A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.
19895 results in Negative / Null Result Report · page 584 of 664
Porter A, Nguyen J, Peng Y et al. · 2026 · The American journal of sports medicine
Background Intra-articular triamcinolone acetonide (TA) injections are commonly used to manage joint synovitis despite reports that they accelerate cartilage degeneration. Previous studies found that TA minimally affected bovine cartilage,…
Van de Perre E, Tielemans C, De Clerck D et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Background and hypothesis Hyperoxaluria is an important risk factor for kidney stone formation. Currently available treatment options for idiopathic hyperoxaluria have limited efficacy and are difficult to maintain in the long-term.…
Islam IS, McGetrick ME, Leon RL et al. · 2026 · The Annals of thoracic surgery
Background We implemented a preoperative screening brain magnetic resonance imaging (MRI) protocol for neonates undergoing cardiac surgery. The intent was to identify unrecognized central nervous system (CNS) injury that might alter the…
Tian Q, Tian B, Li K et al. · 2026 · Neurosurgical review
The effectiveness of surgical intervention for hydrocephalus in patients with prolonged disorders of consciousness (pDoC) remains controversial. To investigate the impact of ventriculoperitoneal shunt (VPS) on secondary hydrocephalus…
Rasmussen JJ, Bisgaard J, Hønge JL et al. · 2026 · Journal of cardiothoracic and vascular anesthesia
Objectives Managing pain after median sternotomy is a clinical challenge of balancing adequate pain relief with avoidance of excessive opioid consumption. While regional anesthesia techniques are increasingly recommended and applied in…
Tuzlali M, Baki N, Avcu GY et al. · 2026 · Preprint
Background: /Objectives: Full-arch zirconia prostheses for mandibular All-on-4 rehabilitations are provided as screw-retained monolithic zirconia or as a zirconia suprastructure luted to a CAD/CAM titanium bar. Because zirconia is a…
Thorpe A, Lee RA, Szymczak JE et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Antimicrobial resistance (AMR) is an urgent health threat. Effective communication about AMR and avoiding antibiotics for viral infections is a public health priority. Here, we evaluated whether comparing the AMR crisis to the…
Zelaya IO, Soto ORR, Ventura GPM et al. · 2026 · European journal of midwifery
Introduction Pain and anxiety are common during labor. Evidence on non-pharmacological tools like the peanut ball from public hospital settings in Honduras is limited. This study evaluated its efficacy in reducing pain and anxiety. Methods…
Placidi V, Lisi MP, Vabba A et al. · 2025 · Preprint
Although Mafia-type criminal organizations (MCOs) exert severe societal harm, evidence-based interventions fostering anti-mafia motives remain scarce. We investigated whether embodying virtual heroic characters enhances opposition to MCOs.…
Özmen S, Yurttaş A · 2026 · Behavioural neurology
The purpose of this study is to assess the impact of progressive muscle relaxation exercises on fatigue, stress, and quality of life among individuals with epilepsy. This study was conducted as a randomized controlled intervention,…
Zheng Z, Wang F, Wang X et al. · 2026 · British journal of anaesthesia
Background Myocardial injury after noncardiac surgery is associated with both short-term and long-term mortality. However, effective preventive strategies remain limited. Remote ischaemic preconditioning (RIPC) confers distinct early and…
Zhang YH, Xiao Y, Li YT et al. · 2026 · Drug design, development and therapy
Background Liposomal bupivacaine provides prolonged analgesia, but evidence for its efficacy in anterior quadratus lumborum block (QLB) for laparoscopic gynecological surgery remains limited. This study compared liposomal bupivacaine…
Su PL, Ho MF, Liu PH et al. · 2026 · The journal of ECT
Objectives Electroconvulsive therapy (ECT) provides rapid relief for severe psychiatric disorders, but its impact on hospital length of stay (LOS) remains unclear in Asian settings. We hypothesized that early ECT (≤7 d after admission)…
Aguirre BA, Mudrak EL, Wright AJ et al. · 2026 · Journal of Ecology.
Plant diversity in wild and agricultural plant communities has been shown to protect plant communities from pathogens, and the effects of many aspects of diversity (genetic diversity, species richness, evenness and their combination) on…
Sheng Q, Zhang P, Zhang T et al. · 2026 · Journal of investigative surgery : the official journal of the Academy of Surgical Research
Background Ischemic preconditioning of parathyroid glands (IPCP) is biologically plausible but clinical evidence is limited. In this single-center randomized trial (ChiCTR2000039788), we compared IPCP versus control during total…
Yoshimura M, Sakamoto S, Nakanishi T et al. · 2026 · International journal of obstetric anesthesia
Background Intravenous dexmedetomidine may be given to reduce shivering and discomfort during cesarean delivery under neuraxial anesthesia. Dexmedetomidine lowers heart rate and blood pressure, reduces catecholamine release, may have a…
Moreira SE, Debs AL, de Oliveira EH et al. · 2026 · Brazilian journal of physical therapy
Background Diastasis recti abdominis (DRA) is a common postpartum condition that can persist for months, impair abdominal function, and negatively affect quality of life. Despite its prevalence, there is no gold standard treatment.…
Su M, Saxon-Filipe S, Ahn C et al. · 2025 · Clinical breast cancer
Background Metaplastic breast carcinoma (MpBC) is an aggressive subtype of breast cancer that is usually resistant to chemotherapy. Few studies have analyzed the role of immunotherapy and other treatments in early stage MpBC. We identified…
Narayan P · 2025 · Indian journal of thoracic and cardiovascular surgery
Dual antiplatelet therapy (DAPT) is recommended after acute coronary syndrome (ACS), but evidence in coronary artery bypass graft (CABG) patients is limited. The TACSI (Dual Antiplatelet Therapy with Ticagrelor and Acetylsalicylic Acid…
Marr J, Meyers DJ, Ryan AM · 2026 · Health affairs (Project Hope)
The Centers for Medicare and Medicaid Services (CMS) is increasingly experimenting with prior authorization in traditional Medicare. In 2016, CMS began using pre-claim review, a prior authorization-like system in which claims are reviewed…
Liu S, Song X, Li D et al. · 2025 · Wetlands.
Constructed Wetland (CW) is a low-carbon, sustainable ecological treatment technology widely used for deep treatment of wastewater treatment plant tailwater. However, constrained by the lack of available carbon source in the tailwater, the…
Martínez-Ocón J, Pérez M, Calvo A et al. · 2026 · Journal of clinical anesthesia
Background Sedation during endoscopic retrograde cholangiopancreatography procedures (ERCP) increases the risk of hypoxemia and the need for respiratory support in high-risk patients. High flow nasal cannula (HFNC) provides humidified gas…
Diener J, Krafft J, Rayling S et al. · 2025 · Preprint
The global rise in nursing home (NH) populations presents substantial challenges, as residents frequently experience physical and cognitive decline, low physical activity, and high fall risk. This study evaluated the effectiveness of the…
Linares LAR, Martinez RCR, Carvalho VH et al. · 2026 · Preprint
Abstract Background and Objectives: Pain control after cardiac surgery remains suboptimal, and concerns about neuraxial techniques under anticoagulation limit the use of thoracic epidurals. The erector spinae plane (ESP) block offers a…
Michaan N, Michaan N, Laskov I et al. · 2026 · Journal of lower genital tract disease
Objectives Cervical conization (loop electrosurgical excision procedure) under local anesthesia is often associated with anxiety and procedural pain. Virtual reality (VR) glasses may enhance patient experience and reduce discomfort during…
Khun Jush B, Biswas MAAJ, Lim HJJ et al. · 2026 · Pancreas
Background Routine feeding tube (FT) placement during pancreaticoduodenectomy (PD) has not reduced complication rates. Nonetheless, FTs are often selectively placed in patients with poor nutritional status such as those with significant…
Bücken CA, Riesthuis P, Caon G et al. · 2026 · Memory (Hove, England)
False autobiographical memories can have serious implications in legal settings, where the case outcomes may hinge entirely on memory-based eyewitness testimony. This study investigated whether a sensitisation memory training could reduce…
Sato T · 2025 · Preprint
Background: Active-fluidics phacoemulsification can maintain anterior chamber stability at lower intraoperative intraocular pressure (IOP) levels. However, whether reducing IOP alone—without additional stabilizing technologies such as the…
Ruiz-Tagle C, Seguel R, Villarroel L et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bundled intervention designed to decrease respiratory exposure was feasible and would reduce…
Ringer AJ, Hanel RA, Baig AA et al. · 2025 · Journal of neurointerventional surgery
Background The optimal duration for dual antiplatelet therapy (DAPT) after stent-assisted coiling (SAC) of intracranial aneurysms is unclear. Longer-term therapy may reduce thrombotic complications but increase the risk of bleeding…