A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
21363 results · page 636 of 713
Liu Y, Wang X, Qian P et al. · 2026 · Preprint
Abstract Background Patients with locally advanced esophageal squamous cell carcinoma (ESCC) undergoing surgery after neoadjuvant chemotherapy (NCT) or neoadjuvant chemoimmunotherapy (NICT) remain at risk of disease progression. Currently,…
Kitowski A, Heise C, Sperling S et al. · 2026 · British journal of pharmacology
Background and purpose Nano-formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to…
Grossmann I, Rudnev M, Clark CJ et al. · 2026 · Preprint
Experts and pundits routinely forecast societal trends, yet these predictions often fall short, leading to poor policy decisions. What distinguishes accurate forecasters? In a three-year longitudinal tournament (N = 520), we tested whether…
Talathi R, Hubbard RA, Somasundar P et al. · 2026 · Surgery
Background The Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma (STRASS 2) trial is evaluating the impact of neoadjuvant chemotherapy versus surgery in patients with high-risk, resectable…
Zhao A, Chen W, Liang Y et al. · 2026 · Cancer treatment and research communications
Objective To compare and analyze the efficacy and safety of an overall strategy of immunotherapy combined with chemoradiotherapy in patients with limited-stage small cell lung cancer (LS-SCLC)-including induction immunotherapy plus…
Sarica C, Darmani G, Ramezanpour H et al. · 2026 · Science translational medicine
Transcranial ultrasound stimulation (TUS) is a promising noninvasive technique for modulating deep brain targets and circuits with high spatial precision. For its successful clinical translation, confirmation of target engagement, together…
Riestra JM, Levin-Carrion Y, Sutar R et al. · 2026 · Human psychopharmacology
Treatment-resistant depression (TRD) remains a formidable challenge in psychiatry, with nearly one-third of patients with major depressive disorder (MDD) failing to respond adequately to first-line pharmacological treatments.…
Nandi D, Gajarski RJ, Zhao H et al. · 2026 · Pediatric transplantation
Purpose Human Leukocyte Antigen (HLA) sensitization can adversely impact heart transplant (HTx) outcomes. We evaluated the effect of panel-reactive antibody (PRA) and desensitization (DS) strategies on outcomes of pediatric HTx recipients…
Silva-García J, Eurolo I, Fuentes-Flores R et al. · 2026 · Brain research
Ischemic stroke is a leading cause of death and disability worldwide. Among survivors, one-third live with permanent impairments, and two-thirds experience upper limb dysfunction. Despite advances in acute care, no universally effective…
Hayashi T, Go M, Kawasumi K et al. · 2026 · Preprint
Abstract Introduction Maintaining dose intensity is essential for the efficacy of adjuvant S-1 chemotherapy in gastric cancer. Although pharmacist interventions can reduce toxicity and improve adherence, multicenter evidence regarding…
Saloojee H, Gramanie MC, Mwale R et al. · 2026 · Medical teacher
Background Generative artificial intelligence (AI) tools are entering clinical training faster than curricula and assessments can adapt. It is currently unknown whether point-of-care access to large language models (LLMs) improves…
An DW, Wang Y, Cheng YB et al. · 2026 · Hypertension (Dallas, Tex. : 1979)
Background Whether central systolic blood pressure (cSBP) compared with brachial systolic blood pressure (bSBP) improves risk stratification remains debated. This study investigated whether cSBP is more closely associated with total and…
Durmuş Ece BŞ, Yozgat Z, Işık MU et al. · 2026 · Journal francais d'ophtalmologie
Purpose To determine the effect of trabecular meshwork (TM) peeling on gonioscopy-assisted transluminal trabeculotomy (GATT) surgical outcomes in patients with open-angle glaucoma. Methods In this retrospective cross-sectional study,…
Forville H, Coppla FM, Naupari-Villasante R et al. · 2026 · Journal of dentistry
Objective To evaluate whether dentin airborne-particle abrasion (APA) with aluminum oxide affects the retention and clinical performance of composite resin restorations in non-carious cervical lesions (NCCLs). Methods This prospective,…
Vedrenne-Cloquet M, de Montmollin E, Gaudemer A et al. · 2026 · Journal of educational evaluation for health professions
Purpose To assess the effectiveness of a short multimodal workshop, including stress-management and communication-skills training, on objective structured clinical examination (OSCE) performance and exam-related anxiety among medical…
Tortajada M, Rodriguez-Larios J, Martínez-Pérez V et al. · 2026 · Preprint
Recent findings have shown the influential role of theta-gamma cross-frequency coupling in the maintenance of items in Working Memory (WM). Specifically, it has been proposed that individual items are represented within gamma oscillations…
Badulescu S, Gill H, Shah H et al. · 2026 · Med (New York, N.Y.)
Background Evidence suggests that glucagon-like peptide 1 receptor agonists (GLP-1RAs) might have pro-cognitive effects. No prior study has evaluated the efficacy and safety of a GLP-1RA for the treatment of cognitive dysfunction in adults…
Muller M, Agrawal A, Thomas N et al. · 2026 · Substance use & addiction journal
Background Patients with opioid use disorder (OUD) are frequently hospitalized and often need post-acute care, but face high rates of rejection from post-acute and long-term care (PALTC) facilities. This study aimed to assess the impact of…
Munazir M, Kausar N, Qureshi R et al. · 2026 · Scientific reports
Untreated municipal wastewater is widely used for irrigation in peri-urban agriculture where freshwater is limited, yet its effects on edible vegetable crops remain context dependent. This study evaluated the morphological, physiological,…
Liang XQ, Han L, Yan T et al. · 2026 · Journal of anesthesia
Purpose Postoperative pulmonary complications are common and associated with worse long-term outcomes. In our previous trial, prophylactic penehyclidine inhalation reduced pulmonary complications in high-risk patients. Herein, we tested…
Toft M, Hansen MS, Vestergaard JD et al. · 2026 · British journal of sports medicine
Objective To evaluate whether individualised treatment using the Copenhagen Achilles Rupture Treatment Algorithm (CARTA) is superior to default operative or non-operative strategies. Methods We conducted a multicentre, three-arm,…
Chau IJ, Dixon PR, Lin V et al. · 2026 · Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Objective To identify patient characteristics associated with improvements in speech recognition scores (SRS) and Cochlear Implant Quality of Life (CIQOL-35) scores following cochlear implantation. Study design Multi-institutional…
Alansare AB, Muldoon MF, Perera S et al. · 2026 · Experimental physiology
Lower sedentary behaviour (SB) has been associated with reduced cardiovascular disease and mortality. Yet, few trials have evaluated cardiovascular mechanisms of benefit. We examined the effects of a SB reduction intervention on heart rate…
David-Neto E, David AER, Alves B et al. · 2026 · Transplantation
Background Chronic allograft dysfunction (CAD) remains a leading cause of graft loss after kidney transplantation. Dapagliflozin (DAPA) has shown renal and cardiometabolic benefits in nontransplanted patients with chronic kidney disease.…
dong y, Liu S, Wang Y · 2026 · Preprint
Abstract Background Recent research on spread through air spaces (STAS) has gained prominence. The presence of STAS is not only an independent factor associated with lung cancer recurrence and prognosis, but it remains unclear whether…
Yoo C, Jeong H, Park I et al. · 2026 · Annals of surgical oncology
Background Prospective data on stereotactic body radiation therapy (SBRT) combined with modified 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (mFOLFIRINOX) in patients with locally advanced unresectable pancreatic adenocarcinoma…
Akbas F, Baykan O, Avcikurt AS et al. · 2026 · BMC psychiatry
Background Major depressive disorder (MDD) has been increasingly associated with low-grade inflammation, with neutrophils playing a central role. Calprotectin is a mainly neutrophil-derived inflammatory mediator. We investigated whether…
Li M, Jiang C, Wang R et al. · 2026 · Clinical rehabilitation
DesignPragmatic, two-arm, parallel-group, superiority randomised controlled trial with assessor-blinding and statistician-blinding.SettingSingle orthopaedic centre in Shanghai, China.ParticipantsOne hundred and eighty adults (aged 18-50…
Anteby M, Wertheimer KO, Dominsky O et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Objective To compare maternal and neonatal outcomes between women with hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome with and without associated hypertension. Methods This was a retrospective cohort study at a…
Otowa Y, Matsuda T, Ando M et al. · 2026 · Surgery today
Background The benefit of neoadjuvant chemoradiotherapy (NACRT) for elderly patients with locally advanced rectal cancer (LARC) remains unclear because these patients are often excluded from trials. We evaluated the safety and oncologic…