A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19786 results in Negative / Null Result Report · page 62 of 660
Steven D. Mittelman, Katie Klier, Sharon Braun et al. · 2010 · Obesity
Ghrelin and peptide YY (PYY) stimulate hunger and satiety, respectively. The physiology of these hormones during normal meal intake remains unclear. This study was designed to compare the responses of these two hormones to meal intake…
Yoshiyuki Konishi, Yoshihiro Muragaki, Hiroshi Iseki et al. · 2012 · Neurologia medico-chirurgica
The present retrospective study evaluated the recurrence patterns after aggressive surgical removal of intracranial glioblastomas in 43 consecutive adult patients. The resection rate of the enhanced lesion on magnetic resonance imaging was…
Abu R. Ayman, Tawfik Khoury, Jonah Cohen et al. · 2016 · Journal of Clinical Gastroenterology
BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tubes are commonly utilized as a method of enteral feeding in patients unable to obtain adequate oral nutrition. Although some studies have shown improved mortality in select…
Claudia Trenkwalder, Fabrizio Stocchi, Werner Poewe et al. · 2016 · Movement Disorders
BACKGROUND: Two phase 2 randomized, double-blind studies were designed to evaluate efficacy and safety of immediate-release (study 1) and modified-release (study 2) mavoglurant formulations in PD l-dopa-induced dyskinesia. METHODS:…
Sigrid Hatse, Barbara Brouwers, Bruna Dalmasso et al. · 2014 · PLoS ONE
Circulating microRNAs (miRNAs) hold great promise as easily accessible biomarkers for diverse (patho)physiological processes, including aging. We have compared miRNA expression profiles in cell-free blood from older versus young breast cancer patients, in order to identify "aging miRNAs" that can be used in the future to monitor the impact of chemotherapy on the patient's biological age. First, we assessed 175 miRNAs that may possibly be present in serum/plasma in an exploratory screening in 10 young and 10 older patients. The top-15 ranking miRNAs showing differential expression between young
Daniel Alcolea, Constance Delaby, Laia Muñoz et al. · 2021 · Journal of Neurology Neurosurgery & Psychiatry
OBJECTIVES: All categories included in the AT(N) classification can now be measured in plasma. However, their agreement with cerebrospinal fluid (CSF) markers is not fully established. A blood signature to generate the AT(N) classification…
James F. Morley, Abigail Cohen, Laura Silveira‐Moriyama et al. · 2018 · npj Parkinson s Disease
The 40-item University of Pennsylvania Smell Identification Test (UPSIT) is an effective instrument to detect olfactory dusfunction in Parkinson's disease (PD). It is not clear, however, whether tests of this length are necessary to detect such dysfunction. Several studies have suggested that detection of certain odors is selectively compromised in PD, and that a test comprised of these odors could be shorter and more specific for this purpose. Therefore, we attempted to identify a subset of UPSIT odors that distinguish PD from controls with similar or improved test characteristics compared to
Baptiste A.J. Poursat, Rob J. M. van Spanning, Martin Braster et al. · 2019 · Ecotoxicology and Environmental Safety
) under the test conditions. Inoculation of the chemostat led to a rapid shift in the community composition and abundance. The community exposed to 1.5 mg/l of MET was still able to completely consume MET in the RBTs after one-month exposure, but three- and nine-months exposure resulted in reduced removal of MET in the RBTs. The ability of the activated sludge community to degrade MET and GUA is the result of environmental exposure to these chemicals as well as of conditions that could not be reproduced in the laboratory system. A MET-degrading strain belonging to the genus Aminobacter has bee
Eisaku Fujimoto, Yoshiaki Sasashige, Yasuji Masuda et al. · 2012 · Knee Surgery Sports Traumatology Arthroscopy
PURPOSE: The intra-operative femorotibial joint gap and ligament balance, the predictors affecting these gaps and their balances, as well as the postoperative knee flexion, were examined. These factors were assessed radiographically after…
Annette A. Angus, David J. Evans, Joseph Barbieri et al. · 2010 · Infection and Immunity
Pseudomonas aeruginosa can establish a niche within the plasma membrane of epithelial cells (bleb niches) within which bacteria can survive, replicate, and swim at speeds detectable by real-time phase-contrast imaging. This novel virulence…
Carine Meslot, Aurélie Gauchet, B. Allenet et al. · 2016 · Frontiers in Psychology
Interventions to assist individuals in initiating and maintaining regular participation in physical activity are not always effective. Psychological and behavioural theories advocate the importance of both motivation and volition in interventions to change health behaviour. Interventions adopting self-regulation strategies that foster motivational and volitional components may, therefore, have utility in promoting regular physical activity participation. We tested the efficacy of an intervention adopting motivational (mental simulation) and volitional (implementation intentions) components to
Mohammed Saqib, Ying Sha, May D. Wang · 2018
Sepsis is a life-threatening condition caused by infection and subsequent overreaction by the immune system. Physicians effectively treat sepsis with early administration of antibiotics. However, excessive use of antibiotics on false…
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al. · 2022 · Science Advances
Studies purporting to show changes in brain structure following the popular, 8-week mindfulness-based stress reduction (MBSR) course are widely referenced despite major methodological limitations. Here, we present findings from a large, combined dataset of two, three-arm randomized controlled trials with active and waitlist (WL) control groups. Meditation-naïve participants ( n = 218) completed structural magnetic resonance imaging scans during two visits: baseline and postintervention period. After baseline, participants were randomly assigned to WL ( n = 70), an 8-week MBSR program ( n = 75)
Zebin Hu, Janhavi Gupta, Zhenwei Zhang et al. · 2012 · Human Gene Therapy
We have examined whether Ad.sTβRFc and TAd.sTβRFc, two oncolytic viruses expressing soluble transforming growth factor-β receptor II fused with human Fc (sTGFβRIIFc), can be developed to treat bone metastasis of prostate cancer. Incubation…
Rui Ran, Haofei Wang, Fei Hou et al. · 2019 · Advanced Healthcare Materials
Two principal methods for cancer drug testing are widely used, namely, in vitro 2D cell monolayers and in vivo animal models. In vitro 2D culture systems are simple and convenient but are unable to capture the complexity of biological…
Salome Musau, Stephen Muathe, Lucy Wamugo · 2017 · International Journal of Financial Research
This paper provides an empirical analysis of the synergies and trade-offs between financial inclusion and credit risk of commercial banks in Kenya. The paper analyzed the effect of financial inclusion on credit risk and the mediation effect of bank competitiveness of commercial banks in Kenya. Financial inclusion was measured using three dimensions of bank availability, bank accessibility and bank usage, bank competitiveness used (HHI) while credit risk was represented by the non performing loans ratio. The study was anchored on financial intermediation theory supported by finance growth theor
Tewodros Eshete, Gemechu Kumera, Yibelu Bazezew et al. · 2018 · Agriculture & Food Security
Inadequate feeding practices are a significant reason for the onset of malnutrition in young children, and their consequences are one of the major obstacles to sustainable socioeconomic development and poverty reduction. Dietary diversity is one of the useful indicators to assess the nutrient adequacy and can examine how different food groups contribute to the nutrient adequacy of the diet in a specific area. Minimum dietary diversity is the intake of at least four food types from the seven categories. Secondary data analysis of Ethiopian Demographic health survey of 2016 was conducted to expl
Petar Kurečić, Filip Kokotović · 2017 · Economies
This paper studies the relevance of political stability on foreign direct investment (FDI) and the relevance of FDI on economic growth, in three panels. The first panel contains 11 very small economies; the second contains five well-developed and politically stable economies with highly positive FDI net inflows, while the third is a panel with economies that are prone to political violence or targeted by the terrorist attacks. We employ a Granger causality test and implement a vector autoregressive (VAR) framework within the panel setting. In order to test the sensitivity of the results and av
Scott L. Zuckerman, Gary S. Solomon, Jonathan A. Forbes et al. · 2012 · Journal of Neurosurgery Pediatrics
OBJECT: Several studies have suggested a gender difference in response to sports-related concussion (SRC). The Concussion in Sport group did not include gender as a modifying factor in SRC, concluding that the evidence at that point was…
Yngvar Krukhaug, Stein Atle Lie, Leif I Havelin et al. · 2014 · Journal of Hand Surgery (European Volume)
In this study we report the results of thumb carpometacarpal (CMC) joint replacements in the Norwegian population over a 17-year period. In total, 479 primary replacements performed from 1994 to 2011 were identified in the Norwegian…
Yi‐Hsuan Huang, Meei‐Shyuan Lee, Yu-Sheng Lou et al. · 2019 · PLoS ONE
BACKGROUND: Breast cancer is the most common cancer in women and several perioperative factors may account for tumor recurrence and metastasis. The anesthetic agents employed during cancer surgery might play a crucial role in cancer cell survival and patient outcomes. We conducted a retrospective cohort study to investigate the relationship between the type of anesthesia and overall survival in patients who underwent breast cancer surgery performed by one experienced surgeon. METHODS: All patients who underwent breast cancer surgery by an experienced surgeon between January 2006 and December 2
Donald C. Hood, Emmanouil Tsamis, Nikhil Bommakanti et al. · 2019 · Investigative Ophthalmology & Visual Science
Purpose: To assess the agreement between structural (optical coherence tomography [OCT]) and functional (visual field [VF]) glaucomatous damage with an automated method and deviation/probability maps, and to compare this method to a metric method. Methods: Wide-field spectral-domain OCT scans, including the disc and macula, and 24-2 and 10-2 VFs were obtained from 45 healthy control (H) eyes/individuals, and 53 eyes/patients with 24-2 mean deviation (MD) better than -6 dB diagnosed as "definite glaucoma" (DG) by experts. Abnormal structure-abnormal function (aS-aF) agreement was assessed with
Haixia Xie, LU Jin-fang, Ying Zhou et al. · 2015 · Infection and Immunity
Edwardsiella tarda is a Gram-negative enteric pathogen that causes hemorrhagic septicemia in fish and gastro- and extraintestinal infections in humans. The type III secretion system (T3SS) of E. tarda has been identified as a key virulence…
David F. Feldon, Soojeong Jeong, James Peugh et al. · 2017 · Proceedings of the National Academy of Sciences
Many PhD programs incorporate boot camps and summer bridge programs to accelerate the development of doctoral students' research skills and acculturation into their respective disciplines. These brief, high-intensity experiences span no…
Andrew J. Gunderson, Tomoko Yamazaki, Kayla McCarty et al. · 2019 · PLoS ONE
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune escape via exclusion of anti-tumor CD8+ T cells from cancer cells, upregulation of immune checkpoint ligand expression, immunosuppressive cytokine production, and polarization of tumor infiltrating inflammatory cells. FAP is a post-proline peptidase selectively expressed during tissue remodeling and repair, such as with wound healing, and in the tumor
Sharon A. Robinson, David J. Erickson · 2014 · Global Change Biology
Abstract Climate scientists have concluded that stratospheric ozone depletion has been a major driver of Southern Hemisphere climate processes since about 1980. The implications of these observed and modelled changes in climate are likely…
Olga Karginova, Marni B. Siegel, Amanda E.D. Van Swearingen et al. · 2015 · Molecular Cancer Therapeutics
Patients with breast cancer brain metastases have extremely limited survival and no approved systemic therapeutics. Triple-negative breast cancer (TNBC) commonly metastasizes to the brain and predicts poor prognosis. TNBC frequently…
Martin D. Hoffman, Kristin J. Stuempfle, Ian R. Rogers et al. · 2012 · International Journal of Sports Physiology and Performance
PURPOSE: To determine the incidence of exercise-associated hyponatremia (EAH), the associated biochemical measurements and risk factors for EAH, and whether there is an association between postrace blood sodium concentration ([Na+]) and…
Philippe A. Cassier, Anne Lefranc, Éric Amela et al. · 2013 · British Journal of Cancer
BACKGROUND: Soft tissue sarcomas (STS) are rare tumours for which treatment options are limited in the advanced setting. Histone deacetylase inhibitors have shown activity in preclinical models of STS. METHODS: We conducted a single-arm,…
Constantine Mavroudis, Tiffany S. Ko, Ryan W. Morgan et al. · 2020 · Critical Care
BACKGROUND: Despite controversies, epinephrine remains a mainstay of cardiopulmonary resuscitation (CPR). Recent animal studies have suggested that epinephrine may decrease cerebral blood flow (CBF) and cerebral oxygenation, possibly potentiating neurological injury during CPR. We investigated the cerebrovascular effects of intravenous epinephrine in a swine model of pediatric in-hospital cardiac arrest. The primary objectives of this study were to determine if (1) epinephrine doses have a significant acute effect on CBF and cerebral tissue oxygenation during CPR and (2) if the effect of each