Negative / Null Result ReportMedicine
Farhat MR, Jacobson KR · 2024 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Active case finding leveraging new molecular diagnostics and chest X-rays with automated interpretation algorithms is increasingly being developed for high-risk populations to drive down tuberculosis incidence. We consider why such an…
View details →DOI: 10.1093/cid/ciae058 Negative / Null Result ReportOpen accessMedicine
Yokoyama M, Kaida R, Miyamoto K et al. · 2024 · Plant biotechnology (Tokyo, Japan)
α-Ketol octadecadienoic acid (KODA), an oxylipin, is generated from linolenic acid by 9-specific lipoxygenase, while jasmonic acid is ultimately synthesized from the same linolenic acid by 13-specific lipoxygenase. KODA has a unique action…
View details →DOI: 10.5511/plantbiotechnology.24.0721b Negative / Null Result ReportOpen accessMedicine
Queiroz MG, Tobar KDL, Damazo AS et al. · 2026 · International journal of environmental research and public health
This randomized crossover study aimed to evaluate the effect of a single session of aerobic exercise on 24 h ambulatory blood pressure (BP) and heart rate variability (HRV) in young adults with a family history of hypertension, FHH +…
View details →DOI: 10.3390/ijerph23050602 Negative / Null Result Report
Galante H, Czaczkes TJ · 2022 · Preprint
Nectar-feeding insects are often the victims of psychoactive manipulation, with plants lacing their nectar with secondary metabolites such as alkaloids and non-protein amino acids which often boost learning, foraging, or recruitment.…
View details →DOI: 10.1101/2022.11.01.514620 Negative / Null Result ReportOpen accessMedicine
Winter AL, Peter M, Thunell E et al. · 2026 · Neural plasticity
Absence of sensory input is associated with alterations in brain morphology; mainly in or near cerebral regions normally devoted to processing of the missing sense. However, multiple recent studies demonstrate that the only consistent…
View details →DOI: 10.1155/np/3960593 Negative / Null Result ReportMedicine
Chen P, Lv J · 2024 · Nephrology (Carlton, Vic.)
This mini-review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP-IgAN regarding glucocorticoid…
View details →DOI: 10.1111/nep.14369 Failed Experiment ReportOpen accessMedicine
Alizadeh A, Moradi M, Vafaeimastanabad M et al. · 2025 · Galen medical journal
Background Major spine surgeries often involve significant blood loss, increasing transfusion risks and postoperative complications. Desmopressin, a synthetic vasopressin analog, may reduce bleeding by enhancing clotting factor release,…
View details →DOI: 10.31661/gmj.v14i.3871 Failed Experiment ReportOpen accessMedicine
Galante H, Lane SJ, Elderbrock EK et al. · 2026 · Integrative organismal biology (Oxford, England)
Organisms in natural environments often undergo life history stage transitions that optimize behaviors (i.e., migration, reproduction, and foraging) with environmental conditions. These changes in behavior are facilitated by changes in…
View details →DOI: 10.1093/iob/obag013 Failed Experiment ReportOpen accessMedicine
García MA, Aceituno A, Díaz NB et al. · 2025 · Pharmaceutics
Background/Objectives: The static in vitro permeability assay based on cell monolayers has been widely used in the pharmaceutical industry and recognized by regulatory agencies as a surrogate method for BCS classification. However, the…
View details →DOI: 10.3390/pharmaceutics17091110 Failed Experiment ReportOpen accessMedicine
Miskelly MG, Lindqvist A, Jujić A et al. · 2026 · The Journal of clinical endocrinology and metabolism
Context Statin use is associated with increased risk of type 2 diabetes (T2D) and mild hyperglycemia. The underlying mechanisms are not well studied, and the effect of statin treatment on glucagon-like peptide 1 (GLP-1) secretion or…
View details →DOI: 10.1210/clinem/dgaf608 Negative / Null Result ReportOpen accessMedicine
Alam KA, Martí-Solans J, Schall D et al. · 2026 · ACS chemical neuroscience
Voltage-gated potassium channel KCNQ1 (Kv7.1) plays a critical role in electrical excitability in the heart, gut, and brain. Together with the auxiliary subunit KCNE1, KCNQ1 generates a slow delayed rectifier current ( I Ks ) that is…
View details →DOI: 10.1021/acschemneuro.6c00197 Negative / Null Result ReportOpen accessMedicine
Wilkes S, Kalfsvel L, van Rosse F et al. · 2026 · European journal of hospital pharmacy : science and practice
Objectives Specialised hospital pharmacists, integrated in medical teams on the ward, can improve medication safety. When a specialised hospital pharmacist is temporarily not available, the pharmaceutical care will be conducted by a…
View details →DOI: 10.1136/ejhpharm-2024-004392 Negative / Null Result ReportOpen accessMedicine
Uysal Yeler G, Sivaslıoğlu A, Gülsün T et al. · 2025 · International journal of molecular sciences
Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in the differentiation and maturation of preadipocytes. PPARγ promotes adipogenesis by inducing the expression of fatty acid-binding protein 4 (FABP4). Uncoupling…
View details →DOI: 10.3390/ijms27010139 Negative / Null Result ReportOpen accessMedicine
Crucitta S, Cinacchi P, Bargagna I et al. · 2026 · Therapeutic advances in drug safety
Background CDK4/6 inhibitors abemaciclib, palbociclib, and ribociclib have rapidly become an established oral treatment for patients with ER+, HER2- locally advanced or metastatic breast cancer. The use of the oral route offers convenience…
View details →DOI: 10.1177/20420986251414591 Negative / Null Result ReportOpen accessMedicine
Shah V, Pankratz VS, Cardona M et al. · 2024
Background Given the existence of firmly entrenched and rapidly increasing health disparities, novel approaches are needed to improve the health of socioeconomically disadvantaged groups, including American Indian communities. In a prior…
Negative / Null Result ReportOpen accessMedicine
van Oosterwijk JG, Richer L, Beimfohr-Griffing LK et al. · 2026 · Parasites & vectors
Background The lack of effective and affordable new environmental tick control products is one of the major challenges to the existing control strategies against the blacklegged tick (Ixodes scapularis), the vector of Lyme disease…
View details →DOI: 10.1186/s13071-026-07380-7 Negative / Null Result ReportOpen accessMedicine
Pfeifer P, Mathys B, Alan EM et al. · 2025 · Psychiatry and clinical psychopharmacology
Background Therapeutic drug monitoring (TDM) is an important tool to personalize psychopharmacotherapy, thereby optimizing its effectiveness and tolerability. Despite consensus on medications, indications, and implementation of TDM,…
View details →DOI: 10.5152/pcp.2025.24981 Negative / Null Result ReportOpen accessMedicine
Goff PS, Budd P, Logan DW et al. · 2025 · Pigment cell & melanoma research
We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the G α s subunit of…
View details →DOI: 10.1111/pcmr.70025 Negative / Null Result ReportOpen accessMedicine
Tseng M, Middleton SJ, Farah A et al. · 2025 · Pain reports
Introduction Hyperexcitability, particularly of DRG neurons, is a key driver of persistent pain states including neuropathic pain. Contactin-associated protein-like 2 (CASPR2) is transmembrane protein known to interact and regulate the…
View details →DOI: 10.1097/pr9.0000000000001309 Negative / Null Result ReportOpen accessMedicine
Poljo A, Reichl JJ, Bürgi S et al. · 2025 · Obesity surgery
Background Obesity, a chronic disease with serious associated medical problems, remains a global health challenge. While metabolic bariatric surgery (MBS) is the most effective treatment for weight loss, GLP-1 receptor agonists (RAs) are…
View details →DOI: 10.1007/s11695-025-08136-5 Negative / Null Result ReportMedicine
Falvey A, Palandira SP, Chavan SS et al. · 2024 · Brain, behavior, and immunity
Background The vagus nerve plays an important role in neuroimmune interactions and in the regulation of inflammation. A major source of efferent vagus nerve fibers that contribute to the regulation of inflammation is the brainstem dorsal…
View details →DOI: 10.1016/j.bbi.2024.04.027 Negative / Null Result ReportOpen accessMedicine
Ragamin A, Schappin R, Pasmans SGMA et al. · 2023 · Skin health and disease
National prescription data for therapeutic clothing in atopic dermatitis was analysed to investigate the role of therapeutic clothing in atopic dermatitis. Therapeutic clothing is most frequently prescribed by dermatologists in a hospital…
View details →DOI: 10.1002/ski2.303 Negative / Null Result ReportOpen accessMedicine
Merlo JK, da Silva AV, Casonatto J et al. · 2024 · Healthcare (Basel, Switzerland)
Objective To investigate the effects of combining a Pilates program with photobiomodulation therapy (PBMT) in patients with chronic nonspecific low back pain (CNLBP). Methods Thirty-eight adults with CNLBP were randomly assigned to two…
View details →DOI: 10.3390/healthcare12141416 Negative / Null Result ReportMedicine
Stroemel-Scheder C, Lautenbacher S · 2023 · The journal of pain
Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the…
View details →DOI: 10.1016/j.jpain.2022.10.009 Negative / Null Result ReportOpen accessMedicine
Moretti L, Richelmi L, Cosentini D et al. · 2024 · Breast (Edinburgh, Scotland)
The efficacy of adjuvant denosumab in combination with hormonotherapy in breast cancer patients was investigated in two randomized trials, ABCSG-18 and D-Care, but the results were mixed with respect to the impact of this drug on…
View details →DOI: 10.1016/j.breast.2024.103826 Negative / Null Result ReportOpen accessMedicine
Góis KS, Braga M, Souza VH et al. · 2026 · Einstein (Sao Paulo, Brazil)
Objective This study aimed to analyze the possible association between rs2814778, rs12075 ( ACKR1 gene), and rs4073 ( CXCL8 gene) single nucleotide variants and COVID-19 severity. Methods This cross-sectional study included 319 COVID-19…
View details →DOI: 10.31744/einstein_journal/2026ao1543 Negative / Null Result ReportMedicine
Hosier H, Lipkind HS, Rasheed H et al. · 2023 · Hypertension (Dallas, Tex. : 1979)
Background Preeclampsia is a leading cause of maternal morbidity, and dyslipidemia has been associated with preeclampsia in observational studies. We use Mendelian randomization analyses to estimate the association between lipid levels,…
View details →DOI: 10.1161/hypertensionaha.122.20426 Negative / Null Result ReportOpen accessMedicine
Richardson KE, Suo C, Albertella L et al. · 2025 · JAMA psychiatry
Importance Cannabis is the most commonly used illicit drug, with 10% to 30% of regular users developing cannabis use disorder (CUD), a condition linked to altered hippocampal integrity. Evidence suggests high-intensity interval training…
View details →DOI: 10.1001/jamapsychiatry.2025.2319 Negative / Null Result ReportOpen accessMedicine
da Silva NIS, de Araújo TLAC, Firmino SS et al. · 2026 · Tropical animal health and production
This study aimed to evaluate the effects of supplementing high-concentrate diets for sheep with green propolis extract (PRO) from Mimosa tenuiflora or with salinomycin (SAL) on feed intake, apparent digestibility, nitrogen balance, and…
View details →DOI: 10.1007/s11250-026-05012-x Negative / Null Result ReportOpen accessMedicine
Luzuriaga AL, Madrigal-González J, de la Cruz M et al. · 2026 · Ecology
The relationship between taxonomic and phylogenetic diversities remains underexplored. Our goal was to determine whether a causal link exists between species richness and phylogenetic diversity and to determine the direction of this…
View details →DOI: 10.1002/ecy.70361 