Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Zhuan Li, Yohei Yamauchi, Maki Kamakura et al. · 2011 · Journal of Virology
Tankyrase 1 is a poly(ADP-ribose) polymerase (PARP) which localizes to multiple subcellular sites, including telomeres and mitotic centrosomes. Poly(ADP-ribosyl)ation of the nuclear mitotic apparatus (NuMA) protein by tankyrase 1 during…
View details →DOI: 10.1128/jvi.05897-11Cited by 55 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Dipongkor Saha, Samuel D. Rabkin, Robert L. Martuza · 2020 · Journal for ImmunoTherapy of Cancer
Background Temozolomide (TMZ) chemotherapy is a current standard of care for glioblastoma (GBM), however it has only extended overall survival by a few months. Because it also modulates the immune system, both beneficially and negatively,…
View details →DOI: 10.1136/jitc-2019-000345Cited by 55 Negative / Null Result ReportOpen accessMedicine
Sumit K. Subudhi, Bilal A. Siddiqui, Ana M. Aparicio et al. · 2021 · Journal for ImmunoTherapy of Cancer
BACKGROUND: Immune checkpoint therapy (ICT) has low response rates in patients with metastatic castration-resistant prostate cancer (mCRPC), in part due to few T cells in the tumor microenvironment (TME). Anti-cytotoxic T…
View details →DOI: 10.1136/jitc-2021-002919Cited by 55 Negative / Null Result ReportImmunology and Microbiology
Edwin Hoe, Fiona C. McKay, Stephen D. Schibeci et al. · 2010 · The Journal of Immunology
Common genetic variants of IL-7 receptor alpha (IL-7Ralpha) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation. Transcription of the gene…
View details →DOI: 10.4049/jimmunol.0902900Cited by 55 Negative / Null Result ReportOpen accessMedicine
Katja Werlenius, Sara Kinhult, Tora S. Solheim et al. · 2023 · JAMA Network Open
Importance: Disulfiram has demonstrated broad antitumoral effect in several preclinical studies. One of the proposed indications is for the treatment of glioblastoma. Objective: To evaluate the efficacy and safety of disulfiram and copper as add-on to alkylating chemotherapy in patients with recurrent glioblastoma. Design, Setting, and Participants: This was a multicenter, open-label, randomized phase II/III clinical trial with parallel group design. Patients were recruited at 7 study sites in Sweden and 2 sites in Norway between January 2017 and November 2020. Eligible patients were 18 years
View details →DOI: 10.1001/jamanetworkopen.2023.4149Cited by 55 Negative / Null Result Report
Safina Islam, Olivia Joseph, Atiha Chaudry et al. · 2021 · Research Involvement and Engagement
Abstract Background Public involvement in clinical translational research is increasingly recognised as essential for relevant and reliable research. Public involvement must be diverse and inclusive to enable research that has the…
View details →DOI: 10.1186/s40900-021-00292-zCited by 55 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Karolina Strzebońska, Marcin Waligóra · 2019 · BMC Medical Ethics
BACKGROUND: Novel precision oncology trial designs, such as basket and umbrella trials, are designed to test new anticancer agents in more effective and affordable ways. However, they present some ethical concerns referred to scientific validity, risk-benefit balance and informed consent. Our aim is to discuss these issues in basket and umbrella trials, giving examples of two ongoing cancer trials: NCI-MATCH (National Cancer Institute - Molecular Analysis for Therapy Choice) and Lung-MAP (Lung Cancer Master Protocol) study. MAIN BODY: We discuss three ethical requirements for clinical trials w
View details →DOI: 10.1186/s12910-019-0395-5Cited by 55 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Mayukh Chakrabarti, Hyunbum Jang, Ruth Nussinov · 2016 · The Journal of Physical Chemistry B
Human HRAS, KRAS, and NRAS genes encode four isoforms of Ras, a p21 GTPase. Mutations in KRAS account for the majority of RAS-driven cancers. The KRAS has two splice variants, K-Ras4A and K-Ras4B. Due to their reversible palmitoylation,…
View details →DOI: 10.1021/acs.jpcb.5b11110Cited by 55 Negative / Null Result ReportOpen accessMedicine
Gil Awada, Laïla Ben Salama, Jennifer Cremer et al. · 2020 · Journal for ImmunoTherapy of Cancer
BACKGROUND: No treatment demonstrated to improve survival in patients with recurrent glioblastoma (rGB) in a randomized trial. Combining axitinib with the programmed cell death ligand 1 blocking monoclonal antibody avelumab may result in…
View details →DOI: 10.1136/jitc-2020-001146Cited by 55 Negative / Null Result ReportEnvironmental Science
Britta Jänicke, Fred Meier, Daniel Fenner et al. · 2016 · International Journal of Climatology
ABSTRACT Model‐based studies on urban heat islands can be seriously affected by errors in near‐surface air temperature ( T 2), especially if errors differ between cities and their rural surroundings. Furthermore, errors in T 2 strongly…
View details →DOI: 10.1002/joc.4835Cited by 55 Negative / Null Result ReportSocial Sciences
Toru Ishikawa · 2012 · The Professional Geographer
Abstract This study examined the relationships between geospatial thinking and spatial ability, focusing on knowledge and reasoning about fundamental concepts in geospatial science. Scores on a geospatial thinking test had low correlations…
View details →DOI: 10.1080/00330124.2012.724350Cited by 55 Negative / Null Result ReportMedicine
Yong‐Hao Pua, Hakmook Kang, Julian Thumboo et al. · 2019 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: Machine-learning methods are flexible prediction algorithms with potential advantages over conventional regression. This study aimed to use machine learning methods to predict post-total knee arthroplasty (TKA) walking limitation,…
View details →DOI: 10.1007/s00167-019-05822-7Cited by 54 Negative / Null Result ReportOpen accessEnvironmental Science
Yinxue Liu, Paul Bates, Jeffrey Neal et al. · 2021 · Water Resources Research
Abstract Accurate terrain representation is critical to estimating flood risk in urban areas. However, all current global elevation data sets can be regarded as digital surface models in urban areas as they contain building artifacts that…
View details →DOI: 10.1029/2020wr028516Cited by 54 Negative / Null Result ReportSocial Sciences
Chun‐Yen Tsai · 2014 · International Journal of Science Education
The scientific competencies advocated by the Programme for International Student Assessment (PISA) focus on the abilities needed in students' adult lives. This study investigated how such scientific competencies could be improved by using…
View details →DOI: 10.1080/09500693.2014.987712Cited by 54 Negative / Null Result ReportOpen accessMedicine
Yoshimasa Miyagawa, Kazuhiro Araki, Ayako Bun et al. · 2018 · Clinical Breast Cancer
INTRODUCTION: Although eribulin and nab-paclitaxel are chemotherapy agents widely used for locally advanced or metastatic breast cancer (MBC), their predictive factors remain unknown. Because the absolute neutrophil-to-lymphocyte ratio…
View details →DOI: 10.1016/j.clbc.2018.03.002Cited by 54 Negative / Null Result ReportOpen accessMedicine
Simone Baldi, Marta Menicatti, Giulia Nannini et al. · 2021 · Nutrients
Altered circulating levels of free fatty acids (FFAs), namely short chain fatty acids (SCFAs), medium chain fatty acids (MCFAs), and long chain fatty acids (LCFAs), are associated with metabolic, gastrointestinal, and malignant diseases. Hence, we compared the serum FFA profile of patients with celiac disease (CD), adenomatous polyposis (AP), and colorectal cancer (CRC) to healthy controls (HC). We enrolled 44 patients (19 CRC, 9 AP, 16 CD) and 16 HC. We performed a quantitative FFA evaluation with the gas chromatography-mass spectrometry method (GC-MS), and we performed Dirichlet-multinomial
View details →DOI: 10.3390/nu13030742Cited by 54 Negative / Null Result ReportOpen accessMedicine
Tom Koeman, Pauline Slottje, Leo J. Schouten et al. · 2017 · Occupational and Environmental Medicine
OBJECTIVE: To prospectively study suspected occupational risk factors for amyotrophic lateral sclerosis (ALS). METHODS: For this case-cohort analysis within the prospective Netherlands Cohort Study, 58 279 men and 62 573 women aged 55-69…
View details →DOI: 10.1136/oemed-2016-103780Cited by 54 Negative / Null Result ReportOpen accessEconomics, Econometrics and Finance
Hassan Mohammadi, Yuting Tan · 2015 · Econometrics
Examinations of the dynamics of daily returns and volatility in stock markets of the U.S., Hong Kong and mainland China (Shanghai and Shenzhen) over 2 January 2001 to 8 February 2013 suggest: (1) evidence of unidirectional return spillovers from the U.S. to the other three markets; but no spillover between Hong Kong and either of the two mainland China markets; (2) evidence of unidirectional ARCH and GARCH effects from the U.S. to the other three markets; (3) correlations of returns vary across markets, with the highest correlation of 93.5% between the two Chinese markets, medium correlation o
View details →DOI: 10.3390/econometrics3020215Cited by 54 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Susan C. Kleiman, Emily Bulik-Sullivan, Elaine M. Glenny et al. · 2017 · PLoS ONE
OBJECTIVE: This study examined associations between the composition and diversity of the intestinal microbiota and measures of depression, anxiety, eating disorder psychopathology, stress, and personality in a group of healthy adult females. METHODS: Female participants (n = 91) ages 19-50 years with BMI 18.5-25 kg/m2 were recruited from central North Carolina between July 2014 and March 2015. Participants provided a single fecal sample and completed an online psychiatric questionnaire that included five measures: (i) Beck Anxiety Inventory; (ii) Beck Depression Inventory-II; (iii) Eating Diso
View details →DOI: 10.1371/journal.pone.0170208Cited by 54 Negative / Null Result ReportOpen accessMathematics
Konrad Neumann, Ulrike Grittner, Sophie K. Piper et al. · 2017 · PLoS Biology
Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the existing methodology of group sequential designs to the attention of researchers in the preclinical field and to clearly illustrate its potential utility. Group sequential designs can offer higher efficiency than traditional methods and are increasingly used in clinical trials. Using simulation of data, we demonstrate that group sequential designs have t
View details →DOI: 10.1371/journal.pbio.2001307Cited by 54 Negative / Null Result Report
I. A. G. Snellen, L. Guzman-Ramirez, M. R. Hogerheijde et al. · 2020 · Astronomy & Astrophysics
Context. ALMA observations of Venus at 267 GHz that show the apparent presence of phosphine (PH 3 ) in its atmosphere have been presented in the literature. Phosphine currently has no evident production routes on the planet’s surface or in…
View details →DOI: 10.1051/0004-6361/202039717Cited by 54 Negative / Null Result ReportOpen accessSocial Sciences
Patrick Kline, Christopher Walters · 2021 · Econometrica
This paper develops methods for detecting discrimination by individual employers using correspondence experiments that send fictitious resumes to real job openings. We establish identification of higher moments of the distribution of…
View details →DOI: 10.3982/ecta17489Cited by 54 Negative / Null Result ReportOpen accessMedicine
Shoji Kawakami, Yoshio Tahara, Teruo Noguchi et al. · 2016 · Circulation Journal
BACKGROUND: Prehospital ECG improves survival following ST-segment elevation myocardial infarction (STEMI). Although a new International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment…
View details →DOI: 10.1253/circj.cj-15-1322Cited by 54 Negative / Null Result ReportOpen accessMedicine
Sae‐Won Han, Hyun‐Jung Lee, Jeong Mo Bae et al. · 2012 · International Journal of Cancer
The prognostic impact of CpG island methylator phenotype (CIMP) and microsatellite instability (MSI) on the treatment outcome of colon cancer patients receiving adjuvant 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX) is unclear. We…
View details →DOI: 10.1002/ijc.27888Cited by 54 Negative / Null Result ReportMedicine
Hyehyun Jeong, Kyu‐pyo Kim, Jae Ho Jeong et al. · 2023 · Hepatology
BACKGROUND AND AIMS: The effectiveness of gemcitabine-based adjuvant chemotherapy is unclear in cholangiocarcinoma. We investigated the role of adjuvant gemcitabine plus cisplatin (GemCis) in a homogeneous group of high-risk patients with…
View details →DOI: 10.1097/hep.0000000000000046Cited by 54 Negative / Null Result ReportOpen accessBiochemistry, Genetics and Molecular Biology
Heidi Lynch, Matthew P. Buman, Jared M. Dickinson et al. · 2020 · International Journal of Environmental Research and Public Health
There are conflicting reports regarding the efficacy of plant versus animal-derived protein to support muscle and strength development with resistance training. The purpose of this study was to determine whether soy and whey protein supplements matched for leucine would comparably support strength increases and muscle growth following 12 weeks of resistance training. Sixty-one untrained young men (n = 19) and women (n = 42) (18–35 year) enrolled in this study, and 48 completed the trial (17 men, 31 women). All participants engaged in supervised resistance training 3×/week and consumed 19 grams
View details →DOI: 10.3390/ijerph17113871Cited by 54 Negative / Null Result ReportOpen accessHealth Professions
Ton Wang, Brooke C. Bredbeck, Brandy Sinco et al. · 2021 · JAMA Surgery
Importance: Through the Choosing Wisely campaign, surgical specialties identified 4 low-value breast cancer operations. Preliminary data suggest varying rates of deimplementation and have identified patient-level and clinician-level…
View details →DOI: 10.1001/jamasurg.2020.6942Cited by 54 Negative / Null Result ReportSocial Sciences
Richard Stansfield, Thomas J. Mowen, Thomas P. O’Connor et al. · 2016 · Journal of Research in Crime and Delinquency
Objective: Research on the relationship between religion and criminal recidivism has produced encouraging but ultimately inconclusive findings. This study offers a new direction for studying the role of religious support in reentry,…
View details →DOI: 10.1177/0022427816657578Cited by 54 Negative / Null Result ReportOpen accessMedicine
Shigeyuki Tamura, Atsushi Takeno, Hirofumi Miki · 2011 · International Journal of Surgical Oncology
Gastric cancer is one of the most common causes of cancer-related death worldwide. Surgical resection with lymph node dissection is the only potentially curative therapy for gastric cancer. However, the appropriate extent of lymph node dissection accompanied by gastrectomy for cancer remains controversial. In East Asian countries, especially in Japan and Korea, D2 lymph node dissection has been regularly performed as a standard procedure. In Western countries, surgeons perform gastrectomy with D1 dissection only because D2 is associated with high mortality and morbidity compared to those assoc
View details →DOI: 10.1155/2011/748745Cited by 54 Negative / Null Result ReportMedicine
Kevin J. McHale, Joshua C. Rozell, Andrew H. Milby et al. · 2016 · The American Journal of Sports Medicine
BACKGROUND: Tarsometatarsal (Lisfranc) joint injuries commonly occur in National Football League (NFL) competition; however, the career effect of these injuries is unknown. PURPOSE: To define the time to return to competition for NFL…
View details →DOI: 10.1177/0363546516645082Cited by 54 