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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19906 results in Negative / Null Result Report · page 629 of 664

Negative / Null Result ReportMedicine

Effects of Ultrasound-Mediated Treatments on Dental Biofilm Attachment and Viability.

De Grandi D, LuTheryn G, Stoffels M et al. · 2026 · Ultrasound in medicine & biology

Objective Dental biofilms are responsible for the majority of oral cavity diseases (e.g., caries, periodontitis and gingivitis). In this work, we evaluate the effects of therapeutic ultrasound on a Streptococcus mutans biofilm model. The…

View details →DOI: 10.1016/j.ultrasmedbio.2026.05.008
Negative / Null Result ReportMedicine

Omega-3 Long-Chain Polyunsaturated Fatty Acid Supplementation Did Not Reduce Inflammation to Improve Iron Absorption in South African Women Living with Overweight or Obesity.

Uyoga MA, Baumgartner J, Malan L et al. · 2026 · The Journal of nutrition

Background Young South African women face a double-burden of overweight or obesity and iron deficiency, with the former predicting the latter. Omega-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementation can reduce inflammation.…

View details →DOI: 10.1016/j.tjnut.2025.101280
Negative / Null Result ReportMedicine

Ultrasound-Guided Superficial Parasternal Intercostal Plane Block for Early Pain Management in Patients Undergoing Cardiac Surgery-A Randomized Controlled Trial.

Kalli AJ, Mäkelä P, Huhtala H et al. · 2026 · Acta anaesthesiologica Scandinavica

Background Sternotomy causes substantial postoperative pain. Recently, several less invasive nerve blocks have been described that are safer to use even on anticoagulated patients. This study aims to evaluate early pain management using…

View details →DOI: 10.1111/aas.70253
Negative / Null Result ReportMedicine

Thoracic duct ligation during esophagectomy fails to prevent chylothorax or improve survival: a propensity score matched cohort study.

Quan S, Xie H, Zhang D et al. · 2026 · Esophagus : official journal of the Japan Esophageal Society

Background Postoperative chylothorax is a serious complication following esophagectomy. The efficacy of thoracic duct ligation (TDL) for chylothorax prevention is controversial. This study aimed to evaluate the impact of TDL on chylothorax…

View details →DOI: 10.1007/s10388-026-01219-x
Negative / Null Result ReportMedicine

Daily administration of long-acting adrenocorticotropic hormone (ACTH) alters the developmental pattern of plasma fibrinogen in juvenile rats.

Takeda Y, Sakakibara T, Horiuchi K et al. · 2026 · Brain & development

Background We previously reported that adrenocorticotropic hormone (ACTH) therapy for infantile epileptic spasm syndrome (IESS) decreases plasma fibrinogen (Fbg) levels. However, the underlying mechanism(s) has not been elucidated. An…

View details →DOI: 10.1016/j.braindev.2026.104541
Negative / Null Result ReportMedicine

Exploring the Effects of Saturated and Transition-Metal-Substituted Dawson Doping on Electrocatalytic CO<sub>2</sub> Reduction Activity in P<sub>2</sub>W<sub>18</sub>@PCN-222 and P<sub>2</sub>W<sub>17</sub>M@PCN-222 (M = Co, Mn, Ni) Composites.

Li C, Shu L, Teng YL et al. · 2026 · Inorganic chemistry

To exploit the electron-sponge properties of polyoxometalates (POMs) and elucidate the mechanistic impact of doping with saturated versus metal-substituted Dawson-type POMs on electrocatalytic CO 2 reduction, P 2 W 18 @PCN-222 and P 2 W 17…

View details →DOI: 10.1021/acs.inorgchem.6c01667
Negative / Null Result ReportMedicine

Preventive maintenance has limited effect on decreasing incidence of post pastuerization contamination in single serve milk cartons.

Shaposhnikov MM, Trmcic A, Martin NH · 2026 · Journal of dairy science

The microbial quality of fluid milk is improved via processing steps, such as pasteurization which reduces the overall microbial population of milk and in particular is effective against Gram-negative, heat sensitive bacteria. Therefore,…

View details →DOI: 10.3168/jds.2026-28244
Negative / Null Result ReportMedicine

Effect of a parent-supported psychosocial development program on psychosocial outcomes of children aged 1-3 years: a waiting-list randomized controlled trial.

Cirlak A, Kacan H · 2026 · Irish journal of medical science

BACKGROUND: Parent-supported psychosocial development programs aim to strengthen the parent-child relationship and promote healthy early childhood development, particularly in settings where access to structured preventive interventions is…

View details →DOI: 10.1007/s11845-026-04361-8
Negative / Null Result ReportMedicine

Overcoming doramectin failure: field efficacy of pour-on 5% fluralaner and an experimental 1% oral formulation for the prevention of Cochliomyia hominivorax-associated umbilical myiasis in newborn calves.

de Freitas MDB, Rodrigues DC, de Paiva PEM et al. · 2026 · Parasites & vectors

Background Myiasis caused by Cochliomyia hominivorax larvae is a reemerging challenge in the Americas due to the recent reappearance of this species in areas where it had been eradicated and reports of doramectin inefficacy, despite its…

View details →DOI: 10.1186/s13071-026-07455-5
Negative / Null Result ReportMedicine

Disinfectant-Based and Chlorinated Water Inactivation of Wild-Type <i>Salmonella enterica</i> Bacteriophages.

Vaz CSL, Voss-Rech D, da Fonseca FN et al. · 2026 · Foodborne pathogens and disease

Oral phage therapy is a promising strategy for reducing harmful bacteria in broilers. However, it may lead to the spread of therapeutic phages in the farm environment, potentially increasing bacterial host tolerance. To determine the…

View details →DOI: 10.1177/15353141251366377
Negative / Null Result Report

Freshwater history exerts a larger effect than the feeding regime at sea on the occurrence of rainbow trout sexual maturation in seawater cages

Pino-Martinez E, Pedrosa C, Silva-Marrero JI et al. · 2026 · Preprint

Abstract Sexual maturation of rainbow trout during grow-out at sea poses economic risks for aquaculture due to reduced growth, feed intake, and downgraded harvest quality. This study evaluated the effects of freshwater rearing systems and…

View details →DOI: 10.21203/rs.3.rs-9042484/v1
Negative / Null Result ReportOpen accessMedicine

Cardiovascular pharmacotherapy in 2025.

Tamargo J, Agewall S, Ambrosio G et al. · 2026 · European heart journal. Cardiovascular pharmacotherapy

Despite recent advances in cardiovascular pharmacotherapy, prevention and treatment of many cardiovascular diseases remain limited with a clear need for more effective and safer pharmacological strategies. Here, we summarize the most…

View details →DOI: 10.1093/ehjcvp/pvag016
Negative / Null Result ReportMedicine

Intra-abdominal pressure and pelvic floor muscle activation observed during hypopressive exercises performed in supine and standing: An observational cohort study.

Saraiva S, McLean L · 2026 · Physiotherapy

Primary objectives (1) To evaluate whether hypopressive exercises (HEs) cause changes in intra-abdominal pressure (IAP) and/or electromyographic (EMG) activation of the levator ani muscles (LAMs), (2) to determine whether these effects…

View details →DOI: 10.1016/j.physio.2026.102316
Negative / Null Result ReportMedicine

Myofilament-level effects of aficamten increase diastolic chamber volumes and maintain cardiac output through preserved length-dependent force generation in healthy rat and canine myocardium.

Sárkány F, Priksz D, Juhász B et al. · 2026 · Basic research in cardiology

Clinical trial experience supports the use of myosin inhibitors in hypertrophic cardiomyopathy (HCM), while early proof-of-concept studies suggest potential benefit in selected patients with heart failure with preserved ejection fraction…

View details →DOI: 10.1007/s00395-026-01194-5
Negative / Null Result ReportMedicine

Testosterone replacement therapy in older men: skeletal outcomes and fracture risk.

Szarpak L, Al-Jeabory M, Pecold J et al. · 2026 · The aging male : the official journal of the International Society for the Study of the Aging Male

Introduction Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain. Objectives To synthesise current…

View details →DOI: 10.1080/13685538.2026.2655544
Negative / Null Result ReportMedicine

Densiron 68 Tamponade Duration and Redetachment Risk after Removal in Inferior Proliferative Vitreoretinopathy-Associated Retinal Detachment.

Carnevali A, Chisari D, Mancini A et al. · 2026 · Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde

Introduction Inferior retinal detachment (I-RD) complicated by proliferative vitreoretinopathy (PVR) is challenging to treat and prone to recurrence (retinal detachment recurrence [RDR]). Heavy silicone oil (HSO) tamponades such as…

View details →DOI: 10.1159/000551398
Negative / Null Result ReportMedicine

Original research: surfactant administration using less invasive surfactant administration (LISA) versus enhanced intubate-surfactant-extubate (ENSURE) in preterm infants.

Khera P, Jain S, Khurana S et al. · 2026 · European journal of pediatrics

Surfactant replacement therapy improves outcomes in preterm neonates with respiratory distress syndrome (RDS). While the less invasive surfactant administration (LISA) technique offers advantages over intubate-surfactant-extubate (INSURE),…

View details →DOI: 10.1007/s00431-026-06904-8
Negative / Null Result ReportMedicine

Low-fat dietary pattern and dementia mortality: a secondary analysis of the Women's Health Initiative dietary modification randomized clinical trial with long-term follow-up.

Chlebowski RT, Rapp S, Aragaki AK et al. · 2026 · Menopause (New York, N.Y.)

Objectives In the Women's Health Initiative (WHI) Dietary Modification (DM) randomized trial, the dietary intervention significantly reduced breast cancer mortality and, in a subgroup of women 65 years old or above, significantly lowered…

View details →DOI: 10.1097/gme.0000000000002808
Negative / Null Result ReportMedicine

Anterior quadratus lumborum block in total hip arthroplasty: a two-center, randomized, placebo-controlled trial showing no additional benefit over multimodal analgesia.

Rozier R, Loiseleur A, Ciais C et al. · 2026 · Regional anesthesia and pain medicine

Background Total hip arthroplasty (THA) frequently causes postoperative pain, hindering recovery and prolonging hospital stays. While multimodal analgesia aims to minimize opioid use and enhance outcomes, the optimal regional anesthesia…

View details →DOI: 10.1136/rapm-2024-106247
Negative / Null Result ReportMedicine

Targeted Antimicrobial Agent Prophylaxis Fails to Reduce Peristomal Infections by Multi-Drug-Resistant Bacteria Following Percutaneous Endoscopic Gastrostomy: A Prospective Cohort Study.

Marzo-Escartín B, Villamarín-Melio M, Márquez-Algaba E et al. · 2026 · Surgical infections

Background Peristomal infection (PI) is the most frequent complication following percutaneous gastrostomy, and the increase of multi-drug-resistant (MDR) bacteria poses a therapeutic challenge. We evaluated whether targeted antimicrobial…

View details →DOI: 10.1177/10962964261438723
Negative / Null Result ReportMedicine

A Single-Centre, Single-Blinded Randomized Control Trial Evaluating the Role of Distraction Therapy in Pain Management Following Major Abdominal Surgeries in Adult Cancer Patients.

Rana CJ, Bakshi SG, Tarhane S et al. · 2026 · Indian journal of surgical oncology

Distract trial In the post-operative period, analgesics are complemented with non-pharmacological methods (NPM). However, the evidence is limited. Objectives Randomised control trial aimed to determine the effectiveness of NPMs of pain…

View details →DOI: 10.1007/s13193-026-02583-x