A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19902 results in Negative / Null Result Report · page 602 of 664
Ragamin A, Schappin R, Pasmans SGMA et al. · 2023 · Skin health and disease
National prescription data for therapeutic clothing in atopic dermatitis was analysed to investigate the role of therapeutic clothing in atopic dermatitis. Therapeutic clothing is most frequently prescribed by dermatologists in a hospital…
Merlo JK, da Silva AV, Casonatto J et al. · 2024 · Healthcare (Basel, Switzerland)
Objective To investigate the effects of combining a Pilates program with photobiomodulation therapy (PBMT) in patients with chronic nonspecific low back pain (CNLBP). Methods Thirty-eight adults with CNLBP were randomly assigned to two…
Stroemel-Scheder C, Lautenbacher S · 2023 · The journal of pain
Recent research suggests that recovery sleep (RS) has the potential to restore pain sensitivity and modulation after hyperalgesia due to preceding sleep deprivation. However, it has not yet been systematically examined whether the…
Moretti L, Richelmi L, Cosentini D et al. · 2024 · Breast (Edinburgh, Scotland)
The efficacy of adjuvant denosumab in combination with hormonotherapy in breast cancer patients was investigated in two randomized trials, ABCSG-18 and D-Care, but the results were mixed with respect to the impact of this drug on…
Góis KS, Braga M, Souza VH et al. · 2026 · Einstein (Sao Paulo, Brazil)
Objective This study aimed to analyze the possible association between rs2814778, rs12075 ( ACKR1 gene), and rs4073 ( CXCL8 gene) single nucleotide variants and COVID-19 severity. Methods This cross-sectional study included 319 COVID-19…
Nikouli E, Vasilaki A, Nengas I et al. · 2026 · Preprint
The aim of this study was to evaluate the impact of two sustainable dietary protein sources on the structure and composition of the gut microbiota in European sea bass (Dicentrarchus labrax) juveniles. These protein sources were…
Aloud A, Alzahrani H, Arzoo S et al. · 2026 · Acta pharmaceutica (Zagreb, Croatia)
This study examined the effects of omega-3 fatty acids supplementation on gut barrier integrity, systemic inflammation, neurotrans-mission and oxidative stress, in an aged rat model of propionic acid (PPA)-induced neurotoxicity.…
Dong T, Sun R, Xiao J · 2026 · Revista espanola de enfermedades digestivas
Prophylactic defect closure has been considered to prevent delayed bleeding after polypectomy. However, recent evidence has demonstrated its beneficial effect is limited to those ≥20 mm proximal nonpedunculated lesions. Despite this,…
Fink J, Norceide DJ, Kahlon A et al. · 2026 · JSES reviews, reports, and techniques
Background Tranexamic acid (TXA) is increasingly used in total shoulder arthroplasty to minimize perioperative blood loss; however, the quality and objectivity of evidence supporting its use remain uncertain. Systematic reviews and…
Vakka A, Kyriakoulis KG, Tatakis F et al. · 2026 · Hypertension research : official journal of the Japanese Society of Hypertension
Overactivation of sympathetic nervous system (SNS) has a key role in the pathophysiology of hypertension, as well as in chronic kidney disease, heart failure, atrial fibrillation, type 2 diabetes mellitus, obstructive sleep apnea, and…
Vediya N, Jain V, Sritharan P et al. · 2025 · Arthroplasty today
Background Systematic reviews (SRs) are vital for evidence consolidation in clinical research, utilized for their robust, reproducible methodology. SRs are prone to misrepresentation as they are based on primary studies and the…
Lewis-Hoeber E, Darainy M, Ebrahimi S et al. · 2026 · Journal of neurophysiology
In verbal memory, retrieval cues can facilitate recall of otherwise inaccessible information. Recent work, using passive movements following a motor learning task, suggests that somatic retrieval cues similarly access motor memories. The…
· 2006
Oxytocin is an essential lactation hormone released during breastfeeding that causes milk ejection and appears to have calming effect on the mother.[1] Administration of exogenous oxytocin to mothers having difficulty in breastfeeding has…
Wynne R, Dharmalingam R, Omarit R et al. · 2026 · Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
Objectives To assess whether high flow nasal oxygen (HFNO) therapy reduces the need for endotracheal intubation in adults with acute hypoxaemic respiratory failure (AHRF) in the intensive care unit (ICU). Methods Systematic reviews were…
Zhang J, Pan Q, Jin L et al. · 2026 · The British journal of ophthalmology
Aims To investigate the effect of switching to a different type of myopia control spectacles on myopia progression. Methods This retrospective matched-cohort study involved 1012 children or adolescents who were prescribed myopia control…
Nagai T, Kuwaki A, Kodama K · 2026 · Nanoscale advances
Developing oxygen reduction reaction (ORR) catalysts with both high catalytic activity and durability is essential for the commercialization of polymer electrolyte fuel cells (PEFCs). One promising strategy to simultaneously enhance the…
Gažarová M, Lenártová P, Kopčeková J et al. · 2026 · Nutrients
Background/Objectives: The aim of the study was to assess the metabolic response of women to a six-week consumption of full-fat sheep milk yogurt, with a focus on cardiovascular risk markers, lipid profile, and subfractions of low-density…
Majewska A, J NW, Chambers J et al. · 2026 · Preprint
Abstract Objective: To evaluate the association between metformin treatment in gestational diabetes mellitus and severity of intrahepatic cholestasis of pregnancy (ICP). Design: Retrospective multicentre cohort study. Setting: Six…
Starowicz M, Domínguez-Soberanes J, Garcia-Gutierrez E et al. · 2026 · Preprint
Bread is an important source of energy and is ubiquitous in human diets. As a carbohydrate-rich food, it is often considered to impair glycaemic homeostasis; however, clinical and molecular evidence suggests that its effects may vary…
Vogel MJ, Hacker K, Herting J et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Electrical cardioversion (ECV) is an effective treatment for restoring sinus rhythm in supraventricular tachycardias such as atrial fibrillation (AFib) and atrial flutter (AFlu). In clinical practice, serum potassium is often…
Treat T, Jones D, Lorenzano N et al. · 2026 · Journal of periodontology
Background Evidence for whether and how non-surgical periodontal treatment (NSPT) improves systemic outcomes remains equivocal. Inconclusive findings may in part be due to design variations of randomized controlled trials (RCTs) in this…
Abapolnikova M, Coyne AE, Glushka L et al. · 2026 · Psychotherapy research : journal of the Society for Psychotherapy Research
Objective Although interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT) for depression are comparably efficacious, less is known about the respective patient-level processes that help transmit their beneficial effect.…
Ersoy O, Kizilay G · 2026 · Biotechnic & histochemistry : official publication of the Biological Stain Commission
Clinical and experimental studies have shown that sitagliptin regulates blood glucose levels. This study was designed because it is thought that sitagliptin may reduce diabetes-induced apoptosis in testes by affecting blood glucose levels…
Sosnówka-Czajka E, Skomorucha I, Wojtysiak D et al. · 2026 · Animals : an open access journal from MDPI
The growing greenhouse gas emissions from agricultural production are increasing the pressure on poultry producers to use practices that reduce the environmental impact of farms, mainly by reducing ammonia emissions. The study evaluated…
Adeva-Andany MM · 2025 · World journal of nephrology
Sodium-glucose cotransporter-2 (SGLT2) inhibitors suppress glucose reabsorption in the kidney proximal tubule through the SGLT2 protein, leading to glucosuria and osmotic diuresis. Randomized placebo-controlled clinical trials show that…
Chommaux T, Renault PO, Godard P et al. · 2026 · ACS applied materials & interfaces
The electrical and mechanical behaviors of 400 nm thick indium tin oxide (ITO) thin films on polyimide substrates were investigated by means of electrical resistivity and synchrotron X-ray diffraction (XRD) measurements during equibiaxial…
Vaidie J, Demiselle J, Gabriel A et al. · 2025 · Intensive care medicine
Purpose Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. This study aimed to evaluate the impact of a temporary suspension strategy (interruption of…
Gröning M, Smerup MH, Nissen H et al. · 2026 · Pediatric cardiology
To assess temporal changes in the timing of pulmonary valve replacement (PVR) among patients with tetralogy of Fallot and to determine whether temporal shifts toward earlier PVR were accompanied by differences in ventricular volumes,…
Pascoe B, Cocks K, Clarke N et al. · 2026 · Schizophrenia research
Cognitive impairment associated with schizophrenia (CIAS) is a fundamental symptom of the disorder, which significantly affects individuals' daily functioning and overall quality of life. Currently available antipsychotic drugs have little…
Thimmesch M, Cheping Simo C, Boulay M et al. · 2026 · Revue medicale de Liege
Cystic fibrosis, the most common genetic disorder in Caucasian populations, is caused by mutations in the CFTR gene (Cystic Fibrosis Transmembrane Conductance Regulator), which disrupts chloride ion transport and leads to the production of…