A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
750 results in Failed Experiment Report · page 6 of 25
Harder K, Thöle M · 2026 · Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
Objective The aim of this study was to evaluate the therapeutic success of a conservative treatment approach for macrodontic molars in guinea pigs. To this end, longitudinal data from conservative management were analyzed and parameters of…
Lizwan, Cynthia Chia · 2026 · Journal of cardiothoracic surgery
Early chest drain removal and discharge are standard in enhanced-recovery protocols after video-assisted thoracoscopic surgery (VATS) lobectomy, but rare wound complications may arise. We report a 71-year-old man who underwent uneventful…
Xu, Hu, Cai · 2026 · PloS one
The layout of the image and the positional distribution of the objects directly affect the audience's visual focus and the effect of the message conveyed. By setting up a specific layout structure, the viewer's attention can be more…
Terry, Isenberg, Gomoll et al. · 2026 · Video journal of sports medicine
Multifocal cartilage defects about the knee have become increasingly prevalent. When left untreated, these injuries may progress to diffuse knee osteoarthritis. Operative management for patients with multifocal chondral defects typically…
Yang, Han, Cui et al. · 2026 · Pharmacology research & perspectives
JKN2306 is a novel, highly selective Nav1.8 inhibitor under development for the treatment of acute pain. This first-in-human study aimed to evaluate its safety, tolerability, pharmacokinetics, and food effect (FE). This was a single…
Ellis, Perry, Tabbara et al. · 2026 · Journal of vascular surgery cases and innovative techniques
Renovascular hypertension can be clinically challenging to diagnose. The most common etiology remains atherosclerotic disease. When medical management fails, renal artery revascularization is considered. Since the advent of endovascular…
Connacher, Hu, Roden et al. · 2026 · RNA biology
Brain tumor (Brat) is a Drosophila TRIM-NHL protein required for embryogenesis and neural stem cell differentiation. Although structural and biochemical studies established that the Brat NHL domain specifically binds RNA, the in vivo…
LaRue-Nolan, Flores, Vera et al. · 2026 · Molecular and cellular biology
Nuclear envelope (NE) proteins are essential for maintaining nuclear morphology, a central process controlling cellular phenotypes. While these proteins and structures are largely characterized in developmental biology, their function and…
Carmine Abate, Arthur Azevedo de Amorim, Roberto Blanco et al. · 2018 · arXiv
We propose a new formal criterion for evaluating secure compilation schemes for unsafe languages, expressing end-to-end security guarantees for software components that may become compromised after encountering undefined behavior---for example, by accessing an array out of bounds. Our criterion is the first to model dynamic compromise in a system of mutually distrustful components with clearly specified privileges. It articulates how each component should be protected from all the others---in particular, from components that have encountered undefined behavior and become compromised. Each comp
Isaac Unah · 2026 · SSRN Electronic Journal
The paper argues that Eritrea's Constitution — ratified after a costly independence struggle and designed to establish democracy, rule of law, and human rights — has never been implemented in nearly 30 years. The failure is attributed…
Chen-Rong Liu, Chuang Li, Runxia Tao et al. · 2026 · arXiv
Conventional noise analysis in atomic-ensemble sensing assumes a continuous-medium approximation, thereby treating the atomic system as a deterministic dielectric. Here, we demonstrate that this assumption breaks down due to the discrete, particulate nature of the ensemble, giving rise to an intrinsic "atomic granularity noise" (AGN) that fundamentally competes with the optical measurement noise (OMN, typically photon shot noise). By introducing a discrete-atom statistical framework, we derive a unified noise-scaling law governed by a single dimensionless resource ratio, $\mathcal{R} = \bar{N}
Feroze-Bakht, Espinoza, Sosa et al. · 2026 · Pharmaceutics
Background/Objectives: Carprofen (CP) is a potent non-steroidal anti-inflammatory drug whose clinical use is limited by systemic adverse effects associated with oral administration. The aim of this study was to develop and evaluate a…
Zixian Huang, Kaichen Yang, Xu Huang et al. · 2026 · arXiv
A widely adopted strategy for model enhancement is to use synthetic data generated by a stronger model for supervised fine-tuning (SFT). However, for emerging reasoning models like Qwen3-8B, this approach often fails to improve reasoning capabilities and can even lead to a substantial drop in performance. In this work, we identify substantial stylistic divergence between teacher generated data and the distribution of student as a major factor impacting SFT. To bridge this gap, we propose a Teacher-Student Cooperation Data Synthesis framework (TESSY), which interleaves teacher and student model
Baier, Miao, Schirrmacher et al. · 2026 · Pharmaceuticals (Basel, Switzerland)
Background : Zirconium-89 ( 89 Zr) is a key PET radionuclide and the limited in vivo stability of its clinically used 89 Zr-DFO complexes has driven the pursuit of improved chelator architectures. Among these, DFO* has attracted particular…
Alan Lee, Harry Tong · 2025 · arXiv
We propose reinforcement learning (RL) strategies tailored for reasoning in large language models (LLMs) under strict memory and compute limits, with a particular focus on compatibility with LoRA fine-tuning. Building on early policy gradient methods with baseline subtraction, we design critic-free methods that operate on a small, informative subset of output tokens to reduce memory usage and stabilize training. We introduce S-GRPO, a stochastic variant of Group Relative Policy Optimization, and T-SPMO, a token-level prefix matching approach for fine-grained credit assignment. Applied to Qwen2
Sameh Ahmed Abdel-bary, Eslam Safwat, Hany Ali Hussein et al. · 2014 · The Egyptian Journal of Radiology and Nuclear Medicine
Background: Hyperdynamic circulatory state in liver cirrhosis is characterized by increased splanchnic blood flow and renal vasoconstriction. Aim: To evaluate the relationship between renal resistive indices (RI) and HCV liver cirrhosis severity and RI value in predicting 6 month survival of those patients. Also we aimed to assess the effect of midodrine on RI. Patients and methods: 120 patients with HCV liver cirrhosis and 40 healthy controls were enrolled in the study. INR, total bilirubin, albumin, creatinine and sodium were measured in all patients. Both patients and controls underwent abd
Xinzhe Chen, Jianjiang Li · 2023 · arXiv
The escalating surge in data generation presents formidable challenges to information technology, necessitating advancements in storage, retrieval, and utilization. With the proliferation of artificial intelligence and big data, the "Data Age 2025" report forecasts an exponential increase in global data production. The escalating data volumes raise concerns about efficient data processing. The paper addresses the predicament of achieving a lower compression ratio while maintaining or surpassing the compression performance of state-of-the-art techniques. This paper introduces a lossy compressio
Zhang T, Xiang J, Yu N et al. · 2026 · Frontiers in microbiology
Mastitis in dairy cows is one of the most prevalent infectious diseases in the dairy industry, leading to reduced milk production, increased production costs, and substantial economic losses. Antibiotics are commonly used to prevent and…
Liyun Zhang, Jiayi Guo · 2026 · arXiv
We document an empirical phenomenon in chain-of-thought and ReAct agents driven by ten large language models from seven architecture families: meaning-bearing perturbations (e.g., paraphrase, synonym) alter final answers more often than presentation perturbations (e.g., formatting, reordering) of comparable severity. Across 68 cells spanning GSM8K, MATH, and HotpotQA (1,530 originals and $\sim$11,150 variants), the inconsistency gap averages +19.69 pp after severity matching (paired $t=9.58$, $p<0.0001$), with 64/68 cells positive. The gap survives four severity-proxy audits and remains signif
Nicholas J Douville, Lisa Bastarache, Emily Bertucci-Richter et al. · 2024 · PLoS ONE
Background Kidney dysfunction is a common complication in septic patients. Studies have identified numerous risk factors for sepsis-associated acute kidney injury (S-AKI), yet there is wide variability in the incidence even among patients with similar risk factors, suggesting the presence of additional uncharacterized risk factors, including genetic differences. The expansion of biobanks, advances in genotyping, and standardized diagnostic criteria have enabled large-scale, hypothesis-generating studies into the genetic mechanisms underlying S-AKI. We hypothesize that the genetic pathway behin
Nicolas Tancogne-Dejean, Martin Lüders, Carsten A. Ullrich · 2023 · arXiv
We extend some of the well established self-interaction correction (SIC) schemes of density-functional theory to the case of systems with noncollinear magnetism. Our proposed SIC schemes are tested on a set of molecules and metallic clusters in combination with the widely used local spin-density approximation. As expected from the collinear SIC, we show that the averaged-density SIC works well for improving ionization energies but fails to improve more subtle quantities like the dipole moments of polar molecules. We investigate the exchange-correlation magnetic field produced by our extension
Gaoxing Mei, Mofen Cen, Xu Luo et al. · 2021 · Frontiers in Psychology
Prolonged exposure to an oriented stimulus causes a subsequent test stimulus to be perceived as tilted in the opposite direction, a phenomenon referred to as the tilt aftereffect (TAE). Previous studies have demonstrated that high-level cognitive functions such as attention can modulate the TAE, which is generally well-known as a low-level perceptual process. However, it is unclear whether working memory load, another high-level cognitive function, could modulate the TAE. To address this issue, here we developed a new paradigm by combining a working memory load task with a TAE task. Participan
Frits de Nijs, Daan Wilmer · 2012 · arXiv
The goal of this paper is to critically evaluate a heuristic algorithm for the Inverse Banzhaf Index problem by Laruelle and Widgrén. Few qualitative results are known about the approximation quality of the heuristics for this problem. The intuition behind the operation of this approximation algorithm is analysed and evaluated. We found that the algorithm can not handle general inputs well, and often fails to improve inputs. It is also shown to diverge after only tens of iterations. We present three alternative extensions of the algorithm that do not alter the complexity but can result in up t
Masataka Takebe, Kenta Tsumura, Ken'ichiro Nakashima · 2023 · Current Research in Ecological and Social Psychology
Rodeheffer et al. (2012) showed that when people perceive resource scarcity, they are more likely to judge racially ambiguous people as out-group members. In their first experiment, 71 White participants viewed a slideshow depicting either resource scarcity or abundance; subsequently, they judged 20 biracial faces created by averaging a White and a Black face. We conducted this experiment's preregistered conceptual replication study in Japan. Specifically, after observing a slideshow depicting either resource scarcity or abundance, East Asian participants judged 20 biracial faces produced by a
Khadijeh Najafi, M. A. Rajabpour · 2017 · arXiv
In a recent letter, J. Cardy, Phys. Rev. Lett. \textbf{112}, 220401 (2014), the author made a very interesting observation that complete revivals of quantum states after quantum quench can happen in a period which is a fraction of the system size. This is possible for critical systems that can be described by minimal conformal field theories (CFT) with central charge $c<1$. In this article, we show that these complete revivals are impossible in microscopic realizations of those minimal models. We will prove the absence of the mentioned complete revivals for the critical transverse field Ising
· 2015 · Strategic Direction
Purpose – This paper aims to review the latest management developments across the globe and pinpoint practical implications from cutting-edge research and case studies. Design/methodology/approach – This briefing is prepared by an…
Kyle Admire, Stephen Gegick · 2026 · BMJ Case Reports
Tumours within the pulmonary arteries provide a diagnostic challenge due to their similar appearance to pulmonary emboli. Often, the decision to sample is multidisciplinary and the best approach to take is often unknown. Here we describe a…
Pavlasová K, Bizovská L, Rupčík L et al. · 2026 · European journal of sport science
The aim of this study was to assess the effect of gaze direction instruction on postural stabilisation and muscle activity during landings after various motor tasks in artistic gymnastics. Eighteen female gymnasts (aged 14.0 ± 2.7 years)…
J. Stöhr, L. Maurer, B. Zimmer et al. · 2016 · Reproduction, Fertility and Development
In humans, intracytoplasmic sperm injection (ICSI) has become widely applied to overcome infertility. In addition to its clinical usefulness, ICSI is also a valuable research tool for studying fundamental aspects of gamete interaction…
Adam Wilson · 2012 · Journal of Petroleum Technology
This article, written by Editorial Manager Adam Wilson, contains highlights of paper SPE 151518, ’Automated Managed-Pressure Drilling Allows Identification of New Reserves in an HP/HT Exploration Well in SB Field, Offshore Malaysia,’ by…