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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20289 results in Negative / Null Result Report · page 661 of 677

Negative / Null Result ReportMedicine

Magnetic fields from indoor transformer stations and risk of cancer in adults: a cohort study.

Juutilainen J, Khan MW, Naarala J et al. · 2024 · Occupational and environmental medicine

Objectives Studies assessing the association of adult cancers with extremely low frequency (ELF) magnetic fields (MF) have provided inconclusive results, probably affected by limitations such as low exposure levels, confounding and various…

View details →DOI: 10.1136/oemed-2024-109466
Negative / Null Result ReportOpen accessMedicine

The Role of Inflammasomes in LPS and Gram-Negative Bacterial Sepsis.

Hernández-Cuellar E, Tsuchiya K, Medina-Contreras O et al. · 2025 · Journal of clinical medicine

Background/Objectives : Sepsis is a life-threatening condition characterized by an uncontrolled immune response due to systemic infections. It is responsible for millions of deaths worldwide. Although inflammasomes play an important role…

View details →DOI: 10.3390/jcm14197102
Negative / Null Result ReportMedicine

Ivermectin performance against equine strongylids: Efficacy, egg reappearance periods, and fecal egg counting method comparison.

Nielsen MK, Bartholdy ID, Kristensen KS et al. · 2025 · Veterinary parasitology

Equine strongylids are ubiquitous and can cause severe health issues. Anthelmintic resistance is widely common in cyathostomin parasites, and recent studies have documented increasing incidence of resistance to the macrocyclic lactone drug…

View details →DOI: 10.1016/j.vetpar.2025.110465
Negative / Null Result ReportMedicine

Clinical utility of comprehensive gene panel testing for common and rare causes of skeletal dysplasia and other skeletal disorders: Results from the largest cohort to date.

MacCarrick G, Aradhya S, Bailey M et al. · 2024 · American journal of medical genetics. Part A

Molecular genetics enables more precise diagnoses of skeletal dysplasia and other skeletal disorders (SDs). We investigated the clinical utility of multigene panel testing for 5011 unrelated individuals with SD in the United States…

View details →DOI: 10.1002/ajmg.a.63646
Negative / Null Result ReportOpen accessMedicine

Upfront Exercise Hemodynamic Phenotyping of Patients with Pulmonary Hypertension and Left Heart Disease Risk Factors: A Prospective Experience.

Karvasarski E, Park J, Savaris S et al. · 2026 · CJC open

Background Resting hemodynamic assessment of suspected pulmonary hypertension (PH) in older adults with cardiovascular risk factors may not effectively discriminate pre-capillary from post-capillary disease. Exercise right-heart…

View details →DOI: 10.1016/j.cjco.2026.02.005
Negative / Null Result ReportMedicine

Pathophysiological mechanisms of gut dysbiosis and food allergy and an investigation of probiotics as an intervention for atopic disease.

Crabtree D, Seidler K, Barrow M · 2025 · Clinical nutrition ESPEN

Background and aims Epidemiological studies have associated reduced bacterial diversity and abundance and food allergy. This mechanistic review investigated the link between gut dysbiosis and food allergy with a focus on the role of…

View details →DOI: 10.1016/j.clnesp.2024.11.019
Negative / Null Result ReportOpen accessMedicine

Synthesis, Docking Profiles, and Biological Insights into Selenium-NHC Adducts and Benzimidazolium Salts with Antimicrobial Potential.

Boualia B, Sandeli A, Boulebd H et al. · 2026 · ACS omega

In this research, we present the successful synthesis of benzimidazolium salts ( 2a - e ) and their corresponding selenium-NHC adducts ( 3a - e ), achieved with satisfactory yields ranging from 75% to 88%, and characterized using…

View details →DOI: 10.1021/acsomega.5c10880
Negative / Null Result ReportOpen accessMedicine

Anticoccidial efficacy of a cinnamon-Rumex nervosus phytobiotic mixture on growth performance, carcass traits, cecal morphology, and cecal health in Eimeria tenella-challenged broilers.

Qaid MM, Al-Garadi MA, Al-Abdullatif AA et al. · 2026 · Poultry science

Coccidiosis remains a major constraint in poultry production; therefore, this study evaluated the anticoccidial efficacy of a phytogenic blend of cinnamon bark and Rumex nervosus leaf in Eimeria tenella-challenged broilers. Birds were…

View details →DOI: 10.1016/j.psj.2026.107288
Negative / Null Result ReportOpen accessMedicine

Discrepant Intracranial and Extracranial Responses to Tarlatamab in Relapsed Small-Cell Lung Cancer With Untreated Brain Metastases: A Case Report.

Hayashi E, Kano H, Nakamura K et al. · 2026 · Respirology case reports

Small-cell lung cancer (SCLC) has a poor prognosis, and the efficacy of tarlatamab for untreated brain metastases remains unclear. We report a case demonstrating a discrepant response between extracranial and intracranial lesions after…

View details →DOI: 10.1002/rcr2.70615
Negative / Null Result ReportMedicine

Pulmonary function trajectories in children with symptom-controlled asthma -a 10-year retrospective cohort study in China.

Wei X, Xue M, Fan B et al. · 2026 · BMC pulmonary medicine

Background Long-term changes in lung function in children with symptom control asthma are rare. To assess the trajectory of pulmonary function in children and analyze the influence factors. Methods The effects of gender, age, Body Mass…

View details →DOI: 10.1186/s12890-026-04442-5
Negative / Null Result ReportMedicine

Utility of ultrasensitive, US Food and Drug Administration-approved κ and λ dual in situ hybridization assay in the diagnosis of Hodgkin lymphomas.

Eltahir M, Young K, Younes S et al. · 2026 · American journal of clinical pathology

Objectives Determination of B-cell clonality in formalin-fixed, paraffin-embedded tissues is challenging, especially in cases where tumor B cells are sparse. Flow cytometry is of limited utility in Hodgkin lymphomas, at least in part due…

View details →DOI: 10.1093/ajcp/aqag043
Negative / Null Result ReportMedicine

Performance of a new bone-level tapered two-piece zirconia implant manufactured by injection moulding: A pilot preclinical study in minipig mandibles.

Hauck F, Herber V, Moecke S et al. · 2026 · International journal of oral implantology (Berlin, Germany)

Purpose The aim of this pilot preclinical study was to investigate the performance of a novel double-lead thread, conical bone-level ceramic implant manufactured by injection moulding (test group) in comparison to a well-established…

Negative / Null Result ReportMedicine

Serum Apelin-13 and Galectin-3 in COVID-19: Associations With Routine Biochemical Parameters and Diagnostic Performance in a Case-Control Study.

Uğurlu İ · 2026 · Journal of clinical laboratory analysis

Background Apelin-13 and Galectin-3 (Gal-3) are bioactive mediators linked to inflammation and cardiometabolic pathways. Their clinical utility in COVID-19 alongside routine laboratory tests remains unclear. Methods In this case-control…

View details →DOI: 10.1002/jcla.70284
Negative / Null Result ReportMedicine

Clinical and Neuroimaging Predictors of Outcome and Impact of Surgical Intervention in Cryptococcal Meningitis: An Observational Study.

Qian MY, He LY, Lan P et al. · 2026 · International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia. We conducted a single-center…

View details →DOI: 10.1016/j.ijid.2026.108923
Negative / Null Result ReportOpen accessMedicine

Development of a low-cost external fixation system: an off-label solution for resource-limited settings.

Seiser M, Deininger C, Fierlbeck J et al. · 2026 · European journal of trauma and emergency surgery : official publication of the European Trauma Society

Purpose External fixators are essential for the surgical management of long-bone fractures, particularly in resource-limited settings where access to commercial systems is often restricted by cost and logistics. This study aimed to develop…

View details →DOI: 10.1007/s00068-026-03246-w
Negative / Null Result ReportMedicine

Preoperative prediction of pathological pelvic lymph node metastasis in prostate cancer using an elastic net model integrating clinicopathologic and <sup>68</sup>Ga-PSMA PET/CT features: development and temporal validation.

Chen Y, Gao L, Zheng Z et al. · 2026 · Scientific reports

Preoperative decision-making regarding extended pelvic lymph node dissection (ePLND) in prostate cancer remains challenging. Existing nodal-risk prediction tools are mainly based on clinicopathologic variables and may show suboptimal…

View details →DOI: 10.1038/s41598-026-55589-4
Negative / Null Result ReportOpen accessMedicine

Enhanced periodontal regeneration using formulated injectable hyaluronic acid with or without PRP: A rat ligature model.

Alghonemy WY, Ahmed NM, Abou Samra AA et al. · 2026 · Journal of oral biology and craniofacial research

Objective To evaluate the regenerative effects of platelet-rich plasma (PRP) combined with 3% low-molecular-weight hyaluronic acid (HA) gel in treating ligature-induced periodontitis in rats. Methods •40 male albino rats divided into 5…

View details →DOI: 10.1016/j.jobcr.2026.101465
Negative / Null Result ReportMedicine

Schiff base chromones from natural Benzofuran as potential scaffold for anti-<i>Staphylococcus aureus</i>: synthesis of <i>cis</i> and <i>trans isomers, in vitro and in silico studies</i>.

Selim AAMA · 2026 · Natural product research

Three hydrazone chromones 3a-c ( 3a, b in trans isomer while 3c was a mixture) and three hydrazone furanochromones 7a-c ( 7a in trans while 7b, c in cis ) carrying carboxylic acid or its bioisostere sulphonamide group were synthesised.…

View details →DOI: 10.1080/14786419.2026.2674712
Negative / Null Result ReportMedicine

UPLC Multiwavelength Quantification and PLS-DA Reveal Stir-Baking Degree-Dependent Marker Dynamics in Paeoniae Radix Alba.

Chen L, Liang W, Guo Y et al. · 2026 · Biomedical chromatography : BMC

Paeoniae Radix Alba (PRA, roots of Paeonia lactiflora Pall.) yields stir-baked (sbPRA), charred (cPRA), and carbonized (caPRA) specifications through increasing degrees of stir-baking. In this study, an ultrahigh-performance liquid…

View details →DOI: 10.1002/bmc.70518
Negative / Null Result ReportOpen accessMedicine

Novel bioactive compounds from marine-derived endosymbiotic Penicillium fungi reported during 2020-2025.

Omran SA, Elnaggar MS, Youssef FS et al. · 2026 · Natural products and bioprospecting

Marine-derived Penicillium fungus gained significant attention in recent years due to their potential as a valuable source of unique natural compounds with a wide range of chemical structures and bioactive capabilities. The primary origins…

View details →DOI: 10.1007/s13659-026-00633-z
Negative / Null Result ReportMedicine

Validating ICD code case definitions for condition case ascertainment in multimorbidity measurement: a retrospective chart review.

Kang AJ, Tseng CH, Wei MY · 2026 · The journals of gerontology. Series A, Biological sciences and medical sciences

Background Accurate case ascertainment of chronic conditions is critical for research, clinical decision-making, and population health management, especially for older adults with high multimorbidity. However, validation of ICD-based case…

View details →DOI: 10.1093/gerona/glag157
Negative / Null Result ReportMedicine

Assessment of improvements in exercise tolerance following pulmonary valve replacement using physical accelerometry.

Joy N, Soslow JH, Crum K et al. · 2026 · Cardiology in the young

Background Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom…

View details →DOI: 10.1017/s1047951126113493