Negative / Null Result ReportOpen accessDiseases of the circulatory (Cardiovascular) system
Masatake Kobayashi, Susan Stienen, Jozine M. terMaaten et al. · 2020 · ESC Heart Failure
Abstract Aims Activation of the renin–angiotensin–aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis. There are limited data on the associations of renin and aldosterone levels with clinical profiles, treatment response, and study outcomes in patients with HF. Methods and results We analysed 2,039 patients with available baseline renin and aldosterone levels in BIOSTAT‐CHF (a systems BIOlogy study to Tailored Treatment in Chronic Heart Failure). The primary outcome was the composite of all‐cause mortality or HF ho
View details →DOI: 10.1002/ehf2.12634 Negative / Null Result ReportOpen accessComputer applications to medicine. Medical informatics
Maheswari S Mukherjee, Amber D Donnelly, Elizabeth R Lyden et al. · 2015 · Journal of Pathology Informatics
Background: Interest in developing more feasible and affordable applications of virtual microscopy in the field of cytology continues to grow. Aims: The aim of this study was to investigate the scanning parameters for the thyroid fine needle aspiration (FNA) cytology specimens. Subjects and Methods: A total of twelve glass slides from thyroid FNA cytology specimens were digitized at ×40 with 1 micron (μ) interval using seven focal plane (FP) levels (Group 1), five FP levels (Group 2), and three FP levels (Group 3) using iScan Coreo Au scanner (Ventana, AZ, USA) producing 36 virtual images (VI)
View details →DOI: 10.4103/2153-3539.161610 Negative / Null Result ReportBusiness
Wuhu Yao, D. Gao, Pengfei Sheng · 2018 · Applied Economics Letters
ABSTRACT With respects to the low level of the healthcare expenditure, China has been experiencing a rapid growth of the education. This article is designed to test the education quantity and the education quality on the healthcare…
View details →DOI: 10.1080/13504851.2018.1542118 Negative / Null Result ReportOpen accessAnimal culture
D.W. Liu, J.J. Zang, L. Liu et al. · 2014 · Czech Journal of Animal Science
Three experiments were conducted to compare raw corn, extruded corn, and dehulled-extruded corn in piglets' feeding. In Experiment (Exp.) 1, 8 barrows (19.9 ± 0.6 kg) were fed experimental diets containing one out of three corn samples and a rice-soybean meal basal diet in a double 4 × 4 Latin square design to determine the digestible energy (DE) and metabolizable energy (ME) in the corn samples using the difference method. The DE content in extruded (14.29 MJ/kg) and dehulled-extruded (14.42 MJ/kg) corn was greater (P < 0.05) than in raw corn (13.57 MJ/kg). In Exp. 2, 5 barrows (26.2 ± 1.3 kg
View details →DOI: 10.17221/7231-cjas Negative / Null Result ReportOpen accessAgriculture
Karin I. Köhl, Gedif Mulugeta Aneley, Manuela Haas et al. · 2021 · Agronomy
Potato is an important food crop with high water-use-efficiency but low drought tolerance. The bottleneck in drought tolerance breeding is phenotyping in managed field environments. Fundamental research on drought tolerance is predominantly done in container-based test systems in controlled environments. However, the portability of results from these systems to performance under field conditions is debated. Thus, we analyzed the effects of climate conditions, container size, starting material, and substrate on yield and drought tolerance assessment of potato genotypes compared to field trials.
View details →DOI: 10.3390/agronomy11050865 Negative / Null Result ReportOpen accessMedicine
Sonia Rekik, Hela Sahli, Khaoula Zouaoui et al. · 2022 · F1000Research
Background: Digital gangrene is a rare but serious complication of systemic lupus erythematosus (SLE). It occurs usually in middle-aged patients with longer disease duration. Case: Herein we report the case of a 56-year-old man (with no history suggestive of Raynaud’s phenomenon, diabetes mellitus, smoking, trauma, infection, or chemical exposure), who presented with SLE and digital gangrene was among the first signs. He presented with a one-month history of joint pain, hair loss, photosensitivity, mouth ulcers, malar rash, dyspnea, and digital pain. Physical examination revealed painful and d
View details →DOI: 10.12688/f1000research.124225.2 Negative / Null Result ReportOpen accessNeurosciences. Biological psychiatry. Neuropsychiatry
M. Oksman, H. Iivonen, E. Hogyes et al. · 2006 · Neurobiology of Disease
The present study assessed the influence of dietary lipids on accumulation of amyloid beta-peptide (Aβ) in the brain. Seven experimental diets with varying n-6/n-3-ratio, saturated and polyunsaturated fatty acid and cholesterol contents were fed to transgenic APPswe/PS1dE9 mice for 3–4 months beginning at a young adult age (6 months). Hippocampal Aβ levels were determined with ELISA and plaque load by using immunocytochemistry. A typical Western diet with 40% saturated fatty acids and 1% of cholesterol increased, while diets supplemented with docosahexaenoic acid (DHA) decreased Aβ levels comp
View details →DOI: 10.1016/j.nbd.2006.04.013 Negative / Null Result ReportOpen accessMedicine
Edward C. Y. Liew, Maureen Phelan, Keith L. McDougall · 2023 · Scientific Reports
Abstract Phytophthora cinnamomi is an oomycete found in the soil and capable of invading the roots of a wide range of host plants globally, potentially killing them and affecting the ecosystems they inhabit. This pathogen is often inadvertently dispersed in natural vegetation on the footwear of humans. A range of equipment is often provided or recommended to be carried for cleaning footwear in places where P. cinnamomi poses a threat to biodiversity. These are typically a brush for mechanically removing soil and/or a disinfectant for killing the pathogen. Despite their widespread use, to our k
View details →DOI: 10.1038/s41598-023-32681-7 Negative / Null Result ReportOpen accessDiseases of the musculoskeletal system
Talia Golan, Ravit Geva, Donald Richards et al. · 2018 · Journal of Cachexia, Sarcopenia and Muscle
Abstract Background Cachexia is a formidable clinical challenge in pancreatic cancer. We assessed LY2495655 (antimyostatin antibody) plus standard‐of‐care chemotherapy in pancreatic cancer using cachexia status as a stratifier. Methods In this randomized, phase 2 trial, patients with stage II–IV pancreatic cancer were randomized to 300 mg LY2495655, 100 mg LY2495655, or placebo, plus physician‐choice chemotherapy from a prespecified list of standard‐of‐care regimens for first and later lines of care. Investigational treatment was continued during second‐line treatment. The primary endpoint was
View details →DOI: 10.1002/jcsm.12331 Negative / Null Result ReportMedicine
Kute, Fujino, Centauri et al. · 2026 · Experimental and therapeutic medicine
Ultra-low anterior resection (ULAR) and total mesorectal excision (TME) are sphincter-preserving treatments for low rectal cancer. However, these techniques face challenges in patients with a narrow pelvis, particularly those with a high…
View details →DOI: 10.3892/etm.2026.13207 Negative / Null Result ReportOpen accessMedicine
Cassandra M Wilkinson, Brittany A Fedor, Jasmine R Aziz et al. · 2019 · PLoS ONE
After intracerebral hemorrhage (ICH), brain edema commonly occurs and can cause death. Along with edema, there are significant alterations in the concentrations of key ions such as sodium, potassium, and chloride, which are essential to brain function. NKCC1, a cation-chloride cotransporter, is upregulated after brain damage, such as traumatic injury and ischemic stroke. NKCC1 brings sodium and chloride into the cell, possibly worsening ion dyshomeostasis. Bumetanide, a specific NKCC1 antagonist, blocks the transport of chloride into cells, and thus should attenuate the increases in chloride,
View details →DOI: 10.1371/journal.pone.0210660 Negative / Null Result ReportOpen accessPsychiatry
Nadine Farnes, Nadine Farnes, Henrik B. Jacobsen et al. · 2024 · Frontiers in Psychiatry
IntroductionDeep rTMS is an increasingly popular noninvasive brain stimulation technique which has shown promise for treating cognitive impairments. However, few studies have investigated the cognitive effects it could exert in patients with chronic peripheral neuropathic pain. Therefore, we aimed to assess the effects of deep rTMS on executive functioning in patients with peripheral neuropathic pain, in a randomized, double-blind crossover trial.MethodsIn total, 17 patients were randomly assigned to receive both active and sham deep H-coil rTMS targeting the primary motor cortex. Each treatme
View details →DOI: 10.3389/fpsyt.2024.1401008 Negative / Null Result Report
V. Yu. Petrov, I. N. Lavrentyeva, V. V. Vdovin et al. · 2024 · Pediatric Hematology/Oncology and Immunopathology
Hemophilia A presents a serious problem, especially in its severe and inhibitor forms, leading to severe bleeding and complications. The importance of studying the effectiveness and safety of new treatment approaches, particularly…
View details →DOI: 10.24287/1726-1708-2024-23-1-99-107 Negative / Null Result Report
Zinaida I Storozheva · 2025 · World Journal of Psychiatry
The startle response (SR) is a generalized defensive response elicited by the presentation of a sudden intense stimulus. The presentation of a less intense signal (prepulse) before the central stimulus (pulse) affects the amplitude and…
View details →DOI: 10.5498/wjp.v15.i8.107791 Negative / Null Result Report
Ekaterina Bagrova, Sergei Kruchinin · 2021 · SHS Web of Conferences
Currently there are many theories about quality education. The paper presents some of them. It also includes some points of Deming’s philosophy and statistical indicators implemented to determine lecturers’ achievements in Russian higher…
View details →DOI: 10.1051/shsconf/20219402003 Negative / Null Result Report
Mayank Bhandari, Sabyasachi Chowdhary, Milind Rao et al. · 2021 · British Journal of Surgery
Abstract Background Roux en Y gastric bypass (RYGB) surgery for morbid obesity is considered as gold standard, but there can be a difference in the length of alimentary and biliopancreatic limb to achieve optimum weight loss. Till now…
View details →DOI: 10.1093/bjs/znab430.001 Negative / Null Result Report
Thomas Dlugosch, Sebastian Kirsch, K. Andreas Friedrich · 2019 · ECS Meeting Abstracts
One key factor for the commercialization of fuel cell vehicles is a sufficient membrane durability. In this context, car manufactures work on reliability accelerated stress test procedures (AST) to measure membrane lifetime. There have…
View details →DOI: 10.1149/ma2019-02/34/1500 Negative / Null Result Report
Vincent Geraldus Enoch Lusida, Bambang Puijo Semedi, Bambang Herwanto · 2020 · Indonesian Journal of Anesthesiology and Reanimation
Introduction: Infant death is most prominent in the neonatal period. The success of neonatal resuscitation practice has many contributing factors. One of which is the health workers’ knowledge of the Neonatal Resuscitation Program (NRP)…
View details →DOI: 10.20473/ijar.v1i22019.38-42 Negative / Null Result Report
· 2019 · Additives for Polymers
Switzerland's Clariant reported sales from continuing operations of CHF1.043 billion (c. €960 million) for the third quarter of 2019, a decline of 1% from sales of CHF1.054 billion in 3Q 2018 but an increase of 2% in local currency terms.…
View details →DOI: 10.1016/s0306-3747(19)30231-3 Negative / Null Result Report
D FERRINGTON · 2013 · Acta Ophthalmologica
Abstract The catalytic core of the proteasome contains three pair of catalytic subunits that perform distinct proteolytic activities referred to as caspase‐like, trypsin‐like, and chymotrypsin‐like. In the standard proteasome, the…
View details →DOI: 10.1111/j.1755-3768.2013.3253.x Negative / Null Result Report
Douglas E. Barre, Kazimiera A. Mizier-Barre, Odette Griscti · 2025 · Endocrine Regulations
Abstract Objective. The objective of the present study was to determine if there would be statistically significant differences among apolipoprotein E genotypes in the responsiveness of members of a cluster of seven measures in persons…
View details →DOI: 10.2478/enr-2025-0016 Negative / Null Result Report
N. Pughazendi, T. S. Suganya, Soorya S. et al. · 2023 · International Journal on Recent and Innovation Trends in Computing and Communication
The developing computation control has made the profound learning calculations so powerful that making an unclear human synthesized video famously called a profound fake has got to be exceptionally straightforward. Scenarios where these…
View details →DOI: 10.17762/ijritcc.v11i11s.8065 Negative / Null Result Report
Eleonora Massa · 2016 · Linguistik Online
This paper develops a theoretical discussion about the definition of the unit of content in spoken language. The issue originates from the applicative field of corpus-based lexico-statistical surveys, which are traditionally and…
View details →DOI: 10.13092/lo.75.2518 Negative / Null Result Report
R. A. Vernyaeva, S. R. Zaynullina · 2020 · Intellekt. Sist. Proizv.
В работе представлено количественно-статистическое исследование языковых единиц древнейших русских летописей. Инструментом для получения необходимых выборок стал модуль n-грамм ИАС «Манускрипт», позволяющий выявить текстовые сочетания с…
View details →DOI: 10.22213/2410-9304-2020-4-54-64 Negative / Null Result Report
Uma G, Hariharan G L · 2025 · International Journal For Multidisciplinary Research
This study explores the awareness and impact of key government welfare schemes in India, with a focus on the Pradhan Mantri Awaas Yojana (PMAY), Pradhan Mantri Gram Sadak Yojana (PMGSY), and Deen Dayal Upadhyaya Grameen Kaushal Yojana…
View details →DOI: 10.36948/ijfmr.2025.v07i06.59810 Negative / Null Result Report
Marinel Costel Temneanu, Codrin Donciu, Elena Serea · 2025 · AppliedMath
This paper presents a non-intrusive method for estimating the distance between a camera and a human subject using a monocular vision system and statistically derived interpupillary distance (IPD) values. The proposed approach eliminates…
View details →DOI: 10.3390/appliedmath5030118 Negative / Null Result Report
Christopher A. Shaw, Ceilidh Beck, Leal Marakoff · 2025 · Exploration of Neuroprotective Therapy
Age-related neurological disorders such as ALS (Lou Gehrig’s disease), Parkinson’s disease, and Alzheimer’s disease have few truly effective treatment options. At best, these may slow the inexorable disease progression without providing a…
View details →DOI: 10.37349/ent.2025.1004133 Negative / Null Result Report
Maryam Khalid, Sadia Tameez Ud Din, Mumtaz Hussain et al. · 2025 · South Eastern European Journal of Public Health
Skin cancer accounts for one-third of all diagnosed cancers, with 132,000 new cases of melanoma detected each year (1). By 2040, the melanoma burden is projected to reach 510,000 new cases (a 50% increase) and 96,000 deaths (a 68%…
View details →DOI: 10.70135/seejph.vi.5288 Negative / Null Result Report
Henry Lam · 2025 · Management Science
When the underlying probability distribution in a stochastic optimization is observed only through data, various data-driven formulations have been studied to obtain approximate optimal solutions. We show that no such formulations can, in…
View details →DOI: 10.1287/mnsc.2024.04482 Negative / Null Result ReportOpen accessMedicine
Wiseman R, Watt C · 2026 · PeerJ
Preregistration is commonly seen as an effective way of reducing questionable research practices within psychology. This procedure happens prior to data collection/analysis and usually involves either sending in a research plan to a study…
View details →DOI: 10.7717/peerj.21360 