Negative / Null Result ReportOpen accessMedicine
Correll CU, Durgam S, Kozauer SG et al. · 2026 · International clinical psychopharmacology
This Phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of lumateperone to treat bipolar depression. Patients (18-75 years) with bipolar I or bipolar II disorder experiencing a major depressive…
View details →DOI: 10.1097/yic.0000000000000597 Negative / Null Result ReportMedicine
Seybold U · 2018 · Deutsche medizinische Wochenschrift (1946)
Vaccination practices in Germany are driven by scientific developments and a complex regulatory environment. Some important developments in 2018 are described here: Starting in 2018 only quadrivalent influenza vaccines will be used for the…
View details →DOI: 10.1055/a-0638-9282 Negative / Null Result ReportOpen accessMedicine
Bremhorst A, Mills DS, Stolzlechner L et al. · 2021 · Frontiers in psychology
The inner brow raiser is a muscle movement that increases the size of the orbital cavity, leading to the appearance of so-called 'puppy dog eyes'. In domestic dogs, this expression was suggested to be enhanced by artificial selection and…
View details →DOI: 10.3389/fpsyg.2021.568935 Negative / Null Result ReportOpen accessMedicine
Mutale W, Freeborn K, Graybill LA et al. · 2021 · The Lancet. Global health
Background Testing men for HIV during their partner's pregnancy can guide couples-based HIV prevention and treatment, but testing rates remain low. We investigated a combination approach, using evidence-based strategies, to increase HIV…
View details →DOI: 10.1016/s2214-109x(21)00393-4 Negative / Null Result ReportOpen accessMedicine
Terpstra JA, van Beugen S, van der Vaart R et al. · 2026 · Internet interventions
Background Rheumatic and musculoskeletal diseases have a high burden. We aimed to evaluate the effectiveness of a therapist-guided internet-based cognitive-behavioral therapy (iCBT) on pain coping and secondary physical, psychological, and…
View details →DOI: 10.1016/j.invent.2026.100908 Negative / Null Result ReportMedicine
Wilkie DJ, Yao Y, Ezenwa MO et al. · 2020 · Journal of pain and symptom management
Context Unrelieved cancer pain at the end of life interferes with achieving patient-centered goals. Objective To compare effects of usual hospice care and PAINRelieveIt® on pain outcomes in patients and their lay caregivers. Methods In a…
View details →DOI: 10.1016/j.jpainsymman.2019.10.028 Negative / Null Result ReportMedicine
Pucha KA, Ma TC, York W et al. · 2023 · Parkinsonism & related disorders
Introduction Impaired autophagy is a pathogenic mechanism in the synucleinopathies. Sirolimus, a potent mTOR inhibitor and autophagy activator, had no beneficial effects in a randomized placebo-controlled trial in patients with multiple…
View details →DOI: 10.1016/j.parkreldis.2023.105821 Negative / Null Result ReportOpen accessMedicine
Thompson KP, Sykes J, Chandakkar P et al. · 2022 · Orphanet journal of rare diseases
Background Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel therapies for epistaxis…
View details →DOI: 10.1186/s13023-022-02539-8 Negative / Null Result ReportMedicine
Allen PM, Dedi S, Kumar D et al. · 2012 · Perception
We manipulated the accommodative response using positive and negative lenses to study any association between symptoms of pattern glare and accommodation. Two groups of eighteen young adults were selected from seventy-eight on the basis…
View details →DOI: 10.1068/p7390 Negative / Null Result ReportOpen accessMedicine
Regel A, Sepriano A, Baraliakos X et al. · 2017 · RMD open
To assess the efficacy and safety of non-biological therapies in patients with axial spondyloarthritis (axSpA) to inform the update of the Assessment of SpondyloArthritis international Society (ASAS)/European League Against Rheumatism…
View details →DOI: 10.1136/rmdopen-2016-000397 Negative / Null Result ReportOpen accessMedicine
Abdelrahman KM, Hackshaw KV · 2021 · Biomedicines
Neuropathic pain affects 7-10% of the population and is often ineffectively and incompletely treated. Although the gold standard for treatment of neuropathic pain includes tricyclic antidepressants (TCAs), serotonin-noradrenaline reuptake…
View details →DOI: 10.3390/biomedicines9060674 Negative / Null Result ReportOpen accessMedicine
Witzel S, Statland JM, Steinacker P et al. · 2024 · European journal of neurology
Background and purpose Rasagiline might be disease modifying in patients with amyotrophic lateral sclerosis (ALS). The aim was to evaluate the effect of rasagiline 2 mg/day on neurofilament light chain (NfL), a prognostic biomarker in ALS.…
View details →DOI: 10.1111/ene.16154 Negative / Null Result ReportMedicine
Kitchin SS, Lakshmanan S, Kinninger A et al. · 2023 · The British journal of cardiology
Atrial fibrillation (AF) is a common arrhythmia associated with poor outcomes. N-3 fatty acids have been shown to provide significant cardiovascular risk reduction, but they may exacerbate the risk of AF. The pathway by which N-3 fatty…
View details →DOI: 10.5837/bjc.2023.022 Negative / Null Result ReportOpen accessMedicine
Konishi K · 2024 · Entropy (Basel, Switzerland)
We comment on the so-called negative result experiments (also known as null measurements, interaction-free measurements, and so on) in quantum mechanics (QM), in the light of the new general understanding of the quantum-measurement…
View details →DOI: 10.3390/e26110958 Negative / Null Result ReportOpen accessMedicine
Yarnall S, Saben JL, Sun N et al. · 2025 · Journal of genetic counseling
This observational study aimed to capture patients' experiences after reviewing carrier screening (CS) and/or noninvasive prenatal cell-free DNA testing (NIPT) results with Natera's Educational Virtual Assistant (NEVA). Patients, partners…
View details →DOI: 10.1002/jgc4.70125 Negative / Null Result ReportMedicine
Van Der Pol B, Ippolito J, Gao R et al. · 2026 · Sexually transmitted diseases
Background Extragenital (oropharyngeal and anorectal) Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (or gonococci [GC]) infections are underdiagnosed. Here we report sensitivity and specificity estimates that were obtained from the…
View details →DOI: 10.1097/olq.0000000000002244 Negative / Null Result ReportMedicine
Ding JJ, Chiu CF, Su YT et al. · 2025 · Pediatric research
Background Maternal hypercalcemia is a rare but potentially serious cause of late-onset neonatal hypocalcemia. Data on the clinical characteristics and outcomes of mother-baby couplets with maternal hypercalcemia and subsequent neonatal…
View details →DOI: 10.1038/s41390-025-04577-x Negative / Null Result ReportMedicine
Džafić F, Ahmetović A, Čoloman N et al. · 2026 · International archives of allergy and immunology
Introduction Allergic rhinitis (AR) is a prevalent health concern. In Europe, 20-40% of the population is affected. Diagnostic methods include skin tests, measurement of serum immunoglobulin E (IgE), nasal smear for eosinophils, and…
View details →DOI: 10.1159/000548221 Negative / Null Result ReportOpen accessMedicine
Kohan R, Gil-Campesino H, García Rodríguez IO et al. · 2026 · Emerging infectious diseases
We report 2 cases of donor-derived Strongyloides stercoralis infection in renal transplant recipients. Despite initial negative serologic testing in donor samples, retrospective testing confirmed transmission. This report underscores the…
View details →DOI: 10.3201/eid3201.251483 Negative / Null Result ReportOpen accessMedicine
Le Duc W, Butler CR, Argyropoulos GPD et al. · 2025 · PLoS biology
Rodent and human data implicate the hippocampus in the arbitration of approach-avoidance conflict (AAC), which arises when an organism is confronted with a stimulus associated simultaneously with reward and punishment. Yet, the precise…
View details →DOI: 10.1371/journal.pbio.3003033 Negative / Null Result ReportOpen accessMedicine
Kim CK, Lee YR, Ong L et al. · 2022 · Journal of Alzheimer's disease : JAD
Given the acknowledged lack of success in Alzheimer's disease (AD) drug development over the past two decades, the objective of this review was to derive key insights from the myriad failures to inform future drug development. A systematic…
View details →DOI: 10.3233/jad-215699 Negative / Null Result ReportOpen accessMedicine
Li W, Bunch CM, Zackariya S et al. · 2025 · Scientific reports
Disordered hemostasis associated with life-threatening hemorrhage commonly afflicts patients in the emergency department, critical care unit, and perioperative settings. Rapid and sensitive hemostasis phenotyping is needed to guide…
View details →DOI: 10.1038/s41598-025-89737-z Negative / Null Result ReportOpen accessMedicine
Shepard S, Anderson JM, Heigle B et al. · 2023 · Journal of orthopaedic surgery and research
Purpose To our knowledge, no study has quantified the rate of discontinuation and nonpublication of randomized controlled trials (RCTs) regarding upper and lower extremity fractures. Methods We searched ClinicalTrials.gov on September 9th,…
View details →DOI: 10.1186/s13018-023-03698-5 Negative / Null Result ReportOpen accessMedicine
Finlay CJ, Jackson MJ, Fisher R et al. · 2024 · Journal of Parkinson's disease
Background Increased activity across corticostriatal glutamatergic synapses may contribute to L-DOPA-induced dyskinesia in Parkinson's disease. Given the weak efficacy and side-effect profile of amantadine, alternative strategies to reduce…
View details →DOI: 10.3233/jpd-230296 Negative / Null Result ReportOpen accessMedicine
Ghomrawi HMK, Marx RG, Pan TJ et al. · 2018 · Contemporary clinical trials communications
Publication of 2 (negative) randomized clinical trials (RCTs) in 2002 and 2008 demonstrating inefficacy of arthroscopic debridement of the knee (ADK) for osteoarthritis, and a 2004 national non-coverage Medicare determination, have…
View details →DOI: 10.1016/j.conctc.2017.11.011 Negative / Null Result ReportOpen accessMedicine
Pochon C, Laroye C, Kimmoun A et al. · 2023 · Frontiers in medicine
Background The COVID-19 pandemic caused a wave of acute respiratory distress syndrome (ARDS) with a high in-hospital mortality, especially in patients requiring invasive mechanical ventilation. Wharton Jelly-derived Mesenchymal Stromal…
View details →DOI: 10.3389/fmed.2023.1224865 Negative / Null Result ReportOpen accessMedicine
Goudman L, Jansen J, Vets N et al. · 2021 · Journal of clinical medicine
The increased awareness of discrepancies between self-reporting outcome measurements and objective outcome measurements within the field of neuromodulation has accelerated the search towards more objective measurements. The aim of this…
View details →DOI: 10.3390/jcm10132921 Negative / Null Result ReportMedicine
Sanderson C, Hardy J, Spruyt O et al. · 2013 · Journal of pain and symptom management
Placebo and nocebo effects are known to contribute significantly to the response to symptom control, including analgesia. Clinical trial methodologies using placebo controls are designed to identify the magnitude of these effects in the…
View details →DOI: 10.1016/j.jpainsymman.2012.12.005 Negative / Null Result ReportOpen accessMedicine
Farooqi AS, Guadagnolo BA, Mitra D et al. · 2023 · Current oncology (Toronto, Ont.)
Locoregional recurrence (LRR) is the predominant pattern of relapse and often the cause of death in patients with retroperitoneal sarcomas (RPS). As a result, reducing LRR is a critical objective for RPS patients. However, unlike soft…
View details →DOI: 10.3390/curroncol30010047 Negative / Null Result ReportOpen accessMedicine
Ou SL, Luo J, Wei H et al. · 2023 · Frontiers in pharmacology
Background: Evidence of efficacy and safety of programmed cell death 1 (PD-1) and programmed death ligand-1 (PD-L1) checkpoint inhibitors in oesophageal cancer (EC), gastric cancer (GC) and colorectal cancer (CRC) was inconsistent,…
View details →DOI: 10.3389/fphar.2023.1106961 