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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 616 of 676

Negative / Null Result ReportMedicine

Multi-omics analysis reveals Parabacteroides distasonis and Kineothrix alysoides as potential key bacterial species associated with anemia in sows.

Sun, Chen, Yang et al. · 2026 · Journal of animal science and biotechnology

Sow anemia has been reported to be associated with reduced reproductive performance. Additionally, anemia may alter gut microbiota composition. However, the gut microbiota and metabolic signatures specifically linked to sow anemia status…

View details →DOI: 10.1186/s40104-026-01443-6
Negative / Null Result ReportMedicine

The Effect of The Changes in Cylinder Power and Axis of Toric Soft Contact Lenses on Vision of Astigmatic Subjects.

Aprina, Rahayu, Prihartono et al. · 2026 · Korean journal of ophthalmology : KJO

To investigate the effect of higher cylindrical power and axis misalignment of toric SCL in mild and moderate astigmatism on visual acuity, contrast sensitivity, visual satisfaction, and vision acceptability. 20 astigmatic participants…

View details →DOI: 10.3341/kjo.2025.0168
Negative / Null Result ReportMedicine

Effect of visual disruption on the lower limb kinematic and kinetic characteristics in athletes after anterior cruciate ligament reconstruction.

Yu, Yu, Sun et al. · 2026 · Frontiers in bioengineering and biotechnology

Proprioceptive deficits following anterior cruciate ligament (ACL) injury increase reliance on visual input in athletes after ACL reconstruction (ACLR). Visual disruption may therefore alter movement patterns and increase re-injury risk.…

View details →DOI: 10.3389/fbioe.2026.1767092
Negative / Null Result ReportMedicine

Measuring the effect of azithromycin in chronic respiratory disease using continuous cough monitoring: an open-label exploratory trial.

Sykes, Brindle, Kazmi et al. · 2026 · ERJ open research

Azithromycin is beneficial in a multitude of respiratory diseases; however, its effects on both subjective and objective measures of cough have been less extensively studied. Traditional 24-h cough counting assessments are highly variable,…

View details →DOI: 10.1183/23120541.00562-2025
Negative / Null Result ReportMedicine

Effects of Hydrogen Water Gargling on Oral Mucositis and Pain in Head and Neck Cancer Patients: A Randomized Controlled Pilot Study.

Tsai, Huang, Wang et al. · 2026 · Integrative cancer therapies

BackgroundTraditional, complementary, and integrative medicine (TCIM) is an evolving field in oncology focused on managing cancer symptoms. Hydrogen water (HW) has gained attention for its antioxidant and anti-inflammatory properties, yet…

View details →DOI: 10.1177/15347354261463550
Negative / Null Result ReportMedicine

HLA selected red cell transfusions to prevent HLA sensitisation: a prospective, double-blinded, randomised controlled trial.

McComish, Brewster, Brizard et al. · 2026 · Transplant immunology

Human Leucocyte Antigen (HLA) sensitisation following red cell transfusion can disrupt planned transplantation and impair outcomes. We conducted a prospective, randomised controlled, double blinded, parallel arm study to evaluate the…

View details →DOI: 10.1016/j.trim.2026.102412
Negative / Null Result ReportMedicine

Hot dogs for snakes: alternative method for feeding coral snakes (Micrurus corallinus) maintained at Butantan Institute.

Ribeiro, Stuginski, do Amaral E Luna et al. · 2026 · Toxicon : official journal of the International Society on Toxinology

Snakebites represent a significant public health concern in tropical and subtropical countries. In 2025, approximately 21,000 incidents of snakebites were reported in Brazil, with 1.7% attributed to coral snakes. Although the incidence of…

View details →DOI: 10.1016/j.toxicon.2026.109197
Negative / Null Result ReportMedicine

Clinical outcome of fiber post and fiber-reinforced resin composite for the full crowns of anterior endodontically treated teeth: a 5-year randomized clinical trial.

Ferrari, Saracutu, Pontoriero et al. · 2026 · Journal of dentistry

To compare the outcome of short fiber reinforced composites, as a core material, with respect to conventional fiber post, for the reconstruction of anterior endodontically treated teeth (ETT), covered by a lithium disilicate crown.…

View details →DOI: 10.1016/j.jdent.2026.106850
Negative / Null Result ReportMedicine

Timing for green prescription: comparing the immediate and cumulative effects of different duration horticultural therapy programs on college students' mental health.

Liu, Chen, Sun et al. · 2026 · Frontiers in psychology

Although the mental health benefits of horticultural therapy (HT) are well-established, the influence of intervention duration and the temporal dynamics of effects remain insufficiently explored, lacking evidence for optimal protocol…

View details →DOI: 10.3389/fpsyg.2026.1838988
Negative / Null Result ReportMedicine

Risk Factors and Survival Analysis of Epstein-Barr Virus Infection After Pediatric Liver Transplantation.

Li, Li, Xie et al. · 2026 · Pediatrics international : official journal of the Japan Pediatric Society

To explore the risk factors affecting Epstein-Barr virus (EBV) infection after pediatric liver transplantation (PLT) and analyze the survival outcomes of EBV infection in PLT. A retrospective analysis was conducted on clinical data from…

View details →DOI: 10.1111/ped.70431
Negative / Null Result ReportMedicine

[Targeted muscle reinnervation for treatment of painful stump neuroma].

Xiong, Shali, Kadier et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the effectiveness of incorporating small gap anastomosis (SGA) and epineurial sheath tube (EST) sleeve coaptation into conventional targeted muscle reinnervation (TMR) for the treatment of post-amputation painful stump…

View details →DOI: 10.7507/1002-1892.202601115
Negative / Null Result ReportMedicine

[Comparative study on effectiveness of bioinductive patch-augmented arthroscopic rotator cuff repair].

Sun, Yao, Gu et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To evaluate the effectiveness of using a bioinductive patch on tendon healing, functional recovery, and safety in arthroscopic rotator cuff repair. A non-concurrent controlled study with prospective enrollment of the intervention group and…

View details →DOI: 10.7507/1002-1892.202512084
Negative / Null Result ReportMedicine

[Effectiveness analysis of single-incision treatment for adjacent two-segmental lumbar disc herniation using uni-portal non-coaxial spinal endoscopic surgery].

He, Li, Xiao et al. · 2026 · Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

To investigate the feasibility and effectiveness of uni-portal non-coaxial spinal endoscopic surgery (UNSES) via a single incision for the treatment of adjacent two-segmental lumbar disc herniation (LDH). A retrospective analysis was…

View details →DOI: 10.7507/1002-1892.202601011
Negative / Null Result ReportMedicine

Effect of ammonia-free silver fluoride and silver diammine fluoride on immediate microshear bond strength of resin-modified glass ionomer to demineralised primary tooth dentine.

Abedinzade Zare, Vafadar, Behroozibakhsh et al. · 2026 · European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

This study aimed to compare the effect of water-based ammonia-free silver fluoride (SF) and silver diammine fluoride (SDF) on the microshear bond strength (MSBS) of resin-modified glass ionomer (RMGIC) to artificially demineralised primary…

View details →DOI: 10.1007/s40368-026-01242-7
Negative / Null Result ReportMedicine

Biologically enhanced anterior cruciate ligament reconstruction: Platelet-rich plasma or bone marrow aspirate concentrate does not lead to better clinical or radiological outcomes-A randomized controlled trial of 175 cases with 2 years of follow-up.

Mokhtar, Gawish, Abdelgawad et al. · 2026 · Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA

To compare the clinical and radiological outcomes of anterior cruciate ligament reconstruction (ACLR) augmented with platelet-rich plasma (PRP) (1) or bone marrow aspirate concentrate (BMAC) (2) against a control group undergoing standard…

View details →DOI: 10.1002/ksa.70484
Negative / Null Result ReportMedicine

Impact of central adiposity on the heart rate and calorie estimation accuracy of diverse smartwatches and the resulting subjective exercise experience.

Lertyongphati, Udomkhwamsuk, Amornrungrojanakul et al. · 2026 · Frontiers in sports and active living

In light of the growing global trend toward health awareness, wearable technologies like smartwatches have become essential for monitoring physiological indicators such as heart rate (HR). However, their utility faces two critical…

View details →DOI: 10.3389/fspor.2026.1829700
Negative / Null Result ReportMedicine

Transcervical carotid artery stenting compared to transfemoral carotid artery stenting and carotid endarterectomy: perioperative and short-term results from a single center.

Jin, Ni, Huang et al. · 2026 · Frontiers in cardiovascular medicine

Carotid artery stenosis is a major cause of ischemic stroke. Various revascularization strategies exist, including Carotid Endarterectomy (CEA), Transfemoral Carotid Artery Stenting (TF-CAS), and Transcervical Carotid Artery Stenting…

View details →DOI: 10.3389/fcvm.2026.1743275
Negative / Null Result ReportMedicine

Accuracy of Visual Inspection of Thickened Liquids: Implications for Multidisciplinary Dysphagia Management and Clinical Nutrition.

Fong, Kwan · 2026 · Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

To evaluate the accuracy of visually estimating thickened liquid volume via video-observed conditions and to determine whether clinical experience or thickener composition influences judgement reliability. A cross-sectional online survey…

View details →DOI: 10.1111/jhn.70294
Negative / Null Result ReportMedicine

The relationship between appetite hormones and body mass index in children with intoxication type metabolic diseases.

Koç, Konyalıgil, Özen Yeşil et al. · 2026 · Orphanet journal of rare diseases

The aim of this study is to comparatively examine the effects of appetite loss and insufficient energy intake, which trigger poor metabolic control parameters, on appetite hormones and body mass index in children with intoxication-type…

View details →DOI: 10.1186/s13023-026-04375-6
Negative / Null Result ReportMedicine

The relationship between depression, falls, dizziness, and physical activity in geriatric individuals with BPPV.

Cengi̇z, Sarioğlu, Mazooğlu et al. · 2026 · BMC geriatrics

Benign Paroxysmal Positional Vertigo (BPPV) represents the most common cause of vertigo in the geriatric population. The condition constitutes a multidimensional clinical presentation characterized by dizziness, imbalance, fear of falling,…

View details →DOI: 10.1186/s12877-026-07838-4
Negative / Null Result ReportMedicine

The Effect of the Temporal Position of a Gap on Its Automatic Detection.

Omidvar, Campbell, Alain et al. · 2026 · The European journal of neuroscience

The presentation of a rarely occurring auditory stimulus that contains a silent interval (or gap) among a sequence of frequently occurring stimuli that do not contain a gap can elicit a negative-going event-related potential known as the…

View details →DOI: 10.1111/ejn.70585
Negative / Null Result ReportMedicine

Prognosis of ER-positive, HER2-negative postmenopausal early breast cancer patients based on response to neoadjuvant endocrine therapy and multigene assay results: findings from the NEOS trial.

Iwata, Masuda, Yamamoto et al. · 2026 · Breast cancer (Tokyo, Japan)

We previously reported the 21-gene Oncotype DX® assay results from TransNEOS in patients enrolled in the phase 3 NEOS trial. However, the association between assay results and long-term prognosis has remained unclear. Of the 296…

View details →DOI: 10.1007/s12282-026-01862-3
Negative / Null Result ReportMedicine

Heterogeneous Systemic IgG Responses to Porphyromonas gingivalis Gingipains in Advanced Periodontitis.

Büttner, Derman, Simonis et al. · 2026 · Clinical and experimental dental research

To evaluate serum IgG responses against Porphyromonas gingivalis gingipains RgpB and Kgp in patients with stage III and IV periodontitis and examine associations with clinical periodontal parameters. This exploratory cross-sectional study…

View details →DOI: 10.1002/cre2.70391