A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19906 results in Negative / Null Result Report · page 615 of 664
Su C, Lu T · 2026 · Preprint
Background Heart failure (HF) and body mass index (BMI) share substantial genetic architecture, which may lead genetically informed target discovery to preferentially identify adiposity-related pathways. We sought to identify circulating…
Howard L, Hawn S, Pitchford KD et al. · 2026 · Behavioral sciences (Basel, Switzerland)
The denial, concealment, or omission of disordered eating behaviors has received limited attention in the eating disorder literature, partly due to the lack of reliable and valid measures. This study re-examined the factor structure of the…
Saengsin K, Jirattikanwong N, Wongyikul P et al. · 2026 · Journal of clinical medicine
Background/Objectives : Post-extubation stridor (PES) is common in pediatric critical care and may contribute to extubation failure, particularly in children with heart disease. Prophylactic corticosteroids are frequently used before…
Figureau T, Priolo D, Sleegers WWA et al. · 2026 · Preprint
Cognitive dissonance, traditionally conceptualized as a fundamental psychological process involving discomfort from inconsistent cognitions, may vary across cultures. These variations could be attributed to self-construal, or how…
Espeche W, Minetto J, Cerri G et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension
Hypertensive disorders of pregnancy are a leading cause of maternal-fetal morbidity and mortality, with preeclampsia representing a major contributor to adverse outcomes. Ambulatory blood pressure monitoring (ABPM) has improved risk…
Vollam S, Roman C, Santos M et al. · 2026 · JMIR medical informatics
Background Many studies have evaluated the use of wearable monitoring systems to improve patient safety in hospital. Although some have demonstrated effects on intensive care admissions, there remains little evidence of impact on patient…
Appiah KN, Sharma N, Adu N et al. · 2026 · Preprint
Abstract Background: Anthracycline-based chemotherapy produces progressive functional decline and cardiotoxicity in adults with cancer. Physical activity interventions may attenuate these effects, yet evidence across multiple domains…
Qin X, Fan L, Tang Y et al. · 2026 · Archives of gynecology and obstetrics
Purpose The potential adverse effects of repeated freezing and thawing processes on embryos remain controversial. This study aimed to investigate the impact of repeated embryo cryopreservation by comparing preimplantation genetic testing…
Kang B · 2026 · Preprint
Abstract Background: Major depressive disorder (MDD) is highly polygenic, yet translating genome-wide association study (GWAS) findings into therapeutics remains challenging. Using PGC MDD2025, we integrated gene-level mapping, brain TWAS,…
Koczur K, Blukacz M, Galbarczyk A et al. · 2026 · American journal of human biology : the official journal of the Human Biology Council
Objectives Microbiota of the urogenital tract is crucial for women's reproductive and sexual health and is largely dominated by Lactobacillus strains. A reduction of these bacteria within the vaginal microbial community has been linked to…
Karl V, Beck D, Dall'Aglio L et al. · 2026 · Preprint
Background: Adolescence is a developmental period involving ongoing white matter (WM) maturation and rising risk for psychopathology. This risk is particularly elevated among youth whose parents have mental health problems. Methods:…
Pongdee T · 2026 · Current allergy and asthma reports
PURPOSE OF REVIEW: Recent strategies to treat nonadvanced SM have focused on targeted therapies to inhibit mast cell activation and/or proliferation. Several investigational approaches are being explored to treat nonadvanced SM in this…
Handeland AH, Indelicato DJ, Engeseth GM et al. · 2026 · International journal of radiation oncology, biology, physics
Introduction Brainstem necrosis is a rare but serious toxicity following radiotherapy for pediatric brain tumors. In proton therapy (PT), concerns have emerged around elevated linear energy transfer (LET) and the relative biological…
Pollet TV, Fitzpatrick B, Meziani S et al. · 2026 · Preprint
Birth order has long been argued to be an important individual difference variable for domains such as personality and achievement. However, after many decades of research, the evidence for a birth order effect is scarce at best. Less is…
Kamionka SL, Sodemann M, Bilenberg N et al. · 2026 · Health (London, England : 1997)
Written information exchange is widely used to share information and coordinate care across services. Yet, its coordinating effects remain unclear. The aim of the study was to explore the textually mediated practices through which…
Nichols JD, Hines JE, Hinz RL et al. · 2026 · Ecology
Experimental and observational studies of effects of fragmentation on biodiversity and population dynamics have produced mixed results, with some reviews concluding strong evidence of negative effects and others concluding small positive…
Carlsson KS, Brommels M, Ohrling M · 2026 · Preprint
Abstract Background Decentralised and market-inspired health system reforms have increased organisational plurality and local autonomy but often intensify fragmentation and complicate system-wide coordination. This study explored how…
Shida T, Hatanaka S, Ohta T et al. · 2026 · Geriatrics & gerontology international
Aim This study examined the association between plasma pentosidine concentrations-an advanced glycation end-product marker-and skeletal muscle morphometric indices, physical function, and sarcopenia among community-dwelling older adults…
Liu P, Zhao S, Yao J et al. · 2026 · Acta parasitologica
Purpose Cultivation of Theileria annulata schizont-transformed cell lines typically relies on fetal bovine serum (FBS), limiting standardization. This study evaluated three serum-free media (SFMs) for the in-vitro cultivation of T.…
Lagacé-Cusiac R, Grahn JA, Ansari D · 2026 · Preprint
Relative magnitudes, such as ratios and proportions, are crucial to everyday life. According to the ratio processing system (RPS) theory, ratios across different formats share a common neural code. Prior neuroimaging studies have shown…
Pollet TV, Fitzpatrick B, Meziani S et al. · 2026 · Preprint
Birth order has long been argued to be an important individual difference variable for domains such as personality and achievement. However, after many decades of research, the evidence for a birth order effect is scarce at best. Less is…
Kim HH, Cragun J, DeScioli P · 2026 · Disasters
Researchers have argued that preventing disasters is more efficient than providing relief. Yet, previous scholarship has found that voters in the United States reward politicians more for relief than for prevention policies. It is unclear,…
Gray SL, Liberman M, Onukwufor E et al. · 2026 · American journal of pharmaceutical education
Objectives Ageism remains a pervasive barrier to delivering high-quality health care to older adults. The objective of this scoping review is to describe studies on educational interventions aimed at improving the empathy and attitudes of…
DeStefano L, Kim H, Erickson C et al. · 2025 · Preprint
Abstract Background: Fragile X syndrome (FXS) is characterized by sensory hypersensitivity and neural hyperexcitability linked to GABAergic dysfunction. BAER-101, formerly known as AZD7325, is a positive allosteric modulator of GABA A…
Hogins J, Mekala S, Resendiz J et al. · 2025 · Preprint
At least half of all women will experience a urinary tract infection (UTI) in their lifetime. Age, sexual activity, hormonal status, and the urinary tract microbiome (urobiome) contribute to the probability of infection. While studies have…
Pollet TV, Fitzpatrick B, Meziani S et al. · 2025 · Preprint
Birth order has long been argued to be an important individual difference variable for domains such as personality and achievement. However, after many decades of research, the evidence for a birth order effect is scarce at best. Less is…
Ishiguro S, Guitard D, Saint-Aubin J · 2025 · Quarterly journal of experimental psychology (2006)
Semantic relatedness of items improves working memory performance. We targeted one type of semantic relatedness, semantic association. The beneficial effect of association is often explained by the spreading-activation process:…
Kemp EC, Dontha M, Du Z et al. · 2025 · Preprint
Background. Callous-unemotional (CU) traits (i.e., “Limited Prosocial Emotions”) characterize a particularly severe group of antisocial youth. “Secondary” CU traits, as opposed to “primary,” are distinguished by co-occurring anxiety and…
Güneş M · 2025 · Medicine
Magnesium has numerous important functions in human metabolism. Low magnesium level is a common finding in type 2 diabetes mellitus (T2DM) but the causes have not been sufficiently investigated. Smoking is associated with major health…
Grant S, Goldberg E, Gadipudi A et al. · 2025 · Journal of racial and ethnic health disparities
Black transgender women report high levels of discrimination, which is associated with poor health outcomes. Some evidence suggests that intersectional discrimination-that is, interacting forms of marginalization related to one's real or…