Failed Experiment ReportOpen accessMedicine
McMullan RR, McGrath C, Cody N et al. · 2026 · Critical care explorations
Objectives Test the hypothesis that conservative fluid management with active deresuscitation would not adversely affect tissue perfusion or kidney injury and would be associated with reduced vascular injury compared with usual care.…
View details →DOI: 10.1097/cce.0000000000001404 Methods Dead-EndOpen accessMedicine
Carroll M, Gao Z, He L · 2026 · Foods (Basel, Switzerland)
Trace quantifications of arsenic (As) in foods by energy-dispersive X-ray fluorescence (ED-XRF) spectrometry are hindered by spectral overlap from lead (Pb) at characteristic emission lines. This study employed artificial neural networks…
View details →DOI: 10.3390/foods15071130 Methods Dead-End
De Laender F, Gonzalez A, Bleeckx O et al. · 2026 · Preprint
We provide a general theoretical explanation for a longstanding result in spatial ecology: weak dispersal among habitat patches promotes local biodiversity. Using analytical approximations of spatial Lotka–Volterra competition models, we…
View details →DOI: 10.64898/2026.02.16.706088 Methods Dead-EndOpen accessMedicine
Zips N, Kulko E, Kath-Schorr S · 2026 · Chembiochem : a European journal of chemical biology
mRNA translation can be controlled through chemical modification of the 5'-Cap, yet systematic insights into structure-reactivity relationships of bioorthogonally activatable Cap analogues remain limited. Here, we report the synthesis of…
View details →DOI: 10.1002/cbic.70420 Negative / Null Result ReportOpen accessMedicine
Strauss R, Wafula ST, Kobbe R et al. · 2026 · Open forum infectious diseases
We assessed baseline C-reactive protein (CRP) and procalcitonin levels in asymptomatic individuals from malaria-endemic West Africa. C-reactive protein remained unaffected by Plasmodium falciparum parasitemia, while procalcitonin (PCT) was…
View details →DOI: 10.1093/ofid/ofag078 Negative / Null Result Report
Bongulto K, Tauchi H, Suzuki S et al. · 2026 · Preprint
Carbapenem-resistant Acinetobacter (CRA) has been associated with increased morbidity and mortality in clinical settings. In this study, we explored the transfer potential of a mobilizable plasmid-harboring blaOXA-72 gene between…
View details →DOI: 10.64898/2026.06.25.734492 Negative / Null Result Report
Hubbe M, Eibl RH · 2026 · Preprint
Leukocyte recruitment from blood into tissues involves sequential adhesive steps, including rolling and integrin-dependent arrest. VLA-4 can support firm adhesion and, in some settings, rolling interactions, whereas CD44–hyaluronan…
View details →DOI: 10.20944/preprints202605.0410.v3 Methods Dead-EndMedicine
La Vignera S, Condorelli RA · 2026 · Diagnostics (Basel, Switzerland)
Normogonadotropic azoospermia (NOAN) represents a diagnostic and therapeutic challenge in male infertility, affecting men with normal gonadotropin levels but absent sperm in the ejaculate. Emerging evidence has identified…
View details →DOI: 10.3390/diagnostics16121830 Methods Dead-EndMedicine
Anam C, Amilia R, Naufal A et al. · 2026 · Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Purpose This study aims to evaluate statistical low-contrast detectability (SLCD) at multiple confidence levels (CLs) in computed tomography (CT) images and to determine the smallest detectable object sizes compared with human observers…
View details →DOI: 10.1016/j.ejmp.2026.105792 Negative / Null Result Report
Aguettaz AK, Arribat Y, Schmitt A et al. · 2026 · Preprint
Perilipin 3 (PLIN3) is a lipid droplet–associated protein implicated in cellular lipid metabolism. We characterize a previously unrecognized alternative splicing event in human PLIN3 . The generated transcript PLIN3B is detectable at the…
View details →DOI: 10.64898/2026.02.18.706587 Negative / Null Result Report
Kakizaki J, Widada AA, Ichihashi N et al. · 2026 · Preprint
The emergence of heritable molecular information is a fundamental step in the origins of life. Prior to the evolution of defined self-reproducing RNAs in the RNA world hypothesis, mixtures of primordial oligonucleotides may have supported…
View details →DOI: 10.64898/2026.06.14.732136 Negative / Null Result ReportOpen accessMedicine
Loghin II, Vaţă A, Rusu ȘA et al. · 2026 · Medicina (Kaunas, Lithuania)
Background and Objectives. Mother-to-child transmission (MTCT) or vertical transmission of human immunodeficiency virus (HIV) is largely preventable in settings where prevention of MTCT (PVT) strategies are consistently implemented.…
View details →DOI: 10.3390/medicina62040632 Negative / Null Result Report
Pisani M, Marcheschi P, Clemente A et al. · 2026 · Preprint
Aortic calcification represents a key marker of cardiovascular disease, detectable through medical imaging. This research investigates the use of artificial intelligence (AI) to assist radiologists in identifying aortic calcification in…
View details →DOI: 10.12688/openreseurope.21896.1 Negative / Null Result Report
Liang A, Veetil S, Groom K et al. · 2026 · Preprint
Abstract Laser Powder Bed Fusion (LPBF) is a widely adopted additive manufacturing technique for producing geometrically metal components. While this process yields fine microstructures beneficial for strength, the associated rapid thermal…
View details →DOI: 10.21203/rs.3.rs-9968290/v1 Negative / Null Result ReportMedicine
Ware A, LaMountain J, White RC et al. · 2026 · Nature communications
The electromagnetic response of materials serves as the foundation for a broad range of vital applications, from imaging, to sensing, to classical and quantum communications. Here we demonstrate, theoretically and experimentally, a…
View details →DOI: 10.1038/s41467-026-74396-z Negative / Null Result ReportOpen accessMedicine
Ajibola G, Nelson BS, Niesar A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Broadly neutralizing antibodies (bNAbs) are a promising treatment option for children with HIV-1, but their long-term impact on virologic, immunologic, and clinical outcomes is unknown. Methods The Tatelo Study investigated dual…
View details →DOI: 10.1093/cid/ciaf568 Negative / Null Result ReportOpen accessMedicine
· 2006
Data from well-conducted studies indicate that metformin levels in milk are low and infants would receive less than 0.5% of their mother's weight-adjusted dosage. Milk metformin levels are relatively constant during maternal metformin use,…
Negative / Null Result Report
Reid L, Ganapathiraju S, Mancinelli S et al. · 2026 · Preprint
Retinoid-related orphan receptor gamma (RORγ) is a lineage-defining transcription factor for T helper 17 (Th17) cells and has long been considered selectively expressed within the immune system. However, accumulating evidence has…
View details →DOI: 10.64898/2026.03.03.709291 Negative / Null Result ReportMedicine
Palenchar PM · 2026 · PloS one
Understanding how evolution shapes variability in gene expression is complicated by the interdependence of expression levels, expression variability, and evolutionary rates. Metrics that quantify variability independently of expression…
View details →DOI: 10.1371/journal.pone.0352202 Negative / Null Result ReportOpen accessMedicine
Senise G, Bodega F, Porta C et al. · 2026 · Cells
Cigarette smoke is a major inducer of oxidative stress, promoting reactive oxygen species (ROS) accumulation and contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD) and lung cancer. Heated tobacco products…
View details →DOI: 10.3390/cells15121112 Negative / Null Result ReportOpen accessMedicine
· 2006
Infants receive citalopram in breastmilk, and it is detectable in low levels in the serum of some. The dosage that the infant receives and serum level achieved are probably related to the genetic metabolic capacity of the mother and…
Negative / Null Result Report
Li B · 2026 · Preprint
The Standard Model describes particle phenomena through continuous gauge structures, chiral assignments, color, generations, and Yukawa masses, but it does not derive these labels from a deeper structural principle. This paper proposes a…
View details →DOI: 10.20944/preprints202606.0775.v1 Negative / Null Result Report
Dai R · 2026 · Preprint
Abstract Recent IsoMemo / Pandora compilations now make it possible to pool archaeological human stable-isotope data across continents. We tested whether a simple latitudinal gradient is detectable in archaeological human δ³⁴S after…
View details →DOI: 10.21203/rs.3.rs-9736542/v1 Negative / Null Result Report
Cabooter Q, Bruyne JD, Casselman B et al. · 2026 · Preprint
Ultrasound mid-air haptics (UMAH) can create touch sensations without physical contact, but it remains unclear whether they evoke steady-state somatosensory evoked potentials (SSSEPs) that could serve as objective markers of user…
View details →DOI: 10.20944/preprints202606.0669.v1 Failed Experiment ReportOpen accessMedicine
Heinemann FM, Hallensleben M, Althaus K et al. · 2026 · HLA
Single antigen (SA) tests are indispensable for an accurate HLA antibody identification in sera of transplant patients. Three commercial tests using purified single antigens combined with microbead or microarray technology are currently…
View details →DOI: 10.1111/tan.70734 Failed Experiment ReportMedicine
Zheng J, Wu M, Wang X et al. · 2026 · Cells
Prime editing (PE) is a precise genome-editing technology that avoids double-strand breaks, holding great promise for clinical and agricultural applications. However, its genome-wide off-target effects are not fully understood, raising…
View details →DOI: 10.3390/cells15050438 Negative / Null Result Report
Lindell H, Lehtilä K, Dinnétz P · 2026 · Preprint
Abstract Background Wild boar ( Sus scrofa ) have expanded in northern Europe, yet their role in the ecology of tick-borne pathogens remains poorly understood. This study investigated the occurrence of Anaplasma phagocytophilum and…
View details →DOI: 10.21203/rs.3.rs-9583918/v1 Negative / Null Result ReportOpen accessMedicine
Stoff R, Routman DM, Yalon M et al. · 2026 · Therapeutic advances in medical oncology
Background Circulating tumor DNA (ctDNA) is predictive of recurrence in resected stage III melanoma, yet its role in the neoadjuvant setting for clinical stage III (cSIII) is unclear. Objective Assess the association between ctDNA and…
View details →DOI: 10.1177/17588359251412729 Negative / Null Result ReportMedicine
Chu NH, Le HD, Quach NT et al. · 2026 · Biochemical genetics
The optical purity of lactic acid is a critical parameter for producing high-performance polylactic acid (PLA). To investigate the genetic basis of stereospecific lactic acid biosynthesis, the present study aimed to functionally…
View details →DOI: 10.1007/s10528-026-11374-6 Negative / Null Result ReportMedicine
Sulaiman AR, Bassit GE · 2026 · BMC oral health
Background Primary Hyperoxaluria Type 1 (PH1) is a rare metabolic disorder characterized by systemic oxalate deposition, which may influence bone metabolism through mechanisms such as oxalate accumulation in alveolar bone, renal…
View details →DOI: 10.1186/s12903-026-08939-7 