A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19902 results in Negative / Null Result Report · page 607 of 664
Saber Tanha A, Hosseini S, Soltani E et al. · 2025 · Clinical nuclear medicine
Abstract A 47-year-old woman, recently diagnosed with breast cancer, underwent staging. A whole-body bone scan revealed an unexpected focal 99m Tc-MDP uptake in her right ovary. Extensive literature review suggested various malignant…
Vezirian K, Beffara B, begue l · 2024 · Preprint
To develop pharmaceutical drugs, people experiment on lab-animals, and a wide variety of factors might predict the involvement into this situation. Using an ultra-realistic protocol mimicking animal research (n = 145), we examined…
Dudnyk A, Tytarenko N, Lytvyniuk O et al. · 2026 · Therapeutic advances in infectious disease
Background Patients with multidrug-resistant tuberculosis (MDR-TB) receive treatment that is at least 20% less effective than drug-susceptible cases globally. Objectives The study evaluated the diagnostic accuracy of mfloDx MDR-TB assay…
Mieites V, Fernández-Manteca MG, Santiuste Torcida I et al. · 2025 · Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
This study explores the potential of conventional Raman spectroscopy and commonly used spectral analysis pipelines for rapid and straightforward assessment of degradation in serum samples resulting from storage delays. Serum samples from…
Mwakibete L, Hoarau AOG, Ahyong V et al. · 2024 · Preprint
Investigations of wildlife diseases and mortality events can sometimes lead to inconclusive results due to limitations in diagnostics combined with an ever-increasing number of emerging viruses. The use of tools such as unbiased…
Juutilainen J, Khan MW, Naarala J et al. · 2024 · Occupational and environmental medicine
Objectives Studies assessing the association of adult cancers with extremely low frequency (ELF) magnetic fields (MF) have provided inconclusive results, probably affected by limitations such as low exposure levels, confounding and various…
Jäggi T, Sato S, Gygax P · 2024 · Preprint
Recently, researchers have started to experimentally investigate the claim that the grammaticalization of the future may impact our mental representations of future events. Yet, this research has mainly focused on the perceived distance of…
Hernández-Cuellar E, Tsuchiya K, Medina-Contreras O et al. · 2025 · Journal of clinical medicine
Background/Objectives : Sepsis is a life-threatening condition characterized by an uncontrolled immune response due to systemic infections. It is responsible for millions of deaths worldwide. Although inflammasomes play an important role…
Teuwen CJ, Vorstermans K, Kusurkar RA et al. · 2024 · Preprint
Interprofessional education is one of the interventions used to increase health care students’ motivation for working with older patients. Previous research about such interventions has been conducted without the use of control groups and…
Nielsen MK, Bartholdy ID, Kristensen KS et al. · 2025 · Veterinary parasitology
Equine strongylids are ubiquitous and can cause severe health issues. Anthelmintic resistance is widely common in cyathostomin parasites, and recent studies have documented increasing incidence of resistance to the macrocyclic lactone drug…
MacCarrick G, Aradhya S, Bailey M et al. · 2024 · American journal of medical genetics. Part A
Molecular genetics enables more precise diagnoses of skeletal dysplasia and other skeletal disorders (SDs). We investigated the clinical utility of multigene panel testing for 5011 unrelated individuals with SD in the United States…
Karvasarski E, Park J, Savaris S et al. · 2026 · CJC open
Background Resting hemodynamic assessment of suspected pulmonary hypertension (PH) in older adults with cardiovascular risk factors may not effectively discriminate pre-capillary from post-capillary disease. Exercise right-heart…
Crabtree D, Seidler K, Barrow M · 2025 · Clinical nutrition ESPEN
Background and aims Epidemiological studies have associated reduced bacterial diversity and abundance and food allergy. This mechanistic review investigated the link between gut dysbiosis and food allergy with a focus on the role of…
Portillo-Gallo JH, Sánchez-González JM, Saldaña-Cruz AM et al. · 2026 · Current issues in molecular biology
Pre-eclampsia is a Hypertensive Disorder of Pregnancy (HDP) characterized by hypertension and proteinuria, affecting 2-8% of pregnancies worldwide and constituting a major public health concern. Genes of the renin-angiotensin system have…
Beissat K, Lattard V, Picard-Meyer E et al. · 2025 · PloS one
Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, a wide range of animal species (pets, mink…) have been naturally infected with this betacoronavirus. The emergence of new variants has…
Xie J, Jiang Y, Zhou Y et al. · 2024 · Maternal-fetal medicine (Wolters Kluwer Health, Inc.)
Objective To conduct a hierarchical classification analysis of the nonreportable results of noninvasive prenatal testing in an attempt to reduce failure rates and provide pregnant women with accurate information to alleviate their anxiety.…
Abdo M, Kunisaki KM, Morris A et al. · 2026 · AIDS research and human retroviruses
People aging with HIV (PAWH) experience greater impairment in physical and pulmonary function than individuals aging without HIV. We examined whether baseline physical function was associated with subsequent pulmonary impairments.…
Patchen BK, Best CM, Boiteau J et al. · 2025 · The Cochrane database of systematic reviews
Background Randomised controlled studies evaluating vitamin D supplementation in pregnancy or early childhood for preventing childhood asthma have yielded inconclusive results. Previous systematic reviews of vitamin D for asthma prevention…
Lang X, Zhao Y, Zhu Y et al. · 2025 · Risk management and healthcare policy
Background To assess the consequence of different degrees of missing primary endpoint data for randomized controlled trials and to find the influence factors. Methods PubMed, Cochrane Library, EMBASE and ClinicalTrials.gov were searched up…
Grillo AR · 2025 · American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
Depression is a major public health problem with a continued need to uncover its etiology. Current models of depression contend that gene-by-environment (G × E) interactions influence depression risk, and further, that depression is…
Buchta C, Aberle SW, Allerberger F et al. · 2023 · The Lancet. Microbe
Background The aim of external quality assessment (EQA) schemes is to evaluate the analytical performance of laboratories and test systems in a near-to-real-life setting. This monitoring service provides feedback to participant…
Struja T, Hansen LH, Matos J et al. · 2026 · BMJ open
Importance Clinical trials have produced inconclusive results regarding the optimal glucose range for a patient with sepsis in the intensive care unit (ICU) receiving insulin treatment. Objective To investigate the optimal glucose range in…
Droste MJ, Remeijer M, Planqué R et al. · 2024 · Preprint
A bstract In isothermal chemical reaction networks, reaction rates depend solely on the reactant concentrations setting their thermodynamic driving force. Living cells can, in addition, alter reaction rates in their enzyme-catalysed…
Klim L, Michalik M, Cichocka-Jarosz E et al. · 2025 · Nutrients
Background: Diagnosing food allergy (FA) typically involves a detailed clinical history and confirmation of allergen-specific IgE. Oral food challenges (OFCs) remain the gold standard in FA diagnosis. This study aimed to present our…
Jain M, Pal DK, Narayan Sahu R et al. · 2025 · World journal of orthopedics
Background Sagittal spinopelvic alignment (SSA) is essential for preserving a stable and effective upright posture and locomotion. Although alterations in the SSA are recognised to induce compensatory modifications in the pelvis, hips, and…
Buchta C, Aberle SW, Görzer I et al. · 2024 · Wiener klinische Wochenschrift
Background External quality assessment (EQA) schemes provide objective feedback to participating laboratories about the performance of their analytical systems and information about overall regional analytical performance. The EQAs are…
Katz A, Kreiner M, Korain Blank P et al. · 2025 · Journal of pediatric orthopedics
Background Clubfoot is a congenital condition affecting 1 to 2 per 1000 live births, with treatment primarily involving the Ponseti method and/or surgical intervention. It is important to ascertain whether children affected by clubfoot are…
Zeinhom MG, Elsayed Khalil MF, Omar Youssif TY et al. · 2025 · Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Although topiramate and valproate are antiseizure medications that have many contraindications and could produce many side effects, they are still used as migraine preventive therapy in middle- and low-income countries. Several trials…
La Jeon Y, Lee SG, Lee EH et al. · 2023 · Diagnostic microbiology and infectious disease
We investigated whether inconclusive results could be interpreted differently depending on the situation. First, data from retesting of the initial samples from subjects without a confirmed COVID-19 history were analyzed. And by analyzing…
Palomino-Padilla S, Caceres-Cardenas G, Calderon R et al. · 2024 · Frontiers in public health
Objectives The COVID-19 pandemic caused a global shortage of nasopharyngeal (NP) swabs, required for RT-PCR testing. Canadian manufacturers were contacted to share NP swab innovations. The primary objective was to determine whether novel…