A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
20261 results in Negative / Null Result Report · page 607 of 676
Dong M, Niimi T, Maturana AD · 2026 · Journal of cellular physiology
Intracellular calcium (Ca 2+ ) signaling controls myoblast proliferation, fusion, and myofiber formation. In myoblasts, Transient Receptor Potential Canonical (TRPC) channels, with TRPC1 as a predominant isoform, mediate store-operated…
Hirlemann M, Garmon M, Ribeiro-Parenti L et al. · 2026 · Preprint
ABSTRACT This study investigates the individual and combined effects of Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and metformin on glucose regulation in a non-obese, insulin-deficient model of type 2 diabetes. Female…
Wongwachira C, Suwajanakorn D, Kongwattananon W et al. · 2026 · Eye (London, England)
Purpose To compare the SITA Standard 24-2 and SITA Faster 24-2 C tests in patients with chloroquine/hydroxychloroquine (CQ/HCQ) retinopathy and those at high risk. Methods A prospective, cross-sectional study of 75 participants who…
Shober A, Qin Z, Pokhrel S et al. · 2026 · Preprint
Abstract Background and Aims Historical manure applications on the Delmarva Peninsula have created legacy soil phosphorus (P) accumulation, yet winter wheat ( Triticum aestivum L.) often faces early-season P deficiency due to fixation in…
Morales Ruiz S, Wang Z, Miura T et al. · 2026 · Virology
We constructed two novel LC16-derived vaccinia viruses as candidate mpox vaccines to clarify the contribution of B5 to vaccine-induced protection. LC16m8Δ2 is a B5R-null mutant derived from LC16mO that contains no artificial sequences.…
Beffara B, Hadj-Bouziane F, Ben Hamed S et al. · 2026 · Preprint
The control of selective visuo-spatial attention is known to rely on multiple signals, including reward. While most attention control signals are well acknowledged to interact with each other, the case of reward has led to mixed findings…
Carboni F, Bechi N, Proietti D et al. · 2026 · Carbohydrate polymers
Glycoconjugate vaccines are effective against bacterial infections. Key characteristics for optimal immunogenicity are the carbohydrate-to-protein ratio and consequent glycosylation density. Directing the conjugation to specific sites is…
Toomey D, Lewis G, Rashid U et al. · 2026 · Neuromodulation : journal of the International Neuromodulation Society
Background Exercise induces short-term pain relief (exercise-induced hypoalgesia, EIH), but this response is often blunted in people with knee osteoarthritis (OA). Transcranial direct current stimulation (tDCS) has been proposed as a…
Beffara B, Hadj-Bouziane F, Ben Hamed S et al. · 2026 · Preprint
The control of selective visuo-spatial attention is known to rely on multiple signals, including reward. While most attention control signals are well acknowledged to interact with each other, the case of reward has led to mixed findings…
Banerjee S, Chopra E, Smith IM et al. · 2026 · Preprint
ABSTRACT Estradiol (E2) is a potent estrogen molecule that plays a crucial role in regulating numerous healthy and pathophysiological processes. To model estrogen-dependent cellular activities in vitro in a physiologically meaningful way,…
El-Karim RMG, Ali REM, Habib MR et al. · 2026 · Acta parasitologica
Bachground Schistosomiasis remains difficult to control due to persistent transmission via freshwater snails and reliance on praziquantel (PZQ) as the primary treatment. Novel adjunctive strategies targeting multiple stages of the parasite…
Gupta BK, Pandey R, Thapa N et al. · 2026 · Preprint
Abstract Background Myocardial infarction (MI) remains a leading cause of morbidity and mortality worldwide, with South Asian populations facing a disproportionately high burden. In Nepal, the incidence of MI has been rising, and recent…
Madrid J, Batzianouli E, Rutz D et al. · 2026 · Journal of Parkinson's disease
BackgroundFreezing of gait (FOG) in Parkinson's disease (PD) is a major cause of disability and falls and often responds incompletely to conventional therapy. Rehabilitative interventions including cognitive strategies and sensory cueing…
Fellin CR, Steiner RC, Buchen JT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery
Background Nerve guidance conduits (NGCs) are a clinically approved option for peripheral nerve repair but remain ineffective compared with autograft "gold standard" treatment options. A combinatorial approach to conduit-based peripheral…
Oncul S, Lee H, Singh S et al. · 2026 · Journal of immunology (Baltimore, Md. : 1950)
B cells constitute ∼15% to 20% of tumor-infiltrating lymphocytes in melanoma. Their presence in the tumor microenvironment correlates with improved survival and enhanced response to immune checkpoint blockade therapy. Yet, the functional…
Bergen MA, Kim J, Piana LE et al. · 2026 · The Journal of hand surgery
Purpose To evaluate the biomechanical performance of the modified Brunelli scapholunate interosseous ligament (SLIL) reconstruction with and without suture augmentation, using a cadaveric model under cyclic loading conditions. Methods…
Broadley D, Le Riche A, Yu Y et al. · 2026 · International journal of molecular sciences
Androgen receptor (AR) signaling plays a key role in male pattern baldness. We investigated whether targeting Dickkopf 1 ( DKK1 ) and Secreted frizzled-related protein 1 ( SFRP1 ), two AR-regulated genes, offers a novel therapeutic…
Chamily FA, Vanderklok BR, Buzinski OD et al. · 2025 · Preprint
Environmental enrichment can have complex, contradictory effects on aggression and animal welfare. Although increasing enrichment may reduce aggression by limiting the visibility of competitors, it may also intensify territorial defense…
Essang S, Iyer A, Durantini AM et al. · 2026 · Photochemistry and photobiology
Singlet oxygen ( 1 O 2 ) is a reactive species that plays a role in environmental and biological surface chemistry; however, the mechanisms of the association of airborne 1 O 2 at the air/surface interface are poorly known. Here, we help…
Pister ML, Brost KN, Campbell JM et al. · 2025 · Journal of dairy science
Feeding plasma protein has been shown to have health benefits and help ameliorate stress in preweaning calves, aiding their ability to handle the challenges of weaning and initial social interactions. We hypothesized that feeding plasma…
Freislederer F, Dimitriu M, Audigé L et al. · 2025 · Preprint
Abstract Background The subacromial bursa is a key source of mesenchymal stem cells that may support rotator cuff tendon healing. Since microvascularization contributes to tendon repair, we aimed to examine postoperative…
Prado E, Argioli AS, Funichello M et al. · 2025 · Preprint
Abstract Agricultural adjuvants are among the most critical factors influencing spray deposition and herbicide efficacy against weeds. This study evaluated spray deposition parameters by spraying different non-ionic adjuvants on Euphorbia…
Bertret V, Latimier RLG, Monbet V · 2025 · Water research
This study compares various modeling approaches to predict ammonium concentration in wastewater treatment plants (WWTPs), with a focus on integrating data assimilation techniques. It explores white-box, grey-box, and black-box models,…
Harlev C, Bue M, Petersen EK et al. · 2025 · European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Background Epithelial ovarian cancer remains a leading cause of mortality among gynecological malignancies, with a high incidence of peritoneal carcinomatosis at diagnosis. Hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as a…
Sato H, Sumida A · 2025 · Preprint
Conifers generally exhibit narrow, deep crowns, whereas broadleaf trees typically form spherical crowns. A widely accepted hypothesis attributes this difference to variation in solar angles: conifers, which prevail in high-latitude regions…
Pihlaja S, Lipsanen J, Ritola V et al. · 2026 · Frontiers in psychology
Among patients receiving internet-delivered cognitive behavioral therapy (iCBT) for depression in routine clinical practice, 101 patients were randomized to either iCBT as usual or to iCBT with add-on scheduled telephone support (STS).…
Kavanagh EW, Joynt AT, Pion AR et al. · 2025 · Preprint
Cystic Fibrosis (CF) is a life-limiting genetic disorder caused by deleterious variants in the CFTR gene that results in altered mucous impairing the airway epithelia. Durable correction of these variants in airway cells remain a…
Bui TH, Le DP, Ho TD et al. · 2026 · Veterinary journal (London, England : 1997)
This study investigated the effects of Saccharomyces cerevisiae fermentation-derived postbiotics (SCFP) on reproductive performance and immunity of sows and their offspring from gestation to weaning in a low biosecurity, small-scale pig…
Klimek K, Kierys A, Matwijczuk A et al. · 2025 · Carbohydrate Polymers.
This work aimed to compare the biomedical potential of thermally obtained hydrogels consisting of curdlan and a curdlan–whey protein isolate mixture. The purpose of this paper was also to investigate and explain the mechanisms responsible…
Toshida K, Sugitani Y, Itoh S et al. · 2025 · Preprint
Abstract Background: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. While systemic therapies have improved outcomes, predicting tumor histopathology remains difficult. Machine learning (ML) offers a…