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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21379 results · page 684 of 713

Negative / Null Result ReportMedicine

Paired analysis of meconium and neonatal hair reveals distinct biomarker profiles of prenatal exposure to trace metal elements.

Alsayegh MMA, Sallom BA, Fadel EA et al. · 2026 · Scientific reports

Prenatal exposure to trace metal elements remains a significant public health concern, particularly because these elements can cross the placental barrier and accumulate in fetal tissues. Meconium and neonatal hair are commonly used as…

View details →DOI: 10.1038/s41598-026-54043-9
Negative / Null Result Report

Hallucination Mitigation in Large Language Model-Based Tool Recommendation: A Cross-Provider Architectural Ablation Study Across Two Model Generations

Menxhiqi L, Marinova G · 2026 · Preprint

In a closed-inventory Large Language Model (LLM) system such as Online-CADCOM, which recommends engineering tools from a verified inventory, mention-level hallucination occurs when the model recommends tools not present in the inventory.…

View details →DOI: 10.20944/preprints202606.0008.v1
Failed Experiment Report

Computational Transcriptional Deconvolution and Purity-Corrected Analysis Characterizes Invasion Programs in IDH-Wildtype Glioblastoma: Proneural Distinctiveness, Transcription Factor Proxy Activity, and Dual Mechanisms of Therapeutic Resistance

Saadawy M, Elkoumi O, Saadawy E · 2026 · Preprint

Abstract Background Glioblastoma (GBM) recurrence originates from the non-resectable invasive margin. While the Mesenchymal (ME) subtype has traditionally been considered the most invasive, this assignment is confounded by tumor purity and…

View details →DOI: 10.21203/rs.3.rs-9716905/v1
Negative / Null Result ReportMedicine

Seroprevalence and molecular detection of Toxoplasma gondii in patients with obsessive-compulsive disorder: a case-control study in northern Iran.

Zakariaei Z, Hosseini SH, Alizadeh-Navaei R et al. · 2026 · BMC infectious diseases

Background The infectious hypothesis of obsessive-compulsive disorder (OCD) has gained traction, with Toxoplasma gondii (T. gondii) proposed as a potential risk factor due to its neurotropic properties and ability to alter neurotransmitter…

View details →DOI: 10.1186/s12879-026-13855-w
Negative / Null Result Report

Application of [ 18 F]NaF and [ 18 F]FDG PET/CT to Assess Molecular Calcification and Glucose Metabolism in Thyroid Cartilage

Motamedi N, Singh SB, Gandhi OH et al. · 2026 · Preprint

Objective: Thyroid cartilage calcification and glucose metabolism may vary with age and gender. This study aimed to investigate the role of [18F]-sodium fluoride ([18F]NaF) and 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) PET/CT for the…

View details →DOI: 10.20944/preprints202605.1265.v1
Negative / Null Result ReportMedicine

Assessment of active fibrotic remodeling in patients with idiopathic pulmonary fibrosis (IPF)/progressive pulmonary fibrosis (PPF) using dual-time-point [<sup>68</sup>Ga]Ga-FAPI-46-PET/CT.

Grunert M, Horn V, Baudrexl JC et al. · 2026 · European journal of radiology

Background Progressive fibrosing interstitial lung diseases (ILD) continue to have a poor prognosis. To date, there is no imaging method that can reliably detect fibrotic remodeling processes or distinguish between active and dormant…

View details →DOI: 10.1016/j.ejrad.2026.113036
Negative / Null Result ReportMedicine

Impact of epidemiological and nutritional factors on outcomes following traumatic brain injury in a prospective cohort study.

Afsar E, Sadeghi-Bazargani H, Salehpour F et al. · 2026 · Scientific reports

Traumatic brain injury (TBI) continues to be one of the world's top causes of mortality and long-term disability. It is a severe and frequently fatal disorder. Patients with traumatic brain injury (TBI) not only sustain neurological…

View details →DOI: 10.1038/s41598-026-56795-w
Negative / Null Result ReportMedicine

Establishing Age-Specific and Sex-Specific Norms for Mitral Valve E-Point Septal Separation (EPSS) Measurements in Pediatric Patients.

Ruffin JC, Stem CT, Pletzer S et al. · 2026 · Pediatric emergency care

Objective Pediatric heart failure is a rare condition with significant morbidity that requires timely diagnosis and treatment. Mitral valve E-point septal separation (EPSS) may be used as an estimate of systolic function in this…

View details →DOI: 10.1097/pec.0000000000003625
Negative / Null Result ReportMedicine

Comparison of neuromelanin-sensitive magnetic resonance imaging using different magnetic resonance protocols on the same patients with Parkinson's disease.

Hirose R, Matsuura K, Ii Y et al. · 2026 · Journal of neural transmission (Vienna, Austria : 1996)

In Parkinson's disease (PD), neuronal loss occurs in the substantia nigra (SN) and locus coeruleus (LC). Previous studies using neuromelanin-sensitive magnetic resonance imaging (NMI) at 3T MRI have described the measurement methods and…

View details →DOI: 10.1007/s00702-026-03179-z
Negative / Null Result ReportMedicine

PNEUMOCOCCAL SEROLOGICAL EVALUATION IN VACCINATED CHILDREN DIAGNOSED WITH TRANSIENT HYPOGAMMAGLOBULINEMIA OF INFANCY AND UNCLASSIFIED HYPOGAMMAGLOBULINEMIA.

Öztürk G, Orhon F, Bayrakoğlu D et al. · 2026 · International archives of allergy and immunology

The severity and incidence of invasive pneumococcal infections increase in inborn errors of immunities. However, there are limited number of studies in the literature evaluating pneumococcal antibody levels in patients with a prediagnosis…

View details →DOI: 10.1159/000552296
Negative / Null Result Report

Tenofovir intracellular concentration as Tenofovir alafenamide in Bictegravir-including versus Dolutegravir-including antiretroviral regimens

Ferrara M, Maccario V, Fantino S et al. · 2026 · Preprint

This study investigates intracellular (IC) exposure to tenofovir alafenamide (TAF) and its clinical determinants in experienced people living with HIV. We conducted a monocentric retrospective analysis of 86 adults treated with either…

View details →DOI: 10.22541/au.177547173.39036280/v1
Negative / Null Result ReportOpen accessMedicine

Exploring the significance of fatty acid-binding protein 4 levels as a biomarker for autism spectrum disorder: a cross-sectional study.

Abdelaziz AW, Alkherkhisy MM, El-Sheikh HR et al. · 2026 · BMC psychiatry

Background Lipid metabolism and its regulatory molecules, especially adipokines, have gained significant attention in recent pathogenesis research of autism spectrum disorder (ASD). Aims To evaluate serum fatty acid-binding protein 4…

View details →DOI: 10.1186/s12888-026-08295-4
Negative / Null Result ReportMedicine

What is the Rate of Occult Vessel Abnormalities in High-Energy Tibial Plateau Fractures (OTA/AO 41)?

Zhang D, Eurich J, Pitz-Goncalves L et al. · 2026 · Journal of orthopaedic trauma

Objectives To determine the rate of occult vascular abnormalities in high-energy tibial plateau fractures using Computed Tomography Angiography (CTA). Methods Design Prospective Cohort Study. Setting Single Academic Level I Trauma Center.…

View details →DOI: 10.1097/bot.0000000000003215
Negative / Null Result ReportMedicine

Smell and taste dysfunction after total laryngectomy: A cross-sectional study comparing patient and physician perspectives.

Bilen YE, Sinanoğlu N, Külekci Ç · 2026 · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

Purpose Total laryngectomy disrupts nasal airflow, often resulting in significant olfactory and gustatory dysfunction. While these sensory losses may adversely affect patients' quality of life and psychological well-being, they typically…

View details →DOI: 10.1007/s00405-025-09855-2
Negative / Null Result ReportMedicine

Comparative Evaluation of Serum Hepcidin and Fecal Calprotectin for Disease Activity Assessment in Inflammatory Bowel Disease.

Akıncıoğlu P, Dağlı Ü, Koca E · 2026 · The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Background/aims Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key…

View details →DOI: 10.5152/tjg.2026.25774
Negative / Null Result ReportMedicine

The Effect of EMG biofeedback in female patients with stress urinary incontinence: a randomized sham controlled blinded clinical study.

Cigdem-Karacay B, Bayramoglu-Demirdogen E, Konar NM et al. · 2026 · Irish journal of medical science

AIM: The effectiveness of EMG-BF in SUI has not yet been proven. This study aimed to the effectiveness of EMG-BF on pelvic floor muscle activity, pad test, severity of complaints, and quality of life in female patients with Stress Urinary…

View details →DOI: 10.1007/s11845-026-04374-3
Negative / Null Result ReportMedicine

Compression Garments and Adaptations to Plyometric Training in Soccer Players: A Randomized-Controlled Study.

Gosset M, Coquart A, Delaval B et al. · 2026 · Journal of strength and conditioning research

Abstract Gosset, M, Coquart, A, Delaval, B, Catalano, J, Huou, G, Boufflers, M, Bozok, D, Bellanger, L, Douchet, T, Viroux, P, Jaffré, C, and Abaïdia, A-E. Compression garments and adaptations to plyometric training in soccer players: A…

View details →DOI: 10.1519/jsc.0000000000005489
Negative / Null Result ReportMedicine

Impact of peptide receptor radionuclide therapy (PRRT) on the quality of life in patients with neuroendocrine tumours.

Fernando H, Vito I, Santillan N et al. · 2026 · Journal of neuroendocrinology

As peptide receptor radionuclide therapy (PRRT) maintains a key role in the treatment of neuroendocrine tumours (NETs), there is growing recognition of the importance of evaluating patient-reported health related quality of life (HRQoL).…

View details →DOI: 10.1111/jne.70201
Negative / Null Result ReportMedicine

Efficacy of Testosterone Replacement Therapy Combined With Exercise on Body Composition in Hypogonadal Men.

Shigehara K, Shinzawa R, Sakatoku N et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Objectives We assessed the efficacy of testosterone replacement therapy (TRT) combined with exercise on body composition in hypogonadal men. Methods Two hundred-fourteen patients were enrolled. All patients were divided into four groups:…

View details →DOI: 10.1111/iju.70524
Negative / Null Result ReportMedicine

Real-World Integrative Oncology in Patients With Cancer and Diabetes: Engagement Patterns, Outcomes.

Kassem S, Gressel O, Samuels N et al. · 2026 · Journal of pain and symptom management

Context and objective Integrative oncology (IO) programs address quality of life (QoL)-related concerns within palliative and supportive cancer care. This study examined adherence to and outcomes of an IO program among patients with both…

View details →DOI: 10.1016/j.jpainsymman.2026.05.013
Negative / Null Result ReportMedicine

Safety and efficacy of Esculin and Digitalis glycosides eye drops in individuals with presbyopia.

Zhang Y, Wang J, Hao M et al. · 2026 · Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

PURPOSE: This proof-of-concept study aimed to detect preliminary signals of efficacy and assess the short-term safety of Esculin and Digitalis glycoside eye drops for the management of presbyopia. METHODS: This study was a 30-day,…

View details →DOI: 10.1007/s00417-026-07184-6
Negative / Null Result ReportMedicine

A person-centred and data-driven approach to phenotyping anorexia nervosa.

Bovenberg C, Keeler JL, Cardi V et al. · 2026 · Journal of eating disorders

Background Anorexia nervosa (AN) is a severe psychiatric disorder (ED) with high mortality, marked functional impairment, and substantial phenotypical heterogeneity. Despite extensive research, treatment outcomes remain poor, and it is…

View details →DOI: 10.1186/s40337-026-01632-8
Negative / Null Result ReportMedicine

Comparison of sesame oil wafers and lozenges as saliva substitutes for dry mouth in head and neck cancer patients: A crossover randomized control trial.

Abbas Amanat M, Srichana T, Takahashi Yupanqui C et al. · 2026 · Pakistan journal of pharmaceutical sciences

Background Dry mouth is a condition associated with significant morbidity. It not only causes discomfort but also increases risk of many health and oral health problems. Objectives This study compared the efficacy and patient satisfaction…

View details →DOI: 10.36721/pjps.2026.39.5.reg.15179.1
Negative / Null Result ReportMedicine

Feasibility and advantages of delivering radiofrequency ablation treatment for haemorrhoids under local anaesthesia in the outpatient setting in the UK: our initial experience.

Rajendiran A, Maharjan A, Gerrard AD et al. · 2026 · Techniques in coloproctology

Introduction Radiofrequency ablation (RFA) for haemorrhoids has emerged as a minimally invasive treatment for grade II-III haemorrhoids, offering reduced postoperative pain and faster recovery compared with conventional surgery. However,…

View details →DOI: 10.1007/s10151-026-03353-1
Negative / Null Result ReportMedicine

Real-Time Perfusion Assessment with Hyperspectral Imaging After Revascularization in Peripheral Artery Disease.

Kluckner M, Hitzl W, Enzmann FK et al. · 2026 · Journal of clinical medicine

Background/Objectives : Hyperspectral imaging (HSI) facilitates noninvasive assessment of tissue perfusion in patients with peripheral arterial disease. However, available studies are either based on small cohorts and provide no comparison…

View details →DOI: 10.3390/jcm15041667