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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

21363 results · page 621 of 713

Negative / Null Result ReportOpen accessMedicine

Achieving target plasma concentrations of beta-lactam antibiotics in critically ill patients: a retrospective study of full-dose administration in the first 24 hours.

Halačová M, Mieresová M, Kubele J et al. · 2026 · Pharmacological reports : PR

BACKGROUND: Beta-lactams are the cornerstone of therapy for the treatment of the most serious infections in the intensive care unit (ICU) setting. However, individualization of dosing remains challenging because pharmacokinetics are highly…

View details →DOI: 10.1007/s43440-026-00836-8
Negative / Null Result ReportOpen accessMedicine

Impaired Cognitive Flexibility With Preserved Learning in an Amyloid Precursor Protein Knock-In Mouse Model of Amyloidopathy.

Dumont JR, Sheppard PAS, Fodor C et al. · 2025 · Genes, brain, and behavior

Alzheimer's disease is a debilitating neurodegenerative condition characterized by amyloid beta plaques and tau neurofibrillary tangles, which leads to progressive cognitive decline. Several new mouse models of fast amyloid deposition have…

View details →DOI: 10.1111/gbb.70024
Negative / Null Result ReportMedicine

Moving from the clinic to telehealth during the COVID-19 pandemic - a pilot clinical trial comparing in-clinic rehabilitation versus telerehabilitation for persisting symptoms following a mild Traumatic brain injury.

Langevin P, Frémont P, Fait P et al. · 2024 · Disability and rehabilitation

Purpose The objective of this study was to compare the effects of an in-clinic cervicovestibular rehabilitation program (education, home exercises, manual techniques, sub-symptom threshold aerobic exercise [STAE] program) to a similar…

View details →DOI: 10.1080/09638288.2023.2236016
Negative / Null Result ReportMedicine

Ovulatory cycle shifts in human motivational prioritisation of sex and food.

Schleifenbaum L, Stern J, Driebe JC et al. · 2024 · Hormones and behavior

Previous research on the endogenous effects of ovarian hormones on motivational states in women has focused on sexual motivation. The Motivational Priority Shifts Hypothesis has a broader scope. It predicts a shift from somatic to…

View details →DOI: 10.1016/j.yhbeh.2024.105542
Negative / Null Result ReportMedicine

Evaluating nutrition in advanced ovarian cancer: which biomarker works best?

Fumagalli D, Sonik R, De Vitis LA et al. · 2024 · Gynecologic oncology

Background Advanced epithelial ovarian cancer (OC) patients often present with malnutrition; however, the ideal nutritional evaluation tool is unclear. We aimed to evaluate the role of preoperative albumin, Prognostic Nutritional Index…

View details →DOI: 10.1016/j.ygyno.2024.06.021
Negative / Null Result ReportOpen accessMedicine

Trajectory of COVID-related tinnitus over the pandemic timeline.

Figueiredo RR, de Azevedo AA, Figueiredo GMR et al. · 2026 · Brazilian journal of otorhinolaryngology

Objectives COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. Previous studies reported cases of tinnitus following COVID infection, most of them mild and with similar characteristics to other forms of tinnitus. Our…

View details →DOI: 10.1016/j.bjorl.2026.101857
Negative / Null Result ReportMedicine

High Prevalence and Clinical Relevance of Intrapulmonary Vascular Dilatations in Patients Undergoing TIPS Implantation.

Mauz JB, Rieland H, Berliner D et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Background & aims Considerate patient selection is vital to ensure the best possible outcomes after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, data regarding the impact of intrapulmonary vascular dilatations…

View details →DOI: 10.1016/j.cgh.2024.04.027
Negative / Null Result ReportMedicine

Impact of morphine dependence and withdrawal on economic demand for fentanyl, cocaine, and methamphetamine in rats.

Seaman RW Jr, Shariatzadeh N, Salinas KA et al. · 2026 · Drug and alcohol dependence

Background Stimulant-opioid co-use has surged in the United States, with methamphetamine use among people who use opioids increasing 82.6 % from 2015 to 2017. This trend contributes to rising overdose deaths, marking a "fourth wave" of the…

View details →DOI: 10.1016/j.drugalcdep.2025.112992
Negative / Null Result ReportOpen accessMedicine

Investigation of Potential Cross-Protection Conferred by the Seasonal Influenza Vaccine Against Swine Influenza A Viruses of Pandemic Potential.

Lilley A, Chiapponi C, Prosperi A et al. · 2026 · Vaccines

Background/Objectives : Influenza A viruses cause seasonal epidemics of respiratory infections in humans, the severity of which can be mitigated by influenza vaccine use. Influenza A viruses circulating in pigs continue to pose a pandemic…

View details →DOI: 10.3390/vaccines14030211
Negative / Null Result ReportOpen accessMedicine

Semaglutide use before single-level lumbar fusion associated with fewer readmissions and 90-day costs.

Ng MK, Mastrokostas PG, Rodriguez AN et al. · 2025 · Journal of craniovertebral junction & spine

Context Semaglutide, a glucagon-like protein-1 receptor agonist used in diabetes and obesity management, has demonstrated perioperative benefits in other surgical populations. However, its role in spine surgery remains unclear. Aims This…

View details →DOI: 10.4103/jcvjs.jcvjs_156_25
Negative / Null Result ReportOpen accessMedicine

The brief pain inventory-Interference Subscale has acceptable reliability but questionable validity in acute back and neck pain populations.

Jones CMP, Lin CC, Zadro J et al. · 2024 · Brazilian journal of physical therapy

Background The Brief Pain Inventory-Interference Subscale (BPI-IS) is a subscale of the BPI assessment tool developed to rapidly assess the impact of a person's pain on their function. It is uncertain whether it has one or two factors, and…

View details →DOI: 10.1016/j.bjpt.2024.101150
Negative / Null Result ReportMedicine

Finland's Flexible Partial Pension - A Bridge to Full-Time Retirement, a Pathway Out of Paid Employment, or an Income Supplement?

Ilmakunnas I, Sten-Gahmberg S · 2026 · Journal of aging & social policy

Flexible partial retirement schemes are intended to give individuals the opportunity to reduce working hours before moving into full retirement, the expectation being that the reduced workload will contribute to postponed old-age…

View details →DOI: 10.1080/08959420.2026.2643643
Negative / Null Result ReportOpen accessMedicine

Comparison of Pharmacokinetic/Pharmacodynamic Parameters and Clinical Outcomes of Vancomycin Administered in Two Different Dosage Regimens in Patients with Acute Kidney Injury.

Soufi R, Salamzadeh J, Alavi Darazam I et al. · 2025 · Iranian journal of pharmaceutical research : IJPR

Background Vancomycin is commonly used in intensive care units (ICUs), but its optimal dosage in patients with acute kidney injury (AKI) remains uncertain. This study aimed to evaluate vancomycin's pharmacokinetic and pharmacodynamic…

View details →DOI: 10.5812/ijpr-159089
Negative / Null Result ReportOpen accessMedicine

Cognitive and Behavioral Effects of Levetiracetam in Juvenile Rats.

Ullal SD, Thomas AG, Acharya SD et al. · 2026 · Pharmacology research & perspectives

Epilepsy is a common neurologic disorder; its incidence in childhood is 2.5 per 1000 children. Levetiracetam (LEV) is an antiepileptic drug with a broad spectrum of action used in localized and generalized epilepsies in both adults and…

View details →DOI: 10.1002/prp2.70226
Negative / Null Result ReportMedicine

Persisting neurobehavioral consequences of gestational exposure to cadmium and benzo[a]pyrene in rats.

Hawkey AB, Fan R, Nwachukwu K et al. · 2025 · Neurotoxicology and teratology

Neurotoxic risks in the environment come from many toxicants, which are often found together in complex mixtures. However, nearly all experimental studies evaluate one chemical at a time. Neurobehavioral effects of developmental exposure…

View details →DOI: 10.1016/j.ntt.2025.107546
Negative / Null Result ReportOpen accessMedicine

Elevated Carcinoembryonic Antigen Levels Predict Failure to Reach Surgery in Patients with Borderline Resectable Pancreatic Cancer Referred to Neoadjuvant Therapy.

Jacover A, Beller T, Mahamid N et al. · 2025 · Annals of surgical oncology

Introduction Neoadjuvant therapy (NT) is generally preferred over upfront surgery for borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC), but many patients fail to reach surgical resection. This study evaluates real-world…

View details →DOI: 10.1245/s10434-025-17433-3
Negative / Null Result ReportOpen accessMedicine

Efficacy and Safety of a Novel Rotatable Sphincterotome for Endoscopic Sphincterotomy in Patients With Roux-en-Y Gastrectomy During Balloon Enteroscopy-Assisted ERCP (With Video).

Tanisaka Y, Ryozawa S, Mizuide M et al. · 2025 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

Endoscopic sphincterotomy (EST) is challenging for patients with surgically altered anatomy (SAA). The blades of conventional sphincterotomes designed for SAA do not always face the correct direction of EST. We aimed to evaluate the…

View details →DOI: 10.1111/den.15066
Negative / Null Result ReportMedicine

The effect of dairy products on liver fat and metabolic risk markers in males with abdominal obesity - a four-arm randomized controlled trial.

Sandby K, Magkos F, Chabanova E et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)

Background & aims In recent years, epidemiological studies have reported links between the consumption of fermented dairy products, such as yogurt, and health; however, evidence from human intervention trials is scarce and inconsistent. We…

View details →DOI: 10.1016/j.clnu.2023.12.018
Negative / Null Result ReportOpen accessMedicine

Serum folate levels and risk of metabolic dysfunction-associated steatotic liver disease: results from a cross-sectional study and Mendelian randomization analysis.

Chen Y, Gao J, Wang X et al. · 2024 · Frontiers in nutrition

Background Evidence from observational studies on the association between folate and metabolic dysfunction-associated steatotic liver disease (MASLD) is conflicting. Aims This study aimed to investigate the association between serum folate…

View details →DOI: 10.3389/fnut.2024.1437183
Negative / Null Result ReportMedicine

Choriocapillaris and choroidal thickness in all Leber hereditary optic neuropathy stages using swept source technology.

Castillo L, Berrozpe-Villabona C, Miserachs-García S et al. · 2024 · Acta ophthalmologica

Purpose The role of the choroid in Leber hereditary optic neuropathy (LHON) remains unclear. The literature is scarce, with conflicting results and lacks axial length measurements. Therefore, we aimed to analyse the choriocapillaris (CC)…

View details →DOI: 10.1111/aos.15811
Negative / Null Result ReportOpen accessMedicine

Modal Backflow Neural Quantum States for Anharmonic Vibrational Calculations.

Ding L, Reiher M · 2026 · Journal of chemical theory and computation

Neural quantum states (NQS) are a promising ansatz for solving many-body quantum problems due to their inherent expressiveness. Yet this expressiveness can only be harnessed efficiently for treating identical particles if the suitable…

View details →DOI: 10.1021/acs.jctc.5c01852
Negative / Null Result ReportMedicine

Does the methane-mitigating feed additive 3-nitrooxypropanol affect additive genetic variance and ranking of methane and yield traits in Holstein dairy cows?

Stephansen RB, Lassen J, Lund MS et al. · 2026 · Journal of dairy science

This study aimed to quantify the effect of the methane-mitigating feed additive 3-NOP on genetic parameters and potential genotype-by-environment (G × E) interaction for gas emission traits, i.e., methane (CH 4 ) and, carbon dioxide (CO 2…

View details →DOI: 10.3168/jds.2026-28686
Negative / Null Result ReportMedicine

Effects of cabin thermal conditions and road type on driver workload and performance: A driving simulator study.

Lu B, Liu X, Zhang P et al. · 2026 · Traffic injury prevention

Objective Driver workload is a safety-relevant factor that may contribute to impaired driving performance and an increased risk of traffic injury. Cabin temperature is a modifiable in-vehicle environmental condition, but its influence on…

View details →DOI: 10.1080/15389588.2026.2682437
Negative / Null Result ReportMedicine

Effect of polymerization mode on dentin bond strength of universal adhesives: influence of aging and application strategy.

Yazici Akbiyik S, Yikici Col C, Bakir E · 2026 · Quintessence international (Berlin, Germany : 1985)

Objectives This study evaluated the effect of polymerization mode on dentin bond strength of universal adhesives applied using etch-and-rinse (ER) and self-etch (SE) strategies, before and after thermocycling. Method and materials A total…

View details →DOI: 10.3290/j.qi.b6982835