A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20289 results in Negative / Null Result Report · page 673 of 677
Pérez Serena A, Martínez Betancourt DP · 2026 · Neurocirugia
We report the case of a 56-year-old female patient with controlled Human Immunodeficiency Virus (HIV) who presented with binocular diplopia and a known sixth cranial nerve palsy. Imaging revealed a lesion centered in the right cavernous…
De Cassai A, Dost B, Karapinar YE et al. · 2026 · Revista espanola de anestesiologia y reanimacion
Background The Erector Spinae Plane (ESP) block is a regional anaesthesia technique with a growing range of clinical applications due to its short learning curve, low complication rate, and effectiveness. However, publication bias can…
Di Noia D, Maiorano MFP, Sanasi A et al. · 2026 · Journal of gynecology obstetrics and human reproduction
Radiation necrosis is a rare but serious complication of pelvic chemoradiotherapy that may closely mimic tumor recurrence on both imaging and clinical examination. We describe the case of a 43-year-old woman with FIGO stage II vaginal…
Ravizzini PC, Lino HA, de Faria Castro Fleury E et al. · 2025 · Cureus
Background This study compares the glomerular yield, mean number of biopsy cores, and complication rates between pediatric and adult populations undergoing ultrasound-guided native kidney biopsies. Additionally, the adult population was…
Mayer A, Bresesti I, Francescato G et al. · 2025 · European journal of pediatrics
The amount of fluid to give in preterm infants with patent ductus arteriosus (PDA) is still highly debated, with no robust evidence that fluid restriction provides a clear benefit. The aim of the study is to evaluate if spontaneous closure…
Song P, Su J, Vraa CLK et al. · 2025 · Preprint
Lipid nanoparticles (LNPs) have proven to be an effective delivery system for RNA therapeutics. The chemical composition of LNPs determines their functional delivery efficiency and targeting properties, which vary between in vitro and in…
Shiba Y, Aoki K, Ohka F et al. · 2025 · AJNR. American journal of neuroradiology
Background and purpose Differentiating between a brain tumor and a nontumorous lesion remains a diagnostic challenge, particularly when conventional imaging modalities such as CT and MRI provide inconclusive results. While 11 C-methionine…
Kumar R, Gravett S, Jelic V et al. · 2026 · Neurology
Background and objectives The α-synuclein (α-syn) seed amplification assay (SAA) has shown promising results for diagnosing dementia with Lewy bodies (DLB) using CSF samples. A barrier to implementing α-syn SAA clinically is the use of…
Tornvall S, Blomberg L, Hirschberg AL · 2025 · Psychoneuroendocrinology
The objective of this study was to investigate the association of menstrual cycle phases on sexual function, well-being, and mood in young healthy women. Previous research has shown inconclusive results likely due to using non-validated…
Wilcox A, Hall M, Menzies J et al. · 2025 · Science of the Total Environment
The biodegradability of water-soluble carboxymethyl cellulose (CMC) polymer, degree of substitution of 0.65, was evaluated in screening and simulation assays using activated sludge as the inoculum. In an OECD 301B, CMC 0.65 was slowly…
Abdulrasak M, Axler O, Kapás B et al. · 2026 · Diagnostics (Basel, Switzerland)
Protein-losing enteropathy (PLE) is an uncommon and often underrecognized manifestation of lymphoproliferative disorders and may be difficult to diagnose when conventional gastrointestinal investigations are unrevealing. We present an…
Brataatmaja RH, Notari CF, Kam A et al. · 2025 · Preprint
Abstract Objectives: This umbrella review aimed to synthesize and critically evaluate the available evidence regarding the association between exposure to per- and polyfluoroalkyl substances (PFAS) and childhood obesity. Methods: A…
Maffezzoli M, Nagpal R, Elewaily M et al. · 2025 · Current oncology reports
PURPOSE OF REVIEW: Adjuvant immunotherapy has improved outcomes in several cancers, although patient selection and toxicity remain challenges. Circulating tumor DNA (ctDNA) has emerged as a biomarker for minimal residual disease (MRD)…
Viderman D, Kalikanov S, Mazhibiyeva A et al. · 2026 · Frontiers in pain research (Lausanne, Switzerland)
Background and objectives Chronic knee pain is highly prevalent in various knee diseases. It significantly decreases patients' quality of life. Among non-surgical interventions, exercise is considered a promising approach for alleviating…
Planello AC, Loureiro T, Alencar-Cupertino D et al. · 2025 · Revista da Associacao Medica Brasileira (1992)
Objective This study aimed to evaluate whether the increased use of exome sequencing as a primary next-generation sequencing test provides a higher diagnostic yield compared to multi-gene panels for various clinical indications within a…
Mansikkaniemi L, Stewart JA, Sinisalo J et al. · 2025 · Scandinavian cardiovascular journal : SCJ
Background. Invasive coronary angiography (ICA) is the gold standard in evaluating stent patency after percutaneous coronary intervention (PCI), but it carries a risk of potentially life-threatening complications. Third-generation coronary…
Naim S, Sraidi S, Salam S et al. · 2025 · Clinical case reports
We present a rare case of bone metastatic Neuroblastoma without a diagnosis of an identifiable primary lesion in a 16-year-old patient who presented with intermittent right knee pain and soft tissue swelling for 7 months. Initial…
Sabatini P, Zhang T, Boruvka N et al. · 2025 · American journal of clinical pathology
Objective Somatic hypermutation at immunoglobulin heavy chain variable (IGHV) genes, an established prognostic and predictive biomarker for chronic lymphocytic leukemia (CLL), is assessed by gene sequencing. We developed a single…
Holopainen A, Verhage ML, Schuengel C et al. · 2025 · Journal of reproductive and infant psychology
Background Fear of childbirth and negative birth experiences have suggested to been associated with parenting behaviour and thereby indirectly with child outcomes. The current study contributes to this knowledge by investigating fear of…
Young RP, Ward RC, Scott RJ et al. · 2025 · Annals of the American Thoracic Society
Rationale: Current eligibility criteria for lung cancer (LC) screening are derived from randomized controlled trials and largely based on age and smoking history. However, the individualized benefits of screening are highly variable and…
Garabedian C, Girault A · 2025 · Journal of gynecology obstetrics and human reproduction
Fetal monitoring during labor is crucial for detecting potential hypoxic situations that could lead to severe outcomes like cerebral palsy or peripartum death. The current standard, fetal heart rate (FHR) monitoring, is subjective and…
Racano E, Spinelli C, Sacco G et al. · 2026 · Scientific reports
Early detection and documentation of anterior segment opacities in infants (aged 1–6 months) is limited by resource constraints and specialist availability. This study aimed to evaluate the usefulness of digital infrared reflex testing…
Shah KV, Jung C, Talian D et al. · 2025 · OTO open
Objective While the etiology of Meniere's disease (MD) is likely multifactorial, genetics are thought to play a role. Several previous studies have yielded inconclusive results, potentially due to phenotypic uncertainty and variable…
Nguyen MD, Park D, Scott JW et al. · 2026 · Science advances
Landau predicted that transverse sound propagates in a Fermi liquid with sufficiently strong interactions such as for liquid 3 He, unlike a classical fluid that cannot support shear oscillations. Previous attempts to observe this unique…
Gay A, Laudet F, Meynard P et al. · 2026 · Orthopaedics & traumatology, surgery & research : OTSR
Introduction Infection is a significant and challenging complication of total hip and knee arthroplasties. Diagnosing chronic periprosthetic joint infection (PJI) can be difficult, particularly when joint aspiration yields inconclusive…
Payton C, Kvaratskhelia N, Chalfin M et al. · 2025 · Journal of immigrant and minority health
Cancer screening can detect cancer at an early stage and decrease cancer morbidity and mortality. Refugee populations may have had limited access to cancer screening before arrival in the United States. A cross-sectional analysis of…
Kaseb A, Benider H, Treglia G et al. · 2025 · European journal of clinical investigation
Background 4D-CT has garnered attention as complementary imaging for patients with primary hyperparathyroidism (pHPT). Herein we evaluated a diagnostic strategy using [ 18 F]Fluorocholine Positron Emission Tomography/Computed Tomography…
Kuyucu M, Erdogan KM, Adiyaman D et al. · 2025 · Medicine
This study shares our 5-year experience with chorionic villus sampling (CVS) and analyzes the indications, results, and complications of this procedure. We conducted a retrospective analysis of data from singleton pregnancies that…
Mwakibete L, Hoarau AOG, Ahyong V et al. · 2024 · Preprint
Investigations of wildlife diseases and mortality events can sometimes lead to inconclusive results due to limitations in diagnostics combined with an ever-increasing number of emerging viruses. The use of tools such as unbiased…
Juutilainen J, Khan MW, Naarala J et al. · 2024 · Occupational and environmental medicine
Objectives Studies assessing the association of adult cancers with extremely low frequency (ELF) magnetic fields (MF) have provided inconclusive results, probably affected by limitations such as low exposure levels, confounding and various…