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Failure-mode index

Search what already failed

A searchable index of real negative results, null findings, and replication failures from the published literature — so you can learn what didn't work before repeating it.

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record (title, authors, DOI) compiled from open scholarly databases, with the abstract shown in full only where the paper is openly licensed (e.g. Creative Commons); otherwise a short excerpt is shown for reference under fair use. WASTE classifies each work by failure type; classifications are automated and approximate.

20261 results in Negative / Null Result Report · page 580 of 676

Negative / Null Result ReportMedicine

Postoperative duloxetine administration did not significantly modify overall pain trajectories following high tibial osteotomy: An open-label randomized controlled trial.

Sengoku M, Ogawa H, Nakamura Y et al. · 2026 · Journal of orthopaedic surgery (Hong Kong)

BackgroundDuloxetine is a potent analgesic that reduces pain associated with knee osteoarthritis. This study aimed to evaluate the analgesic effects of regular postoperative duloxetine after high tibial osteotomy (HTO) and its influence on…

View details →DOI: 10.1177/10225536261437327
Negative / Null Result ReportMedicine

Impact of resistant starch from high amylose wheat compared to inulin on human gut microbiota and host immune responses using an artificial colon associated to human leukocytes.

Couturier I, Denis S, Rossary A et al. · 2026 · Food chemistry

Cooked High Amylose Wheat (HAW) products are dietary sources of resistant starch (RS). While its effects on gut microbiota are known, links to immune responses remain unclear. This study evaluated the antioxidant and anti-inflammatory…

View details →DOI: 10.1016/j.foodchem.2026.149919
Negative / Null Result ReportMedicine

The efficacy of tranexamic acid in prevention and treatment of post-inflammatory hyperpigmentation: a pilot study.

Masood M, Lane B, Maghfour J et al. · 2026 · Clinical and experimental dermatology

Post-inflammatory hyperpigmentation (PIH) is a common complication following trauma or cutaneous inflammation, particularly affecting individuals with skin of colour. Tranexamic acid (TXA) is a lysine analogue with antifibrinolytic…

View details →DOI: 10.1093/ced/llag082
Negative / Null Result ReportMedicine

The impacts of public hospital compensation reform on the health workforce compensation and its structure: quasi-experimental evidence in China.

Zhao Y, Peng Z, Cao D et al. · 2026 · BMC health services research

Background The Chinese government piloted the public hospital's compensation system reform in 2017. It is important for policymakers to understand how this reform has affected the health workforce's compensation and its structure. We…

View details →DOI: 10.1186/s12913-026-14850-2
Negative / Null Result ReportMedicine

Beta cell function and insulin sensitivity during elexacaftor/tezacaftor/ivacaftor therapy in people with cystic fibrosis.

Zazzeron L, Grancini V, Trombetta M et al. · 2026 · Frontiers in endocrinology

Background Cystic fibrosis-related diabetes (CFRD) is the most common extra-pulmonary complication in adults with cystic fibrosis (CF) and is primarily driven by progressive beta-cell dysfunction. The impact of CFTR modulators,…

View details →DOI: 10.3389/fendo.2026.1774728
Negative / Null Result ReportMedicine

The renin angiotensin system in cognitive flexibility: Effects of single-dose losartan on task-switching in healthy volunteers.

Prasad D, Feltham G, De Giorgi R et al. · 2026 · Journal of psychopharmacology (Oxford, England)

Introduction Cognitive flexibility, defined as the ability to shift mental strategies when environmental demands change, may influence psychological well-being and psychiatric treatment outcomes. Research increasingly implicates the renin…

View details →DOI: 10.1177/02698811261456198
Negative / Null Result ReportMedicine

Pharmacokinetic Assessment of Atazanavir and Favipiravir Following Echinacea Supplementation: A Controlled Herb-Drug Interaction Investigation.

Gajula SNR, Kallam JS, Kanukolanu A et al. · 2026 · Biopharmaceutics & drug disposition

Echinacea is a widely used herbal supplement and is frequently co-administered with antiviral drugs, raising concerns regarding potential herb-drug interactions. This study evaluated the effect of repeated Echinacea administration on the…

View details →DOI: 10.1002/bdd.70034
Negative / Null Result ReportMedicine

Multitasking Across Physical and Virtual Displays: The Effect of Spatial Discontinuity and Task Load.

Zhang P, Iskandarani ME, Riggs S · 2026 · IEEE transactions on visualization and computer graphics

Optical see-through head-mounted displays (OST-HMDs) allow users to interact with both physical and virtual displays overlaid in the real world within augmented reality (AR) environments. When arranging these displays in space, spatial…

View details →DOI: 10.1109/tvcg.2026.3679118
Negative / Null Result Report

Ergothioneine, alone or combined with vitamin K2, vitamin D3 and magnesium L-threonate, attenuates bone turnover, inflammatory and oxidative disturbances in ovariectomized mice

Liu W, Tang Y, Ding W et al. · 2026 · Preprint

Purpose: Estrogen deficiency drives bone loss through a complex interplay of endocrine, oxidative, inflammatory, and bone-remodeling disturbances. Ergothioneine (EGT) is a diet-derived thiol/thione antioxidant, yet its effects on the…

View details →DOI: 10.64898/2026.06.23.734114
Negative / Null Result ReportMedicine

Short-term intraocular pressure changes following intravitreal aflibercept 8 mg versus 2 mg in diabetic macular edema: a prospective observational study.

Hoshiyama K, Hirano T, Sekiya E et al. · 2026 · Scientific reports

This prospective observational study evaluated short-term intraocular pressure (IOP) changes and safety following intravitreal injection of aflibercept 8 mg versus 2 mg in diabetic macular edema (DME). We included 40 eyes from 36 patients…

View details →DOI: 10.1038/s41598-026-55363-6
Negative / Null Result ReportMedicine

The impact of the vaginal birth after cesarean as a new delivery mode on quality of life, sexual function, sleep quality and urinary incontinence during the postpartum period and comparison with the results of vaginal birth and cesarean delivery.

Bektaş B, Ulusoy CO, Uslu H et al. · 2026 · International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

Objective In the present study, we aimed to evaluate the impact of vaginal birth after cesarean (VBAC) on quality of life, sexual function, sleep quality, and urinary incontinence and compare the results with those of vaginal birth (VB)…

View details →DOI: 10.1002/ijgo.71150
Negative / Null Result ReportMedicine

Postural threat influences reactive stepping characteristics at the single-step threshold, but not when a step is necessary.

Avalos MA, Shah S, Rosenblatt NJ · 2026 · Experimental brain research

Following a loss of balance, proper reactive responses are needed to avoid a fall. Efforts have focused on how physiological factors affect these responses, but few have addressed psychological states. One psychological factor of…

View details →DOI: 10.1007/s00221-026-07328-4
Negative / Null Result ReportMedicine

Comprehensive assessment of hyperoside: cytotoxic, anti-cancer, genoprotective, radical scavenging and computational toxicity properties through <i>in vitro</i> and <i>in silico</i> approaches.

Burgazli AY, Avuloglu Yilmaz E, Mamur S et al. · 2026 · Toxicology mechanisms and methods

Hyperoside (HYP), a plant-derived flavonoid, was evaluated for its cytotoxic, anti-cancer, genotoxic, antigenotoxic, and antioxidant properties, and potential mechanisms of action using an integrated in vitro and in silico approach.…

View details →DOI: 10.1080/15376516.2026.2691542
Negative / Null Result ReportMedicine

Mitigation of antibiotic resistance risk in aerobic sludge by zero-valent iron: From pathogen reduction to conjugation inhibition and network weakening.

Wu Y, Zhu L, Lin G et al. · 2026 · Bioresource technology

Antibiotic resistance genes (ARGs) are an increasing environmental and public health concern in wastewater treatment systems due to their persistence, mobility, and links to human bacterial pathogens (HBPs). In this study, aerobic…

View details →DOI: 10.1016/j.biortech.2026.135253
Negative / Null Result ReportMedicine

<i>SLC28A3 </i>expression and fludarabine-emergent autoimmune hemolytic anemia in chronic lymphocytic leukemia: A new player in an old equation.

Vukovic V, Karan-Djurasevic T, Antic D et al. · 2026 · Biomolecules & biomedicine

Fludarabine treatment in patients with chronic lymphocytic leukemia (CLL) has been associated with immune dysregulation and the development of autoimmune hemolytic anemia (AIHA). Prior research indicates a potential correlation between the…

View details →DOI: 10.17305/bb.2026.14208
Negative / Null Result ReportMedicine

A pilot, randomized, placebo-controlled trial of rimegepant on visceral sensation and symptoms in nonconstipation IBS pain.

Halawi H, Matar A, Wang I et al. · 2026 · American journal of physiology. Gastrointestinal and liver physiology

Visceral hypersensitivity is a pivotal mechanism in pain associated with irritable bowel syndrome (IBS). Calcitonin gene-related peptide (CGRP) is expressed by visceral afferents. The aim of this study was to evaluate the efficacy of…

View details →DOI: 10.1152/ajpgi.00394.2025
Negative / Null Result ReportMedicine

Increasing Intrinsic Protein Disorder Improves CD8+ Immunogenicity for a SARS CoV2 Vaccine Candidate Antigen.

Wan L, Xie B, Shuda M et al. · 2026 · Molecular therapy : the journal of the American Society of Gene Therapy

CD8+ T cell targeting of the conserved SARS CoV2 RNA-dependent RNA polymerase (RdRp, nsp12) may offer a means for cross-protection against diverse coronavirus strains. Native RdRp, however, displays primary sequence immunoevasion (PSI)…

View details →DOI: 10.1016/j.ymthe.2026.06.027
Negative / Null Result ReportMedicine

Initial static, pseudo-static, dynamic, and cognitive fit evaluation of three passive shoulder exoskeletons while performing simulated manufacturing tasks.

Abbasi D, Schall M, Acosta-Sojo Y et al. · 2026 · Applied ergonomics

Shoulder disorders have been associated with repetitive overhead work and manual lifting. Passive exoskeletons may reduce exposure to physical risk factors associated with shoulder injuries. This repeated-measures study evaluated the…

View details →DOI: 10.1016/j.apergo.2026.104809
Negative / Null Result ReportMedicine

Outcomes of transmediastinal esophagectomy for patients with esophagogastric junction cancers.

Sugawara K, Yagi K, Yajima S et al. · 2026 · International journal of clinical oncology

Purpose We aimed to evaluate the outcomes of transmediastinal esophagectomy (TME) for esophagogastric junction cancer (EGJC) patients. Methods We retrospectively reviewed patients who underwent TME for EGJC (Siewert Type II) between 2018…

View details →DOI: 10.1007/s10147-026-03068-1