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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

19902 results in Negative / Null Result Report · page 589 of 664

Negative / Null Result ReportMedicine

Prospective Trial of Radiofrequency Catheter Ablation of High Dominant Frequencies After Pulmonary Vein Isolation in Non-Paroxysmal Atrial Fibrillation (PAD-AF Trial): A Multicenter, Randomized Clinical Trial.

Kumagai K, Hasegawa T, Kutsuzawa D et al. · 2026 · Journal of cardiovascular electrophysiology

Background The role of dominant frequency (DF)-guided ablation after pulmonary vein isolation (PVI) in persistent atrial fibrillation (AF) remains uncertain. We evaluated the clinical and mechanistic impact of DF mapping in a multicenter…

View details →DOI: 10.1111/jce.70357
Negative / Null Result ReportMedicine

Do wound protectors reduce contamination in total shoulder arthroplasty? A randomized controlled trial.

Kirkham MS, Carlson HB, Merrill E et al. · 2026 · Journal of shoulder and elbow surgery

Hypothesis Cutibacterium acnes is the most frequent cause of shoulder prosthetic joint infection with skin edges as a source of wound contamination. The primary purpose of this study was to determine if the use of a wound protector device…

View details →DOI: 10.1016/j.jse.2026.04.048
Negative / Null Result ReportMedicine

The impact of clinical presentation on one-year major adverse cardiac events in patients with angiographically defined moderate to severe calcified coronary artery disease.

Mkrtchjan A, Ntantou E, Siskos AA et al. · 2026 · The Journal of invasive cardiology

Objectives The authors aimed to investigate the impact of clinical presentation on 1-year major adverse cardiac events (MACE) in patients with angiographically defined moderate or severe calcified coronary artery disease. Methods The…

View details →DOI: 10.25270/jic/26.00022
Negative / Null Result ReportMedicine

Influence of Personalized Advice on Cardiovascular Management in Childhood Cancer Survivors.

Frémont L, Casagranda L, Sudour-Bonnange H et al. · 2026 · Journal of adolescent and young adult oncology

Purpose This study aimed to evaluate the cardiovascular medical management of young adults who had viewed the massive open online course (MOOC) "Childhood Cancer, Living Well, After" four years earlier during the feasibility study…

View details →DOI: 10.1177/21565333261454210
Negative / Null Result ReportMedicine

In neonates, how effective is lung ultrasonography in directing chest physiotherapy intervention when compared to the combination of chest x-ray and auscultation?

Hough J, Gouveia M, Steele M et al. · 2026 · Physiotherapy

Objective Evaluate the impact of lung ultrasound (LUS) compared to current chest physiotherapy (CPT) outcome measures on clinical decision-making in the Neonatal Intensive Care Unit (NICU). Design and setting Single-centre prospective…

View details →DOI: 10.1016/j.physio.2026.102315
Negative / Null Result ReportOpen accessMedicine

Effect of cold atmospheric pressure plasma on wettability of implant prosthetic materials: an in-vitro study.

Bayadse M, Grander L, Steiner L et al. · 2026 · International journal of implant dentistry

Purpose Surface wettability is a key factor in bonding of dental materials. The aim of the present study was to investigate the influence of different exposure times of cold atmospheric pressure plasma at constant power on the surface…

View details →DOI: 10.1186/s40729-026-00685-3
Negative / Null Result ReportMedicine

Peri-Implant Reconstruction With Autogenous Bone and Electrolytic Therapy: A Randomized Controlled Clinical Trial.

Puisys A, Akhondi S, Vindasiute-Narbute E et al. · 2026 · Clinical implant dentistry and related research

Objectives To evaluate the efficacy of peri-implant reconstructive therapy using autogenous tuberosity bone grafts, with or without adjunctive electrolytic therapy, as part of surgical treatment for peri-implantitis. Methods This…

View details →DOI: 10.1111/cid.70123
Negative / Null Result ReportMedicine

How changes to frequency of treatment and mode of treatment improved paediatric speech-language pathology services: A pragmatic clinical trial.

Van Epps VM, Daur-Schierholz M, Dortenzio M et al. · 2026 · International journal of speech-language pathology

Purpose This pragmatic clinical trial examined the functional impact of a modified speech-language pathology intervention delivery model (including telepractice, reduced therapy frequency, and emphasised home programmes with parent…

View details →DOI: 10.1080/17549507.2026.2630835
Negative / Null Result ReportMedicine

Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration.

Dockery R, Zevallos M, McNulty C et al. · 2026 · Developmental biology

All eukaryotes possess the essential mRNA cap-binding protein eIF4E, which initiates translation. This protein is highly conserved, with versions from zebrafish and humans able to rescue yeast. All fish also have an ancestral eIF4E family,…

View details →DOI: 10.1016/j.ydbio.2026.02.014
Negative / Null Result ReportOpen accessMedicine

IgG4-related disease presenting as a gastric mass necessitating total gastrectomy: a case report.

Jiwane M, Karunanithy P, Goonawardhana D et al. · 2026 · Journal of surgical case reports

IgG4-related disease (IgG4-RD) is a multi-system disorder that rarely presents with gastric manifestations. A 26 year old woman presented with post-prandial symptoms of dyspepsia, dysphagia and reflux with a proximal submucosal gastric…

View details →DOI: 10.1093/jscr/rjag465
Negative / Null Result ReportMedicine

Post hoc Population Standardization of Trial Emulation Studies in Claims Data: An RCT-DUPLICATE Analysis.

Htoo PT, Patorno E, Schneeweiss S et al. · 2026 · Clinical pharmacology and therapeutics

Benchmarking evidence from nonrandomized healthcare database studies against randomized clinical trials could strengthen confidence that database studies can reproduce known trial results and extend analyses to questions not directly…

View details →DOI: 10.1002/cpt.70241
Negative / Null Result Report

Neurodevelopmental Outcomes in Infants with Non-Syndromic Trigonocephaly: A Comparative Study of Surgical and Non-Surgical Management

Yaghini O, Eslamian R, Abadi RNS et al. · 2026 · Preprint

Abstract Objective This study investigates the neurodevelopmental outcomes of infants with non-syndromic trigonocephaly managed surgically and conservatively. The aim is to assess whether earlier surgical intervention influences cognitive,…

View details →DOI: 10.21203/rs.3.rs-8631558/v1
Negative / Null Result ReportMedicine

Recombinant FSH as an alternative to pituitary-extracted FSH for superovulation and embryo production in sheep.

Martins BB, Arrais AM, Pinto PHN et al. · 2026 · Animal reproduction science

The aim of this study was to compare recombinant bovine FSH (rbFSH) with a conventional multiple-dose purified porcine FSH (pFSH) for in vivo embryo production in sheep. Forty multiparous Santa Inês ewes were randomly assigned to two…

View details →DOI: 10.1016/j.anireprosci.2026.108232
Negative / Null Result Report

The influence of verbalization versus imagery on trauma memory

Rupietta AE, Meyer T, Margraf J et al. · 2026 · Preprint

Background: Cognitive theories on trauma memory postulate that trauma-related intrusions are associated with more data-driven and less contextual processing. However, contextualisation can be enhanced via verbalization, suggesting that…

View details →DOI: 10.31234/osf.io/tcsre_v4
Negative / Null Result ReportMedicine

Evaluation of Short-Term Stall Size Housing on the Behavior and Welfare of Domestic Horses (Equus caballus).

Outouil M, Daugherity EK, Warnick LD et al. · 2026 · Journal of the American Association for Laboratory Animal Science : JAALAS

Single-stall housing is a common system used for horses in various settings, including racing stables, riding schools, teaching and research facilities. Adequate stall space is necessary for horses to lie down and make postural…

View details →DOI: 10.30802/aalas-jaalas-25-152
Negative / Null Result Report

The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae

Zwyssig M, Schneider J, Selten G et al. · 2026 · Preprint

The plant-beneficial bacterium Pseudomonas protegens CHA0 (CHA0) is widely studied for the biological control of soil-borne plant diseases. Beyond its root-colonising capabilities, CHA0 can also infect and kill insect larvae and thus…

View details →DOI: 10.64898/2026.03.19.712869
Negative / Null Result ReportMedicine

Is multimodal monitoring effective in detecting neurological changes in cases of severe idiopathic scoliosis after halo gravity traction?: a series of 70 patients.

Richard L, Vermersch AI, Saghbini E et al. · 2026 · Neurophysiologie clinique = Clinical neurophysiology

Objective Severe scoliosis, defined by a Cobb angle exceeding 80°, requires surgical correction and is associated with a high risk of postoperative neurological complications. These complications may be reduced by halo gravity traction…

View details →DOI: 10.1016/j.neucli.2026.103144
Negative / Null Result ReportMedicine

Pilot Testing a Narrative Psychoeducational Video to Reduce Stigma and Improve Mental Health Literacy and Help-Seeking Among Latinx Adults: Examining Gender Differences and Contextual Insights.

Saravia DH, Silvan YA, Martinez JI · 2026 · Community mental health journal

Despite similar rates of mental illness, non-Latinx Whites (NLW) received care at higher rates compared to Latinxs (National Institute of Mental Health, 2024). Latinx adults report lower mental health literacy (MHL) and higher stigma…

View details →DOI: 10.1007/s10597-025-01584-4
Negative / Null Result ReportMedicine

Behavioral Incentives for Exercise and Intra-Articular Glucocorticoids for Knee Osteoarthritis: Results From a Factorially Designed Pragmatic Randomized Clinical Trial.

Baker JF, Wysham KD, Quinones M et al. · 2026 · Arthritis & rheumatology (Hoboken, N.J.)

Objective The purpose of this study was to determine the benefit of a behaviorally designed incentive program and glucocorticoid injections in reducing symptoms and promoting physical activity in patients with knee osteoarthritis (KOA).…

View details →DOI: 10.1002/art.70176
Negative / Null Result ReportMedicine

Use of Er:YAG Laser for Disinfection of Infected Carious Dentin: Microbiological Evaluation and Scanning Electron Microscopy Analysis.

Marcondes Pinto MO, Arana-Chavez VE, Trevelin LT et al. · 2026 · Photobiomodulation, photomedicine, and laser surgery

Objective To evaluate the antimicrobial efficacy of Er:YAG laser for disinfection of softened carious dentin using subablative parameters. Background Current literature lacks robust scientific evidence supporting the use of Er:YAG laser…

View details →DOI: 10.1177/25785478261444876
Negative / Null Result ReportMedicine

Impact of Running Shoe Midsole Properties on Energy Cost of Running: Insights Into Midsole Stiffness and Resilience Properties.

Rodrigo-Carranza V, Alda-Blanco A, Kuzmeski J et al. · 2026 · International journal of sports physiology and performance

Purpose The mechanisms behind improvements in running economy (RE) from shoes with supercritical foams (SCF) compared with a traditional midsole material (ethylene vinyl acetate [EVA]) remain only partially understood. This study aimed to…

View details →DOI: 10.1123/ijspp.2025-0475
Negative / Null Result ReportMedicine

'Sawa Aqwa' (Stronger Together): A multi-site randomized controlled trial of a brief family systemic intervention for adolescent mental health in Lebanon.

Bosqui T, Brown FL, Farah S et al. · 2026 · Journal of child psychology and psychiatry, and allied disciplines

Background There are no evaluated family-based mental health and psychosocial support (MHPSS) interventions for adolescents in Southwest Asia (known as the Middle East), and few whole-family interventions in low- and middle-income…

View details →DOI: 10.1111/jcpp.70174
Negative / Null Result ReportMedicine

Treatment with elexacaftor/tezacaftor/ivacaftor does not alter SpiroNose-derived electronic breath profiles in children with cystic fibrosis.

Seidl E, Zikic A, Micic S et al. · 2026 · Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society

Background Breath profile analysis of volatile organic compounds (VOCs) by electronic nose (eNose) technology can distinguish between healthy individuals and people with cystic fibrosis (pwCF). It remains, however, unclear whether CFTR…

View details →DOI: 10.1016/j.jcf.2026.03.014
Negative / Null Result ReportMedicine

Effect of Successive Bleaching Treatments Followed by Staining on Color, Whiteness, and Translucency of Polymer-Based CAD-CAM Materials.

Ramos AC, Mascaro BA, Dos Santos Nunes Reis JM et al. · 2026 · Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.]

Objective To evaluate differences in color, whiteness, and translucency of CAD-CAM materials after successive bleaching treatments and coffee immersion. Materials and methods Lava Ultimate (LU) and VITA Enamic (VE) were divided into four…

View details →DOI: 10.1111/jerd.70168
Negative / Null Result ReportMedicine

Three Decades of Evidence on Pulsatile Cardiopulmonary Bypass in Pediatrics: No Significant Clinical Benefit.

Ündar A, Lussier MJ, Rajesh S et al. · 2026 · World journal for pediatric & congenital heart surgery

BackgroundDrawing on more than 30 years of valuable expertise in in-vitro, in-vivo, and clinical trials, we report the key findings of our institutional research on pulsatile cardiopulmonary bypass (CPB).MethodsA detailed search was…

View details →DOI: 10.1177/21501351251412887
Negative / Null Result ReportOpen accessMedicine

Impact of adding a medical intern to the emergency department night shift.

Glass-Biran AH, Eyre A, Stein G et al. · 2026 · BMJ open quality

Objective To evaluate whether adding a fourth physician to the emergency department night shift would improve metrics. Methods This retrospective cohort study used data from the Meir Medical Centre emergency department, 1 January 2021 to…

View details →DOI: 10.1136/bmjoq-2025-003648