Systemic Delivery of Oncolytic Adenoviruses Targeting Transforming Growth Factor-β Inhibits Established Bone Metastasis in a Prostate Cancer Mouse Model
Zebin Hu; Janhavi Gupta; Zhenwei Zhang; Helen Gerseny; Arthur Berg; Yun‐Ju Chen; Zhiling Zhang; Hongyan Du · 2012 · Human Gene Therapy
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
We have examined whether Ad.sTβRFc and TAd.sTβRFc, two oncolytic viruses expressing soluble transforming growth factor-β receptor II fused with human Fc (sTGFβRIIFc), can be developed to treat bone metastasis of prostate cancer. Incubation…
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Metadata source: OpenAlex · DOI 10.1089/hum.2012.040