedicine
Newman MS, Smeaton J · 2025 · Menopause (New York, N.Y.)
Objectives 3,3'-diindolylmethane (DIM) is a supplement, investigational drug, and the primary in vivo product of indole-3-carbinol. DIM is sometimes recommended to postmenopausal women by functional or integrative medicine providers. Some…
View details →DOI: 10.1097/gme.0000000000002542 Negative / Null Result ReportOpen accessMedicine
Vega-Trejo R, Sanghvi K, Todorova B et al. · 2024 · Scientific reports
Mate availability and social information can influence mating behaviour in both males and females. Social information obtained from conspecifics can influence mate choice, particularly shown by studies on mate choice copying. However, the…
View details →DOI: 10.1038/s41598-024-83465-6 Negative / Null Result ReportOpen accessMedicine
Hemmingsen MG, Zhang GF, Ma Y et al. · 2025 · JCI insight
Methylmalonic acidemia (MMA) is a severe metabolic disorder affecting multiple organs because of a distal block in branched-chain amino acid (BCAA) catabolism. Standard of care is limited to protein restriction and supportive care during…
View details →DOI: 10.1172/jci.insight.187758 Failed Experiment ReportOpen accessMedicine
Tokushige A, Akasaki Y, Shibata K et al. · 2026 · Nutrients
Background/objectives We aimed to evaluate the efficacy and safety of a short-term dietary intervention using trigonelline-rich Sakurajima radish on vascular endothelial function in patients with metabolic syndrome (MetS). Methods In this…
View details →DOI: 10.3390/nu18111801 Failed Experiment ReportOpen accessMedicine
Henriksen IW, Bartholdy C, Koch J et al. · 2026 · Clinical and translational science
Valid pre-clinical animal models are essential for effective drug development in inflammatory skin diseases like atopic dermatitis. Most murine models exhibit low-to-moderate inflammatory responses with significant variability, undermining…
View details →DOI: 10.1111/cts.70593 Failed Experiment ReportOpen accessMedicine
Keith DS, Lessmann E · 2024 · Annals of transplantation
BACKGROUND Mechanical preservation (MP) of deceased donor kidney transplants showed a 30% to 50% reduction in delayed graft function (DGF) as defined by dialysis in the first week, when compared with cold storage. DGF is associated with…
View details →DOI: 10.12659/aot.944338 Negative / Null Result ReportOpen accessMedicine
Beirowski B, Huang H, Babetto E · 2026 · eLife
Axon degeneration (AxD), accompanied by glial remodeling, is a pathological hallmark of many neurodegenerative diseases, leading to the disruption of neuronal connectivity. Understanding the mechanisms in neurons and glia that regulate AxD…
View details →DOI: 10.7554/elife.108389 Negative / Null Result ReportOpen accessMedicine
Levin ME, Mukasa MN, Bowers EM et al. · 2025 · Behavioral sciences (Basel, Switzerland)
Adherence challenges are common among digital mental health interventions (DMHIs). Single-session DMHIs may help by providing a low-intensity intervention that takes less time to complete. This pilot randomized controlled trial sought to…
View details →DOI: 10.3390/bs15010075 Negative / Null Result ReportOpen accessMedicine
Lunde P, Finbråten HS, Pripp AH et al. · 2025 · International journal of cardiology. Cardiovascular risk and prevention
Background and aims Adherence to treatment is a significant challenge for patients with cardiac disease. Optimizing health literacy (HL) is essential in this context. Mobile health (mHealth) interventions have been suggested to improve…
View details →DOI: 10.1016/j.ijcrp.2025.200445 Negative / Null Result ReportOpen accessMedicine
Ferro M, Cilla S, Macchia G et al. · 2026 · Cancer reports (Hoboken, N.J.)
Background This study investigates the impact of radiotherapy (RT) on fatigue levels in prostate cancer (PC) patients, considering the significant physical and psychological impact of fatigue associated with cancer and its treatments.…
View details →DOI: 10.1002/cnr2.70525 Failed Experiment ReportMedicine
Liu Z, Zhao H, Chen X et al. · 2026 · Reproduction in domestic animals = Zuchthygiene
Hormonal stimulation was performed on Japanese black prepubertal calves (8- and 12-month-old) and heifers (2-3-year-old), followed by oocyte retrieval by ovum pick-up (OPU) and in vitro fertilization (IVF). Both calves and heifers…
View details →DOI: 10.1111/rda.70242 Failed Experiment ReportMedicine
Schrag A, Embleton-Thirsk A, Carroll C et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)
Pilot randomised-controlled trial of nortriptyline and escitalopram compared to placebo for depressive symptoms in people with Parkinson's disease (PD). Participants with PD and depressive symptoms received either nortriptyline,…
View details →DOI: 10.1007/s00702-026-03170-8 Negative / Null Result Report
stocker t · 2026 · Preprint
Hyperlactatemia, and/or lactic acidosis, is a common complication in wildlife due to the sensitivity of these species to capture induce complications. The treatment of lactic acidosis in humans is equally as controversial as in veterinary…
View details →DOI: 10.32942/x2p398 Negative / Null Result ReportOpen accessMedicine
Sieborg J, Maul JT, Wu JJ et al. · 2025 · Acta dermato-venereologica
Biosimilars are designed to be analogous to the biologic originators. However, comprehensive comparisons between biosimilars are limited and lacking for patients with psoriasis. This study's objective was to compare 1-year drug survival of…
View details →DOI: 10.2340/actadv.v105.42572 Negative / Null Result ReportMedicine
Hossain SJ, Tofail F, Mehrin SF et al. · 2023 · Pediatrics
Background and objectives Previously, in 30 Bangladeshi villages, 2 groups of children with iron-deficiency anemia (IDA) and nonanemic (NA) iron sufficiency aged 6 to 24 months participated in 2 parallel cluster randomized controlled…
View details →DOI: 10.1542/peds.2023-060221e Negative / Null Result ReportOpen accessMedicine
Bingöl G, Jesurasa S, Stroethoff M et al. · 2025 · Frontiers in cardiovascular medicine
Remote ischemic preconditioning (RIPC) has been shown in several experimental studies as an organ protective procedure against ischemic injury, but the implementation of RIPC into routine clinical practice has so far failed due to…
View details →DOI: 10.3389/fcvm.2025.1631222 